O'Connor SE - Search Results

1

[No authors listed] [No authors listed] PMID: 34752623

2

A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus.

Besseau S, Kellner F, Lanoue A, Thamm AM, Salim V, Schneider B, Geu-Flores F, Höfer R, Guirimand G, Guihur A, Oudin A, Glevarec G, Foureau E, Papon N, Clastre M, Giglioli-Guivarc'h N, St-Pierre B, Werck-Reichhart D, Burlat V, De Luca V, O'Connor SE, Courdavault V. Besseau S, et al. Plant Physiol. 2013 Dec;163(4):1792-803. doi: 10.1104/pp.113.222828. Epub 2013 Oct 9. Plant Physiol. 2013. PMID: 24108213 Free PMC article.

3

De novo production of the plant-derived alkaloid strictosidine in yeast.

Brown S, Clastre M, Courdavault V, O'Connor SE. Brown S, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3205-10. doi: 10.1073/pnas.1423555112. Epub 2015 Feb 9. Proc Natl Acad Sci U S A. 2015. PMID: 25675512 Free PMC article.

4

Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism.

Stavrinides A, Tatsis EC, Foureau E, Caputi L, Kellner F, Courdavault V, O'Connor SE. Stavrinides A, et al. Chem Biol. 2015 Mar 19;22(3):336-41. doi: 10.1016/j.chembiol.2015.02.006. Epub 2015 Mar 12. Chem Biol. 2015. PMID: 25772467 Free PMC article.

5

Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome.

Dugé de Bernonville T, Foureau E, Parage C, Lanoue A, Clastre M, Londono MA, Oudin A, Houillé B, Papon N, Besseau S, Glévarec G, Atehortùa L, Giglioli-Guivarc'h N, St-Pierre B, De Luca V, O'Connor SE, Courdavault V. Dugé de Bernonville T, et al. BMC Genomics. 2015 Aug 19;16(1):619. doi: 10.1186/s12864-015-1678-y. BMC Genomics. 2015. PMID: 26285573 Free PMC article.

6

Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity.

Stavrinides A, Tatsis EC, Caputi L, Foureau E, Stevenson CE, Lawson DM, Courdavault V, O'Connor SE. Stavrinides A, et al. Nat Commun. 2016 Jul 15;7:12116. doi: 10.1038/ncomms12116. Nat Commun. 2016. PMID: 27418042 Free PMC article.

7

Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids.

Parage C, Foureau E, Kellner F, Burlat V, Mahroug S, Lanoue A, Dugé de Bernonville T, Londono MA, Carqueijeiro I, Oudin A, Besseau S, Papon N, Glévarec G, Atehortùa L, Giglioli-Guivarc'h N, St-Pierre B, Clastre M, O'Connor SE, Courdavault V. Parage C, et al. Plant Physiol. 2016 Nov;172(3):1563-1577. doi: 10.1104/pp.16.00801. Epub 2016 Sep 29. Plant Physiol. 2016. PMID: 27688619 Free PMC article.

8

An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole.

Payne RM, Xu D, Foureau E, Teto Carqueijeiro MI, Oudin A, Bernonville TD, Novak V, Burow M, Olsen CE, Jones DM, Tatsis EC, Pendle A, Ann Halkier B, Geu-Flores F, Courdavault V, Nour-Eldin HH, O'Connor SE. Payne RM, et al. Nat Plants. 2017 Jan 13;3:16208. doi: 10.1038/nplants.2016.208. Nat Plants. 2017. PMID: 28085153 Free PMC article.

9

Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses.

Dugé de Bernonville T, Carqueijeiro I, Lanoue A, Lafontaine F, Sánchez Bel P, Liesecke F, Musset K, Oudin A, Glévarec G, Pichon O, Besseau S, Clastre M, St-Pierre B, Flors V, Maury S, Huguet E, O'Connor SE, Courdavault V. Dugé de Bernonville T, et al. Sci Rep. 2017 Jan 17;7:40453. doi: 10.1038/srep40453. Sci Rep. 2017. PMID: 28094274 Free PMC article.

10

A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate.

Tatsis EC, Carqueijeiro I, Dugé de Bernonville T, Franke J, Dang TT, Oudin A, Lanoue A, Lafontaine F, Stavrinides AK, Clastre M, Courdavault V, O'Connor SE. Tatsis EC, et al. Nat Commun. 2017 Aug 22;8(1):316. doi: 10.1038/s41467-017-00154-x. Nat Commun. 2017. PMID: 28827772 Free PMC article.

11

Discovery of a Short-Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid.

Stavrinides AK, Tatsis EC, Dang TT, Caputi L, Stevenson CEM, Lawson DM, Schneider B, O'Connor SE. Stavrinides AK, et al. Chembiochem. 2018 May 4;19(9):940-948. doi: 10.1002/cbic.201700621. Epub 2018 Mar 22. Chembiochem. 2018. PMID: 29424954 Free PMC article.

12

A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids.

Carqueijeiro I, Dugé de Bernonville T, Lanoue A, Dang TT, Teijaro CN, Paetz C, Billet K, Mosquera A, Oudin A, Besseau S, Papon N, Glévarec G, Atehortùa L, Clastre M, Giglioli-Guivarc'h N, Schneider B, St-Pierre B, Andrade RB, O'Connor SE, Courdavault V. Carqueijeiro I, et al. Plant J. 2018 May;94(3):469-484. doi: 10.1111/tpj.13868. Epub 2018 Mar 27. Plant J. 2018. PMID: 29438577 Free article.

13

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.

