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2013 1
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Page 1
A one-week reduced-carbohydrate diet lowers insulin requirements and shifts the IGF axis with no detectable short-term change in endothelial function in a randomized, crossover trial of adults with type 1 diabetes.
Akbar MN, Smith TJ, Chinnarasu S, Welch W, Zuofei W, Litts B, LeStourgeon LM, Saleem M, Khan MM, Kirabo A, Gregory JM. Akbar MN, et al. Cardiovasc Diabetol Endocrinol Rep. 2026 Mar 26;12(1):13. doi: 10.1186/s40842-026-00276-6. Cardiovasc Diabetol Endocrinol Rep. 2026. PMID: 41882799 Free PMC article.
Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts.
Kim ME, Rudravaram G, Saunders A, Gao C, Ramadass K, Newlin NR, Kanakaraj P, Bogdanov S, Archer D, Hohman TJ, Jefferson AL, Morgan VL, Roche A, Englot DJ, Resnick SM, Beason Held LL, Bilgel M, Cutting LE, Barquero LA, D'Archangel MA, Nguyen TQ, Humphreys KL, Niu Y, Vinci-Booher S, Cascio CJ, Pechman KR, Shashikumar N; HABS-HD Study Team; Alzheimer’s Disease Neuroimaging Initiative; BIOCARD Study Team; Li Z, Vandekar SN, Zhang P, Gore JC, Liu Y, Zuo L, Schilling KG, Moyer DC, Landman BA. Kim ME, et al. bioRxiv [Preprint]. 2026 Feb 1:2026.01.28.702453. doi: 10.64898/2026.01.28.702453. bioRxiv. 2026. PMID: 41659596 Free PMC article. Preprint.
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
Strom NI, Verhulst B, Bacanu SA, Cheesman R, Purves KL, Gedik H, Mitchell BL, Kwong AS, Faucon AB, Singh K, Medland S, Colodro-Conde L, Krebs K, Hoffmann P, Herms S, Gehlen J, Ripke S, Awasthi S, Palviainen T, Tasanko EM, Peterson RE, Adkins DE, Shabalin AA, Adams MJ, Iveson MH, Campbell A, Thomas LF, Winsvold BS, Drange OK, Børte S, Ter Kuile AR, Naamanka J, Nguyen TH, Meier SM, Corfield EC, Hannigan L, Levey DF, Czamara D, Weber H, Choi KW, Pistis G, Couvy-Duchesne B, Van der Auwera S, Teumer A, Karlsson R, Garcia-Argibay M, Lee D, Wang R, Bjerkeset O, Stordal E, Bäckman J, Salum GA, Zai CC, Kennedy JL, Zai G, Tiwari AK, Heilmann-Heimbach S, Schmidt B, Kaprio J, Kennedy MM, Boden J, Havdahl A, Middeldorp CM, Lopes FL, Akula N, McMahon FJ, Binder EB, Fehm L, Ströhle A, Castelao E, Tiemeier H, Stein DJ, Whiteman D, Olsen C, Fuller Z, Wang X, Wray NR, Byrne EM, Lewis G, Timpson NJ, Davis LK, Hickie IB, Gillespie NA, Milani L, Schumacher J, Woldbye DP, Forstner AJ, Nöthen MM, Hovatta I, Horwood J, Copeland WE, Maes HH, McIntosh AM, Andreassen OA, Zwart JA, Mors O, Børglum AD, Mortensen PB, Ask H, Reichborn-Kjennerud T, Najman JM, Stein MB, Gelernter J, Milaneschi Y, Penninx BW, Boom… See abstract for full author list ➔ Strom NI, et al. Nat Genet. 2026 Feb;58(2):275-288. doi: 10.1038/s41588-025-02485-8. Epub 2026 Feb 3. Nat Genet. 2026. PMID: 41634414 Free PMC article.
Medication Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Gonzalez JS, Wen H, Butera NM, Uschner D, Krause-Steinrauf H, Gramzinski MR, Wexler DJ, Petrovitch H, Hoogendoorn CJ, Crespo-Ramos G, Presley C, Fattaleh B, Lagari V, Walker EA, Cherrington AL; GRADE Research Group*. Gonzalez JS, et al. Diabetes Care. 2026 Feb 1;49(2):335-343. doi: 10.2337/dc25-2008. Diabetes Care. 2026. PMID: 41557987 Free PMC article. Clinical Trial.
Lessons Learned From Using PCORnet® to Support the Pathways to Cardiovascular Disease Prevention and Impact of Specialty Referral Among People With HIV From Underrepresented Racial and Ethnic Groups in the Southern United States (PATHWAYS Study).
Marsolo K, Chiswell K, Sanders G, Louzao D, Phillips T, Okeke NL, Meissner EG, Pettit A, Morse C, Bloomfield G. Marsolo K, et al. Med Care. 2026 Feb 1;64(2S Suppl 3):S269-S277. doi: 10.1097/MLR.0000000000002235. Epub 2026 Jan 8. Med Care. 2026. PMID: 41504756 Free PMC article.
Investigating the Use of the Fast Health Care Interoperability Resources (FHIR) Standard to Support Data Activities Across the PCORnet® Infrastructure: Lessons Learned From the FHIR Pilots of the Coordinating Center for PCORnet®.
Marsolo K, Louzao D, Hart K, Shrader P, Hawley J, Delacqua F, Thomas E, Wick J, Chamberlain AM, Jones WS, Rothman R, Harris PA, Cheng AC. Marsolo K, et al. Med Care. 2026 Feb 1;64(2S Suppl 3):S233-S241. doi: 10.1097/MLR.0000000000002236. Epub 2026 Jan 8. Med Care. 2026. PMID: 41504752 Free PMC article.
Individual and combined effects of indoor home exposures and ambient PM2.5 during early life on childhood asthma in us birth cohort studies.
Shiroshita A, Zanobetti A, Coull BA, Ryan PH, Datta S, Blossom J, Oken E, Gern JE, Luttmann-Gibson H, Mendonça EA, Ramratnam SK, Rifas-Shiman SL, Sordillo JE, Wang VA, Beamer PI, Jackson DJ, Johnson CC, Hershey GKK, Martinez FD, Miller RL, Rivera-Spoljaric K, Zoratti EM, Hartert TV, Gold DR; ECHO Cohort Consortium. Shiroshita A, et al. Environ Epidemiol. 2025 Dec 23;10(1):e443. doi: 10.1097/EE9.0000000000000443. eCollection 2026 Feb. Environ Epidemiol. 2025. PMID: 41450756 Free PMC article.
