HHSN267200700004C/LM/NLM NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
2008	1
2009	5
2010	14
2011	12
2012	8
2013	13
2014	10
2015	6
2016	8
2017	5
2018	2
2019	2
2020	1
2024	1
2025	2
2026	1

1

Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits.

Alkhawaja AA, Currin KW, Perrin HJ, Vadlamudi S, Etheridge AS, Broadaway KA, Cannon GH, Anderson CW, Moxley AH, Iuga AC, Schuetz EG, Innocenti F, Furey TS, Mohlke KL. Alkhawaja AA, et al. Am J Hum Genet. 2026 Jan 8;113(1):133-148. doi: 10.1016/j.ajhg.2025.11.009. Epub 2025 Dec 2. Am J Hum Genet. 2026. PMID: 41338218 Free PMC article.

2

Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits.

Currin KW, Perrin HJ, Pandey GK, Alkhawaja AA, Vadlamudi S, Musser AE, Etheridge AS, Broadaway KA, Rosen JD, Varshney A, Chaudhry AS, Gallins PJ, Wright FA, Zhou YH, Parker SCJ, Raffield LM, Schuetz EG, Innocenti F, Mohlke KL. Currin KW, et al. Genome Res. 2025 Jul 1;35(7):1485-1502. doi: 10.1101/gr.279741.124. Genome Res. 2025. PMID: 40393811 Free PMC article.

3

Whole-Exome Sequencing (WES) Reveals Novel Sex-Specific Gene Variants in Non-Alcoholic Steatohepatitis (MASH).

Wei J, Wu BJ, Daoud SS. Wei J, et al. Genes (Basel). 2024 Mar 13;15(3):357. doi: 10.3390/genes15030357. Genes (Basel). 2024. PMID: 38540416 Free PMC article.

4

Ontogeny Related Changes in the Pediatric Liver Metabolome.

Wilson CM, Li Q, Gaedigk R, Bi C, de Wildt SN, Leeder JS, Fridley BL. Wilson CM, et al. Front Pediatr. 2020 Sep 29;8:549. doi: 10.3389/fped.2020.00549. eCollection 2020. Front Pediatr. 2020. PMID: 33117761 Free PMC article.

5

Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism.

Ladumor MK, Bhatt DK, Gaedigk A, Sharma S, Thakur A, Pearce RE, Leeder JS, Bolger MB, Singh S, Prasad B. Ladumor MK, et al. Drug Metab Dispos. 2019 Aug;47(8):818-831. doi: 10.1124/dmd.119.086462. Epub 2019 May 17. Drug Metab Dispos. 2019. PMID: 31101678 Free PMC article.

6

Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.

Lake AD, Hardwick RN, Leamon CP, Low PS, Cherrington NJ. Lake AD, et al. Toxicol Appl Pharmacol. 2019 Apr 1;368:49-54. doi: 10.1016/j.taap.2019.02.009. Epub 2019 Feb 19. Toxicol Appl Pharmacol. 2019. PMID: 30794826 Free PMC article.

7

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Bhatt DK, Basit A, Zhang H, Gaedigk A, Lee SB, Claw KG, Mehrotra A, Chaudhry AS, Pearce RE, Gaedigk R, Broeckel U, Thornton TA, Nickerson DA, Schuetz EG, Amory JK, Leeder JS, Prasad B. Bhatt DK, et al. Drug Metab Dispos. 2018 Jun;46(6):888-896. doi: 10.1124/dmd.118.080952. Epub 2018 Mar 30. Drug Metab Dispos. 2018. PMID: 29602798 Free PMC article.

8

Regulation of Cholesterol Sulfotransferase SULT2B1b by Hepatocyte Nuclear Factor 4α Constitutes a Negative Feedback Control of Hepatic Gluconeogenesis.

Bi Y, Shi X, Zhu J, Guan X, Garbacz WG, Huang Y, Gao L, Yan J, Xu M, Ren S, Ren S, Liu Y, Ma X, Li S, Xie W. Bi Y, et al. Mol Cell Biol. 2018 Mar 15;38(7):e00654-17. doi: 10.1128/MCB.00654-17. Print 2018 Apr 1. Mol Cell Biol. 2018. PMID: 29378829 Free PMC article.

9

Effects of Fenofibrate on the Expression of Small Heterodimer Partner (SHP) and Cytochrome P450 (CYP) 2D6.