Caputi L, Franke J, Farrow SC, Chung K, Payne RME, Nguyen TD, Dang TT, Soares Teto Carqueijeiro I, Koudounas K, Dugé de Bernonville T, Ameyaw B, Jones DM, Vieira IJC, Courdavault V, O'Connor SE. Caputi L, et al. Science. 2018 Jun 15;360(6394):1235-1239. doi: 10.1126/science.aat4100. Epub 2018 May 3. Science. 2018. PMID: 29724909

14

Vacuole-Targeted Proteins: Ins and Outs of Subcellular Localization Studies.

Carqueijeiro I, Sepúlveda LJ, Mosquera A, Payne R, Corbin C, Papon N, de Bernonville TD, Besseau S, Lanoue A, Glévarec G, Clastre M, St-Pierre B, Atehortùa L, Giglioli-Guivarc'h N, O'Connor SE, Oudin A, Courdavault V. Carqueijeiro I, et al. Methods Mol Biol. 2018;1789:33-54. doi: 10.1007/978-1-4939-7856-4_4. Methods Mol Biol. 2018. PMID: 29916070

15

Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in Catharanthus roseus.

Carqueijeiro I, Brown S, Chung K, Dang TT, Walia M, Besseau S, Dugé de Bernonville T, Oudin A, Lanoue A, Billet K, Munsch T, Koudounas K, Melin C, Godon C, Razafimandimby B, de Craene JO, Glévarec G, Marc J, Giglioli-Guivarc'h N, Clastre M, St-Pierre B, Papon N, Andrade RB, O'Connor SE, Courdavault V. Carqueijeiro I, et al. Plant Physiol. 2018 Aug;177(4):1473-1486. doi: 10.1104/pp.18.00549. Epub 2018 Jun 22. Plant Physiol. 2018. PMID: 29934299 Free PMC article.

16

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes.

Dang TT, Franke J, Carqueijeiro IST, Langley C, Courdavault V, O'Connor SE. Dang TT, et al. Nat Chem Biol. 2018 Aug;14(8):760-763. doi: 10.1038/s41589-018-0078-4. Epub 2018 Jun 25. Nat Chem Biol. 2018. PMID: 29942076 Free PMC article.

17

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs.

Carqueijeiro I, Langley C, Grzech D, Koudounas K, Papon N, O'Connor SE, Courdavault V. Carqueijeiro I, et al. Curr Opin Biotechnol. 2020 Oct;65:17-24. doi: 10.1016/j.copbio.2019.11.017. Epub 2019 Dec 13. Curr Opin Biotechnol. 2020. PMID: 31841858 Free article. Review.

18

Identifying Missing Biosynthesis Enzymes of Plant Natural Products.

Dugé de Bernonville T, Papon N, Clastre M, O'Connor SE, Courdavault V. Dugé de Bernonville T, et al. Trends Pharmacol Sci. 2020 Mar;41(3):142-146. doi: 10.1016/j.tips.2019.12.006. Epub 2020 Jan 21. Trends Pharmacol Sci. 2020. PMID: 31980250 Free article.

19

Towards the Microbial Production of Plant-Derived Anticancer Drugs.

Courdavault V, O'Connor SE, Oudin A, Besseau S, Papon N. Courdavault V, et al. Trends Cancer. 2020 Jun;6(6):444-448. doi: 10.1016/j.trecan.2020.02.004. Epub 2020 Mar 5. Trends Cancer. 2020. PMID: 32459998 Free article.

20

Virus-Induced Gene Silencing: Hush Genes to Make Them Talk.

Courdavault V, Besseau S, Oudin A, Papon N, O'Connor SE. Courdavault V, et al. Trends Plant Sci. 2020 Jul;25(7):714-715. doi: 10.1016/j.tplants.2020.02.013. Epub 2020 Mar 17. Trends Plant Sci. 2020. PMID: 32526175 No abstract available.

21

Synthesis of (-)-Melodinine K: A Case Study of Efficiency in Natural Product Synthesis.

Walia M, Teijaro CN, Gardner A, Tran T, Kang J, Zhao S, O'Connor SE, Courdavault V, Andrade RB. Walia M, et al. J Nat Prod. 2020 Aug 28;83(8):2425-2433. doi: 10.1021/acs.jnatprod.0c00310. Epub 2020 Jul 29. J Nat Prod. 2020. PMID: 32786883

22

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation.

Dugé de Bernonville T, Maury S, Delaunay A, Daviaud C, Chaparro C, Tost J, O'Connor SE, Courdavault V. Dugé de Bernonville T, et al. Int J Mol Sci. 2020 Aug 21;21(17):6028. doi: 10.3390/ijms21176028. Int J Mol Sci. 2020. PMID: 32825765 Free PMC article.

23

Two bi-functional cytochrome P450 CYP72 enzymes from olive (Olea europaea) catalyze the oxidative C-C bond cleavage in the biosynthesis of secoxy-iridoids - flavor and quality determinants in olive oil.

Rodríguez-López CE, Hong B, Paetz C, Nakamura Y, Koudounas K, Passeri V, Baldoni L, Alagna F, Calderini O, O'Connor SE. Rodríguez-López CE, et al. New Phytol. 2021 Feb;229(4):2288-2301. doi: 10.1111/nph.16975. Epub 2020 Oct 30. New Phytol. 2021. PMID: 33124697 Free article.

24

Identifying Genes Involved in alkaloid Biosynthesis in Vinca minor Through Transcriptomics and Gene Co-Expression Analysis.

