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Page 1
BIO101 in Sarcopenic Seniors at Risk of Mobility Disability: Results of a Double-Blind Randomised Interventional Phase 2b Trial.
Fielding RA, Dao MM, Cannon K, Desvarieux M, Miller SS, Gimness MP, Brandon DM, Villareal DT, Bruyere O, Bautmans I, Rickner K, Perry R, Kritchevsky SB, Musi N, Chehade JM, Kirstein JL, Gielen E, Pickrell P, Dilda P, Lafont R, Margalef C, Rolland Y, Del Signore S, Mariani J, Agus S, Tourette C, Dioh W, van Maanen R, Veillet S. Fielding RA, et al. Among authors: del signore s. J Cachexia Sarcopenia Muscle. 2025 Apr;16(2):e13750. doi: 10.1002/jcsm.13750. J Cachexia Sarcopenia Muscle. 2025. PMID: 40026058 Free PMC article. Clinical Trial.
Real-World Use of Trazodone in Older Persons in Long Term Care Setting: A Retrospective Study.
Coin A, Malara A, Noale M, Trevisan C, Devita M, Abbatecola AM, Gareri P, Del Signore S, Bellelli G, Fumagalli S, Monzani F, Mossello E, Volpato S, Zia G, Antonelli Incalzi R; GeroCovid Observational Working Group. Coin A, et al. Among authors: del signore s. Int J Geriatr Psychiatry. 2024 Nov;39(11):e70009. doi: 10.1002/gps.70009. Int J Geriatr Psychiatry. 2024. PMID: 39482555
Delirium Incidence and Predictors in SARS-CoV-2 Vaccinated Residents in Long-Term Care Facilities (LTCF): Insights from the GeroCovid Vax Study.
Okoye C, Zazzara MB, Ceolin C, Fedele G, Palmieri A, Abbatecola AM, Malara A, Trevisan C, Timmons S, Prato R, Fortunato F, Del Signore S, Bellelli G, Incalzi RA, Onder G, Coin A; GeroCovid Vax Working Group. Okoye C, et al. Among authors: del signore s. J Am Med Dir Assoc. 2024 Nov;25(11):105251. doi: 10.1016/j.jamda.2024.105251. Epub 2024 Sep 5. J Am Med Dir Assoc. 2024. PMID: 39245233 Free article.
ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles.
Dresselhaus EC, Harris KP, Blanchette CR, Koles K, Del Signore SJ, Pescosolido MF, Ermanoska B, Rozencwaig M, Soslowsky RC, Parisi MJ, Stewart BA, Mosca TJ, Rodal AA. Dresselhaus EC, et al. Among authors: del signore sj. J Cell Biol. 2024 Sep 2;223(9):e202405025. doi: 10.1083/jcb.202405025. Epub 2024 Jun 6. J Cell Biol. 2024. PMID: 38842573 Free PMC article.
ESCRT disruption provides evidence against transsynaptic signaling functions for extracellular vesicles.
Dresselhaus EC, Harris KP, Blanchette CR, Koles K, Del Signore SJ, Pescosolido MF, Ermanoska B, Rozencwaig M, Soslowsky RC, Parisi MJ, Stewart BA, Mosca TJ, Rodal AA. Dresselhaus EC, et al. Among authors: del signore sj. bioRxiv [Preprint]. 2024 May 5:2023.04.22.537920. doi: 10.1101/2023.04.22.537920. bioRxiv. 2024. Update in: J Cell Biol. 2024 Sep 2;223(9):e202405025. doi: 10.1083/jcb.202405025. PMID: 38746182 Free PMC article. Updated. Preprint.
Efficacy of COVID-19 control measures on post-vaccination outbreak in Italian Long Term Care Facilities: implications for policies.
Malara A, Noale M, Trevisan C, Abbatecola AM, Borselli G, Cafariello C, Gareri P, Fumagalli S, Mossello E, Volpato S, Monzani F, Coin A, Okoye C, Bellelli G, Del Signore S, Zia G, Antonelli Incalzi R, Palmieri A, Fedele G, Onder G; GeroCovid Vax Working Group. Malara A, et al. Among authors: del signore s. Front Public Health. 2023 Jun 6;11:1091974. doi: 10.3389/fpubh.2023.1091974. eCollection 2023. Front Public Health. 2023. PMID: 37346108 Free PMC article.
Clinical profile of trazodone users in a multisetting older population: data from the Italian GeroCovid Observational study.
