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863 results

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Page 1
Angptl4 integrates dietary and microbial signals to disrupt gut barrier function in MASH.
Chua D, Low ZS, Kim JHS, Lee YH, Kiatbumrung R, Somnark P, Xu M, Shi Y, Kaushal G, Vos MIG, Mahadevan A, Hooi N, Raj M, Sviriaeva E, Cui B, Tan S, Kasahara K, Ho CL, Wahli W, Yew KC, Wong SH, Cheung C, Pal M, Zhang R, Chuaypen N, Tangkijvanich P, Cheng HS, Li L, Tan NS. Chua D, et al. Among authors: ho cl. Nat Commun. 2026 May 22. doi: 10.1038/s41467-026-72575-6. Online ahead of print. Nat Commun. 2026. PMID: 42173835 Free article.
Engineered commensals for targeted nose-to-brain drug delivery.
Shen H, Aggarwal N, Cui B, Foo GW, He Y, Srivastava SK, Li S, Seah MZX, Wun KS, Ling H, Hwang IY, Ho CL, Lee YS, Chang MW. Shen H, et al. Among authors: ho cl. Cell. 2025 Mar 20;188(6):1545-1562.e16. doi: 10.1016/j.cell.2025.01.017. Epub 2025 Feb 5. Cell. 2025. PMID: 39914382 Free article.
Engineered commensals for metabolic modulation of the gut-liver-brain axis.
Aggarwal N, Shen H, Lee LT, Zhou L, Zhu MT, Koh XQ, Ng AXY, Li M, Jumat NHB, Cheah WY, Li S, Saini M, Lee JWJ, Foo JL, Wun KS, Hwang IY, Ho CL, Lee YS, Dan YY, Chang MW. Aggarwal N, et al. Among authors: ho cl. Cell. 2026 Apr 24:S0092-8674(26)00384-3. doi: 10.1016/j.cell.2026.03.048. Online ahead of print. Cell. 2026. PMID: 42034052 Free article.
Reprogramming microbes to be pathogen-seeking killers.
Hwang IY, Tan MH, Koh E, Ho CL, Poh CL, Chang MW. Hwang IY, et al. Among authors: ho cl. ACS Synth Biol. 2014 Apr 18;3(4):228-37. doi: 10.1021/sb400077j. Epub 2013 Sep 13. ACS Synth Biol. 2014. PMID: 24020906
Cinnamaldehyde inhibits the NLRP3 inflammasome and inflammatory response by reducing oxidative stress in Neisseria gonorrhoeae-infected macrophages.
Hua KF, Chiu HW, Chen MM, Wong WT, Tsai WC, Lin WY, Wu CH, Wang CC, Hsu CH, Chernikov OV, Rao YK, Hsu HT, Ho CL, Li LH. Hua KF, et al. Among authors: ho cl. J Tradit Complement Med. 2025 Jun 25;16(3):308-318. doi: 10.1016/j.jtcme.2025.06.003. eCollection 2026 May. J Tradit Complement Med. 2025. PMID: 42222328 Free PMC article.
Response to comment on "Considering the unmeasured impact of 5-fluorouracil dose intensity in the interpretation of optimal initial relative dose intensity of modified FOLFIRINOX".
Ho IW, Li CP, Yang SH, Wang HT, Lin CY, Su YY, Ho CL, Chou WC, Chiu TJ, Shih YH, Feng YH, Chang YS, Hung CC, Chiu CF, Bai LY. Ho IW, et al. Among authors: ho cl. J Formos Med Assoc. 2026 May 22:S0929-6646(26)00542-5. doi: 10.1016/j.jfma.2026.05.045. Online ahead of print. J Formos Med Assoc. 2026. PMID: 42173783 Free article. No abstract available.
Response to Comment on "Optimal initial relative dose intensity of modified FOLFIRINOX in pancreatic ductal adenocarcinoma: A retrospective multi-center cohort".