Stander EA, Sepúlveda LJ, Dugé de Bernonville T, Carqueijeiro I, Koudounas K, Lemos Cruz P, Besseau S, Lanoue A, Papon N, Giglioli-Guivarc'h N, Dirks R, O'Connor SE, Atehortùa L, Oudin A, Courdavault V. Stander EA, et al. Biomolecules. 2020 Nov 24;10(12):1595. doi: 10.3390/biom10121595. Biomolecules. 2020. PMID: 33255314 Free PMC article.

25

Alternative splicing creates a pseudo-strictosidine β-d-glucosidase modulating alkaloid synthesis in Catharanthus roseus.

Carqueijeiro I, Koudounas K, Dugé de Bernonville T, Sepúlveda LJ, Mosquera A, Bomzan DP, Oudin A, Lanoue A, Besseau S, Lemos Cruz P, Kulagina N, Stander EA, Eymieux S, Burlaud-Gaillard J, Blanchard E, Clastre M, Atehortùa L, St-Pierre B, Giglioli-Guivarc'h N, Papon N, Nagegowda DA, O'Connor SE, Courdavault V. Carqueijeiro I, et al. Plant Physiol. 2021 Apr 2;185(3):836-856. doi: 10.1093/plphys/kiaa075. Plant Physiol. 2021. PMID: 33793899 Free PMC article.

26

Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits.

Courdavault V, O'Connor SE, Jensen MK, Papon N. Courdavault V, et al. Nat Prod Rep. 2021 Dec 15;38(12):2145-2153. doi: 10.1039/d0np00092b. Nat Prod Rep. 2021. PMID: 33969366 Review.

27

Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus.

Yamamoto K, Grzech D, Koudounas K, Stander EA, Caputi L, Mimura T, Courdavault V, O'Connor SE. Yamamoto K, et al. Plant Physiol. 2021 Oct 5;187(2):846-857. doi: 10.1093/plphys/kiab285. Plant Physiol. 2021. PMID: 34608956 Free PMC article.

28

Tonoplast and Peroxisome Targeting of γ-tocopherol N-methyltransferase Homologs Involved in the Synthesis of Monoterpene Indole Alkaloids.

Koudounas K, Guirimand G, Hoyos LFR, Carqueijeiro I, Cruz PL, Stander E, Kulagina N, Perrin J, Oudin A, Besseau S, Lanoue A, Atehortùa L, St-Pierre B, Giglioli-Guivarc'h N, Papon N, O'Connor SE, Courdavault V. Koudounas K, et al. Plant Cell Physiol. 2022 Feb 15;63(2):200-216. doi: 10.1093/pcp/pcab160. Plant Cell Physiol. 2022. PMID: 35166361

29

More than a Catharanthus plant: A multicellular and pluri-organelle alkaloid-producing factory.

Kulagina N, Méteignier LV, Papon N, O'Connor SE, Courdavault V. Kulagina N, et al. Curr Opin Plant Biol. 2022 Jun;67:102200. doi: 10.1016/j.pbi.2022.102200. Epub 2022 Mar 24. Curr Opin Plant Biol. 2022. PMID: 35339956 Review.

30

A microbial supply chain for production of the anti-cancer drug vinblastine.

Zhang J, Hansen LG, Gudich O, Viehrig K, Lassen LMM, Schrübbers L, Adhikari KB, Rubaszka P, Carrasquer-Alvarez E, Chen L, D'Ambrosio V, Lehka B, Haidar AK, Nallapareddy S, Giannakou K, Laloux M, Arsovska D, Jørgensen MAK, Chan LJG, Kristensen M, Christensen HB, Sudarsan S, Stander EA, Baidoo E, Petzold CJ, Wulff T, O'Connor SE, Courdavault V, Jensen MK, Keasling JD. Zhang J, et al. Nature. 2022 Sep;609(7926):341-347. doi: 10.1038/s41586-022-05157-3. Epub 2022 Aug 31. Nature. 2022. PMID: 36045295 Free PMC article.

31

Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana.

Dudley QM, Jo S, Guerrero DAS, Chhetry M, Smedley MA, Harwood WA, Sherden NH, O'Connor SE, Caputi L, Patron NJ. Dudley QM, et al. Commun Biol. 2022 Sep 10;5(1):949. doi: 10.1038/s42003-022-03904-w. Commun Biol. 2022. PMID: 36088516 Free PMC article.

32

The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis.

Stander EA, Cuello C, Birer-Williams C, Kulagina N, Jansen HJ, Carqueijeiro I, Méteignier LV, Vergès V, Oudin A, Papon N, Dirks RP, Jensen MK, O'Connor SE, Dugé de Bernonville T, Besseau S, Courdavault V. Stander EA, et al. G3 (Bethesda). 2022 Dec 1;12(12):jkac268. doi: 10.1093/g3journal/jkac268. G3 (Bethesda). 2022. PMID: 36200869 Free PMC article.

33

Genome Assembly of the Medicinal Plant Voacanga thouarsii.

Cuello C, Stander EA, Jansen HJ, Dugé de Bernonville T, Lanoue A, Giglioli-Guivarc'h N, Papon N, Dirks RP, Jensen MK, O'Connor SE, Besseau S, Courdavault V. Cuello C, et al. Genome Biol Evol. 2022 Nov 4;14(11):evac158. doi: 10.1093/gbe/evac158. Genome Biol Evol. 2022. PMID: 36300641 Free PMC article.

34

Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast.

