Langmann T - Search Results

1

The AhR ligand 2, 2'-aminophenyl indole (2AI) regulates microglia homeostasis and reduces pro-inflammatory signaling.

Khan AS, Wolf A, Langmann T. Khan AS, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2021 Nov 19;579:15-21. doi: 10.1016/j.bbrc.2021.09.054. Epub 2021 Sep 23. Biochem Biophys Res Commun. 2021. PMID: 34583190 Free article.

2

Induction of STAP-1 promotes neurotoxic activation of microglia.

Stoecker K, Weigelt K, Ebert S, Karlstetter M, Walczak Y, Langmann T. Stoecker K, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2009 Jan 30;379(1):121-6. doi: 10.1016/j.bbrc.2008.12.021. Epub 2008 Dec 17. Biochem Biophys Res Commun. 2009. PMID: 19100238

3

Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia.

Aslanidis A, Karlstetter M, Scholz R, Fauser S, Neumann H, Fried C, Pietsch M, Langmann T. Aslanidis A, et al. Among authors: langmann t. J Neuroinflammation. 2015 Apr 19;12:77. doi: 10.1186/s12974-015-0296-6. J Neuroinflammation. 2015. PMID: 25928566 Free PMC article.

4

Acid sphingomyelinase (aSMase) deficiency leads to abnormal microglia behavior and disturbed retinal function.

Dannhausen K, Karlstetter M, Caramoy A, Volz C, Jägle H, Liebisch G, Utermöhlen O, Langmann T. Dannhausen K, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2015 Aug 21;464(2):434-40. doi: 10.1016/j.bbrc.2015.06.133. Epub 2015 Jun 27. Biochem Biophys Res Commun. 2015. PMID: 26129774

5

Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration.

Scholz R, Sobotka M, Caramoy A, Stempfl T, Moehle C, Langmann T. Scholz R, et al. Among authors: langmann t. J Neuroinflammation. 2015 Nov 17;12:209. doi: 10.1186/s12974-015-0431-4. J Neuroinflammation. 2015. PMID: 26576678 Free PMC article.

6

Retinal expression and localization of Mef2c support its important role in photoreceptor gene expression.

Wolf A, Aslanidis A, Langmann T. Wolf A, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2017 Jan 29;483(1):346-351. doi: 10.1016/j.bbrc.2016.12.141. Epub 2016 Dec 23. Biochem Biophys Res Commun. 2017. PMID: 28017720

7

Activated microglia trigger inflammasome activation and lysosomal destabilization in human RPE cells.

Nebel C, Aslanidis A, Rashid K, Langmann T. Nebel C, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2017 Mar 11;484(3):681-686. doi: 10.1016/j.bbrc.2017.01.176. Epub 2017 Feb 1. Biochem Biophys Res Commun. 2017. PMID: 28159556

8

Resveratrol induces dynamic changes to the microglia transcriptome, inhibiting inflammatory pathways and protecting against microglia-mediated photoreceptor apoptosis.

Wiedemann J, Rashid K, Langmann T. Wiedemann J, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2018 Jun 18;501(1):239-245. doi: 10.1016/j.bbrc.2018.04.223. Epub 2018 May 4. Biochem Biophys Res Commun. 2018. PMID: 29723528

9

Microglia Activation and Immunomodulatory Therapies for Retinal Degenerations.

Rashid K, Wolf A, Langmann T. Rashid K, et al. Among authors: langmann t. Front Cell Neurosci. 2018 Jun 21;12:176. doi: 10.3389/fncel.2018.00176. eCollection 2018. Front Cell Neurosci. 2018. PMID: 29977192 Free PMC article. Review.

10

Transcriptional regulation of Translocator protein (18 kDa) (TSPO) in microglia requires Pu.1, Ap1 and Sp factors.

Rashid K, Geissl L, Wolf A, Karlstetter M, Langmann T. Rashid K, et al. Among authors: langmann t. Biochim Biophys Acta Gene Regul Mech. 2018 Dec;1861(12):1119-1133. doi: 10.1016/j.bbagrm.2018.10.018. Epub 2018 Nov 6. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 30412797

11

Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina.

Balser C, Wolf A, Herb M, Langmann T. Balser C, et al. Among authors: langmann t. J Neuroinflammation. 2019 Feb 7;16(1):26. doi: 10.1186/s12974-019-1419-2. J Neuroinflammation. 2019. PMID: 30732627 Free PMC article.

12

Anti-VEGF-A/ANG2 combotherapy limits pathological angiogenesis in the eye: a replication study.

Wolf A, Langmann T. Wolf A, et al. Among authors: langmann t. EMBO Mol Med. 2019 May;11(5):e10362. doi: 10.15252/emmm.201910362. EMBO Mol Med. 2019. PMID: 31040129 Free PMC article.

13

Microglia in Retinal Degeneration.

Rashid K, Akhtar-Schaefer I, Langmann T. Rashid K, et al. Among authors: langmann t. Front Immunol. 2019 Aug 20;10:1975. doi: 10.3389/fimmu.2019.01975. eCollection 2019. Front Immunol. 2019. PMID: 31481963 Free PMC article. Review.