Ho IW, Li CP, Yang SH, Wang HT, Lin CY, Su YY, Ho CL, Chou WC, Chiu TJ, Shih YH, Feng YH, Chang YS, Hung CC, Chiu CF, Bai LY. Ho IW, et al. Among authors: ho cl. J Formos Med Assoc. 2026 May 5:S0929-6646(26)00486-9. doi: 10.1016/j.jfma.2026.05.008. Online ahead of print. J Formos Med Assoc. 2026. PMID: 42091388 Free article. No abstract available.
Survival, Toxicity, and Economic Outcomes of Osimertinib Versus Second-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Metastatic Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer.
Chen PH, Jhou HJ, Chang WC, Chen HY, Kao LT, Hsieh TY, Ye RH, Lai SW, Chen JH, Ho CL, Lee CH. Chen PH, et al. Among authors: ho cl. JCO Oncol Pract. 2026 May 6:OP2501390. doi: 10.1200/OP-25-01390. Online ahead of print. JCO Oncol Pract. 2026. PMID: 42090641
A nomogram for predicting recurrence-free survival in patients with high-risk GIST receiving adjuvant imatinib: A nationwide registry study.
Yeh CN, Shan YS, Yang CY, Hsiao CF, Tsai CH, Wang CC, Lin MT, Ting CF, Chan DC, Chen TH, Yen CC, Chen YY, Lin HY, Yeh TS, Ho CL, Shieh TY, Bai LY, Hsu JT, Chen IS, Chen LT, Tsai HJ; Taiwan Cooperative Oncology Group Gist Study Group. Yeh CN, et al. Among authors: ho cl. Exp Ther Med. 2026 Mar 24;31(5):145. doi: 10.3892/etm.2026.13140. eCollection 2026 May. Exp Ther Med. 2026. PMID: 41938995 Free PMC article.
Osimertinib Versus First-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Metastatic EGFR-Mutant Non-Small Cell Lung Cancer: A Target Trial Emulation Study of Real-World Survival and Safety Outcomes.
Ye RH, Jhou HJ, Chen HY, Kao LT, Hsieh TY, Chen YH, Zhang X, Dai MS, Ho CL, Chen PH, Lee CH. Ye RH, et al. Among authors: ho cl. JCO Oncol Pract. 2025 Dec 9:OP2500788. doi: 10.1200/OP-25-00788. Online ahead of print. JCO Oncol Pract. 2025. PMID: 41364874
GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology.
Luben RN, Biradar MI, Stuart KV, Hu R, Sun Z, Li Z, Wang N, Do T, Pang CP, Nakano M, Tashiro K, Ikeda Y, Tokuda Y, Tanaka M, Omi N, Ueno M, Sotozono C, Kinoshita S, Mori K, Kitnarong N, Fea A, Melo MB, Vasconcellos JPC, Costa VP, Nongpiur ME, Ho CL, Perera SA, Craig JE, Kolovos A, Liza-Sharmini AT, Leuenberger EU, Park KH, Vijaya L, George R, Aung T, Khor CC, Foster PJ, Hysi P, Khawaja AP. Luben RN, et al. Among authors: ho cl. Nat Commun. 2025 Nov 14;16(1):10003. doi: 10.1038/s41467-025-64949-z. Nat Commun. 2025. PMID: 41238566 Free PMC article.
Pictorial review of ascariasis in acute abdomen.
Koh KKN, Salah MM, Ho CL. Koh KKN, et al. Among authors: ho cl. Singapore Med J. 2025 Aug 1;66(8):462-467. doi: 10.4103/singaporemedj.SMJ-2022-181. Epub 2025 Aug 20. Singapore Med J. 2025. PMID: 40833758 Free PMC article. No abstract available.
Functionally deficient UBOX5 variants and primary angle-closure glaucoma.