Differential Longitudinal Effects of Glucose-Lowering Medications on Glucagon and C-peptide Responses in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Kahn SE, Tripputi M, Lachin JM, Balasubramanyam A, Banerji MA, Barzilay J, Cohen RM, Garvey WT, Gramzinski MR, Rasouli N, Rhee M, Seegmiller JC, Singh V, Sivitz WI, Steffes MW, Utzschneider K, DeFronzo RA; GRADE Research Group*. Kahn SE, et al. Diabetes Care. 2026 Feb 1;49(2):325-334. doi: 10.2337/dc25-2186. Diabetes Care. 2026. PMID: 41432725 Free PMC article. Clinical Trial.
A multimodal vision knowledge graph of cardiovascular disease.
Rjoob K, McGurk KA, Zheng SL, Curran L, Ibrahim M, Zeng L, Kim V, Tahasildar S, Kalaie S, Senevirathne DS, Gifani P, Losev V, Zheng J, Bai W, de Marvao A, Ware JS, Bender C, O'Regan DP. Rjoob K, et al. Nat Cardiovasc Res. 2026 Jan;5(1):18-33. doi: 10.1038/s44161-025-00757-4. Epub 2025 Dec 29. Nat Cardiovasc Res. 2026. PMID: 41461900 Free PMC article.
Individualised treatment effects of enhanced early mobilisation in mechanically ventilated patients: a secondary analysis of the TEAM trial.
Hodgson CL, Spicer AB, Broadley T, Bailey M, Bellomo R, Brickell K, Buhr H, Gabbe BJ, Gould DW, Harrold M, Higgins AM, Hurford S, Iwashyna TJ, Serpa Neto A, Nichol AD, Presneill JJ, Schaller SJ, Sivasuthan J, Tipping CJ, Webb S, Graham Linck EJ, Sinha P, Semler MW, Young PJ, Churpek MM. Hodgson CL, et al. Intensive Care Med. 2026 Jan;52(1):11-21. doi: 10.1007/s00134-025-08217-0. Epub 2025 Nov 24. Intensive Care Med. 2026. PMID: 41284015 Free PMC article. Clinical Trial.
Estimation and mapping of the missing heritability of human phenotypes.
Wainschtein P, Zhang Y, Schwartzentruber J, Kassam I, Sidorenko J, Fiziev PP, Wang H, McRae J, Border R, Zaitlen N, Sankararaman S, Goddard ME, Zeng J, Visscher PM, Farh KK, Yengo L. Wainschtein P, et al. Nature. 2026 Jan;649(8099):1219-1227. doi: 10.1038/s41586-025-09720-6. Epub 2025 Nov 12. Nature. 2026. PMID: 41225014 Free PMC article.
Near-infrared Spectroscopy and Skin Tone in Children: A Prospective Cohort Study.
Starnes JR, Welch W, Henderson C, Hudson S, McVean B, Risney S, Nicholson GT, Doyle TP, Janssen D, Londergan BP, Parra DA, Slaughter JC, Aliyu MH, Graves JA, Soslow JH. Starnes JR, et al. Anesthesiology. 2026 Jan 1;144(1):134-142. doi: 10.1097/ALN.0000000000005738. Epub 2025 Aug 29. Anesthesiology. 2026. PMID: 40880206 Free PMC article.
The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.
Shao B, Kula B, Le H, Venkhatesh P, Katti P, Marshall AG, Chittaranjan S, Thapilyal S, Namdar HK, Nivedya C, Roszczyk A, Mobley H, Killion M, St John E, Martin P, Rodrigiuez B, Hamilton M, Bell L, Wyckoff SM, Moran LA, Philips M, Hubert D, Tomeau B, Afolabi JM, Kirabo A, Blanco I, Reasonover S, Drake LE, Lippmann ES, Evans C, Santisteban MM, Cheairs TG, Mesenga S, Wanjalla C, Gaddy J, McMillan R, Hernandez Perez CP, Paing HH, Schafer JC, Mobley B, Berry J, Crabtree A, Kovtun O, Goodwin S, Garza Lopez E, Dash C, Dai DF, Miller-Fleming TW, Hinton A Jr, Smith NA. Shao B, et al. bioRxiv [Preprint]. 2025 Dec 16:2025.12.13.693635. doi: 10.64898/2025.12.13.693635. bioRxiv. 2025. PMID: 41446123 Free PMC article. Preprint.
Social vulnerability and the risk of respiratory virus infection in households: a case-ascertained study.
Goodman SH, Mellis A, Sarnquist CC, Grijalva CG, Talbot HK, Stockwell MS, McLaren SH, Sano E, Rao S, Asturias E, Nguyen HQ, Belongia EA, Ellingson KD, Lutrick K, Bowman NM, Lin JT, Rolfes MA, Biddle JE, Smith-Jeffcoat SE, Maldonado Y. Goodman SH, et al. BMC Infect Dis. 2025 Dec 13;26(1):92. doi: 10.1186/s12879-025-12310-6. BMC Infect Dis. 2025. PMID: 41390621 Free PMC article.
Vaccine effectiveness against influenza-associated hospitalizations in adults with liver disease, 2015-2020: US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN).
Huang PH, Nowalk MP, Zimmerman RK, Olson SM, Talbot HK, Zhu Y, Gaglani M, Murthy K, Monto AS, Martin ET, Silveira FP, Balasubramani GK. Huang PH, et al. Hum Vaccin Immunother. 2025 Dec;21(1):2457205. doi: 10.1080/21645515.2025.2457205. Epub 2025 Jan 28. Hum Vaccin Immunother. 2025. PMID: 39875316 Free PMC article.
Measuring Developmental Delays: Comparison of Parent Report and Direct Testing.
Ozonoff S, Gangi D, Corona L, Foster T, Hill MM, Honaker M, Maqbool S, Ni R, Nicholson A, Parikh C, Stone C, Spitler AK, Swanson A, Vehorn A, Wagner L, Weitlauf A, Warren Z. Ozonoff S, et al. J Autism Dev Disord. 2025 Dec;55(12):4492-4498. doi: 10.1007/s10803-024-06292-8. Epub 2024 Feb 26. J Autism Dev Disord. 2025. PMID: 38407697 Free PMC article. Clinical Trial.