14

The role of lymphocytes and phagocytes in age-related macular degeneration (AMD).

Behnke V, Wolf A, Langmann T. Behnke V, et al. Among authors: langmann t. Cell Mol Life Sci. 2020 Mar;77(5):781-788. doi: 10.1007/s00018-019-03419-4. Epub 2020 Jan 2. Cell Mol Life Sci. 2020. PMID: 31897541 Free PMC article. Review.

15

Translocator protein (18 kDa) (TSPO) ligands activate Nrf2 signaling and attenuate inflammatory responses and oxidative stress in human retinal pigment epithelial cells.

Rashid K, Verhoyen M, Taiwo M, Langmann T. Rashid K, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2020 Jul 23;528(2):261-268. doi: 10.1016/j.bbrc.2020.05.114. Epub 2020 May 29. Biochem Biophys Res Commun. 2020. PMID: 32482385 Free article.

16

The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye.

Wolf A, Herb M, Schramm M, Langmann T. Wolf A, et al. Among authors: langmann t. Nat Commun. 2020 Jun 1;11(1):2709. doi: 10.1038/s41467-020-16400-8. Nat Commun. 2020. PMID: 32483169 Free PMC article.

17

Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration.

Khan AS, Langmann T. Khan AS, et al. Among authors: langmann t. J Neuroinflammation. 2020 Nov 3;17(1):327. doi: 10.1186/s12974-020-01999-8. J Neuroinflammation. 2020. PMID: 33143743 Free PMC article.

18

Microglia and Inflammatory Responses in Diabetic Retinopathy.

Kinuthia UM, Wolf A, Langmann T. Kinuthia UM, et al. Among authors: langmann t. Front Immunol. 2020 Nov 6;11:564077. doi: 10.3389/fimmu.2020.564077. eCollection 2020. Front Immunol. 2020. PMID: 33240260 Free PMC article. Review.

19

PDGF Receptor Alpha Signaling Is Key for Müller Cell Homeostasis Functions.

Díaz-Lezama N, Wolf A, Koch S, Pfaller AM, Biber J, Guillonneau X, Langmann T, Grosche A. Díaz-Lezama N, et al. Among authors: langmann t. Int J Mol Sci. 2021 Jan 25;22(3):1174. doi: 10.3390/ijms22031174. Int J Mol Sci. 2021. PMID: 33503976 Free PMC article.

20

Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration.

Tabel M, Wolf A, Szczepan M, Xu H, Jägle H, Moehle C, Chen M, Langmann T. Tabel M, et al. Among authors: langmann t. J Neuroinflammation. 2022 Sep 17;19(1):229. doi: 10.1186/s12974-022-02589-6. J Neuroinflammation. 2022. PMID: 36115971 Free PMC article.

21

High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes.

Neumeier M, Sigruener A, Eggenhofer E, Weigert J, Weiss TS, Schaeffler A, Schlitt HJ, Aslanidis C, Piso P, Langmann T, Schmitz G, Schölmerich J, Buechler C. Neumeier M, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2007 Jan 12;352(2):543-8. doi: 10.1016/j.bbrc.2006.11.058. Epub 2006 Nov 20. Biochem Biophys Res Commun. 2007. PMID: 17129575

22

Microglia activation in retinal degeneration.

Langmann T. Langmann T. J Leukoc Biol. 2007 Jun;81(6):1345-51. doi: 10.1189/jlb.0207114. Epub 2007 Apr 3. J Leukoc Biol. 2007. PMID: 17405851 Review.

23

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis.

Karlstetter M, Nothdurfter C, Aslanidis A, Moeller K, Horn F, Scholz R, Neumann H, Weber BH, Rupprecht R, Langmann T. Karlstetter M, et al. Among authors: langmann t. J Neuroinflammation. 2014 Jan 8;11:3. doi: 10.1186/1742-2094-11-3. J Neuroinflammation. 2014. PMID: 24397957 Free PMC article.

24

Microglia in the aging retina.

Karlstetter M, Langmann T. Karlstetter M, et al. Among authors: langmann t. Adv Exp Med Biol. 2014;801:207-12. doi: 10.1007/978-1-4614-3209-8_27. Adv Exp Med Biol. 2014. PMID: 24664700 Review.

25

Retinal microglia: just bystander or target for therapy?

Karlstetter M, Scholz R, Rutar M, Wong WT, Provis JM, Langmann T. Karlstetter M, et al. Among authors: langmann t. Prog Retin Eye Res. 2015 Mar;45:30-57. doi: 10.1016/j.preteyeres.2014.11.004. Epub 2014 Dec 2. Prog Retin Eye Res. 2015. PMID: 25476242 Review.

26

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration.

Scholz R, Caramoy A, Bhuckory MB, Rashid K, Chen M, Xu H, Grimm C, Langmann T. Scholz R, et al. Among authors: langmann t. J Neuroinflammation. 2015 Nov 2;12:201. doi: 10.1186/s12974-015-0422-5. J Neuroinflammation. 2015. PMID: 26527153 Free PMC article.

27

Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro.