Li Z, Chng WL, Liu Z, Do T, Nakano M, Chen LJ, Loo Y, Chan ASY, Topouzis F, Nongpiur ME, Ozaki M, Nakano S, Kubota T, Perera SA, Husain R, Wong TTL, Cheng CY, Ho CL, Abu-Amero K, Wong HT, Melo MB, Hien NDTN, Van Trinh N, Huong NTT, Azhany Y, Perez-Grossmann R, Chan PP, Stuart KV, Biradar MI, Szabo A, Anastasopoulos E, Giannoulis DA, Ntonti P, Papakonstantinou E, Lambropoulos A, Chatzikyriakidou A, Kilintzis V, Ayub H, Micheal S, Aung YY, Leuenberger EU, Fea A, Mon NN, Anajao A, Bi X, Kok YJ, Chong RS, Boey PY, Tan DZJ, Sin WWL, Chowbay B, Khaing CC, Aung YM, Reyes RD, Panagiotou ES, Mikropoulos DG, Voudouragkaki IC, Panos GD, Xie Z, Chen XY, Lim YT, Meah WY, Lee YS, Ho CEH, Yeo PMX, Ikeda Y, Tokuda Y, Tanaka M, Omi N, Ueno M, de Vasconcellos JPC, Costa VP, Abe RY, de Souza BB, Fong GB, Castro VV, Fujita R, Guevara-Fujita ML, Akhtar F, Ali M, Catacutan MAT, Felarca IR, Liao CS, Lavia C, Than HM, Oo KT, Soe-Kyaw PP, Frezzotti P, Pasutto F, Quino R, Minn-Din Z, Oo NL, Dallorto L, Set SH, Doan VH, Qamar R, Neto JM, Al-Obeidan S, Tham CC, Mori K, Sotozono C, Kinoshita S, Konstas AG, Liza-Sharmini AT, Zenteno JC, Do NH, Foster PJ, Tashiro K, Pang CP, Khawaja AP, Aung T, Wa… See abstract for full author list ➔ Li Z, et al. Among authors: ho ceh, ho cl. Nat Commun. 2025 Aug 15;16(1):7620. doi: 10.1038/s41467-025-62775-x. Nat Commun. 2025. PMID: 40817263 Free PMC article.
Total neoadjuvant therapy for locally advanced rectal cancer.
Mueller S, Kao YS, Kastner C, Chen PH, Hendricks A, Lee GY, Koehler F, Jhou HJ, Germer CT, Kang EY, Janka H, Ho CL, Lee CH, Wiegering A. Mueller S, et al. Among authors: ho cl. Cochrane Database Syst Rev. 2025 May 14;5(5):CD015590. doi: 10.1002/14651858.CD015590. Cochrane Database Syst Rev. 2025. PMID: 40365860 Free PMC article.
Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination.
Zhong Y, Li J, Lee ARYB, Tan JYJ, Tay CJX, Koh CW, Seow EYT, Yap WC, Wong SY, Yau CE, Low CE, Tan KB, Young BE, Su Y, Devasia AG, Dharuman P, Lezhava A, Pandey R, Govindaraju PS, Yee S, Weng R, Khoo C, Tan SSY, Lee M, Lim J, Chan E, Ho CL, Chai LYA, Tan CW, Lee SC, Chan KR, Sundar R. Zhong Y, et al. Among authors: ho cl. NPJ Vaccines. 2025 May 9;10(1):90. doi: 10.1038/s41541-025-01141-w. NPJ Vaccines. 2025. PMID: 40341527 Free PMC article.
Durvalumab, Tremelimumab, and Platinum Chemotherapy in EGFR Mutation-Positive NSCLC: An Open-Label Phase 2 Trial (ILLUMINATE).
Lee CK, Liao BC, Subramaniam S, Chiu CH, Mersiades AJ, Ho CC, Brown C, Lai CL, Hughes BGM, Yang TY, O'Byrne K, Luo YH, Yip S, Ho CL, Bray V, Su WC, Moore M, Feng WL, Bai YY, Ford K, Cummins MM, Stockler MR, Solomon BJ, John T, Chih-Hsin Yang J. Lee CK, et al. Among authors: ho cc, ho cl. JTO Clin Res Rep. 2024 Nov 22;6(2):100771. doi: 10.1016/j.jtocrr.2024.100771. eCollection 2025 Feb. JTO Clin Res Rep. 2024. PMID: 39877028 Free PMC article.
