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Elafibranor upregulates the EMT-inducer S100A4 via PPARβ/δ.
Zhang M, Barroso E, Ruart M, Peña L, Peyman M, Aguilar-Recarte D, Montori-Grau M, Rada P, Cugat C, Montironi C, Zarei M, Jurado-Aguilar J, Camins A, Balsinde J, Valverde ÁM, Wahli W, Palomer X, Vázquez-Carrera M. Zhang M, et al. Among authors: wahli w. Biomed Pharmacother. 2023 Nov;167:115623. doi: 10.1016/j.biopha.2023.115623. Epub 2023 Sep 30. Biomed Pharmacother. 2023. PMID: 37783154 Free article.
Increased hepatic gluconeogenesis and type 2 diabetes mellitus.
Barroso E, Jurado-Aguilar J, Wahli W, Palomer X, Vázquez-Carrera M. Barroso E, et al. Among authors: wahli w. Trends Endocrinol Metab. 2024 Dec;35(12):1062-1077. doi: 10.1016/j.tem.2024.05.006. Epub 2024 May 29. Trends Endocrinol Metab. 2024. PMID: 38816269 Review.
PPARβ/δ prevents inflammation and fibrosis during diabetic cardiomyopathy.
Rostami A, Palomer X, Pizarro-Delgado J, Barroso E, Valenzuela-Alcaraz B, Crispi F, Nistal JF, Hurlé MA, García R, Wahli W, Vázquez-Carrera M. Rostami A, et al. Among authors: wahli w. Pharmacol Res. 2024 Dec;210:107515. doi: 10.1016/j.phrs.2024.107515. Epub 2024 Nov 20. Pharmacol Res. 2024. PMID: 39577755 Free article.
Targeting AMPK as a potential treatment for hepatic fibrosis in MASLD.
Palomer X, Wang JR, Escalona C, Wu S, Wahli W, Vázquez-Carrera M. Palomer X, et al. Among authors: wahli w. Trends Pharmacol Sci. 2025 Jun;46(6):551-566. doi: 10.1016/j.tips.2025.03.008. Epub 2025 Apr 28. Trends Pharmacol Sci. 2025. PMID: 40300935 Review.
348 results