Bradley SA, Lehka BJ, Hansson FG, Adhikari KB, Rago D, Rubaszka P, Haidar AK, Chen L, Hansen LG, Gudich O, Giannakou K, Lengger B, Gill RT, Nakamura Y, de Bernonville TD, Koudounas K, Romero-Suarez D, Ding L, Qiao Y, Frimurer TM, Petersen AA, Besseau S, Kumar S, Gautron N, Melin C, Marc J, Jeanneau R, O'Connor SE, Courdavault V, Keasling JD, Zhang J, Jensen MK. Bradley SA, et al. Nat Chem Biol. 2023 Dec;19(12):1551-1560. doi: 10.1038/s41589-023-01430-2. Epub 2023 Nov 6. Nat Chem Biol. 2023. PMID: 37932529 Free PMC article.

35

The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids.

Stander EA, Lehka B, Carqueijeiro I, Cuello C, Hansson FG, Jansen HJ, Dugé De Bernonville T, Birer Williams C, Vergès V, Lezin E, Lorensen MDBB, Dang TT, Oudin A, Lanoue A, Durand M, Giglioli-Guivarc'h N, Janfelt C, Papon N, Dirks RP, O'connor SE, Jensen MK, Besseau S, Courdavault V. Stander EA, et al. Commun Biol. 2023 Nov 24;6(1):1197. doi: 10.1038/s42003-023-05574-8. Commun Biol. 2023. PMID: 38001233 Free PMC article.

36

OXIDOSQUALENE CYCLASE 1 and 2 influence triterpene biosynthesis and defense in Nicotiana attenuata.

Yang C, Halitschke R, O'Connor SE. Yang C, et al. Plant Physiol. 2024 Mar 29;194(4):2580-2599. doi: 10.1093/plphys/kiad643. Plant Physiol. 2024. PMID: 38101922 Free PMC article.

37

Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis.

Yerkes N, Wu JX, McCoy E, Galan MC, Chen S, O'Connor SE. Yerkes N, et al. Bioorg Med Chem Lett. 2008 May 15;18(10):3095-8. doi: 10.1016/j.bmcl.2007.11.063. Epub 2007 Nov 22. Bioorg Med Chem Lett. 2008. PMID: 18061449 Free PMC article.

38

Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis.

Lee HY, Yerkes N, O'Connor SE. Lee HY, et al. Chem Biol. 2009 Dec 24;16(12):1225-9. doi: 10.1016/j.chembiol.2009.11.016. Chem Biol. 2009. PMID: 20064432 Free PMC article.

39

Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis.

Liscombe DK, Usera AR, O'Connor SE. Liscombe DK, et al. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18793-8. doi: 10.1073/pnas.1009003107. Epub 2010 Oct 18. Proc Natl Acad Sci U S A. 2010. PMID: 20956330 Free PMC article.

40

Integrating carbon-halogen bond formation into medicinal plant metabolism.

Runguphan W, Qu X, O'Connor SE. Runguphan W, et al. Nature. 2010 Nov 18;468(7322):461-4. doi: 10.1038/nature09524. Epub 2010 Nov 3. Nature. 2010. PMID: 21048708 Free PMC article.

41

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis.

Geu-Flores F, Sherden NH, Courdavault V, Burlat V, Glenn WS, Wu C, Nims E, Cui Y, O'Connor SE. Geu-Flores F, et al. Nature. 2012 Dec 6;492(7427):138-42. doi: 10.1038/nature11692. Epub 2012 Nov 21. Nature. 2012. PMID: 23172143

42

Diversification of monoterpene indole alkaloid analogs through cross-coupling.

Runguphan W, O'Connor SE. Runguphan W, et al. Org Lett. 2013 Jun 7;15(11):2850-3. doi: 10.1021/ol401179k. Epub 2013 May 28. Org Lett. 2013. PMID: 23713451

43

Iridoid synthase activity is common among the plant progesterone 5β-reductase family.

Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Müller-Uri F, Burlat V, O'Connor SE, Memelink J, Kreis W, Goossens A. Munkert J, et al. Mol Plant. 2015 Jan;8(1):136-52. doi: 10.1016/j.molp.2014.11.005. Epub 2014 Dec 11. Mol Plant. 2015. PMID: 25578278 Free article.

44

Genome-guided investigation of plant natural product biosynthesis.

Kellner F, Kim J, Clavijo BJ, Hamilton JP, Childs KL, Vaillancourt B, Cepela J, Habermann M, Steuernagel B, Clissold L, McLay K, Buell CR, O'Connor SE. Kellner F, et al. Plant J. 2015 May;82(4):680-92. doi: 10.1111/tpj.12827. Epub 2015 Apr 11. Plant J. 2015. PMID: 25759247 Free article.

45

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids.

Kellner F, Geu-Flores F, Sherden NH, Brown S, Foureau E, Courdavault V, O'Connor SE. Kellner F, et al. Chem Commun (Camb). 2015 May 4;51(36):7626-8. doi: 10.1039/c5cc01309g. Chem Commun (Camb). 2015. PMID: 25850027

46

Identification of Iridoid Glucoside Transporters in Catharanthus roseus.

Larsen B, Fuller VL, Pollier J, Van Moerkercke A, Schweizer F, Payne R, Colinas M, O'Connor SE, Goossens A, Halkier BA. Larsen B, et al. Plant Cell Physiol. 2017 Sep 1;58(9):1507-1518. doi: 10.1093/pcp/pcx097. Plant Cell Physiol. 2017. PMID: 28922750 Free PMC article.

47

Gene Discovery in Gelsemium Highlights Conserved Gene Clusters in Monoterpene Indole Alkaloid Biosynthesis.