Cerebral Blood Flow in Children and Adults With Sickle Cell Anemia.
Jordan LC, Richerson W, Aumann M, Song AK, Waddle S, Juttukonda MR, Jones RS, Davis LT, Pruthi S, Martin D, Rodeghier M, Davis SM, Kassim AA, DeBaun MR, Donahue MJ. Jordan LC, et al. Neurology. 2025 Nov 11;105(9):e214227. doi: 10.1212/WNL.0000000000214227. Epub 2025 Oct 15. Neurology. 2025. PMID: 41092248 Free PMC article.
Genome sequencing of 35,024 predominantly African ancestry persons addresses gaps in genomics and healthcare.
Avery C, Babanejad M, Baker J, Bledsoe X, Blostein F, Corty RW, Ellis K, Hung AM, Lake A, Shelley J, Sheng Q; Vanderbilt University Medical Center and Alliance for Genomic Discovery Investigators; Aldrich M, Basford M, Bastarache L, Below J, Bick AG, Embi P, Feng Q, Gamazon E, Han L, Hirbo J, Marginean K, Mosley J, Pulley J, Roden DM, Ruderfer DM, Shuey M, Shyr Y, Stein CM, Walsh C, Wilkins C. Avery C, et al. medRxiv [Preprint]. 2025 Nov 2:2025.10.30.25338549. doi: 10.1101/2025.10.30.25338549. medRxiv. 2025. PMID: 41282679 Free PMC article. Preprint.
Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.
Miller RL, Wang Y, Aalborg J, Alshawabkeh AN, Braun JM, Breton CV, Carignan CC, Dabelea D, Dunlop AL, Ferrara A, Gao G, Gaylord A, Geiger SD, Gold DR, Abul MH, Hartert TV, Herbstman J, Hoepner LA, Karagas MR, Karr CJ, Kelly RS, Khatchikian CE, Liu M, Lyall K, Meeker JD, Morello-Frosch R, O'Connor TG, Oh J, Sathyanarayana S, Sordillo JE, Trasande L, Woodruff TJ; ECHO Cohort Consortium. Miller RL, et al. Environ Int. 2025 Nov;205:109883. doi: 10.1016/j.envint.2025.109883. Epub 2025 Oct 24. Environ Int. 2025. PMID: 41161078 Free PMC article.
Multisensory assessment for hearing phenotypes.
DeFreese AJ, Gifford RH, Butera IM, Berg KA, Lighterink MA, Wallace MT. DeFreese AJ, et al. Hear Res. 2025 Nov;467:109434. doi: 10.1016/j.heares.2025.109434. Epub 2025 Sep 23. Hear Res. 2025. PMID: 41014885 Free PMC article.
Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-Lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort.
Pop-Busui R, Rosin SP, Butera NM, Krause-Steinrauf H, Abou Assi H, Garg RK, Inzucchi SE, Katona A, McGill JB, Mudaliar S, Schade DS, Seaquist ER, Tiktin M, Soliman EZ, Green JB; GRADE Research Group. Pop-Busui R, et al. Diabetes Care. 2025 Nov 1;48(11):1960-1970. doi: 10.2337/dc25-1087. Diabetes Care. 2025. PMID: 40986645 Free PMC article. Clinical Trial.
Impact of nasal and inhaled corticosteroids on SARS-CoV-2 infection susceptibility.
Rosas-Salazar C, Gebretsadik T, Seibold MA, Moore CM, Arbes SJ, Bacharier LB, Brunwasser SM, Camargo CA Jr, Dupont WD, Furuta GT, Gruchalla RS, Gupta RS, Jackson DJ, Johnson CC, Kattan M, Khurana Hershey GK, Liu AH, O'Connor GT, Phipatanakul W, Ramratnam SK, Rothenberg ME, Sajuthi SP, Sanders J, Seroogy CM, Snyder BM, Stelzig L, Teach SJ, Zoratti EM, Togias A, Fulkerson PC, Hartert TV; HEROS Study Group. Rosas-Salazar C, et al. J Allergy Clin Immunol. 2025 Nov;156(5):1379-1389.e10. doi: 10.1016/j.jaci.2025.07.006. Epub 2025 Jul 21. J Allergy Clin Immunol. 2025. PMID: 40701496 Free PMC article.
RISING STARS: Effects of a GLP-1 receptor polymorphism on responses to liraglutide.
Mashayekhi M, Safa BI, Nian H, Devin JK, Gamboa JL, Yu C, Chen R, Beckman JA, Koethe JR, Silver HJ, Niswender K, Luther JM, Brown NJ. Mashayekhi M, et al. J Endocrinol. 2025 Oct 23;267(1):e250174. doi: 10.1530/JOE-25-0174. Print 2025 Oct 1. J Endocrinol. 2025. PMID: 41042549 Free PMC article. Clinical Trial.
Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa.
Broadaway KA, Sun Q, Edmiston SN, Currin KW, Vadlamudi S, Miller-Fleming TW, Shi Y, Fajgenbaum K, Melendez-Gonzalez M, Bui H, Blum FR, Westerkam L, Shams R, Mallela T, Levitt B, Lin L, Hao H, Memili A, Straub P, Zhou W, Harris KM, Martin A, Cox NJ, Liu Z, Thomas NE, Li Y, Mohlke KL, Sayed CJ. Broadaway KA, et al. Br J Dermatol. 2025 Oct 17;193(5):948-958. doi: 10.1093/bjd/ljaf277. Br J Dermatol. 2025. PMID: 40650879 Free PMC article.
Common genetic variants near SLC2A2 and glycemic response to glimepiride in the GRADE comparative effectiveness clinical trial.
Li JH, Szczerbinski L, Tripputi M, Liu H, Nam S, Mujica E, Emmanouilidou A, Wangden TY, Citko-Rojewska A, Konopka P, Czajkowski M, Huerta-Chagoya A, Vora M, Leong A, Meigs JB, Ng MY, Loos RJF, Pigeyre M, Gerstein HC, Moura FA, Lai YP, Bhatt DL, Marston NA, Ruff CT, Sabatine MS, Dawed AY, Pearson ER, Satin LS, den Hoed M, Kretowski A, Kahn SE, Younes N, Mercader JM, Florez JC. Li JH, et al. medRxiv [Preprint]. 2025 Oct 8:2025.10.07.25336827. doi: 10.1101/2025.10.07.25336827. medRxiv. 2025. PMID: 41282760 Free PMC article. Preprint.