Kent R, Jeong H. Kent R, et al. Drug Metab Lett. 2017 Nov 17;11(1):68-72. doi: 10.2174/1872312811666170407164631. Drug Metab Lett. 2017. PMID: 28403802

10

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.

Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B. Xu M, et al. J Pharmacol Exp Ther. 2017 Nov;363(2):265-274. doi: 10.1124/jpet.117.243113. Epub 2017 Aug 17. J Pharmacol Exp Ther. 2017. PMID: 28819071 Free PMC article.

11

Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver.

Bhatt DK, Gaedigk A, Pearce RE, Leeder JS, Prasad B. Bhatt DK, et al. Drug Metab Dispos. 2017 Sep;45(9):1044-1048. doi: 10.1124/dmd.117.076463. Epub 2017 Jun 12. Drug Metab Dispos. 2017. PMID: 28607029 Free PMC article.

12

Impaired N-linked glycosylation of uptake and efflux transporters in human non-alcoholic fatty liver disease.

Clarke JD, Novak P, Lake AD, Hardwick RN, Cherrington NJ. Clarke JD, et al. Liver Int. 2017 Jul;37(7):1074-1081. doi: 10.1111/liv.13362. Epub 2017 Feb 7. Liver Int. 2017. PMID: 28097795 Free PMC article.

13

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.

Boberg M, Vrana M, Mehrotra A, Pearce RE, Gaedigk A, Bhatt DK, Leeder JS, Prasad B. Boberg M, et al. Drug Metab Dispos. 2017 Feb;45(2):216-223. doi: 10.1124/dmd.116.072652. Epub 2016 Nov 28. Drug Metab Dispos. 2017. PMID: 27895113 Free PMC article.

14

Transcription factor binding site enrichment analysis predicts drivers of altered gene expression in nonalcoholic steatohepatitis.

Lake AD, Chaput AL, Novak P, Cherrington NJ, Smith CL. Lake AD, et al. Biochem Pharmacol. 2016 Dec 15;122:62-71. doi: 10.1016/j.bcp.2016.11.006. Epub 2016 Nov 9. Biochem Pharmacol. 2016. PMID: 27836672 Free PMC article.

15

Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.

Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder JS, Salphati L, Chu X, Xiao G, Hop C, Evers R, Gan L, Unadkat JD. Prasad B, et al. Clin Pharmacol Ther. 2016 Oct;100(4):362-70. doi: 10.1002/cpt.409. Epub 2016 Aug 13. Clin Pharmacol Ther. 2016. PMID: 27301780 Free PMC article.

16

Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.

Dinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JS. Dinh JC, et al. Drug Metab Dispos. 2016 Jul;44(7):1070-9. doi: 10.1124/dmd.116.069518. Epub 2016 Apr 6. Drug Metab Dispos. 2016. PMID: 27052878 Free PMC article.

17

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis.

Bala S, Csak T, Saha B, Zatsiorsky J, Kodys K, Catalano D, Satishchandran A, Szabo G. Bala S, et al. J Hepatol. 2016 Jun;64(6):1378-87. doi: 10.1016/j.jhep.2016.01.035. Epub 2016 Feb 8. J Hepatol. 2016. PMID: 26867493 Free PMC article.

18

Human pregnane X receptor compromises the function of p53 and promotes malignant transformation.

Robbins D, Cherian M, Wu J, Chen T. Robbins D, et al. Cell Death Discov. 2016 Apr 18;2:16023. doi: 10.1038/cddiscovery.2016.23. eCollection 2016. Cell Death Discov. 2016. PMID: 27547448 Free PMC article.

19

Bisphenol A sulfonation is impaired in metabolic and liver disease.

Yalcin EB, Kulkarni SR, Slitt AL, King R. Yalcin EB, et al. Toxicol Appl Pharmacol. 2016 Feb 1;292:75-84. doi: 10.1016/j.taap.2015.12.009. Epub 2015 Dec 19. Toxicol Appl Pharmacol. 2016. PMID: 26712468 Free PMC article.

20

Soy isoflavone metabolism in cats compared with other species: urinary metabolite concentrations and glucuronidation by liver microsomes.

Redmon JM, Shrestha B, Cerundolo R, Court MH. Redmon JM, et al. Xenobiotica. 2016;46(5):406-15. doi: 10.3109/00498254.2015.1086038. Epub 2015 Sep 14. Xenobiotica. 2016. PMID: 26366946 Free PMC article.

21

Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver.