Coin A, Noale M, Gareri P, Trevisan C, Bellio A, Fini F, Abbatecola AM, Del Signore S, Malara A, Mossello E, Fumagalli S, Volpato S, Monzani F, Bellelli G, Zia G, Incalzi RA; GeroCovid Observational Working Group. Coin A, et al. Among authors: del signore s. Eur Geriatr Med. 2023 Jun;14(3):465-476. doi: 10.1007/s41999-023-00790-1. Epub 2023 May 19. Eur Geriatr Med. 2023. PMID: 37204681 Free PMC article.
COVID-19 as a Paradigmatic Model of the Heterogeneous Disease Presentation in Older People: Data from the GeroCovid Observational Study.
Trevisan C, Remelli F, Fumagalli S, Mossello E, Okoye C, Bellelli G, Coin A, Malara A, Gareri P, Monzani F, Del Signore S, Zia G, Antonelli Incalzi R, Volpato S; GeroCovid Acute Ward Working Group. Trevisan C, et al. Among authors: del signore s. Rejuvenation Res. 2022 Jun;25(3):129-140. doi: 10.1089/rej.2021.0063. Epub 2022 Jun 6. Rejuvenation Res. 2022. PMID: 35570723
Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project).
Bernabei R, Landi F, Calvani R, Cesari M, Del Signore S, Anker SD, Bejuit R, Bordes P, Cherubini A, Cruz-Jentoft AJ, Di Bari M, Friede T, Gorostiaga Ayestarán C, Goyeau H, Jónsson PV, Kashiwa M, Lattanzio F, Maggio M, Mariotti L, Miller RR, Rodriguez-Mañas L, Roller-Wirnsberger R, Rýznarová I, Scholpp J, Schols AMWJ, Sieber CC, Sinclair AJ, Skalska A, Strandberg T, Tchalla A, Topinková E, Tosato M, Vellas B, von Haehling S, Pahor M, Roubenoff R, Marzetti E; SPRINTT consortium. Bernabei R, et al. Among authors: del signore s. BMJ. 2022 May 11;377:e068788. doi: 10.1136/bmj-2021-068788. BMJ. 2022. PMID: 35545258 Free PMC article. Clinical Trial.
Monitoring COVID-19 vaccine use in Italian long term care centers: The GeroCovid VAX study.
Abbatecola AM, Incalzi RA, Malara A, Palmieri A, Di Lonardo A, Fedele G, Stefanelli P, Borselli G, Russo M, Noale M, Fumagalli S, Gareri P, Mossello E, Trevisan C, Volpato S, Monzani F, Coin A, Bellelli G, Okoye C, Del Signore S, Zia G, Bottoni E, Cafariello C, Onder G; GeroCovid Vax Working Group. Abbatecola AM, et al. Among authors: del signore s. Vaccine. 2022 Apr 1;40(15):2324-2330. doi: 10.1016/j.vaccine.2022.02.064. Epub 2022 Feb 22. Vaccine. 2022. PMID: 35248424 Free PMC article.
Computed tomography findings and prognosis in older COVID-19 patients.
Okoye C, Finamore P, Bellelli G, Coin A, Del Signore S, Fumagalli S, Gareri P, Malara A, Mossello E, Trevisan C, Volpato S, Zia G, Monzani F, Incalzi RA. Okoye C, et al. Among authors: del signore s. BMC Geriatr. 2022 Mar 1;22(1):166. doi: 10.1186/s12877-022-02837-7. BMC Geriatr. 2022. PMID: 35227201 Free PMC article.
Clinical Features of SARS-CoV-2 Infection in Italian Long-Term Care Facilities: GeroCovid LTCFs Observational Study.
Malara A, Noale M, Abbatecola AM, Borselli G, Cafariello C, Fumagalli S, Gareri P, Mossello E, Trevisan C, Volpato S, Monzani F, Coin A, Bellelli G, Okoye C, Del Signore S, Zia G, Antonelli Incalzi R; GeroCovid LTCFs Working Group. Malara A, et al. Among authors: del signore s. J Am Med Dir Assoc. 2022 Jan;23(1):15-18. doi: 10.1016/j.jamda.2021.10.009. Epub 2021 Oct 23. J Am Med Dir Assoc. 2022. PMID: 34774494 Free PMC article. No abstract available.
Atrial fibrillation and COVID-19 in older patients: how disability contributes to shape the risk profile. An analysis of the GeroCovid registry.
Fumagalli S, Trevisan C, Del Signore S, Pelagalli G, Fumagalli C, Herbst A, Volpato S, Gareri P, Mossello E, Malara A, Monzani F, Okoye C, Coin A, Bellelli G, Zia G, Ungar A, Ranhoff AH, Antonelli Incalzi R; GeroCovid Working Group. Fumagalli S, et al. Among authors: del signore s. Aging Clin Exp Res. 2022 Jan;34(1):249-256. doi: 10.1007/s40520-021-02008-5. Epub 2021 Oct 30. Aging Clin Exp Res. 2022. PMID: 34716570 Free PMC article.
