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Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity.
Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N. Zanou N, et al. Nat Commun. 2021 Dec 10;12(1):7219. doi: 10.1038/s41467-021-27422-1. Nat Commun. 2021. PMID: 34893614 Free PMC article.
CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.
Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, Fajas L. Lopez-Mejia IC, et al. Mol Cell. 2017 Oct 19;68(2):336-349.e6. doi: 10.1016/j.molcel.2017.09.034. Mol Cell. 2017. PMID: 29053957 Free article.
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy.
Laurila PP, Luan P, Wohlwend M, Zanou N, Crisol B, Imamura de Lima T, Goeminne LJE, Gallart-Ayala H, Shong M, Ivanisevic J, Place N, Auwerx J. Laurila PP, et al. Sci Adv. 2022 Jan 28;8(4):eabh4423. doi: 10.1126/sciadv.abh4423. Epub 2022 Jan 28. Sci Adv. 2022. PMID: 35089797 Free PMC article.
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia.
Laurila PP, Wohlwend M, Imamura de Lima T, Luan P, Herzig S, Zanou N, Crisol B, Bou-Sleiman M, Porcu E, Gallart-Ayala H, Handzlik MK, Wang Q, Jain S, D'Amico D, Salonen M, Metallo CM, Kutalik Z, Eichmann TO, Place N, Ivanisevic J, Lahti J, Eriksson JG, Auwerx J. Laurila PP, et al. Nat Aging. 2022 Dec;2(12):1159-1175. doi: 10.1038/s43587-022-00309-6. Epub 2022 Dec 16. Nat Aging. 2022. PMID: 37118545
31 results