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A method for the generation of human stem cell-derived alpha cells.
Peterson QP, Veres A, Chen L, Slama MQ, Kenty JHR, Hassoun S, Brown MR, Dou H, Duffy CD, Zhou Q, Matveyenko AV, Tyrberg B, Sörhede-Winzell M, Rorsman P, Melton DA. Peterson QP, et al. Among authors: Tyrberg B. Nat Commun. 2020 May 7;11(1):2241. doi: 10.1038/s41467-020-16049-3. Nat Commun. 2020. PMID: 32382023 Free PMC article.
Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.
Skrtic S, Tyrberg B, Broberg M, Ericsson H, Schnecke V, Kjaer M, Hompesch M, Andersson EM, Ryberg E, Aivazidis A, Wennberg Huldt C, Löfgren L, Morrow L, Parkinson J, Rydén-Bergsten T, Watkins E, Sörhede Winzell M. Skrtic S, et al. Among authors: Tyrberg B. PLoS One. 2018 Dec 17;13(12):e0208998. doi: 10.1371/journal.pone.0208998. eCollection 2018. PLoS One. 2018. PMID: 30557325 Free PMC article. Clinical Trial.
No direct effect of SGLT2 activity on glucagon secretion.
Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ. Kuhre RE, et al. Among authors: Tyrberg B. Diabetologia. 2019 Jun;62(6):1011-1023. doi: 10.1007/s00125-019-4849-6. Epub 2019 Mar 22. Diabetologia. 2019. PMID: 30903205 Free PMC article.
The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets.
Ghiasi SM, Hansen JB, Christensen DP, Tyrberg B, Mandrup-Poulsen T. Ghiasi SM, et al. Among authors: Tyrberg B. Int J Mol Sci. 2020 Jun 17;21(12):E4311. doi: 10.3390/ijms21124311. Int J Mol Sci. 2020. PMID: 32560352 Free article.
The No-Go and Nonsense-Mediated RNA Decay Pathways Are Regulated by Inflammatory Cytokines in Insulin-Producing Cells and Human Islets and Determine β-Cell Insulin Biosynthesis and Survival.
Ghiasi SM, Krogh N, Tyrberg B, Mandrup-Poulsen T. Ghiasi SM, et al. Among authors: Tyrberg B. Diabetes. 2018 Oct;67(10):2019-2037. doi: 10.2337/db18-0073. Epub 2018 Jul 31. Diabetes. 2018. PMID: 30065031 Free article.
Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.
Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F. Hao E, et al. Nat Med. 2006 Mar;12(3):310-6. doi: 10.1038/nm1367. Epub 2006 Feb 19. Nat Med. 2006. PMID: 16491084
The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β.
Khilji MS, Verstappen D, Dahlby T, Burstein Prause MC, Pihl C, Bresson SE, Bryde TH, Keller Andersen PA, Klindt K, Zivkovic D, Bousquet-Dubouch MP, Tyrberg B, Mandrup-Poulsen T, Marzec MT. Khilji MS, et al. Among authors: Tyrberg B. PLoS One. 2020 Feb 13;15(2):e0222432. doi: 10.1371/journal.pone.0222432. eCollection 2020. PLoS One. 2020. PMID: 32053590 Free PMC article.
Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice.
Kyriazis GA, Smith KR, Tyrberg B, Hussain T, Pratley RE. Kyriazis GA, et al. Endocrinology. 2014 Jun;155(6):2112-21. doi: 10.1210/en.2013-2015. Epub 2014 Apr 8. Endocrinology. 2014. PMID: 24712876 Free PMC article.
Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling.
Ghiasi SM, Dahlby T, Hede Andersen C, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, Klindt K, Cheta O, Perone MJ, Tyrberg B, Prats C, Barg S, Tengholm A, Arvan P, Mandrup-Poulsen T, Marzec MT. Ghiasi SM, et al. Among authors: Tyrberg B. Diabetes. 2019 Apr;68(4):747-760. doi: 10.2337/db18-0671. Epub 2019 Jan 22. Diabetes. 2019. PMID: 30670477 Free PMC article.
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