Franke J, Kim J, Hamilton JP, Zhao D, Pham GM, Wiegert-Rininger K, Crisovan E, Newton L, Vaillancourt B, Tatsis E, Buell CR, O'Connor SE. Franke J, et al. Chembiochem. 2019 Jan 2;20(1):83-87. doi: 10.1002/cbic.201800592. Epub 2018 Nov 13. Chembiochem. 2019. PMID: 30300974

48

Nicotiana benthamiana as a Transient Expression Host to Produce Auxin Analogs.

Davis K, Gkotsi DS, Smith DRM, Goss RJM, Caputi L, O'Connor SE. Davis K, et al. Front Plant Sci. 2020 Nov 20;11:581675. doi: 10.3389/fpls.2020.581675. eCollection 2020. Front Plant Sci. 2020. PMID: 33329644 Free PMC article.

49

Early and Late Steps of Quinine Biosynthesis.

Trenti F, Yamamoto K, Hong B, Paetz C, Nakamura Y, O'Connor SE. Trenti F, et al. Org Lett. 2021 Mar 5;23(5):1793-1797. doi: 10.1021/acs.orglett.1c00206. Epub 2021 Feb 24. Org Lett. 2021. PMID: 33625237 Free PMC article.

50

[No title available]

[No authors listed] [No authors listed] PMID: 35555561

51

Imaging MS Analysis in Catharanthus roseus.

Yamamoto K, Takahashi K, O'Connor SE, Mimura T. Yamamoto K, et al. Methods Mol Biol. 2022;2505:33-43. doi: 10.1007/978-1-0716-2349-7_2. Methods Mol Biol. 2022. PMID: 35732934

52

Directed Biosynthesis of New to Nature Alkaloids in a Heterologous Nicotiana benthamiana Expression Host.

Boccia M, Grzech D, Lopes AA, O'Connor SE, Caputi L. Boccia M, et al. Front Plant Sci. 2022 Jun 22;13:919443. doi: 10.3389/fpls.2022.919443. eCollection 2022. Front Plant Sci. 2022. PMID: 35812900 Free PMC article.

53

Directed Biosynthesis of Mitragynine Stereoisomers.

Schotte C, Jiang Y, Grzech D, Dang TT, Laforest LC, León F, Mottinelli M, Nadakuduti SS, McCurdy CR, O'Connor SE. Schotte C, et al. J Am Chem Soc. 2023 Mar 8;145(9):4957-4963. doi: 10.1021/jacs.2c13644. Epub 2023 Feb 22. J Am Chem Soc. 2023. PMID: 36883326 Free PMC article.

54

Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition.

Laforest LC, Kuntz MA, Kanumuri SRR, Mukhopadhyay S, Sharma A, O'Connor SE, McCurdy CR, Nadakuduti SS. Laforest LC, et al. J Nat Prod. 2023 Apr 28;86(4):1042-1052. doi: 10.1021/acs.jnatprod.3c00092. Epub 2023 Mar 13. J Nat Prod. 2023. PMID: 36913648

55

Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle.

Bernhardt P, McCoy E, O'Connor SE. Bernhardt P, et al. Chem Biol. 2007 Aug;14(8):888-97. doi: 10.1016/j.chembiol.2007.07.008. Chem Biol. 2007. PMID: 17719488 Free PMC article.

56

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture.

Runguphan W, Maresh JJ, O'Connor SE. Runguphan W, et al. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13673-8. doi: 10.1073/pnas.0903393106. Epub 2009 Aug 5. Proc Natl Acad Sci U S A. 2009. PMID: 19666570 Free PMC article.

57

A stereoselective hydroxylation step of alkaloid biosynthesis by a unique cytochrome P450 in Catharanthus roseus.

Giddings LA, Liscombe DK, Hamilton JP, Childs KL, DellaPenna D, Buell CR, O'Connor SE. Giddings LA, et al. J Biol Chem. 2011 May 13;286(19):16751-7. doi: 10.1074/jbc.M111.225383. Epub 2011 Mar 24. J Biol Chem. 2011. PMID: 21454651 Free PMC article.

58

Strategies for engineering plant natural products: the iridoid-derived monoterpene indole alkaloids of Catharanthus roseus.

O'Connor SE. O'Connor SE. Methods Enzymol. 2012;515:189-206. doi: 10.1016/B978-0-12-394290-6.00009-4. Methods Enzymol. 2012. PMID: 22999175

59

Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids.

Caputi L, Franke J, Bussey K, Farrow SC, Vieira IJC, Stevenson CEM, Lawson DM, O'Connor SE. Caputi L, et al. Nat Chem Biol. 2020 Apr;16(4):383-386. doi: 10.1038/s41589-019-0460-x. Epub 2020 Feb 17. Nat Chem Biol. 2020. PMID: 32066966 Free PMC article.

60

Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants.

Florean M, Luck K, Hong B, Nakamura Y, O'Connor SE, Köllner TG. Florean M, et al. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2307981120. doi: 10.1073/pnas.2307981120. Epub 2023 Oct 9. Proc Natl Acad Sci U S A. 2023. PMID: 37812727 Free PMC article.

61

The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics.

Yamamoto K, Takahashi K, Caputi L, Mizuno H, Rodriguez-Lopez CE, Iwasaki T, Ishizaki K, Fukaki H, Ohnishi M, Yamazaki M, Masujima T, O'Connor SE, Mimura T. Yamamoto K, et al. New Phytol. 2019 Oct;224(2):848-859. doi: 10.1111/nph.16138. Epub 2019 Sep 20. New Phytol. 2019. PMID: 31436868 Free article.

