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Continuous evolution of SpCas9 variants compatible with non-G PAMs.
Miller SM, Wang T, Randolph PB, Arbab M, Shen MW, Huang TP, Matuszek Z, Newby GA, Rees HA, Liu DR. Miller SM, et al. Among authors: shen mw. Nat Biotechnol. 2020 Apr;38(4):471-481. doi: 10.1038/s41587-020-0412-8. Epub 2020 Feb 10. Nat Biotechnol. 2020. PMID: 32042170 Free PMC article.
Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.
Koblan LW, Arbab M, Shen MW, Hussmann JA, Anzalone AV, Doman JL, Newby GA, Yang D, Mok B, Replogle JM, Xu A, Sisley TA, Weissman JS, Adamson B, Liu DR. Koblan LW, et al. Among authors: shen mw. Nat Biotechnol. 2021 Nov;39(11):1414-1425. doi: 10.1038/s41587-021-00938-z. Epub 2021 Jun 28. Nat Biotechnol. 2021. PMID: 34183861 Free PMC article.
Machine learning based CRISPR gRNA design for therapeutic exon skipping.
Louie W, Shen MW, Tahiry Z, Zhang S, Worstell D, Cassa CA, Sherwood RI, Gifford DK. Louie W, et al. Among authors: shen mw. PLoS Comput Biol. 2021 Jan 8;17(1):e1008605. doi: 10.1371/journal.pcbi.1008605. eCollection 2021 Jan. PLoS Comput Biol. 2021. PMID: 33417623 Free PMC article.
Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis.
Xiao J, Jin R, Yu X, Shen M, Wagner JD, Pai A, Song C, Zhuang M, Klasfeld S, He C, Santos AM, Helliwell C, Pruneda-Paz JL, Kay SA, Lin X, Cui S, Garcia MF, Clarenz O, Goodrich J, Zhang X, Austin RS, Bonasio R, Wagner D. Xiao J, et al. Nat Genet. 2017 Oct;49(10):1546-1552. doi: 10.1038/ng.3937. Epub 2017 Aug 21. Nat Genet. 2017. PMID: 28825728 Free article.
67 results