Burgess KS, Philips S, Benson EA, Desta Z, Gaedigk A, Gaedigk R, Segar MW, Liu Y, Skaar TC. Burgess KS, et al. Clin Pharmacol Ther. 2015 Aug;98(2):205-15. doi: 10.1002/cpt.145. Clin Pharmacol Ther. 2015. PMID: 25968989 Free PMC article.

22

CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.

Cherian MT, Lin W, Wu J, Chen T. Cherian MT, et al. Mol Pharmacol. 2015 May;87(5):878-89. doi: 10.1124/mol.115.097782. Epub 2015 Mar 11. Mol Pharmacol. 2015. PMID: 25762023 Free PMC article.

23

GW4064, an agonist of farnesoid X receptor, represses CYP3A4 expression in human hepatocytes by inducing small heterodimer partner expression.

Zhang S, Pan X, Jeong H. Zhang S, et al. Drug Metab Dispos. 2015 May;43(5):743-8. doi: 10.1124/dmd.114.062836. Epub 2015 Feb 27. Drug Metab Dispos. 2015. PMID: 25725071 Free PMC article.

24

Functional characterization of CYP2D6 enhancer polymorphisms.

Wang D, Papp AC, Sun X. Wang D, et al. Hum Mol Genet. 2015 Mar 15;24(6):1556-62. doi: 10.1093/hmg/ddu566. Epub 2014 Nov 7. Hum Mol Genet. 2015. PMID: 25381333 Free PMC article.

25

Transcriptional regulation of human hydroxysteroid sulfotransferase SULT2A1 by LXRα.

Ou Z, Jiang M, Hu B, Huang Y, Xu M, Ren S, Li S, Liu S, Xie W, Huang M. Ou Z, et al. Drug Metab Dispos. 2014 Oct;42(10):1684-9. doi: 10.1124/dmd.114.058479. Epub 2014 Jul 15. Drug Metab Dispos. 2014. PMID: 25028566 Free PMC article.

26

Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.

Court MH, Almutairi FE, Greenblatt DJ, Hazarika S, Sheng H, Klein K, Zanger UM, Bourgea J, Patten CJ, Kwara A. Court MH, et al. Antimicrob Agents Chemother. 2014 Jul;58(7):4145-52. doi: 10.1128/AAC.02532-14. Epub 2014 May 12. Antimicrob Agents Chemother. 2014. PMID: 24820076 Free PMC article.

27

STAT4 knockout mice are more susceptible to concanavalin A-induced T-cell hepatitis.

Wang Y, Feng D, Wang H, Xu MJ, Park O, Li Y, Gao B. Wang Y, et al. Am J Pathol. 2014 Jun;184(6):1785-94. doi: 10.1016/j.ajpath.2014.02.023. Epub 2014 Apr 13. Am J Pathol. 2014. PMID: 24731448 Free PMC article.

28

Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.

Ong SS, Goktug AN, Elias A, Wu J, Saunders D, Chen T. Ong SS, et al. Biochem J. 2014 Apr 1;459(1):193-203. doi: 10.1042/BJ20130558. Biochem J. 2014. PMID: 24438055 Free PMC article.

29

Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes.

Lee JK, Chung HJ, Fischer L, Fischer J, Gonzalez FJ, Jeong H. Lee JK, et al. Drug Metab Dispos. 2014 Apr;42(4):492-9. doi: 10.1124/dmd.113.055384. Epub 2014 Jan 9. Drug Metab Dispos. 2014. PMID: 24408518 Free PMC article.

30

Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4α.

Shi X, Cheng Q, Xu L, Yan J, Jiang M, He J, Xu M, Stefanovic-Racic M, Sipula I, O'Doherty RM, Ren S, Xie W. Shi X, et al. Mol Cell Biol. 2014 Feb;34(3):485-97. doi: 10.1128/MCB.01094-13. Epub 2013 Nov 25. Mol Cell Biol. 2014. PMID: 24277929 Free PMC article.

31

Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.

Clarke JD, Novak P, Lake AD, Shipkova P, Aranibar N, Robertson D, Severson PL, Reily MD, Futscher BW, Lehman-McKeeman LD, Cherrington NJ. Clarke JD, et al. Dig Dis Sci. 2014 Feb;59(2):365-74. doi: 10.1007/s10620-013-2873-9. Epub 2013 Sep 19. Dig Dis Sci. 2014. PMID: 24048683 Free PMC article.

32

Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.