62

The Progesterone 5β-Reductase/Iridoid Synthase Family: A Catalytic Reservoir for Specialized Metabolism across Land Plants.

Nguyen TD, O'Connor SE. Nguyen TD, et al. ACS Chem Biol. 2020 Jul 17;15(7):1780-1787. doi: 10.1021/acschembio.0c00220. Epub 2020 Jun 11. ACS Chem Biol. 2020. PMID: 32501002 Free PMC article.

63

Chemistry and biology of monoterpene indole alkaloid biosynthesis.

O'Connor SE, Maresh JJ. O'Connor SE, et al. Nat Prod Rep. 2006 Aug;23(4):532-47. doi: 10.1039/b512615k. Epub 2006 May 26. Nat Prod Rep. 2006. PMID: 16874388 Review. No abstract available.

64

Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus.

McCoy E, O'Connor SE. McCoy E, et al. J Am Chem Soc. 2006 Nov 8;128(44):14276-7. doi: 10.1021/ja066787w. J Am Chem Soc. 2006. PMID: 17076499

65

Metabolic reprogramming of periwinkle plant culture.

Runguphan W, O'Connor SE. Runguphan W, et al. Nat Chem Biol. 2009 Mar;5(3):151-3. doi: 10.1038/nchembio.141. Epub 2009 Jan 18. Nat Chem Biol. 2009. PMID: 19151732 Free PMC article.

66

In vivo characterization of key iridoid biosynthesis pathway genes in catnip (Nepeta cataria).

Palmer L, Chuang L, Siegmund M, Kunert M, Yamamoto K, Sonawane P, O'Connor SE. Palmer L, et al. Planta. 2022 Oct 12;256(5):99. doi: 10.1007/s00425-022-04012-z. Planta. 2022. PMID: 36222913 Free PMC article.

67

Recycling Upstream Redox Enzymes Expands the Regioselectivity of Cycloaddition in Pseudo-Aspidosperma Alkaloid Biosynthesis.

Kamileen MO, DeMars MD 2nd, Hong B, Nakamura Y, Paetz C, Lichman BR, Sonawane PD, Caputi L, O'Connor SE. Kamileen MO, et al. J Am Chem Soc. 2022 Nov 2;144(43):19673-19679. doi: 10.1021/jacs.2c08107. Epub 2022 Oct 14. J Am Chem Soc. 2022. PMID: 36240425 Free PMC article.

68

Promiscuous CYP87A enzyme activity initiates cardenolide biosynthesis in plants.

Kunert M, Langley C, Lucier R, Ploss K, Rodríguez López CE, Serna Guerrero DA, Rothe E, O'Connor SE, Sonawane PD. Kunert M, et al. Nat Plants. 2023 Oct;9(10):1607-1617. doi: 10.1038/s41477-023-01515-9. Epub 2023 Sep 18. Nat Plants. 2023. PMID: 37723202 Free PMC article.

69

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus.

Van Moerkercke A, Steensma P, Schweizer F, Pollier J, Gariboldi I, Payne R, Vanden Bossche R, Miettinen K, Espoz J, Purnama PC, Kellner F, Seppänen-Laakso T, O'Connor SE, Rischer H, Memelink J, Goossens A. Van Moerkercke A, et al. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8130-5. doi: 10.1073/pnas.1504951112. Epub 2015 Jun 15. Proc Natl Acad Sci U S A. 2015. PMID: 26080427 Free PMC article.

70

Phylogeny-Aware Chemoinformatic Analysis of Chemical Diversity in Lamiaceae Enables Iridoid Pathway Assembly and Discovery of Aucubin Synthase.

Rodríguez-López CE, Jiang Y, Kamileen MO, Lichman BR, Hong B, Vaillancourt B, Buell CR, O'Connor SE. Rodríguez-López CE, et al. Mol Biol Evol. 2022 Apr 10;39(4):msac057. doi: 10.1093/molbev/msac057. Mol Biol Evol. 2022. PMID: 35298643 Free PMC article.

71

Biosynthesis of iridoid sex pheromones in aphids.

Köllner TG, David A, Luck K, Beran F, Kunert G, Zhou JJ, Caputi L, O'Connor SE. Köllner TG, et al. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2211254119. doi: 10.1073/pnas.2211254119. Epub 2022 Oct 13. Proc Natl Acad Sci U S A. 2022. PMID: 36227916 Free PMC article.

72

Single-cell multi-omics in the medicinal plant Catharanthus roseus.

Li C, Wood JC, Vu AH, Hamilton JP, Rodriguez Lopez CE, Payne RME, Serna Guerrero DA, Gase K, Yamamoto K, Vaillancourt B, Caputi L, O'Connor SE, Robin Buell C. Li C, et al. Nat Chem Biol. 2023 Aug;19(8):1031-1041. doi: 10.1038/s41589-023-01327-0. Epub 2023 May 15. Nat Chem Biol. 2023. PMID: 37188960 Free PMC article.

73

Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family.

Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Müller-Uri F, Burlat V, O'Connor SE, Memelink J, Kreis W, Goossens A. Munkert J, et al. Mol Plant. 2014 Sep 19:ssu100. doi: 10.1093/mp/ssu100. Online ahead of print. Mol Plant. 2014. PMID: 25239067

74

Biosynthesis of an Anti-Addiction Agent from the Iboga Plant.

Farrow SC, Kamileen MO, Caputi L, Bussey K, Mundy JEA, McAtee RC, Stephenson CRJ, O'Connor SE. Farrow SC, et al. J Am Chem Soc. 2019 Aug 21;141(33):12979-12983. doi: 10.1021/jacs.9b05999. Epub 2019 Aug 6. J Am Chem Soc. 2019. PMID: 31364847 Free PMC article.