C4 photosynthesis and hydraulics in grasses.
Zhou H, Akçay E, Edwards EJ, Ho CL, Abdullahi A, Zheng Y, Helliker BR. Zhou H, et al. Among authors: ho cl. New Phytol. 2025 Feb;245(4):1481-1495. doi: 10.1111/nph.20284. Epub 2025 Jan 2. New Phytol. 2025. PMID: 39746467 Free article.
eLemur: A cellular-resolution 3D atlas of the mouse lemur brain.
Jeon H, Kim J, Kim J, Choi YK, Ho CLA, Pifferi F, Huber D, Feng L, Kim J. Jeon H, et al. Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2413687121. doi: 10.1073/pnas.2413687121. Epub 2024 Dec 4. Proc Natl Acad Sci U S A. 2024. PMID: 39630862 Free PMC article.
Registry of Genetic Alterations of Taiwan Non-Small Cell Lung Cancer by Comprehensive Next-Generation Sequencing: A Real-World Cohort Study-Taiwan Cooperative Oncology Group T1521.
Liao BC, Chiang NJ, Chang GC, Su WC, Luo YH, Chong IW, Yang TY, Lai CL, Hsia TC, Ho CL, Lee KY, Hsiao CF, Ku FC, Fang WT, Chih-Hsin Yang J. Liao BC, et al. Among authors: ho cl. JCO Glob Oncol. 2024 Sep;10:e2400125. doi: 10.1200/GO.24.00125. Epub 2024 Sep 30. JCO Glob Oncol. 2024. PMID: 39348626 Free PMC article.
Immune killer cells treatment for previously treated stage IV NSCLC patients.
Tseng YH, Ho CL, Chian CF, Chiang CL, Chao HS, Tsai CL, Perng WC, Hsiao CF, Chuang MH, Ko KH, Cheng YC, Chen SJ, Wang CJ, Chen YM. Tseng YH, et al. Among authors: ho cl. Sci Rep. 2024 Aug 21;14(1):19374. doi: 10.1038/s41598-024-69587-x. Sci Rep. 2024. PMID: 39169058 Free PMC article. Clinical Trial.
Survival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study.
Tsai HJ, Shan YS, Yang CY, Hsiao CF, Tsai CH, Wang CC, Lin MT, Ting CF, Chan DC, Chen TH, Yen CC, Chen YY, Lin HY, Yeh TS, Ho CL, Shieh TY, Bai LY, Hsu JT, Chen IS, Chen LT, Yeh CN; Taiwan Cooperative Oncology Group (TCOG) GIST Study Group. Tsai HJ, et al. Among authors: ho cl. BMC Cancer. 2024 Jul 11;24(1):828. doi: 10.1186/s12885-024-12567-1. BMC Cancer. 2024. PMID: 38992597 Free PMC article.
RESILIENT Part 2: A Randomized, Open-Label Phase III Study of Liposomal Irinotecan Versus Topotecan in Adults With Relapsed Small Cell Lung Cancer.
Spigel DR, Dowlati A, Chen Y, Navarro A, Yang JC, Stojanovic G, Jove M, Rich P, Andric ZG, Wu YL, Rudin CM, Chen H, Zhang L, Yeung S, Benzaghou F, Paz-Ares L, Bunn PA; RESILIENT Trial Investigators. Spigel DR, et al. J Clin Oncol. 2024 Jul 1;42(19):2317-2326. doi: 10.1200/JCO.23.02110. Epub 2024 Apr 22. J Clin Oncol. 2024. PMID: 38648575 Free PMC article. Clinical Trial.
