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A method for the generation of human stem cell-derived alpha cells.
Peterson QP, Veres A, Chen L, Slama MQ, Kenty JHR, Hassoun S, Brown MR, Dou H, Duffy CD, Zhou Q, Matveyenko AV, Tyrberg B, Sörhede-Winzell M, Rorsman P, Melton DA. Peterson QP, et al. Among authors: tyrberg b. Nat Commun. 2020 May 7;11(1):2241. doi: 10.1038/s41467-020-16049-3. Nat Commun. 2020. PMID: 32382023 Free PMC article.
Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.
Skrtic S, Tyrberg B, Broberg M, Ericsson H, Schnecke V, Kjaer M, Hompesch M, Andersson EM, Ryberg E, Aivazidis A, Wennberg Huldt C, Löfgren L, Morrow L, Parkinson J, Rydén-Bergsten T, Watkins E, Sörhede Winzell M. Skrtic S, et al. Among authors: tyrberg b. PLoS One. 2018 Dec 17;13(12):e0208998. doi: 10.1371/journal.pone.0208998. eCollection 2018. PLoS One. 2018. PMID: 30557325 Free PMC article. Clinical Trial.
No direct effect of SGLT2 activity on glucagon secretion.
Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ. Kuhre RE, et al. Among authors: tyrberg b. Diabetologia. 2019 Jun;62(6):1011-1023. doi: 10.1007/s00125-019-4849-6. Epub 2019 Mar 22. Diabetologia. 2019. PMID: 30903205 Free PMC article.
The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β.
Khilji MS, Verstappen D, Dahlby T, Burstein Prause MC, Pihl C, Bresson SE, Bryde TH, Keller Andersen PA, Klindt K, Zivkovic D, Bousquet-Dubouch MP, Tyrberg B, Mandrup-Poulsen T, Marzec MT. Khilji MS, et al. Among authors: tyrberg b. PLoS One. 2020 Feb 13;15(2):e0222432. doi: 10.1371/journal.pone.0222432. eCollection 2020. PLoS One. 2020. PMID: 32053590 Free PMC article.
Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling.
Ghiasi SM, Dahlby T, Hede Andersen C, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, Klindt K, Cheta O, Perone MJ, Tyrberg B, Prats C, Barg S, Tengholm A, Arvan P, Mandrup-Poulsen T, Marzec MT. Ghiasi SM, et al. Among authors: tyrberg b. Diabetes. 2019 Apr;68(4):747-760. doi: 10.2337/db18-0671. Epub 2019 Jan 22. Diabetes. 2019. PMID: 30670477 Free PMC article.
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