Court MH, Peter I, Hazarika S, Vasiadi M, Greenblatt DJ, Lee WM; Acute Liver Failure Study Group. Court MH, et al. Drug Metab Dispos. 2014 Jan;42(1):28-32. doi: 10.1124/dmd.113.053546. Epub 2013 Oct 8. Drug Metab Dispos. 2014. PMID: 24104197 Free PMC article.

33

Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions.

Hansel MC, Gramignoli R, Blake W, Davila J, Skvorak K, Dorko K, Tahan V, Lee BR, Tafaleng E, Guzman-Lepe J, Soto-Gutierrez A, Fox IJ, Strom SC. Hansel MC, et al. Cell Transplant. 2014 Jan;23(1):27-38. doi: 10.3727/096368912X662453. Epub 2013 Feb 4. Cell Transplant. 2014. PMID: 23394081 Free PMC article.

34

Reduced mitochondrial DNA content and heterozygous nuclear gene mutations in patients with acute liver failure.

Helbling D, Buchaklian A, Wang J, Wong LJ, Dimmock D. Helbling D, et al. J Pediatr Gastroenterol Nutr. 2013 Oct;57(4):438-43. doi: 10.1097/MPG.0b013e31829ef4b4. J Pediatr Gastroenterol Nutr. 2013. PMID: 23783014 Free PMC article.

35

Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation.

Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W. Kittayaruksakul S, et al. Pharm Res. 2013 Sep;30(9):2199-208. doi: 10.1007/s11095-013-1101-9. Epub 2013 Jul 30. Pharm Res. 2013. PMID: 23896737 Free PMC article.

36

Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease.

Smalling RV, Delker DA, Zhang Y, Nieto N, McGuiness MS, Liu S, Friedman SL, Hagedorn CH, Wang L. Smalling RV, et al. Am J Physiol Gastrointest Liver Physiol. 2013 Sep 1;305(5):G364-74. doi: 10.1152/ajpgi.00077.2013. Epub 2013 Jun 27. Am J Physiol Gastrointest Liver Physiol. 2013. PMID: 23812039 Free PMC article.

37

A feedback inhibition between miRNA-127 and TGFβ/c-Jun cascade in HCC cell migration via MMP13.

Yang Z, Zhang Y, Wang L. Yang Z, et al. PLoS One. 2013 Jun 7;8(6):e65256. doi: 10.1371/journal.pone.0065256. Print 2013. PLoS One. 2013. PMID: 23762330 Free PMC article.

38

High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.

Twist GP, Gaedigk R, Leeder JS, Gaedigk A. Twist GP, et al. Pharmacogenomics. 2013 Jun;14(8):913-22. doi: 10.2217/pgs.13.66. Pharmacogenomics. 2013. PMID: 23746185 Free PMC article.

39

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease.

Lake AD, Novak P, Shipkova P, Aranibar N, Robertson D, Reily MD, Lu Z, Lehman-McKeeman LD, Cherrington NJ. Lake AD, et al. Toxicol Appl Pharmacol. 2013 Apr 15;268(2):132-40. doi: 10.1016/j.taap.2013.01.022. Epub 2013 Feb 4. Toxicol Appl Pharmacol. 2013. PMID: 23391614 Free PMC article.

40

Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease.

Hardwick RN, Ferreira DW, More VR, Lake AD, Lu Z, Manautou JE, Slitt AL, Cherrington NJ. Hardwick RN, et al. Drug Metab Dispos. 2013 Mar;41(3):554-61. doi: 10.1124/dmd.112.048439. Epub 2012 Dec 7. Drug Metab Dispos. 2013. PMID: 23223517 Free PMC article.

41

Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone.

Choi SY, Koh KH, Jeong H. Choi SY, et al. Drug Metab Dispos. 2013 Feb;41(2):263-9. doi: 10.1124/dmd.112.046276. Epub 2012 Jul 26. Drug Metab Dispos. 2013. PMID: 22837389 Free PMC article.

42

Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.

Ou Z, Shi X, Gilroy RK, Kirisci L, Romkes M, Lynch C, Wang H, Xu M, Jiang M, Ren S, Gramignoli R, Strom SC, Huang M, Xie W. Ou Z, et al. Mol Endocrinol. 2013 Jan;27(1):106-15. doi: 10.1210/me.2012-1145. Epub 2012 Dec 4. Mol Endocrinol. 2013. PMID: 23211525 Free PMC article.

43

Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.