Management of Older Outpatients during the COVID-19 Pandemic: The GeroCovid Ambulatory Study.
Gareri P, Fumagalli S, Malara A, Mossello E, Trevisan C, Volpato S, Coin A, Calsolaro V, Bellelli G, Del Signore S, Zia G, Ranhoff AH, Incalzi RA; GeroCovid Ambulatory Study Group. Gareri P, et al. Among authors: del signore s. Gerontology. 2022;68(4):412-417. doi: 10.1159/000516969. Epub 2021 Jun 28. Gerontology. 2022. PMID: 34182557 Free PMC article.
COVID-19 and Atrial Fibrillation in Older Patients: Does Oral Anticoagulant Therapy Provide a Survival Benefit?-An Insight from the GeroCovid Registry.
Fumagalli S, Trevisan C, Del Signore S, Pelagalli G, Volpato S, Gareri P, Mossello E, Malara A, Monzani F, Coin A, Bellelli G, Zia G, Antonelli Incalzi R; GeroCovid Working Group. Fumagalli S, et al. Among authors: del signore s. Thromb Haemost. 2022 Jan;122(1):105-112. doi: 10.1055/a-1503-3875. Epub 2021 Jun 18. Thromb Haemost. 2022. PMID: 33962480
Assessing the impact of COVID-19 on the health of geriatric patients: The European GeroCovid Observational Study.
Trevisan C, Del Signore S, Fumagalli S, Gareri P, Malara A, Mossello E, Volpato S, Monzani F, Coin A, Bellelli G, Zia G, Ranhoff AH, Antonelli Incalzi R; GeroCovid Working Group. Trevisan C, et al. Among authors: del signore s. Eur J Intern Med. 2021 May;87:29-35. doi: 10.1016/j.ejim.2021.01.017. Epub 2021 Jan 31. Eur J Intern Med. 2021. PMID: 33573885 Free PMC article.
Are vaccines against COVID-19 tailored to the most vulnerable people?
Antonelli Incalzi R, Trevisan C, Del Signore S, Volpato S, Fumagalli S, Monzani F, Bellelli G, Gareri P, Mossello E, Malara A, Coin A, Zia G, Ranhoff AH. Antonelli Incalzi R, et al. Among authors: del signore s. Vaccine. 2021 Apr 22;39(17):2325-2327. doi: 10.1016/j.vaccine.2021.03.066. Epub 2021 Mar 22. Vaccine. 2021. PMID: 33810907 Free PMC article. No abstract available.
The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants.
Marzetti E, Cesari M, Calvani R, Msihid J, Tosato M, Rodriguez-Mañas L, Lattanzio F, Cherubini A, Bejuit R, Di Bari M, Maggio M, Vellas B, Dantoine T, Cruz-Jentoft AJ, Sieber CC, Freiberger E, Skalska A, Grodzicki T, Sinclair AJ, Topinkova E, Rýznarová I, Strandberg T, Schols AMWJ, Schols JMGA, Roller-Wirnsberger R, Jónsson PV, Ramel A, Del Signore S, Pahor M, Roubenoff R, Bernabei R, Landi F; SPRINTT Consortium. Marzetti E, et al. Among authors: del signore s. Exp Gerontol. 2018 Nov;113:48-57. doi: 10.1016/j.exger.2018.09.017. Epub 2018 Sep 24. Exp Gerontol. 2018. PMID: 30261246 Free article. Clinical Trial.
Implications of ICD-10 for Sarcopenia Clinical Practice and Clinical Trials: Report by the International Conference on Frailty and Sarcopenia Research Task Force.
Vellas B, Fielding RA, Bens C, Bernabei R, Cawthon PM, Cederholm T, Cruz-Jentoft AJ, Del Signore S, Donahue S, Morley J, Pahor M, Reginster JY, Rodriguez Mañas L, Rolland Y, Roubenoff R, Sinclair A, Cesari M. Vellas B, et al. Among authors: del signore s. J Frailty Aging. 2018;7(1):2-9. doi: 10.14283/jfa.2017.30. J Frailty Aging. 2018. PMID: 29412436
dOCRL maintains immune cell quiescence by regulating endosomal traffic.
Del Signore SJ, Biber SA, Lehmann KS, Heimler SR, Rosenfeld BH, Eskin TL, Sweeney ST, Rodal AA. Del Signore SJ, et al. PLoS Genet. 2017 Oct 13;13(10):e1007052. doi: 10.1371/journal.pgen.1007052. eCollection 2017 Oct. PLoS Genet. 2017. PMID: 29028801 Free PMC article.
Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial.
Cesari M, Landi F, Calvani R, Cherubini A, Di Bari M, Kortebein P, Del Signore S, Le Lain R, Vellas B, Pahor M, Roubenoff R, Bernabei R, Marzetti E; SPRINTT Consortium. Cesari M, et al. Among authors: del signore s. Aging Clin Exp Res. 2017 Feb;29(1):81-88. doi: 10.1007/s40520-016-0716-1. Epub 2017 Feb 10. Aging Clin Exp Res. 2017. PMID: 28188558
Erratum to: Making sense of big data in health research: towards an EU action plan.
Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, Bernal-Delgado E, Blomberg N, Bock C, Conesa A, Del Signore S, Delogne C, Devilee P, Di Meglio A, Eijkemans M, Flicek P, Graf N, Grimm V, Guchelaar HJ, Guo YK, Gut IG, Hanbury A, Hanif S, Hilgers RD, Honrado Á, Hose DR, Houwing-Duistermaat J, Hubbard T, Janacek SH, Karanikas H, Kievits T, Kohler M, Kremer A, Lanfear J, Lengauer T, Maes E, Meert T, Müller W, Nickel D, Oledzki P, Pedersen B, Petkovic M, Pliakos K, Rattray M, I Màs JR, Schneider R, Sengstag T, Serra-Picamal X, Spek W, Vaas LA, van Batenburg O, Vandelaer M, Varnai P, Villoslada P, Vizcaíno JA, Wubbe JP, Zanetti G. Auffray C, et al. Among authors: del signore s. Genome Med. 2016 Nov 7;8(1):118. doi: 10.1186/s13073-016-0376-y. Genome Med. 2016. PMID: 27821178 Free PMC article. No abstract available.
Making sense of big data in health research: Towards an EU action plan.
Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, Bernal-Delgado E, Blomberg N, Bock C, Conesa A, Del Signore S, Delogne C, Devilee P, Di Meglio A, Eijkemans M, Flicek P, Graf N, Grimm V, Guchelaar HJ, Guo YK, Gut IG, Hanbury A, Hanif S, Hilgers RD, Honrado Á, Hose DR, Houwing-Duistermaat J, Hubbard T, Janacek SH, Karanikas H, Kievits T, Kohler M, Kremer A, Lanfear J, Lengauer T, Maes E, Meert T, Müller W, Nickel D, Oledzki P, Pedersen B, Petkovic M, Pliakos K, Rattray M, I Màs JR, Schneider R, Sengstag T, Serra-Picamal X, Spek W, Vaas LA, van Batenburg O, Vandelaer M, Varnai P, Villoslada P, Vizcaíno JA, Wubbe JP, Zanetti G. Auffray C, et al. Among authors: del signore s. Genome Med. 2016 Jun 23;8(1):71. doi: 10.1186/s13073-016-0323-y. Genome Med. 2016. PMID: 27338147 Free PMC article.
Sarcopenia Trials in Specific Diseases: Report by the International Conference on Frailty and Sarcopenia Research Task Force.
Vellas B, Fielding R, Bhasin S, Cerreta F, Goodpaster B, Guralnik JM, Kritchevsky S, Legrand V, Forkin C, Magaziner J, Morley JE, Rodriguez-Manas L, Roubenoff R, Studenski S, Villareal DT, Cesari M; International Conference on Frailtyand Sarcopenia Research Task Force. Vellas B, et al. J Frailty Aging. 2016;5(4):194-200. doi: 10.14283/jfa.2016.110. J Frailty Aging. 2016. PMID: 27883164
From adaptive licensing to adaptive pathways: delivering a flexible life-span approach to bring new drugs to patients.
Eichler HG, Baird LG, Barker R, Bloechl-Daum B, Børlum-Kristensen F, Brown J, Chua R, Del Signore S, Dugan U, Ferguson J, Garner S, Goettsch W, Haigh J, Honig P, Hoos A, Huckle P, Kondo T, Le Cam Y, Leufkens H, Lim R, Longson C, Lumpkin M, Maraganore J, O'Rourke B, Oye K, Pezalla E, Pignatti F, Raine J, Rasi G, Salmonson T, Samaha D, Schneeweiss S, Siviero PD, Skinner M, Teagarden JR, Tominaga T, Trusheim MR, Tunis S, Unger TF, Vamvakas S, Hirsch G. Eichler HG, et al. Among authors: del signore s. Clin Pharmacol Ther. 2015 Mar;97(3):234-46. doi: 10.1002/cpt.59. Epub 2015 Feb 4. Clin Pharmacol Ther. 2015. PMID: 25669457 Free PMC article.
