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15 results

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Page 1
The Pseudomonas aeruginosa protease LasB directly activates IL-1β.
Sun J, LaRock DL, Skowronski EA, Kimmey JM, Olson J, Jiang Z, O'Donoghue AJ, Nizet V, LaRock CN. Sun J, et al. Among authors: larock dl. EBioMedicine. 2020 Oct;60:102984. doi: 10.1016/j.ebiom.2020.102984. Epub 2020 Sep 23. EBioMedicine. 2020. PMID: 32979835 Free PMC article.
IL-1β is an innate immune sensor of microbial proteolysis.
LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM, Nizet V. LaRock CN, et al. Among authors: larock dl. Sci Immunol. 2016 Aug;1(2):eaah3539. doi: 10.1126/sciimmunol.aah3539. Epub 2016 Aug 19. Sci Immunol. 2016. PMID: 28331908 Free PMC article.
Inflammasome inhibition blocks cardiac glycoside cell toxicity.
LaRock DL, Sands JS, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN. LaRock DL, et al. J Biol Chem. 2019 Aug 23;294(34):12846-12854. doi: 10.1074/jbc.RA119.008330. Epub 2019 Jul 12. J Biol Chem. 2019. PMID: 31300552 Free PMC article.
Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds with a Multifunctional Wound Dressing.
Atashgah RB, Ghasemi A, Raoufi M, Abdollahifar MA, Zanganeh S, Nejadnik H, Abdollahi A, Sharifi S, Lea B, Cuerva M, Akbarzadeh M, Alvarez-Lorenzo C, Ostad SN, Theus AS, LaRock DL, LaRock CN, Serpooshan V, Sarrafi R, Lee KB, Vali H, Schönherr H, Gould L, Taboada P, Mahmoudi M. Atashgah RB, et al. Among authors: larock dl. Mol Pharm. 2021 Aug 2;18(8):3171-3180. doi: 10.1021/acs.molpharmaceut.1c00400. Epub 2021 Jul 19. Mol Pharm. 2021. PMID: 34279974
[No title available]
[No authors listed] [No authors listed] PMID: 35554153
Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models.
Everett MJ, Davies DT, Leiris S, Sprynski N, Llanos A, Castandet JM, Lozano C, LaRock CN, LaRock DL, Corsica G, Docquier JD, Pallin TD, Cridland A, Blench T, Zalacain M, Lemonnier M. Everett MJ, et al. Among authors: larock dl. ACS Infect Dis. 2023 Feb 10;9(2):270-282. doi: 10.1021/acsinfecdis.2c00418. Epub 2023 Jan 20. ACS Infect Dis. 2023. PMID: 36669138 Free PMC article.
Salmonellae interactions with host processes.
LaRock DL, Chaudhary A, Miller SI. LaRock DL, et al. Nat Rev Microbiol. 2015 Apr;13(4):191-205. doi: 10.1038/nrmicro3420. Epub 2015 Mar 9. Nat Rev Microbiol. 2015. PMID: 25749450 Free PMC article. Review.
Activation of a bacterial virulence protein by the GTPase RhoA.
Christen M, Coye LH, Hontz JS, LaRock DL, Pfuetzner RA, Megha, Miller SI. Christen M, et al. Among authors: larock dl. Sci Signal. 2009 Nov 3;2(95):ra71. doi: 10.1126/scisignal.2000430. Sci Signal. 2009. PMID: 19887681 Free PMC article.