Madeira MH, Rashid K, Ambrósio AF, Santiago AR, Langmann T. Madeira MH, et al. Among authors: langmann t. Sci Rep. 2018 Feb 2;8(1):2272. doi: 10.1038/s41598-018-20733-2. Sci Rep. 2018. PMID: 29396515 Free PMC article.

28

Microglia Analysis in Retinal Degeneration Mouse Models.

Dannhausen K, Rashid K, Langmann T. Dannhausen K, et al. Among authors: langmann t. Methods Mol Biol. 2018;1753:159-166. doi: 10.1007/978-1-4939-7720-8_10. Methods Mol Biol. 2018. PMID: 29564787

29

IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration.

Behnke V, Langmann T. Behnke V, et al. Among authors: langmann t. Biochem Biophys Rep. 2020 Nov 26;24:100866. doi: 10.1016/j.bbrep.2020.100866. eCollection 2020 Dec. Biochem Biophys Rep. 2020. PMID: 33299932 Free PMC article.

30

VEGFR1 signaling in retinal angiogenesis and microinflammation.

Uemura A, Fruttiger M, D'Amore PA, De Falco S, Joussen AM, Sennlaub F, Brunck LR, Johnson KT, Lambrou GN, Rittenhouse KD, Langmann T. Uemura A, et al. Among authors: langmann t. Prog Retin Eye Res. 2021 Sep;84:100954. doi: 10.1016/j.preteyeres.2021.100954. Epub 2021 Feb 25. Prog Retin Eye Res. 2021. PMID: 33640465 Free PMC article. Review.

31

MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia.

Hansen JN, Brückner M, Pietrowski MJ, Jikeli JF, Plescher M, Beckert H, Schnaars M, Fülle L, Reitmeier K, Langmann T, Förster I, Boche D, Petzold GC, Halle A. Hansen JN, et al. Among authors: langmann t. Mol Biol Cell. 2022 Sep 15;33(11):ar99. doi: 10.1091/mbc.E21-11-0585. Epub 2022 Jun 22. Mol Biol Cell. 2022. PMID: 35731557 Free PMC article.

32

Transcriptomic profiling identifies a PU.1 regulatory network in macrophages.

Weigelt K, Lichtinger M, Rehli M, Langmann T. Weigelt K, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2009 Mar 6;380(2):308-12. doi: 10.1016/j.bbrc.2009.01.067. Epub 2009 Jan 22. Biochem Biophys Res Commun. 2009. PMID: 19167354

33

Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization.

Lückoff A, Caramoy A, Scholz R, Prinz M, Kalinke U, Langmann T. Lückoff A, et al. Among authors: langmann t. EMBO Mol Med. 2016 Jun 1;8(6):670-8. doi: 10.15252/emmm.201505994. Print 2016 Jun. EMBO Mol Med. 2016. PMID: 27137488 Free PMC article.

34

Crocin, a plant-derived carotenoid, modulates microglial reactivity.

Yorgun MA, Rashid K, Aslanidis A, Bresgen C, Dannhausen K, Langmann T. Yorgun MA, et al. Among authors: langmann t. Biochem Biophys Rep. 2017 Oct 2;12:245-250. doi: 10.1016/j.bbrep.2017.09.007. eCollection 2017 Dec. Biochem Biophys Rep. 2017. PMID: 29214225 Free PMC article.

35

Immunomodulation with minocycline rescues retinal degeneration in juvenile neuronal ceroid lipofuscinosis mice highly susceptible to light damage.

Dannhausen K, Möhle C, Langmann T. Dannhausen K, et al. Among authors: langmann t. Dis Model Mech. 2018 Sep 5;11(9):dmm033597. doi: 10.1242/dmm.033597. Dis Model Mech. 2018. PMID: 30042155 Free PMC article.

36

Modulation of three key innate immune pathways for the most common retinal degenerative diseases.

Akhtar-Schäfer I, Wang L, Krohne TU, Xu H, Langmann T. Akhtar-Schäfer I, et al. Among authors: langmann t. EMBO Mol Med. 2018 Oct;10(10):e8259. doi: 10.15252/emmm.201708259. EMBO Mol Med. 2018. PMID: 30224384 Free PMC article. Review.

37

Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype.

Laffer B, Bauer D, Wasmuth S, Busch M, Jalilvand TV, Thanos S, Meyer Zu Hörste G, Loser K, Langmann T, Heiligenhaus A, Kasper M. Laffer B, et al. Among authors: langmann t. Front Cell Neurosci. 2019 Oct 9;13:430. doi: 10.3389/fncel.2019.00430. eCollection 2019. Front Cell Neurosci. 2019. PMID: 31649508 Free PMC article.

38

AMD-Associated HTRA1 Variants Do Not Influence TGF-β Signaling in Microglia.

Akhtar-Schaefer I, Reuten R, Koch M, Pietsch M, Langmann T. Akhtar-Schaefer I, et al. Among authors: langmann t. Adv Exp Med Biol. 2019;1185:3-7. doi: 10.1007/978-3-030-27378-1_1. Adv Exp Med Biol. 2019. PMID: 31884580

39

Phenotypic Differences in Primary Murine Microglia Treated with NOD1, NOD2, and NOD1/2 Agonists.