Koh KH, Jurkovic S, Yang K, Choi SY, Jung JW, Kim KP, Zhang W, Jeong H. Koh KH, et al. Biochem Pharmacol. 2012 Jul 1;84(1):93-103. doi: 10.1016/j.bcp.2012.03.016. Epub 2012 Mar 30. Biochem Pharmacol. 2012. PMID: 22484313 Free PMC article.

44

Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.

Zhang Y, Andrews GK, Wang L. Zhang Y, et al. Nucleic Acids Res. 2012 Jun;40(11):4850-60. doi: 10.1093/nar/gks159. Epub 2012 Feb 22. Nucleic Acids Res. 2012. PMID: 22362755 Free PMC article.

45

Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis.

Hardwick RN, Fisher CD, Street SM, Canet MJ, Cherrington NJ. Hardwick RN, et al. Drug Metab Dispos. 2012 Mar;40(3):450-60. doi: 10.1124/dmd.111.041095. Epub 2011 Nov 23. Drug Metab Dispos. 2012. PMID: 22112382 Free PMC article.

46

Molecular profiles of HCV cirrhotic tissues derived in a panel of markers with clinical utility for hepatocellular carcinoma surveillance.

Gehrau RC, Archer KJ, Mas VR, Maluf DG. Gehrau RC, et al. PLoS One. 2012;7(7):e40275. doi: 10.1371/journal.pone.0040275. Epub 2012 Jul 5. PLoS One. 2012. PMID: 22792259 Free PMC article.

47

Frequent aneuploidy among normal human hepatocytes.

Duncan AW, Hanlon Newell AE, Smith L, Wilson EM, Olson SB, Thayer MJ, Strom SC, Grompe M. Duncan AW, et al. Gastroenterology. 2012 Jan;142(1):25-8. doi: 10.1053/j.gastro.2011.10.029. Epub 2011 Nov 2. Gastroenterology. 2012. PMID: 22057114 Free PMC article.

48

Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver disease.

Hardwick RN, Fisher CD, Canet MJ, Scheffer GL, Cherrington NJ. Hardwick RN, et al. Drug Metab Dispos. 2011 Dec;39(12):2395-402. doi: 10.1124/dmd.111.041012. Epub 2011 Aug 30. Drug Metab Dispos. 2011. PMID: 21878559 Free PMC article.

49

c-Met activation through a novel pathway involving osteopontin mediates oncogenesis by the transcription factor LSF.

Yoo BK, Gredler R, Chen D, Santhekadur PK, Fisher PB, Sarkar D. Yoo BK, et al. J Hepatol. 2011 Dec;55(6):1317-24. doi: 10.1016/j.jhep.2011.02.036. Epub 2011 Apr 13. J Hepatol. 2011. PMID: 21703197 Free PMC article.

50

Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease.

Lake AD, Novak P, Fisher CD, Jackson JP, Hardwick RN, Billheimer DD, Klimecki WT, Cherrington NJ. Lake AD, et al. Drug Metab Dispos. 2011 Oct;39(10):1954-60. doi: 10.1124/dmd.111.040592. Epub 2011 Jul 7. Drug Metab Dispos. 2011. PMID: 21737566 Free PMC article.

51

Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver.

O'Brien TR, Kohaar I, Pfeiffer RM, Maeder D, Yeager M, Schadt EE, Prokunina-Olsson L. O'Brien TR, et al. Genes Immun. 2011 Sep;12(6):428-33. doi: 10.1038/gene.2011.11. Epub 2011 Feb 24. Genes Immun. 2011. PMID: 21346778 Free PMC article.

52

Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis.

Zhang Y, Bonzo JA, Gonzalez FJ, Wang L. Zhang Y, et al. J Biol Chem. 2011 Aug 26;286(34):29635-43. doi: 10.1074/jbc.M111.253039. Epub 2011 Jul 3. J Biol Chem. 2011. PMID: 21725089 Free PMC article.

53

Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue.

Innocenti F, Cooper GM, Stanaway IB, Gamazon ER, Smith JD, Mirkov S, Ramirez J, Liu W, Lin YS, Moloney C, Aldred SF, Trinklein ND, Schuetz E, Nickerson DA, Thummel KE, Rieder MJ, Rettie AE, Ratain MJ, Cox NJ, Brown CD. Innocenti F, et al. PLoS Genet. 2011 May;7(5):e1002078. doi: 10.1371/journal.pgen.1002078. Epub 2011 May 26. PLoS Genet. 2011. PMID: 21637794 Free PMC article.

54

Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).