75

The Mitragyna speciosa (Kratom) Genome: a resource for data-mining potent pharmaceuticals that impact human health.

Brose J, Lau KH, Dang TTT, Hamilton JP, Martins LDV, Hamberger B, Hamberger B, Jiang J, O'Connor SE, Buell CR. Brose J, et al. G3 (Bethesda). 2021 Apr 15;11(4):jkab058. doi: 10.1093/g3journal/jkab058. G3 (Bethesda). 2021. PMID: 33677570 Free PMC article.

76

Cell-Free Total Biosynthesis of Plant Terpene Natural Products using an Orthogonal Cofactor Regeneration System.

Bat-Erdene U, Billingsley JM, Turner WC, Lichman BR, Ippoliti FM, Garg NK, O'Connor SE, Tang Y. Bat-Erdene U, et al. ACS Catal. 2021 Aug 6;11(15):9898-9903. doi: 10.1021/acscatal.1c02267. Epub 2021 Jul 23. ACS Catal. 2021. PMID: 35355836 Free PMC article.

77

Biosynthesis of strychnine.

Hong B, Grzech D, Caputi L, Sonawane P, López CER, Kamileen MO, Hernández Lozada NJ, Grabe V, O'Connor SE. Hong B, et al. Nature. 2022 Jul;607(7919):617-622. doi: 10.1038/s41586-022-04950-4. Epub 2022 Jul 6. Nature. 2022. PMID: 35794473 Free PMC article.

78

Recent progress in the metabolic engineering of alkaloids in plant systems.

Glenn WS, Runguphan W, O'Connor SE. Glenn WS, et al. Curr Opin Biotechnol. 2013 Apr;24(2):354-65. doi: 10.1016/j.copbio.2012.08.003. Epub 2012 Sep 3. Curr Opin Biotechnol. 2013. PMID: 22954587 Free PMC article. Review.

79

Virus-Induced Gene Silencing in Nepeta.

Palmer L, O'Connor SE. Palmer L, et al. Methods Mol Biol. 2020;2172:111-121. doi: 10.1007/978-1-0716-0751-0_9. Methods Mol Biol. 2020. PMID: 32557365

80

Metabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants.

Dávila-Lara A, Rodríguez-López CE, O'Connor SE, Mithöfer A. Dávila-Lara A, et al. Int J Mol Sci. 2020 Jun 19;21(12):4376. doi: 10.3390/ijms21124376. Int J Mol Sci. 2020. PMID: 32575527 Free PMC article.

81

Redesign of a central enzyme in alkaloid biosynthesis.

Chen S, Galan MC, Coltharp C, O'Connor SE. Chen S, et al. Chem Biol. 2006 Nov;13(11):1137-41. doi: 10.1016/j.chembiol.2006.10.009. Chem Biol. 2006. PMID: 17113995

82

Publisher Correction: Biosynthesis of strychnine.

Hong B, Grzech D, Caputi L, Sonawane P, López CER, Kamileen MO, Hernández Lozada NJ, Grabe V, O'Connor SE. Hong B, et al. Nature. 2022 Aug;608(7924):E37. doi: 10.1038/s41586-022-05177-z. Nature. 2022. PMID: 35931767 Free PMC article. No abstract available.

83

Chemoselective derivatization of alkaloids in periwinkle.

Galan MC, McCoy E, O'Connor SE. Galan MC, et al. Chem Commun (Camb). 2007 Aug 21;(31):3249-51. doi: 10.1039/b708919h. Epub 2007 Jul 11. Chem Commun (Camb). 2007. PMID: 17668090

84

A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus.

Liscombe DK, O'Connor SE. Liscombe DK, et al. Phytochemistry. 2011 Nov;72(16):1969-77. doi: 10.1016/j.phytochem.2011.07.001. Epub 2011 Jul 27. Phytochemistry. 2011. PMID: 21802100 Free PMC article.

85

Biocatalytic routes to stereo-divergent iridoids.

Hernández Lozada NJ, Hong B, Wood JC, Caputi L, Basquin J, Chuang L, Kunert M, Rodríguez López CE, Langley C, Zhao D, Buell CR, Lichman BR, O'Connor SE. Hernández Lozada NJ, et al. Nat Commun. 2022 Aug 11;13(1):4718. doi: 10.1038/s41467-022-32414-w. Nat Commun. 2022. PMID: 35953485 Free PMC article.

86

Author Correction: Biocatalytic routes to stereo-divergent iridoids.

Hernández Lozada NJ, Hong B, Wood JC, Caputi L, Basquin J, Chuang L, Kunert M, Rodríguez López CE, Langley C, Zhao D, Buell CR, Lichman BR, O'Connor SE. Hernández Lozada NJ, et al. Nat Commun. 2022 Sep 27;13(1):5678. doi: 10.1038/s41467-022-33380-z. Nat Commun. 2022. PMID: 36167838 Free PMC article. No abstract available.

87

Substrate specificity of strictosidine synthase.

McCoy E, Galan MC, O'Connor SE. McCoy E, et al. Bioorg Med Chem Lett. 2006 May 1;16(9):2475-8. doi: 10.1016/j.bmcl.2006.01.098. Epub 2006 Feb 14. Bioorg Med Chem Lett. 2006. PMID: 16481164

88

Biocatalysts from alkaloid producing plants.

Kries H, O'Connor SE. Kries H, et al. Curr Opin Chem Biol. 2016 Apr;31:22-30. doi: 10.1016/j.cbpa.2015.12.006. Epub 2016 Jan 13. Curr Opin Chem Biol. 2016. PMID: 26773811 Free article. Review.