Wasmuth S, Jalilvand TV, Laffer B, Busch M, Bauer D, Langmann T, Thanos S, Kasper M, Heiligenhaus A. Wasmuth S, et al. Among authors: langmann t. J Mol Neurosci. 2020 Apr;70(4):600-609. doi: 10.1007/s12031-019-01466-x. Epub 2020 Jan 7. J Mol Neurosci. 2020. PMID: 31907866

40

Cytokine signaling as key regulator of pathological angiogenesis in the eye.

Langmann T. Langmann T. EBioMedicine. 2021 Nov;73:103662. doi: 10.1016/j.ebiom.2021.103662. Epub 2021 Oct 28. EBioMedicine. 2021. PMID: 34740107 Free PMC article. No abstract available.

41

Differentiation-dependent expression of a human carboxylesterase in monocytic cells and transcription factor binding to the promoter.

Langmann T, Aslanidis C, Schuierer M, Schmitz G. Langmann T, et al. Biochem Biophys Res Commun. 1997 Jan 3;230(1):215-9. doi: 10.1006/bbrc.1996.5912. Biochem Biophys Res Commun. 1997. PMID: 9020049

42

Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver.

Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G. Schwer H, et al. Among authors: langmann t. Biochem Biophys Res Commun. 1997 Apr 7;233(1):117-20. doi: 10.1006/bbrc.1997.6413. Biochem Biophys Res Commun. 1997. PMID: 9144407

43

Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.

Langmann T, Klucken J, Reil M, Liebisch G, Luciani MF, Chimini G, Kaminski WE, Schmitz G. Langmann T, et al. Biochem Biophys Res Commun. 1999 Apr 2;257(1):29-33. doi: 10.1006/bbrc.1999.0406. Biochem Biophys Res Commun. 1999. PMID: 10092505

44

Isomer specific effects of Conjugated Linoleic Acid on macrophage ABCG1 transcription by a SREBP-1c dependent mechanism.

Ecker J, Langmann T, Moehle C, Schmitz G. Ecker J, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2007 Jan 19;352(3):805-11. doi: 10.1016/j.bbrc.2006.11.087. Epub 2006 Nov 27. Biochem Biophys Res Commun. 2007. PMID: 17141191

45

Murine Müller cells are progenitor cells for neuronal cells and fibrous tissue cells.

Florian C, Langmann T, Weber BH, Morsczeck C. Florian C, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2008 Sep 19;374(2):187-91. doi: 10.1016/j.bbrc.2008.06.119. Epub 2008 Jul 9. Biochem Biophys Res Commun. 2008. PMID: 18619415

46

Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo.

Langmann T, Ebert S, Walczak Y, Weigelt K, Ehrengruber MU, Stiewe T, Weber BH. Langmann T, et al. Neuromolecular Med. 2009;11(2):87-96. doi: 10.1007/s12017-009-8061-6. Epub 2009 Apr 14. Neuromolecular Med. 2009. PMID: 19365618

47

Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells.

Storti F, Raphael G, Griesser V, Klee K, Drawnel F, Willburger C, Scholz R, Langmann T, von Eckardstein A, Fingerle J, Grimm C, Maugeais C. Storti F, et al. Among authors: langmann t. Exp Eye Res. 2017 Dec;165:65-77. doi: 10.1016/j.exer.2017.09.008. Epub 2017 Sep 21. Exp Eye Res. 2017. PMID: 28943268

48

Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina.

Beck SC, Karlstetter M, Garcia Garrido M, Feng Y, Dannhausen K, Mühlfriedel R, Sothilingam V, Seebauer B, Berger W, Hammes HP, Seeliger MW, Langmann T. Beck SC, et al. Among authors: langmann t. Sci Rep. 2018 Apr 13;8(1):5970. doi: 10.1038/s41598-018-24476-y. Sci Rep. 2018. PMID: 29654250 Free PMC article.

49

Systemic knockout of Tspo in mice does not affect retinal morphology, function and susceptibility to degeneration.

Klee K, Storti F, Barben M, Samardzija M, Langmann T, Dunaief J, Grimm C. Klee K, et al. Among authors: langmann t. Exp Eye Res. 2019 Nov;188:107816. doi: 10.1016/j.exer.2019.107816. Epub 2019 Sep 25. Exp Eye Res. 2019. PMID: 31562844 Free article.

50

Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily.

Ritter M, Buechler C, Langmann T, Schmitz G. Ritter M, et al. Among authors: langmann t. Biochem Biophys Res Commun. 1999 Jul 5;260(2):466-74. doi: 10.1006/bbrc.1999.0866. Biochem Biophys Res Commun. 1999. PMID: 10403791

51

Induction of Raf kinase inhibitor protein contributes to macrophage differentiation.

Schuierer MM, Heilmeier U, Boettcher A, Ugocsai P, Bosserhoff AK, Schmitz G, Langmann T. Schuierer MM, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1083-7. doi: 10.1016/j.bbrc.2006.02.083. Epub 2006 Feb 23. Biochem Biophys Res Commun. 2006. PMID: 16513087

52

A Circulating MicroRNA Profile in a Laser-Induced Mouse Model of Choroidal Neovascularization.