The Angiotensin II Receptor Neprilysin Inhibitor LCZ696 Inhibits the NLRP3 Inflammasome By Reducing Mitochondrial Dysfunction in Macrophages and Alleviates Dextran Sulfate Sodium-induced Colitis in a Mouse Model.
Chiu HW, Wu CH, Lin WY, Wong WT, Tsai WC, Hsu HT, Ho CL, Cheng SM, Cheng CC, Yang SP, Li LH, Hua KF. Chiu HW, et al. Among authors: ho cl. Inflammation. 2024 Apr;47(2):696-717. doi: 10.1007/s10753-023-01939-7. Epub 2024 Feb 6. Inflammation. 2024. PMID: 38319541
Binary Classification with Imbalanced Data.
Chiang JY, Lio Y, Hsu CY, Ho CL, Tsai TR. Chiang JY, et al. Among authors: ho cl. Entropy (Basel). 2023 Dec 22;26(1):15. doi: 10.3390/e26010015. Entropy (Basel). 2023. PMID: 38248141 Free PMC article.
Maintenance therapy for chronic lymphocytic leukaemia.
Lee CH, Wu YY, Huang TC, Lin C, Zou YF, Cheng JC, Chen PH, Jhou HJ, Ho CL. Lee CH, et al. Among authors: ho cl. Cochrane Database Syst Rev. 2024 Jan 4;1(1):CD013474. doi: 10.1002/14651858.CD013474.pub2. Cochrane Database Syst Rev. 2024. PMID: 38174814 Free PMC article. Review.
First-Line Selpercatinib or Chemotherapy and Pembrolizumab in RET Fusion-Positive NSCLC.
Zhou C, Solomon B, Loong HH, Park K, Pérol M, Arriola E, Novello S, Han B, Zhou J, Ardizzoni A, Mak MP, Santini FC, Elamin YY, Drilon A, Wolf J, Payakachat N, Uh MK, Rajakumar D, Han H, Puri T, Soldatenkova V, Lin AB, Lin BK, Goto K; LIBRETTO-431 Trial Investigators. Zhou C, et al. N Engl J Med. 2023 Nov 16;389(20):1839-1850. doi: 10.1056/NEJMoa2309457. Epub 2023 Oct 21. N Engl J Med. 2023. PMID: 37870973 Free PMC article. Clinical Trial.
Focal therapy versus radical prostatectomy and external beam radiotherapy as primary treatment options for non-metastatic prostate cancer: results of a cost-effectiveness analysis.
Reddy D, van Son M, Peters M, Bertoncelli Tanaka M, Dudderidge T, Cullen E, Ho CLT, Hindley RG, Emara A, McCracken S, Orczyk C, Shergill I, Mangar S, Nigam R, Virdi J, Moore CM, Arya M, Shah TT, Winkler M, Emberton M, Falconer A, Belsey J, Ahmed HU. Reddy D, et al. J Med Econ. 2023 Jan-Dec;26(1):1099-1107. doi: 10.1080/13696998.2023.2251849. J Med Econ. 2023. PMID: 37656223 Free article.
Carbohydrate Antigen 19-9 Response to Initial Adjuvant Chemotherapy Predicts Survival and Failure Pattern of Resected Pancreatic Adenocarcinoma but Not Which Patients Are Suited for Additional Adjuvant Chemoradiation Therapy: From a Prospective Randomized Study.
Chiu YF, Liu TW, Shan YS, Chen JS, Li CP, Ho CL, Hsieh RK, Hwang TL, Chen LT, Ch'ang HJ; Taiwan Cooperative Oncology Group pancreatic cancer study group. Chiu YF, et al. Among authors: ho cl. Int J Radiat Oncol Biol Phys. 2023 Sep 1;117(1):74-86. doi: 10.1016/j.ijrobp.2023.02.061. Epub 2023 Apr 11. Int J Radiat Oncol Biol Phys. 2023. PMID: 37055279 Clinical Trial.
Clinical efficacy and long-term immunogenicity of an early triple dose regimen of SARS-CoV-2 mRNA vaccination in cancer patients.