Somatic Mutations in MCOLN3 Are Associated With Aldosterone-Producing Adenomas.
van Rooyen D, Bandulik S, Coon GA, Laukemper M, Kumar-Sinha C, Udager AM, Lerario AM, Lee C, Wachtel H, Cohen DL, Luther JM, Giordano TJ, Scholl UI, Butz F, Popp B, Turcu AF, Warth R, Rainey WE, Rege J. van Rooyen D, et al. Hypertension. 2025 Oct;82(10):1778-1788. doi: 10.1161/HYPERTENSIONAHA.125.24909. Epub 2025 Aug 7. Hypertension. 2025. PMID: 40772318 Free PMC article.
FDG PET of the brain to screen for neurodegenerative disease in older liver transplant candidates.
Jones N, Schwartz TM, Bishay S, Robb WH, Sams A, Kogan J, Nable M, Nelson S, Zhao OS, Hohman T, Huang S, Martinez F, Nguyen B, Shin C, Yang M, Westervelt H, Szymkowicz SM, Omary LT, Aqel BA, Dickson R, Lizaola B, Mathur A, Izzy M, Koran MEI. Jones N, et al. Eur J Nucl Med Mol Imaging. 2025 Oct;52(12):4652-4660. doi: 10.1007/s00259-025-07382-0. Epub 2025 Jun 5. Eur J Nucl Med Mol Imaging. 2025. PMID: 40471321 Free PMC article.
Lifespan Trajectories of Asymmetry in White Matter Tracts.
Kanakaraj P, Bogdanov S, Kim ME, Samir J, Gao C, Ramadass K, Rudravaram G, Newlin NR, Archer D, Hohman TJ, Jefferson AL, Morgan VL, Roche A, Englot DJ, Resnick SM, Held LLB, Cutting L, Barquero LA, D'Archangel MA, Nguyen TQ, Humphreys KL, Niu Y, Vinci-Booher S, Cascio CJ; HABS-HD Study Team; Alzheimer’s Disease Neuroimaging Initiative; BIOCARD Study Team; Li Z, Vandekar SN, Zhang P, Gore JC, Forkel SJ, Landman BA, Schilling KG. Kanakaraj P, et al. bioRxiv [Preprint]. 2025 Sep 29:2025.09.29.678806. doi: 10.1101/2025.09.29.678806. bioRxiv. 2025. PMID: 41256533 Free PMC article. Preprint.
Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways.
Vujkovic M, Kaplan DE, Ghouse J, Loza BL, Brancale J, Lewis A, Zhang DY, Levin MG, Veatch OJ, Johnson JP, Schneider CV, Verma A, Wangensteen KJ, Scorletti E, Gill D, Konkwo C, Garófalo AM, Guare LA, Schwantes-An TW, Abreu MV, Gellert-Kristensen H, Pedersen OB, Erikstrup C, Bundgaard JS, Sørensen E, Ostrowski SR, Bundgaard H, Lee KM, Shaked A, Olthoff KM, Hoteit MA, Speliotes EK, Chen Y, Oliveri A, Yin L, Valenti LV, Malvestiti F, Marchelli D, Miano L, Anstee QM, Daly AK, Cordell HJ, Darlay R, Verweij N, Hindy G, Locke A, Matsuura K, Asrani SK, Testa G, Lotta LA, Jones MB, Dochtermann DR, Norden-Krichmar TM, Teerlink CC, Devineni P, Pyarajan S, Rader DJ, Tanaka Y, Voight BF, Vilarinho S, Bastarache LA, Stender S, Tsao PS; Penn Medicine Biobank; DBDS Genomic Consortium; BioVU Biobank; Michigan Genomics Initiative; Regeneron Genetics Center; Indiana Biobank; All Of Us Research Program; Milano Biobank; LITMUS Consortium; VA Million Veteran Program; Morgan TR, Lynch JA, Chang KM. Vujkovic M, et al. medRxiv [Preprint]. 2025 Sep 18:2025.09.16.25335186. doi: 10.1101/2025.09.16.25335186. medRxiv. 2025. PMID: 41001506 Free PMC article. Preprint.
Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia.
Preiss A, Bhatia A, Aragon LV, Baratta JM, Baskaran M, Blancero F, Brannock MD, Chew RF, Díaz I, Fitzgerald M, Kelly EP, Zhou AG, Carton TW, Chute CG, Haendel M, Moffitt R, Pfaff E; N3C Consortium and the RECOVER Cohort. Preiss A, et al. PLoS Med. 2025 Sep 15;22(9):e1004711. doi: 10.1371/journal.pmed.1004711. eCollection 2025 Sep. PLoS Med. 2025. PMID: 40953059 Free PMC article.
Diastolic Blood Pressure Rise During Valsalva as a Surrogate for Sympathetic Activation to Identify Functional Hyperadrenergic Postural Tachycardia Syndrome.
Kulapatana S, Okamoto LE, Rigo S, Urechie V, Cayton TW, Han RE, Jacob G, Dupont WD, Furlan R, Biaggioni I, Diedrich A. Kulapatana S, et al. Res Sq [Preprint]. 2025 Sep 5:rs.3.rs-7377025. doi: 10.21203/rs.3.rs-7377025/v1. Res Sq. 2025. Update in: Clin Auton Res. 2026 Apr;36(2):271-283. doi: 10.1007/s10286-025-01183-z. PMID: 40951270 Free PMC article. Updated. Preprint.
Mild kidney dysfunction affects the predictive accuracy of blood-based biomarkers for neuropsychological and neuroimaging outcomes over a 9 year follow-up period.
Bolton CJ, Zhang P, Nair D, Liu D, Davis LT, Pechman KR, Shashikumar N, Wilhoite S, Roby D, Beeson C, Komorowski H, Gifford KA, Hohman TJ, Blennow K, Zetterberg H, Jefferson AL. Bolton CJ, et al. Alzheimers Dement. 2025 Sep;21(9):e70651. doi: 10.1002/alz.70651. Alzheimers Dement. 2025. PMID: 40970383 Free PMC article.
Toileting and Bladder Health in the Gig Economy.