89

Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism.

Langley C, Tatsis E, Hong B, Nakamura Y, Paetz C, Stevenson CEM, Basquin J, Lawson DM, Caputi L, O'Connor SE. Langley C, et al. Angew Chem Int Ed Engl. 2022 Nov 25;61(48):e202210934. doi: 10.1002/anie.202210934. Epub 2022 Oct 26. Angew Chem Int Ed Engl. 2022. PMID: 36198083 Free PMC article.

90

Inverted stereocontrol of iridoid synthase in snapdragon.

Kries H, Kellner F, Kamileen MO, O'Connor SE. Kries H, et al. J Biol Chem. 2017 Sep 1;292(35):14659-14667. doi: 10.1074/jbc.M117.800979. Epub 2017 Jul 12. J Biol Chem. 2017. PMID: 28701463 Free PMC article.

91

Bypassing stereoselectivity in the early steps of alkaloid biosynthesis.

Bernhardt P, Yerkes N, O'Connor SE. Bernhardt P, et al. Org Biomol Chem. 2009 Oct 21;7(20):4166-8. doi: 10.1039/b916027m. Epub 2009 Aug 13. Org Biomol Chem. 2009. PMID: 19795053 Free PMC article.

92

Opportunities for enzyme engineering in natural product biosynthesis.

Bernhardt P, O'Connor SE. Bernhardt P, et al. Curr Opin Chem Biol. 2009 Feb;13(1):35-42. doi: 10.1016/j.cbpa.2009.01.005. Epub 2009 Feb 5. Curr Opin Chem Biol. 2009. PMID: 19201253 Free PMC article. Review.

93

Mechanistic advances in plant natural product enzymes.

Usera AR, O'Connor SE. Usera AR, et al. Curr Opin Chem Biol. 2009 Oct;13(4):492-8. doi: 10.1016/j.cbpa.2009.06.019. Epub 2009 Jul 23. Curr Opin Chem Biol. 2009. PMID: 19632140 Free PMC article. Review.

94

The evolutionary origins of the cat attractant nepetalactone in catnip.

Lichman BR, Godden GT, Hamilton JP, Palmer L, Kamileen MO, Zhao D, Vaillancourt B, Wood JC, Sun M, Kinser TJ, Henry LK, Rodriguez-Lopez C, Dudareva N, Soltis DE, Soltis PS, Buell CR, O'Connor SE. Lichman BR, et al. Sci Adv. 2020 May 13;6(20):eaba0721. doi: 10.1126/sciadv.aba0721. eCollection 2020 May. Sci Adv. 2020. PMID: 32426505 Free PMC article.

95

The important ergot alkaloid intermediate chanoclavine-I produced in the yeast Saccharomyces cerevisiae by the combined action of EasC and EasE from Aspergillus japonicus.

Nielsen CA, Folly C, Hatsch A, Molt A, Schröder H, O'Connor SE, Naesby M. Nielsen CA, et al. Microb Cell Fact. 2014 Aug 12;13:95. doi: 10.1186/s12934-014-0095-2. Microb Cell Fact. 2014. PMID: 25112180 Free PMC article.

96

Independent evolution of plant natural products: Formation of benzoxazinoids in Consolida orientalis (Ranunculaceae).

Florean M, Schultz H, Wurlitzer J, O'Connor SE, Köllner TG. Florean M, et al. Among authors: o connor se. J Biol Chem. 2024 Nov 26:108019. doi: 10.1016/j.jbc.2024.108019. Online ahead of print. J Biol Chem. 2024. PMID: 39608711 Free article.

97

Biosynthetic Origin of the Methoxy Group in Quinine and Related Alkaloids.

Lombe BK, Zhou T, Caputi L, Ploss K, O'Connor SE. Lombe BK, et al. Among authors: o connor se. Angew Chem Int Ed Engl. 2024 Nov 7:e202418306. doi: 10.1002/anie.202418306. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 39508515

98

Cell-type-aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant Catharanthus roseus.

Li C, Colinas M, Wood JC, Vaillancourt B, Hamilton JP, Jones SL, Caputi L, O'Connor SE, Buell CR. Li C, et al. Among authors: o connor se. New Phytol. 2025 Jan;245(1):347-362. doi: 10.1111/nph.20208. Epub 2024 Oct 25. New Phytol. 2025. PMID: 39456129 Free PMC article.

99

Genome-based discovery of pachysiphine synthases in Tabernaemontana elegans.

Lezin E, Durand M, Birer Williams C, Lopez Vazquez AL, Perrot T, Gautron N, Pétrignet J, Cuello C, Jansen HJ, Magot F, Szwarc S, Le Pogam P, Beniddir MA, Koudounas K, Oudin A, St-Pierre B, Giglioli-Guivarc'h N, Sun C, Papon N, Jensen MK, Dirks RP, O'Connor SE, Besseau S, Courdavault V. Lezin E, et al. Among authors: o connor se. Plant J. 2024 Oct 20. doi: 10.1111/tpj.17085. Online ahead of print. Plant J. 2024. PMID: 39427334

100

A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants.

Boccia M, Kessler D, Seibt W, Grabe V, Rodríguez López CE, Grzech D, Heinicke S, O'Connor SE, Sonawane PD. Boccia M, et al. Among authors: o connor se. Science. 2024 Oct 17:eado3409. doi: 10.1126/science.ado3409. Online ahead of print. Science. 2024. PMID: 39418343

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