Biomarkers for Alzheimer's disease therapeutic trials.
Hampel H, Wilcock G, Andrieu S, Aisen P, Blennow K, Broich K, Carrillo M, Fox NC, Frisoni GB, Isaac M, Lovestone S, Nordberg A, Prvulovic D, Sampaio C, Scheltens P, Weiner M, Winblad B, Coley N, Vellas B; Oxford Task Force Group. Hampel H, et al. Prog Neurobiol. 2011 Dec;95(4):579-93. doi: 10.1016/j.pneurobio.2010.11.005. Epub 2010 Dec 2. Prog Neurobiol. 2011. PMID: 21130138 Review.
Fighting against age discrimination in clinical trials.
Cherubini A, Del Signore S, Ouslander J, Semla T, Michel JP. Cherubini A, et al. Among authors: del signore s. J Am Geriatr Soc. 2010 Sep;58(9):1791-6. doi: 10.1111/j.1532-5415.2010.03032.x. J Am Geriatr Soc. 2010. PMID: 20863340 Review.
Cardiac support devices.
Rodger M, McRae ME, Jaffer M, Bailey B, Del Signore S. Rodger M, et al. Among authors: del signore s. Prog Cardiovasc Nurs. 2009 Dec;24(4):169-80. doi: 10.1111/j.1751-7117.2009.00056.x. Prog Cardiovasc Nurs. 2009. PMID: 20002342 Review.
Towards harmonisation of outcome measures for DMD and SMA within TREAT-NMD; report of three expert workshops: TREAT-NMD/ENMC workshop on outcome measures, 12th--13th May 2007, Naarden, The Netherlands; TREAT-NMD workshop on outcome measures in experimental trials for DMD, 30th June--1st July 2007, Naarden, The Netherlands; conjoint Institute of Myology TREAT-NMD meeting on physical activity monitoring in neuromuscular disorders, 11th July 2007, Paris, France.
Mercuri E, Mayhew A, Muntoni F, Messina S, Straub V, Van Ommen GJ, Voit T, Bertini E, Bushby K; TREAT-NMD Neuromuscular Network. Mercuri E, et al. Neuromuscul Disord. 2008 Nov;18(11):894-903. doi: 10.1016/j.nmd.2008.07.003. Epub 2008 Sep 24. Neuromuscul Disord. 2008. PMID: 18818076 No abstract available.
Modulation of nucleosome dynamics in Huntington's disease.
Stack EC, Del Signore SJ, Luthi-Carter R, Soh BY, Goldstein DR, Matson S, Goodrich S, Markey AL, Cormier K, Hagerty SW, Smith K, Ryu H, Ferrante RJ. Stack EC, et al. Among authors: del signore sj. Hum Mol Genet. 2007 May 15;16(10):1164-75. doi: 10.1093/hmg/ddm064. Epub 2007 Apr 2. Hum Mol Genet. 2007. PMID: 17403718 Free article.
Switching from levodopa to the long-acting dopamine D2/D3 agonist piribedil reduces the expression of dyskinesia while maintaining effective motor activity in MPTP-treated primates.
Smith LA, Jackson MJ, Johnston L, Kuoppamaki M, Rose S, Al-Barghouthy G, Del Signore S, Jenner P. Smith LA, et al. Among authors: del signore s. Clin Neuropharmacol. 2006 May-Jun;29(3):112-25. doi: 10.1097/01.WNF.0000220818.71231.DF. Clin Neuropharmacol. 2006. PMID: 16772809
The Parkinson-Control study: a 1-year randomized, double-blind trial comparing piribedil (150 mg/day) with bromocriptine (25 mg/day) in early combination with levodopa in Parkinson's disease.
Castro-Caldas A, Delwaide P, Jost W, Merello M, Williams A, Lamberti P, Aguilar M, Del Signore S, Cesaro P; Parkinson-Control Study Group. Castro-Caldas A, et al. Among authors: del signore s. Mov Disord. 2006 Apr;21(4):500-9. doi: 10.1002/mds.20750. Mov Disord. 2006. PMID: 16267842 Clinical Trial.
Early development of patella infera after knee fractures.
Mariani PP, Del Signore S, Perugia L. Mariani PP, et al. Among authors: del signore s. Knee Surg Sports Traumatol Arthrosc. 1994;2(3):166-9. doi: 10.1007/BF01467919. Knee Surg Sports Traumatol Arthrosc. 1994. PMID: 7584199