Lee MX, Peng S, Lee ARYB, Wong SY, Tay RYK, Li J, Tariq A, Goh CXY, Tan YK, Tan BKJ, Teo CB, Chan E, Ooi M, Chng WJ, Chee CE, Ho CLF, Walsh RJ, Wong M, Su Y, Alexander L, Sethi SK, Tan SSY, Chan YH, Tan KB, Lee SC, Chai LYA, Sundar R. Lee MX, et al. Ann Acad Med Singap. 2023 Jan;52(1):8-16. doi: 10.47102/annals-acadmedsg.2022302. Ann Acad Med Singap. 2023. PMID: 36730801 Free article.
Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study.
Chau SWH, Liu Y, Zhang J, Leung E, Chen S, Ho CL, Chan JWY, Tsang CC, Li SX, Huang B, Lam SP, Mok VC, Wing YK. Chau SWH, et al. Among authors: ho cl. Parkinsonism Relat Disord. 2023 Feb;107:105271. doi: 10.1016/j.parkreldis.2022.105271. Epub 2022 Dec 26. Parkinsonism Relat Disord. 2023. PMID: 36634468
Clinics in diagnostic imaging (214).
Li J, Ho CL. Li J, et al. Among authors: ho cl. Singapore Med J. 2022 Sep;63(9):527-534. doi: 10.4103/SINGAPOREMEDJ.SMJ-2021-306. Epub 2022 Oct 28. Singapore Med J. 2022. PMID: 36367031 Free PMC article. No abstract available.
Tip-Mediated Bandgap Tuning for Monolayer Transition Metal Dichalcogenides.
Lin MK, Chen GH, Ho CL, Chueh WC, Hlevyack JA, Kuo CN, Fu TY, Lin JJ, Lue CS, Chang WH, Takagi N, Arafune R, Chiang TC, Lin CL. Lin MK, et al. Among authors: ho cl. ACS Nano. 2022 Sep 27;16(9):14918-14924. doi: 10.1021/acsnano.2c05841. Epub 2022 Aug 29. ACS Nano. 2022. PMID: 36036754
Large-scale transcriptomic analysis of coding and non-coding pathological biomarkers, associated with the tumor immune microenvironment of thyroid cancer and potential target therapy exploration.
Shih ML, Lawal B, Cheng SY, Olugbodi JO, Babalghith AO, Ho CL, Cavalu S, Batiha GE, Albogami S, Alotaibi SS, Lee JC, Wu ATH. Shih ML, et al. Among authors: ho cl. Front Cell Dev Biol. 2022 Aug 3;10:923503. doi: 10.3389/fcell.2022.923503. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35990603 Free PMC article.
Retroperitoneal Testicular Artery Pseudoaneurysm.
Ho CL, Tan GW, Da Zhuang K. Ho CL, et al. J Vasc Interv Radiol. 2022 Jul;33(7):868. doi: 10.1016/j.jvir.2022.02.001. J Vasc Interv Radiol. 2022. PMID: 35777895 No abstract available.
A Phase IIIb Open-Label, Single-Arm Study of Afatinib in EGFR TKI-Naïve Patients with EGFRm+ NSCLC: Final Analysis, with a Focus on Patients Enrolled at Sites in China.
Tu HY, Feng J, Shi M, Zhao J, Wang Y, Chang J, Wang J, Cheng Y, Zhu J, Tan EH, Li K, Zhang Y, Lee V, Yang CT, Su WC, Lam DC, Srinivasa BJ, Rajappa S, Ho CL, Lam KC, Hu Y, Bondarde SA, Liu X, Tian Y, Xue Z, Cseh A, Huang DC, Zhou C, Wu YL. Tu HY, et al. Among authors: ho cl. Target Oncol. 2022 Jan;17(1):1-13. doi: 10.1007/s11523-021-00859-6. Epub 2022 Jan 12. Target Oncol. 2022. PMID: 35020119 Free PMC article. Clinical Trial.
863 results