Chisholm L, Li AN, Samimi P, Kaufman MR, Dmochowski RR, Reynolds WS, Sebesta EM. Chisholm L, et al. Neurourol Urodyn. 2025 Sep;44(7):1439-1447. doi: 10.1002/nau.70122. Epub 2025 Jul 27. Neurourol Urodyn. 2025. PMID: 40717426 Free PMC article.
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Martínez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, Lüll K, Machado M, Malden DE, Medina-Gomez C, Moore A, Rüeger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Cañadas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, Giulianini F, Gjesing AP, Goel A, Gordon SD, Gorski M, Grove J, Guo X, Gustafsson S, Haessler J, Hansen TF, Havulinna AS, Haworth SJ, Heard-Costa N, Hemerich D, Highland HM, Hi… See abstract for full author list ➔ Smit RAJ, et al. Nat Med. 2025 Sep;31(9):3151-3168. doi: 10.1038/s41591-025-03827-z. Epub 2025 Jul 21. Nat Med. 2025. PMID: 40691366 Free PMC article.
Persistent Tic Disorders Are Associated With 17q12 Duplications.
Halvorsen M, Wang S, Miller-Fleming T, Yu D, Topaloudi A, de Schipper E, Bäckman J, Mataix-Cols D, Rück C, Mahjani B, Buxbaum J, Grice D, Cavallari L, Angiolillo D, Franchi F, Davis L, Han L, Ruderfer D, Dietrich A, Hoekstra P, Mattheisen M, Porras L, Giusti-Rodríguez P, Mathews C, Paschou P, Scharf J, Willsey J, Crowley J. Halvorsen M, et al. Res Sq [Preprint]. 2025 Aug 19:rs.3.rs-7031850. doi: 10.21203/rs.3.rs-7031850/v1. Res Sq. 2025. PMID: 40894066 Free PMC article. Preprint.
White matter hyperintensities and relapse risk in late-life depression.
Pearcy LB, Karim HT, Butters MA, Krafty R, Boyd BD, Banihashemi L, Szymkowicz SM, Landman BA, Ajilore O, Taylor WD, Andreescu C. Pearcy LB, et al. J Affect Disord. 2025 Aug 15;383:298-305. doi: 10.1016/j.jad.2025.04.116. Epub 2025 Apr 24. J Affect Disord. 2025. PMID: 40286936 Free article.
Unmasking Pathogen Traits for Chronic Colonization in Neurogenic Bladder Patients.
Reasoner SA, Frainey BT, Hale OF, Borden A, Graham MK, Turner E, Brenes LR, Soderstrom CBW, Green H, Schmitz JE, Laub MT, Kelly MS, Clayton DB, Hadjifrangiskou M. Reasoner SA, et al. bioRxiv [Preprint]. 2025 Aug 14:2025.08.14.669717. doi: 10.1101/2025.08.14.669717. bioRxiv. 2025. PMID: 40832318 Free PMC article. Preprint.
Re-engineering a machine learning phenotype to adapt to the changing COVID-19 landscape: a machine learning modelling study from the N3C and RECOVER consortia.
Crosskey M, McIntee T, Preiss S, Brannock D, Baratta JM, Yoo YJ, Hadley E, Blanceró F, Chew R, Loomba J, Bhatia A, Chute CG, Haendel M, Moffitt R, Pfaff ER; N3C Consortium and the RECOVER EHR cohort. Crosskey M, et al. Lancet Digit Health. 2025 Aug;7(8):100887. doi: 10.1016/j.landig.2025.100887. Epub 2025 Aug 25. Lancet Digit Health. 2025. PMID: 40858480 Free PMC article.
Lack of Association of Emotional Distress With Insulin Initiation in the GRADE Randomized Diabetes Comparative Effectiveness Trial.
Presley CA, Butera NM, Krause-Steinrauf H, Desouza CV, Hollander PA, Hoogendoorn CJ, Lagari VS, Legowski EA, Martin CL, Rasouli N, Gonzalez JS, Cherrington AL. Presley CA, et al. Sci Diabetes Self Manag Care. 2025 Aug;51(4):382-393. doi: 10.1177/26350106251361363. Epub 2025 Aug 1. Sci Diabetes Self Manag Care. 2025. PMID: 40751289 Clinical Trial.
2-Hydroxybenzylamine for Treatment of Atrial Fibrillation: A First-in-Human Clinical Pilot Trial.
Yoneda ZT, O'Neill M, Crawford DM, Ao M, Sun L, El-Harasis MA, Pitchford L, Rathmacher JA, Montgomery J, Shen ST, Estrada JC, Saavedra PJ, Ellis CR, Richardson T, Kangasundram A, Crossley GH, Akers WS, Ye F, Roden DM, Michaud GF, Shoemaker MB. Yoneda ZT, et al. Circ Arrhythm Electrophysiol. 2025 Aug;18(8):e013378. doi: 10.1161/CIRCEP.124.013378. Epub 2025 Jul 25. Circ Arrhythm Electrophysiol. 2025. PMID: 40709466 Free PMC article. Clinical Trial.
Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children.
Thompson EE, Zhong X, Carbonetto P, Morin A, Willwerscheid J, Visness CM, Bacharier LB, Kattan M, O'Connor GT, Rivera-Spoljaric K, Wood RA, Gold DR, Khurana Hershey GK, Johnson CC, Miller RL, Seroogy CM, Zoratti EM, Gergen PJ, Levin AM, Altman MC, Hartert T, Stephens M, Jackson DJ, Gern JE, McKennan CG, Ober C. Thompson EE, et al. Am J Hum Genet. 2025 Jul 3;112(7):1610-1624. doi: 10.1016/j.ajhg.2025.05.006. Am J Hum Genet. 2025. PMID: 40614707 Free PMC article.
Recordability of the vestibular cerebellar evoked potential.
Romero DJ, Roberts RA, Clay D, Picou E, Feller JJ, Englund J, Jacobson GP. Romero DJ, et al. Int J Audiol. 2025 Jul 3:1-9. doi: 10.1080/14992027.2025.2523904. Online ahead of print. Int J Audiol. 2025. PMID: 40607711
Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE.
Hsia DS, Younes N, Ghosh A, Kazemi EJ, Krause-Steinrauf H, Buse JB, Baker C, Brown-Friday J, Diaz E, Diner J, Groessl EJ, Legowski EA, Mariash CN, Waltje AH, Wexler DJ, Martin CL; GRADE Research Group. Hsia DS, et al. Diabetes Care. 2025 Jul 1;48(7):1288-1294. doi: 10.2337/dc24-2839. Diabetes Care. 2025. PMID: 40424051 Clinical Trial.