Kiel C, Berber P, Karlstetter M, Aslanidis A, Strunz T, Langmann T, Grassmann F, Weber BHF. Kiel C, et al. Among authors: langmann t. Int J Mol Sci. 2020 Apr 13;21(8):2689. doi: 10.3390/ijms21082689. Int J Mol Sci. 2020. PMID: 32294914 Free PMC article.

53

Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype.

Ebert S, Schoeberl T, Walczak Y, Stoecker K, Stempfl T, Moehle C, Weber BH, Langmann T. Ebert S, et al. Among authors: langmann t. J Leukoc Biol. 2008 Sep;84(3):736-40. doi: 10.1189/jlb.0208138. Epub 2008 Jun 12. J Leukoc Biol. 2008. PMID: 18550791

54

Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation.

Mirza M, Volz C, Karlstetter M, Langiu M, Somogyi A, Ruonala MO, Tamm ER, Jägle H, Langmann T. Mirza M, et al. Among authors: langmann t. PLoS One. 2013 Oct 4;8(10):e75963. doi: 10.1371/journal.pone.0075963. eCollection 2013. PLoS One. 2013. PMID: 24124525 Free PMC article.

55

Comprehensive analysis of mouse retinal mononuclear phagocytes.

Lückoff A, Scholz R, Sennlaub F, Xu H, Langmann T. Lückoff A, et al. Among authors: langmann t. Nat Protoc. 2017 Jun;12(6):1136-1150. doi: 10.1038/nprot.2017.032. Epub 2017 May 4. Nat Protoc. 2017. PMID: 28471458 Free article.

56

Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation.

Weigelt K, Ernst W, Walczak Y, Ebert S, Loenhardt T, Klug M, Rehli M, Weber BH, Langmann T. Weigelt K, et al. Among authors: langmann t. J Leukoc Biol. 2007 Dec;82(6):1564-74. doi: 10.1189/jlb.0707447. Epub 2007 Sep 7. J Leukoc Biol. 2007. PMID: 17827340

57

An integrated workflow for analysis of ChIP-chip data.

Weigelt K, Moehle C, Stempfl T, Weber B, Langmann T. Weigelt K, et al. Among authors: langmann t. Biotechniques. 2008 Aug;45(2):131-2, 134, 136 passim. doi: 10.2144/000112819. Biotechniques. 2008. PMID: 18687062 Free article.

58

CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene.

Langmann T, Lai CC, Weigelt K, Tam BM, Warneke-Wittstock R, Moritz OL, Weber BH. Langmann T, et al. Nucleic Acids Res. 2008 Nov;36(20):6523-34. doi: 10.1093/nar/gkn737. Epub 2008 Oct 16. Nucleic Acids Res. 2008. PMID: 18927113 Free PMC article.

59

High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages.

Mauerer R, Ebert S, Langmann T. Mauerer R, et al. Among authors: langmann t. Exp Mol Med. 2009 Feb 28;41(2):126-32. doi: 10.3858/emm.2009.41.2.015. Exp Mol Med. 2009. PMID: 19287193 Free PMC article.

60

Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration.

Ebert S, Weigelt K, Walczak Y, Drobnik W, Mauerer R, Hume DA, Weber BH, Langmann T. Ebert S, et al. Among authors: langmann t. J Neurochem. 2009 Sep;110(6):1863-75. doi: 10.1111/j.1471-4159.2009.06286.x. Epub 2009 Jul 17. J Neurochem. 2009. PMID: 19627444 Free article.

61

Comprehensive mRNA profiling of lipid-related genes in microglia and macrophages using taqman arrays.

Mauerer R, Walczak Y, Langmann T. Mauerer R, et al. Among authors: langmann t. Methods Mol Biol. 2009;580:187-201. doi: 10.1007/978-1-60761-325-1_10. Methods Mol Biol. 2009. PMID: 19784600

62

Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype.

Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T. Dirscherl K, et al. Among authors: langmann t. J Neuroinflammation. 2010 Jan 14;7:3. doi: 10.1186/1742-2094-7-3. J Neuroinflammation. 2010. PMID: 20074346 Free PMC article.

63

Microglia in the healthy and degenerating retina: insights from novel mouse models.

Karlstetter M, Ebert S, Langmann T. Karlstetter M, et al. Among authors: langmann t. Immunobiology. 2010 Sep-Oct;215(9-10):685-91. doi: 10.1016/j.imbio.2010.05.010. Epub 2010 Jun 4. Immunobiology. 2010. PMID: 20573418 Free article. Review.

64

CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors.

Corbo JC, Lawrence KA, Karlstetter M, Myers CA, Abdelaziz M, Dirkes W, Weigelt K, Seifert M, Benes V, Fritsche LG, Weber BH, Langmann T. Corbo JC, et al. Among authors: langmann t. Genome Res. 2010 Nov;20(11):1512-25. doi: 10.1101/gr.109405.110. Epub 2010 Aug 6. Genome Res. 2010. PMID: 20693478 Free PMC article.

65

Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa.