Anderson LE, Dring AM, Hamel LD, Stoner MA. Anderson LE, et al. Toxicol Lett. 2011 Apr 25;202(2):148-54. doi: 10.1016/j.toxlet.2011.02.004. Epub 2011 Feb 18. Toxicol Lett. 2011. PMID: 21315811 Free PMC article.

55

MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation.

Ou Z, Wada T, Gramignoli R, Li S, Strom SC, Huang M, Xie W. Ou Z, et al. Mol Endocrinol. 2011 Apr;25(4):584-96. doi: 10.1210/me.2010-0360. Epub 2011 Feb 10. Mol Endocrinol. 2011. PMID: 21310851 Free PMC article.

56

Guo L, Dial S, Shi L, Branham W, Liu J, Fang JL, Green B, Deng H, Kaput J, Ning B. Guo L, et al. Drug Metab Dispos. 2011 Mar;39(3):528-38. doi: 10.1124/dmd.110.035873. Epub 2010 Dec 13. Drug Metab Dispos. 2011. PMID: 21149542 Free PMC article.

57

Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells.

He H, Mennone A, Boyer JL, Cai SY. He H, et al. Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10. Hepatology. 2011. PMID: 21274875 Free PMC article.

58

Bioassay-directed fractionation for discovery of bioactive neutral lipids guided by relative mass defect filtering and multiplexed collision-induced dissociation.

Stagliano MC, DeKeyser JG, Omiecinski CJ, Jones AD. Stagliano MC, et al. Rapid Commun Mass Spectrom. 2010 Dec 30;24(24):3578-84. doi: 10.1002/rcm.4796. Rapid Commun Mass Spectrom. 2010. PMID: 21080510 Free PMC article.

59

Metabolism and action of proteasome inhibitors in primary human hepatocytes.

Lee CM, Kumar V, Riley RI, Morgan ET. Lee CM, et al. Drug Metab Dispos. 2010 Dec;38(12):2166-72. doi: 10.1124/dmd.110.035501. Epub 2010 Sep 13. Drug Metab Dispos. 2010. PMID: 20837660 Free PMC article.

60

Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease.

Hardwick RN, Fisher CD, Canet MJ, Lake AD, Cherrington NJ. Hardwick RN, et al. Drug Metab Dispos. 2010 Dec;38(12):2293-301. doi: 10.1124/dmd.110.035006. Epub 2010 Aug 30. Drug Metab Dispos. 2010. PMID: 20805291 Free PMC article.

61

Intracellular processing of alpha1-antitrypsin.

Sifers RN. Sifers RN. Proc Am Thorac Soc. 2010 Nov;7(6):376-80. doi: 10.1513/pats.201001-011AW. Proc Am Thorac Soc. 2010. PMID: 21030516 Free PMC article. Review.

62

Induction of CYP2B6 and CYP3A4 expression by 1-aminobenzotriazole (ABT) in human hepatocytes.

Yang K, Koh KH, Jeong H. Yang K, et al. Drug Metab Lett. 2010 Aug;4(3):129-33. doi: 10.2174/187231210791698410. Drug Metab Lett. 2010. PMID: 20642445 Free PMC article.

63

Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.

Cai SY, He H, Nguyen T, Mennone A, Boyer JL. Cai SY, et al. J Lipid Res. 2010 Aug;51(8):2265-74. doi: 10.1194/jlr.M005546. Epub 2010 Mar 25. J Lipid Res. 2010. PMID: 20338915 Free PMC article.

64

A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis.

Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W. Lee JH, et al. Gastroenterology. 2010 Aug;139(2):653-63. doi: 10.1053/j.gastro.2010.03.033. Epub 2010 Mar 17. Gastroenterology. 2010. PMID: 20303349 Free PMC article.

65

Quantitative evaluation of the mitochondrial DNA depletion syndrome.

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A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.

Han S, Li T, Ellis E, Strom S, Chiang JY. Han S, et al. Mol Endocrinol. 2010 Jun;24(6):1151-64. doi: 10.1210/me.2009-0482. Epub 2010 Apr 6. Mol Endocrinol. 2010. PMID: 20371703 Free PMC article.

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Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma.

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ATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes.

Chen F, Ellis E, Strom SC, Shneider BL. Chen F, et al. Pediatr Res. 2010 Feb;67(2):183-7. doi: 10.1203/PDR.0b013e3181c2df16. Pediatr Res. 2010. PMID: 19809379 Free PMC article.

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Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids.

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Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes.

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Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury.

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Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.

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Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency.

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Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase.

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