3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes.
Scudese E, Marshall AG, Vue Z, Exil V, Rodriguez BI, Demirci M, Vang L, López EG, Neikirk K, Shao B, Le H, Stephens D, Hall DD, Rostami R, Rodman T, Kabugi K, Shao JQ, Mungai M, AshShareef ST, Hicsasmaz I, Manus S, Wanjalla CN, Whiteside A, Dasari R, Williams CR, Damo SM, Gaddy JA, Glancy B, Dantas EHM, Kinder A, Kadam A, Tomar D, Scartoni F, Baffi M, McReynolds MR, Phillips MA, Cooper A, Murray SA, Quintana AM, Wandira N, Ochayi OM, Ameka M, Kirabo A, Masenga SK, Harris C, Oliver A, Martin P, Gaye A, Korolkova O, Sharma V, Mobley BC, Katti P, Hinton A. Scudese E, et al. Aging Cell. 2025 Jul;24(7):e70054. doi: 10.1111/acel.70054. Epub 2025 Apr 25. Aging Cell. 2025. PMID: 40285369 Free PMC article.
Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules.
Lentz RJ, Frederick-Dyer K, Planz VB, Koyama T, Aboudara MC, Avasarala SK, Casey JD, Cheng GZ, D'Haese PF, Duke JD, Grogan EL, Hoopman TC, Johnson J, Katsis JM, Kurman JS, Low SW, Mahmood K, Rickman OB, Roller L, Salmon C, Shojaee S, Swanner B, Wahidi MM, Walston C, Silvestri GA, Yarmus L, Rahman NM, Maldonado F; Interventional Pulmonary Outcomes Group. Lentz RJ, et al. N Engl J Med. 2025 Jun 5;392(21):2100-2112. doi: 10.1056/NEJMoa2414059. Epub 2025 May 18. N Engl J Med. 2025. PMID: 40387025 Free PMC article. Clinical Trial.
Phenotypes of Atopic Dermatitis and Development of Allergic Diseases.
Sitarik AR, Eapen AA, Biagini JM, Jackson DJ, Joseph CLM, Kim H, Martin LJ, Rivera-Spoljaric K, Schauberger EM, Wegienka G, Bendixsen C, Calatroni A, Datta S, Gold DR, Gress L, Hartert TV, Johnson CC, Khurana Hershey GK, Martinez FD, Miller RL, Seroogy CM, Singh S, Wright AL, Gern JE, Singh AM; ECHO Children’s Respiratory and Environmental Workgroup. Sitarik AR, et al. JAMA Netw Open. 2025 Jun 2;8(6):e2515094. doi: 10.1001/jamanetworkopen.2025.15094. JAMA Netw Open. 2025. PMID: 40504529 Free PMC article.
LC-MS/MS proteomics identifies plasma proteins related to cognition over 9-year follow-up.
Adegboye HA, Patterson KL, Libby J, Sun Y, Zhang P, Liu D, Robb WH, Peterson AJ, Cole KR, Arul AB, Oliver NC, Whitaker MD, Pechman KR, Dumitrescu L, Bolton CJ, Blennow K, Zetterberg H, Hohman TJ, Robinson RAS, Jefferson AL. Adegboye HA, et al. Alzheimers Dement. 2025 Jun;21(6):e70276. doi: 10.1002/alz.70276. Alzheimers Dement. 2025. PMID: 40469059 Free PMC article.
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckman J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt A… See abstract for full author list ➔ Strom NI, et al. Nat Genet. 2025 Jun;57(6):1389-1401. doi: 10.1038/s41588-025-02189-z. Epub 2025 May 13. Nat Genet. 2025. PMID: 40360802 Free PMC article.
Weight Gain Was Associated With Worsening Glycemia and Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes Independent of Diabetes Medication in the GRADE Randomized Controlled Trial.
Wexler DJ, Garvey WT, Ghosh A, Kazemi EJ, Krause-Steinrauf H, Ahmann AJ, Brown-Friday J, Casula S, Cherrington AL, Elasy TA, Fortmann SP, Krakoff JA, Mudaliar S, Tiktin M, Younes N; GRADE Study Research Group. Wexler DJ, et al. Diabetes Care. 2025 Jun 1;48(6):935-944. doi: 10.2337/dc24-2825. Diabetes Care. 2025. PMID: 40267365 Clinical Trial.
Pharmacogenetics of plasma dolutegravir exposure during 1-month rifapentine/isoniazid treatment of latent tuberculosis.
Covington N, Luetkemeyer AF, Imperial MZ, Dawson R, Cramer Y, Rosenkranz S, Swindells S, Gelmanova I, Avihingsanon A, Arduino RC, Samaneka W, Dooley KE, Savic R, Podany AT, Haas DW. Covington N, et al. Pharmacogenet Genomics. 2025 Jun 1;35(4):140-144. doi: 10.1097/FPC.0000000000000562. Epub 2025 Feb 12. Pharmacogenet Genomics. 2025. PMID: 39960813 Free PMC article.
White matter microstructure and macrostructure brain charts across the human lifespan.
Kim ME, Gao C, Ramadass K, Newlin NR, Kanakaraj P, Bogdanov S, Rudravaram G, Archer D, Hohman TJ, Jefferson AL, Morgan VL, Roche A, Englot DJ, Resnick SM, Beason Held LL, Cutting L, Barquero LA, D'archangel MA, Nguyen TQ, Humphreys KL, Niu Y, Vinci-Booher S, Cascio CJ; HABS-HD Study Team; Alzheimer’s Disease Neuroimaging Initiative; BIOCARD Study Team; Li Z, Vandekar SN, Zhang P, Gore JC, Landman BA, Schilling KG. Kim ME, et al. bioRxiv [Preprint]. 2025 May 9:2025.05.08.652953. doi: 10.1101/2025.05.08.652953. bioRxiv. 2025. PMID: 40654938 Free PMC article. Preprint.
Perspectives of Parents of LGBTQ+ Youth with Mental Health Service Needs in the US Southeast: Challenges, Needs, and Recommendations for Improving LGBTQ+ Youth and Family Support.