Langmann T, Di Gioia SA, Rau I, Stöhr H, Maksimovic NS, Corbo JC, Renner AB, Zrenner E, Kumaramanickavel G, Karlstetter M, Arsenijevic Y, Weber BH, Gal A, Rivolta C. Langmann T, et al. Am J Hum Genet. 2010 Sep 10;87(3):376-81. doi: 10.1016/j.ajhg.2010.07.018. Epub 2010 Aug 12. Am J Hum Genet. 2010. PMID: 20705278 Free PMC article.

66

The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response.

Karlstetter M, Walczak Y, Weigelt K, Ebert S, Van den Brulle J, Schwer H, Fuchshofer R, Langmann T. Karlstetter M, et al. Among authors: langmann t. J Immunol. 2010 Sep 15;185(6):3379-90. doi: 10.4049/jimmunol.0903300. Epub 2010 Aug 13. J Immunol. 2010. PMID: 20709948 Free article.

67

Retinal expression of the X-linked juvenile retinoschisis (RS1) gene is controlled by an upstream CpG island and two opposing CRX-bound regions.

Kraus D, Karlstetter M, Walczak Y, Hilfinger D, Langmann T, Weber BH. Kraus D, et al. Among authors: langmann t. Biochim Biophys Acta. 2011 Apr-Jun;1809(4-6):245-54. doi: 10.1016/j.bbagrm.2011.03.001. Epub 2011 Mar 23. Biochim Biophys Acta. 2011. PMID: 21392589

68

Curcumin is a potent modulator of microglial gene expression and migration.

Karlstetter M, Lippe E, Walczak Y, Moehle C, Aslanidis A, Mirza M, Langmann T. Karlstetter M, et al. Among authors: langmann t. J Neuroinflammation. 2011 Sep 29;8:125. doi: 10.1186/1742-2094-8-125. J Neuroinflammation. 2011. PMID: 21958395 Free PMC article.

69

Microglial activation and transcriptomic changes in the blue light-exposed mouse retina.

Ebert S, Walczak Y, Remé C, Langmann T. Ebert S, et al. Among authors: langmann t. Adv Exp Med Biol. 2012;723:619-32. doi: 10.1007/978-1-4614-0631-0_79. Adv Exp Med Biol. 2012. PMID: 22183386 No abstract available.

70

[Immune mechanisms in retinal degeneration].

Karlstetter M, Langmann T. Karlstetter M, et al. Among authors: langmann t. Klin Monbl Augenheilkd. 2012 Mar;229(3):221-6. doi: 10.1055/s-0031-1282050. Epub 2012 Feb 1. Klin Monbl Augenheilkd. 2012. PMID: 22297848 Review. German.

71

Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus.

Zollbrecht C, Grassl M, Fenk S, Höcherl R, Hubauer U, Reinhard W, Esslinger UB, Ebert S, Langmann T, Stark K, Hengstenberg C. Zollbrecht C, et al. Among authors: langmann t. Atherosclerosis. 2013 Apr;227(2):244-9. doi: 10.1016/j.atherosclerosis.2012.12.030. Epub 2013 Jan 17. Atherosclerosis. 2013. PMID: 23375685

72

Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina.

Hlawatsch J, Karlstetter M, Aslanidis A, Lückoff A, Walczak Y, Plank M, Böck J, Langmann T. Hlawatsch J, et al. Among authors: langmann t. PLoS One. 2013;8(4):e60633. doi: 10.1371/journal.pone.0060633. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565263 Free PMC article.

73

Genetic and environmental risk factors for age-related macular degeneration in persons 90 years and older.

Ersoy L, Ristau T, Hahn M, Karlstetter M, Langmann T, Dröge K, Caramoy A, den Hollander AI, Fauser S. Ersoy L, et al. Among authors: langmann t. Invest Ophthalmol Vis Sci. 2014 Mar 25;55(3):1842-7. doi: 10.1167/iovs.13-13420. Invest Ophthalmol Vis Sci. 2014. PMID: 24576882 Free article.

74

RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl).

Aslanidis A, Karlstetter M, Walczak Y, Jägle H, Langmann T. Aslanidis A, et al. Among authors: langmann t. Adv Exp Med Biol. 2014;801:31-41. doi: 10.1007/978-1-4614-3209-8_5. Adv Exp Med Biol. 2014. PMID: 24664678

75

Early-onset autosomal recessive cerebellar ataxia associated with retinal dystrophy: new human hotfoot phenotype caused by homozygous GRID2 deletion.

Van Schil K, Meire F, Karlstetter M, Bauwens M, Verdin H, Coppieters F, Scheiffert E, Van Nechel C, Langmann T, Deconinck N, De Baere E. Van Schil K, et al. Among authors: langmann t. Genet Med. 2015 Apr;17(4):291-9. doi: 10.1038/gim.2014.95. Epub 2014 Aug 14. Genet Med. 2015. PMID: 25122145 Free article.

76

Autosomal recessive retinitis pigmentosa with homozygous rhodopsin mutation E150K and non-coding cis-regulatory variants in CRX-binding regions of SAMD7.

Van Schil K, Karlstetter M, Aslanidis A, Dannhausen K, Azam M, Qamar R, Leroy BP, Depasse F, Langmann T, De Baere E. Van Schil K, et al. Among authors: langmann t. Sci Rep. 2016 Feb 18;6:21307. doi: 10.1038/srep21307. Sci Rep. 2016. PMID: 26887858 Free PMC article.

77

Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination.

Coppieters F, Ascari G, Dannhausen K, Nikopoulos K, Peelman F, Karlstetter M, Xu M, Brachet C, Meunier I, Tsilimbaris MK, Tsika C, Blazaki SV, Vergult S, Farinelli P, Van Laethem T, Bauwens M, De Bruyne M, Chen R, Langmann T, Sui R, Meire F, Rivolta C, Hamel CP, Leroy BP, De Baere E. Coppieters F, et al. Among authors: langmann t. Am J Hum Genet. 2016 Aug 4;99(2):470-80. doi: 10.1016/j.ajhg.2016.06.017. Am J Hum Genet. 2016. PMID: 27486781 Free PMC article.

78

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina.

Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A, Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T, Neumann H. Karlstetter M, et al. Among authors: langmann t. EMBO Mol Med. 2017 Feb;9(2):154-166. doi: 10.15252/emmm.201606627. EMBO Mol Med. 2017. PMID: 28003336 Free PMC article.

79

[Polysialic Acid for Immunomodulation in an Animal Model for Wet Age-Related Macular Degeneration (AMD)].

Langmann T, Fauser S. Langmann T, et al. Klin Monbl Augenheilkd. 2017 May;234(5):657-661. doi: 10.1055/s-0043-105138. Epub 2017 Apr 5. Klin Monbl Augenheilkd. 2017. PMID: 28380648 German.

80

Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number variations.

Van Schil K, Naessens S, Van de Sompele S, Carron M, Aslanidis A, Van Cauwenbergh C, Kathrin Mayer A, Van Heetvelde M, Bauwens M, Verdin H, Coppieters F, Greenberg ME, Yang MG, Karlstetter M, Langmann T, De Preter K, Kohl S, Cherry TJ, Leroy BP; CNV Study Group; De Baere E. Van Schil K, et al. Among authors: langmann t. Genet Med. 2018 Feb;20(2):202-213. doi: 10.1038/gim.2017.97. Epub 2017 Jul 27. Genet Med. 2018. PMID: 28749477 Free PMC article.

81

Correction: Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number variations.

Van Schil K, Naessens S, Van de Sompele S, Carron M, Aslanidis A, Van Cauwenbergh C, Mayer AK, Van Heetvelde M, Bauwens M, Verdin H, Coppieters F, Greenberg ME, Yang MG, Karlstetter M, Langmann T, De Preter K, Kohl S, Cherry TJ, Leroy BP; CNV Study Group; De Baere E. Van Schil K, et al. Among authors: langmann t. Genet Med. 2019 Aug;21(8):1998. doi: 10.1038/s41436-018-0305-0. Genet Med. 2019. PMID: 30297699 Free PMC article.

82

Testing for Known Retinal Degeneration Mutants in Mouse Strains.

Rashid K, Dannhausen K, Langmann T. Rashid K, et al. Among authors: langmann t. Methods Mol Biol. 2019;1834:45-58. doi: 10.1007/978-1-4939-8669-9_3. Methods Mol Biol. 2019. PMID: 30324435

83

A mega-analysis of expression quantitative trait loci in retinal tissue.

Strunz T, Kiel C, Grassmann F, Ratnapriya R, Kwicklis M, Karlstetter M, Fauser S, Arend N, Swaroop A, Langmann T, Wolf A, Weber BHF. Strunz T, et al. Among authors: langmann t. PLoS Genet. 2020 Sep 1;16(9):e1008934. doi: 10.1371/journal.pgen.1008934. eCollection 2020 Sep. PLoS Genet. 2020. PMID: 32870927 Free PMC article.

84

[Neuroinflammation in neuronal ceroid lipofuscinosis].

Behnke V, Langmann T. Behnke V, et al. Among authors: langmann t. Ophthalmologe. 2021 Feb;118(2):98-105. doi: 10.1007/s00347-020-01301-4. Epub 2021 Jan 7. Ophthalmologe. 2021. PMID: 33411040 Review. German.

85

Structural organization and characterization of the promoter region of a human carboxylesterase gene.

Langmann T, Becker A, Aslanidis C, Notka F, Ullrich H, Schwer H, Schmitz G. Langmann T, et al. Biochim Biophys Acta. 1997 Jan 3;1350(1):65-74. doi: 10.1016/s0167-4781(96)00142-x. Biochim Biophys Acta. 1997. PMID: 9003459

86

Identification and characterization of the human adipocyte apM-1 promoter.

Schäffler A, Langmann T, Palitzsch KD, Schölmerich J, Schmitz G. Schäffler A, et al. Among authors: langmann t. Biochim Biophys Acta. 1998 Aug 20;1399(2-3):187-97. doi: 10.1016/s0167-4781(98)00106-7. Biochim Biophys Acta. 1998. PMID: 9765595

87

Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2.

Ries S, Büchler C, Langmann T, Fehringer P, Aslanidis C, Schmitz G. Ries S, et al. Among authors: langmann t. J Lipid Res. 1998 Nov;39(11):2125-34. J Lipid Res. 1998. PMID: 9799798 Free article.