Bettis AH, Argiros A, Kittleson AR, Sheffer P, Holladay M, Cyperski MA, Malhotra M, Moussougan A, Merritt JA, Clark KA. Bettis AH, et al. Evid Based Pract Child Adolesc Ment Health. 2025 May 2:10.1080/23794925.2025.2497081. doi: 10.1080/23794925.2025.2497081. Online ahead of print. Evid Based Pract Child Adolesc Ment Health. 2025. PMID: 40895371 Free PMC article.
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity.
Gogniat MA, Khan OA, Li J, Park C, Hudson Robb W, Zhang P, Sun Y, Moore EE, Houston ML, Pechman KR, Shashikumar N, Taylor Davis L, Liu D, Landman BA, Cole KR, Bolton CJ, Gifford KA, Hohman TJ, Full K, Jefferson AL. Gogniat MA, et al. Alzheimers Dement. 2025 May;21(5):e70157. doi: 10.1002/alz.70157. Alzheimers Dement. 2025. PMID: 40357887 Free PMC article.
Identifying a Genetic Link Between Lung Function and Psoriasis.
Tanimura K, Aldrich MC, Jaworski J, Xing J, Okawa S, Chandra D, Nouraie SM, Nyunoya T. Tanimura K, et al. Ann Hum Genet. 2025 May;89(2-3):89-95. doi: 10.1111/ahg.12587. Epub 2024 Dec 24. Ann Hum Genet. 2025. PMID: 39718377 Free PMC article.
Association of COVID-19 With Risk of Posttransplant Diabetes Mellitus.
Vinson AJ, Anzalone AJ, Schissel M, Dai R, Olex AL, Mannon RB; on behalf of the National COVID Cohort Collaborative. Vinson AJ, et al. Transplantation. 2025 May 1;109(5):e253-e261. doi: 10.1097/TP.0000000000005227. Epub 2024 Nov 6. Transplantation. 2025. PMID: 39531312 Free PMC article.
COVID-19 Vaccination Timing, Relative to Acute COVID-19, and Subsequent Risk of Long COVID.
Butzin-Dozier Z, Ji Y, Wang LC, Anzalone AJ, Coyle J, Phillips RV, Patel RC, Sun J, Hurwitz E, Deshpande S, Shi JS, Mertens A, van der Laan MJ, Colford JM Jr, Hubbard AE. Butzin-Dozier Z, et al. medRxiv [Preprint]. 2025 Apr 23:2025.04.22.25326224. doi: 10.1101/2025.04.22.25326224. medRxiv. 2025. PMID: 40313290 Free PMC article. Preprint.
Admission Neutrophil-to-Lymphocyte Ratio Is Superior to WBC Count at Predicting the Presence and Severity of Pediatric Musculoskeletal Infection.
Hou BQ, Chandrashekar AS, Jamal NH, Hefley WF 3rd, Anand M, Hajdu KS, Chenard SW, Greenberg M, Nian H, Pennings JS, Seltzer RA, Cassat JE, Moore-Lotridge SN, Schoenecker JG. Hou BQ, et al. J Bone Joint Surg Am. 2025 Apr 16;107(8):868-877. doi: 10.2106/JBJS.24.00481. Epub 2025 Feb 25. J Bone Joint Surg Am. 2025. PMID: 39999195 Free PMC article.
Effectiveness of mRNA COVID-19 Vaccines and Hybrid Immunity in Preventing SARS-CoV-2 Infection and Symptomatic COVID-19 Among Adults in the United States.
Feldstein LR, Ruffin J, Wiegand RE, Borkowf CB, James-Gist J, Babu TM, Briggs-Hagen M, Chappell J, Chu HY, Englund JA, Kuntz JL, Lauring AS, Lo N, Carone M, Lockwood C, Martin ET, Midgley CM, Monto AS, Naleway AL, Ogilvie T, Saydah S, Schmidt MA, Schmitz JE, Smith N, Sohn I, Starita L, Talbot HK, Weil AA, Grijalva CG. Feldstein LR, et al. J Infect Dis. 2025 Apr 15;231(4):e743-e753. doi: 10.1093/infdis/jiaf007. J Infect Dis. 2025. PMID: 39774936 Free PMC article.
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckmann J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt … See abstract for full author list ➔ Strom NI, et al. medRxiv [Preprint]. 2025 Apr 8:2024.03.13.24304161. doi: 10.1101/2024.03.13.24304161. medRxiv. 2025. Update in: Nat Genet. 2025 Jun;57(6):1389-1401. doi: 10.1038/s41588-025-02189-z. PMID: 38712091 Free PMC article. Updated. Preprint.
EFFECT OF PAXLOVID TREATMENT DURING ACUTE COVID-19 ON LONG COVID ONSET: AN EHR-BASED TARGET TRIAL EMULATION FROM THE N3C AND RECOVER CONSORTIA.
Preiss A, Bhatia A, Aragon LV, Baratta JM, Baskaran M, Blancero F, Brannock MD, Chew RF, Díaz I, Fitzgerald M, Kelly EP, Zhou A, Carton TW, Chute CG, Haendel M, Moffitt R, Pfaff E. Preiss A, et al. medRxiv [Preprint]. 2025 Apr 7:2024.01.20.24301525. doi: 10.1101/2024.01.20.24301525. medRxiv. 2025. Update in: PLoS Med. 2025 Sep 15;22(9):e1004711. doi: 10.1371/journal.pmed.1004711. PMID: 38343863 Free PMC article. Updated. Preprint.
Long COVID after SARS-CoV-2 during pregnancy in the United States.
Zang C, Guth D, Bruno AM, Xu Z, Li H, Ammar N, Chew R, Guthe N, Hadley E, Kaushal R, Love T, McGrath BM, Patel RC, Seibert EC, Senathirajah Y, Singh SK, Wang F, Weiner MG, Wilkins KJ, Zhang Y, Metz TD, Hill E, Carton TW; RECOVER PCORnet EHR Consortia; RECOVER N3C EHR Consortia; RECOVER Pregnancy Consortia. Zang C, et al. Nat Commun. 2025 Apr 1;16(1):3005. doi: 10.1038/s41467-025-57849-9. Nat Commun. 2025. PMID: 40169569 Free PMC article.