88

Transcription factors Sp1 and AP-2 mediate induction of acid sphingomyelinase during monocytic differentiation.

Langmann T, Buechler C, Ries S, Schaeffler A, Aslanidis C, Schuierer M, Weiler M, Sandhoff K, de Jong PJ, Schmitz G. Langmann T, et al. J Lipid Res. 1999 May;40(5):870-80. J Lipid Res. 1999. PMID: 10224156 Free article.

89

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease.

Bodzioch M, Orsó E, Klucken J, Langmann T, Böttcher A, Diederich W, Drobnik W, Barlage S, Büchler C, Porsch-Ozcürümez M, Kaminski WE, Hahmann HW, Oette K, Rothe G, Aslanidis C, Lackner KJ, Schmitz G. Bodzioch M, et al. Among authors: langmann t. Nat Genet. 1999 Aug;22(4):347-51. doi: 10.1038/11914. Nat Genet. 1999. PMID: 10431237

90

Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli.

Buechler C, Ritter M, Orsó E, Langmann T, Klucken J, Schmitz G. Buechler C, et al. Among authors: langmann t. J Leukoc Biol. 2000 Jan;67(1):97-103. J Leukoc Biol. 2000. PMID: 10648003

91

The scavenger receptor CD163: regulation, promoter structure and genomic organization.

Ritter M, Buechler C, Langmann T, Orso E, Klucken J, Schmitz G. Ritter M, et al. Among authors: langmann t. Pathobiology. 1999;67(5-6):257-61. doi: 10.1159/000028105. Pathobiology. 1999. PMID: 10725797

92

Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene.

Langmann T, Porsch-Ozcürümez M, Unkelbach U, Klucken J, Schmitz G. Langmann T, et al. Biochim Biophys Acta. 2000 Nov 15;1494(1-2):175-80. doi: 10.1016/s0167-4781(00)00215-3. Biochim Biophys Acta. 2000. PMID: 11072082

93

Structure, function and regulation of the ABC1 gene product.

Schmitz G, Langmann T. Schmitz G, et al. Among authors: langmann t. Curr Opin Lipidol. 2001 Apr;12(2):129-40. doi: 10.1097/00041433-200104000-00006. Curr Opin Lipidol. 2001. PMID: 11264984 Review.

94

The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux.

Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G. Porsch-Ozcurumez M, et al. Among authors: langmann t. J Biol Chem. 2001 Apr 13;276(15):12427-33. doi: 10.1074/jbc.M100218200. Epub 2001 Jan 22. J Biol Chem. 2001. PMID: 11279031 Free article.

95

ABCA6, a novel a subclass ABC transporter.

Kaminski WE, Wenzel JJ, Piehler A, Langmann T, Schmitz G. Kaminski WE, et al. Among authors: langmann t. Biochem Biophys Res Commun. 2001 Aug 3;285(5):1295-301. doi: 10.1006/bbrc.2001.5326. Biochem Biophys Res Commun. 2001. PMID: 11478798

96

Role of ABCG1 and other ABCG family members in lipid metabolism.

Schmitz G, Langmann T, Heimerl S. Schmitz G, et al. Among authors: langmann t. J Lipid Res. 2001 Oct;42(10):1513-20. J Lipid Res. 2001. PMID: 11590207 Free article. Review.

97

Rapid quantification of human ABCA1 mRNA in various cell types and tissues by real-time reverse transcription-PCR.

Kielar D, Dietmaier W, Langmann T, Aslanidis C, Probst M, Naruszewicz M, Schmitz G. Kielar D, et al. Among authors: langmann t. Clin Chem. 2001 Dec;47(12):2089-97. Clin Chem. 2001. PMID: 11719471

98

Native LDL upregulation of ATP-binding cassette transporter-1 in human vascular endothelial cells.

Liao H, Langmann T, Schmitz G, Zhu Y. Liao H, et al. Among authors: langmann t. Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):127-32. doi: 10.1161/hq1201.101772. Arterioscler Thromb Vasc Biol. 2002. PMID: 11788472

99

Identification of sterol-independent regulatory elements in the human ATP-binding cassette transporter A1 promoter: role of Sp1/3, E-box binding factors, and an oncostatin M-responsive element.

Langmann T, Porsch-Ozcürümez M, Heimerl S, Probst M, Moehle C, Taher M, Borsukova H, Kielar D, Kaminski WE, Dittrich-Wengenroth E, Schmitz G. Langmann T, et al. J Biol Chem. 2002 Apr 26;277(17):14443-50. doi: 10.1074/jbc.M110270200. Epub 2002 Feb 11. J Biol Chem. 2002. PMID: 11839742 Free article.

100

Mutations in the human ATP-binding cassette transporters ABCG5 and ABCG8 in sitosterolemia.

Heimerl S, Langmann T, Moehle C, Mauerer R, Dean M, Beil FU, von Bergmann K, Schmitz G. Heimerl S, et al. Among authors: langmann t. Hum Mutat. 2002 Aug;20(2):151. doi: 10.1002/humu.9047. Hum Mutat. 2002. PMID: 12124998

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