Differential Treatment Effects on β-Cell Function Using Model-Based Parameters in Type 2 Diabetes: Results From the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Utzschneider KM, Tripputi M, Butera NM, Mari A, Rosin SP, Banerji MA, Bergenstal RM, Brown N, Carlson AL, DeFronzo RA, Gramzinski MR, Harindhanavudhi T, Kozedub A, Sivitz WI, Steffes MW, Balasubramanyam A, Rasouli N; GRADE Research Group. Utzschneider KM, et al. Diabetes Care. 2025 Apr 1;48(4):623-631. doi: 10.2337/dc24-2419. Diabetes Care. 2025. PMID: 39998948 Free PMC article. Clinical Trial.
Germline genetics, disease, and exposure to medication influence longitudinal dynamics of clonal hematopoiesis.
Mack T, Pershad Y, Vlasschaert C, Bejan CA, Heimlich JB, Li Y, Mickels NA, Van Amburg JC, Ulloa J, Silver AJ, Luo LY, Jones A, Ferrell PB, Kishtagari A, Xu Y, Savona MR, Bick AG. Mack T, et al. Haematologica. 2025 Apr 1;110(4):1010-1018. doi: 10.3324/haematol.2024.286513. Epub 2024 Nov 14. Haematologica. 2025. PMID: 39540221 Free PMC article. No abstract available.
Polygenic Associations between Motor Behaviour, Neuromotor Traits, and Active Music Engagement in Four Cohorts.
Henechowicz TL, Coleman PL, Gustavson DE, Mekki YN, Nayak S, Nitin R, Scartozzi AC, Tio ES, van Klei R, Felsky D, Thaut MH, Gordon RL. Henechowicz TL, et al. bioRxiv [Preprint]. 2025 Mar 30:2025.03.27.645667. doi: 10.1101/2025.03.27.645667. bioRxiv. 2025. Update in: Ann N Y Acad Sci. 2026 Feb;1556(1):e70191. doi: 10.1111/nyas.70191. PMID: 40196524 Free PMC article. Updated. Preprint.
Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrier.
Sorets AG, Schwensen KR, Francini N, Kjar A, Lyons S, Park JC, Palmer D, Abdulrahman AM, Cowell RP, Katdare KA, Hoogenboezem EN, Wang A, Dani N, Duvall CL, Lippmann ES. Sorets AG, et al. bioRxiv [Preprint]. 2025 Mar 17:2025.03.14.642142. doi: 10.1101/2025.03.14.642142. bioRxiv. 2025. Update in: J Control Release. 2025 Nov 10;387:114226. doi: 10.1016/j.jconrel.2025.114226. PMID: 40166171 Free PMC article. Updated. Preprint.
The Burden of All-Cause Mortality Following Influenza-Associated Hospitalizations: Influenza Hospitalization Surveillance Network, 2010-2019.
O'Halloran AC, Millman AJ, Holstein R, Olsen SJ, Cummings CN, Chai SJ, Kirley PD, Alden NB, Yousey-Hindes K, Meek J, Openo KP, Fawcett E, Ryan PA, Leegwater L, Henderson J, McMahon M, Lynfield R, Angeles KM, Bleecker M, McGuire S, Spina NL, Tesini BL, Gaitan MA, Lung K, Shiltz E, Thomas A, Talbot HK, Schaffner W, Hill M, Reed C, Garg S. O'Halloran AC, et al. Clin Infect Dis. 2025 Mar 17;80(3):e43-e45. doi: 10.1093/cid/ciae547. Clin Infect Dis. 2025. PMID: 39495002 Free PMC article.
Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.
Kim J, Williams A, Noh H, Jasper EA, Jones SH, Jaworski JA, Shuey MM, Ruiz-Narváez EA, Wise LA, Palmer JR, Connolly J, Keaton JM, Denny JC, Khan A, Abbass MA, Rasmussen-Torvik LJ, Kottyan LC, Madhivanan P, Krupp K, Wei WQ, Edwards TL, Velez Edwards DR, Hellwege JN. Kim J, et al. Nat Commun. 2025 Mar 6;16(1):2273. doi: 10.1038/s41467-025-57483-5. Nat Commun. 2025. PMID: 40050615 Free PMC article.
Pulse Oximetry and Skin Tone in Children.
Starnes JR, Welch W, Henderson CC, Hudson S, Risney S, Nicholson GT, Doyle TP, Janssen DR, Londergan BP, Parra DA, Slaughter JC, Aliyu MH, Graves JA, Soslow JH. Starnes JR, et al. N Engl J Med. 2025 Mar 6;392(10):1033-1034. doi: 10.1056/NEJMc2414937. Epub 2025 Feb 12. N Engl J Med. 2025. PMID: 39938116 Free PMC article. No abstract available.
A one-week reduced-carbohydrate diet to mitigate iatrogenic peripheral hyperinsulinemia does not improve insulin sensitivity or endothelial function in a randomized, crossover trial in patients with type 1 diabetes.
Gregory JM, Smith TJ, Duffus SH, Brooks D, Akbar MN, Huntley MA, Gottlieb JA, LeStourgeon LM, Wilson CS, Beckman JA, Cherrington AD. Gregory JM, et al. Cardiovasc Diabetol. 2025 Mar 5;24(1):107. doi: 10.1186/s12933-025-02658-z. Cardiovasc Diabetol. 2025. PMID: 40045281 Free PMC article. Clinical Trial.
CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance.
Obare LM, Simmons J, Oakes J, Zhang X, Nochowicz C, Priest S, Bailin SS, Warren CM, Mashayekhi M, Beasley HK, Shao J, Meenderink LM, Sheng Q, Stolze J, Gangula R, Absi T, Ru Su Y, Neikirk K, Chopra A, Gabriel CL, Temu T, Pakala S, Wilfong EM, Gianella S, Phillips EJ, Harrison DG, Hinton A, Kalams SA, Kirabo A, Mallal SA, Koethe JR, Wanjalla CN. Obare LM, et al. J Immunol. 2025 Mar 1;214(3):516-531. doi: 10.1093/jimmun/vkae054. J Immunol. 2025. PMID: 40073149 Free PMC article.
Estimating the generation time for influenza transmission using household data in the United States.
Chan LYH, Morris SE, Stockwell MS, Bowman NM, Asturias E, Rao S, Lutrick K, Ellingson KD, Nguyen HQ, Maldonado Y, McLaren SH, Sano E, Biddle JE, Smith-Jeffcoat SE, Biggerstaff M, Rolfes MA, Talbot HK, Grijalva CG, Borchering RK, Mellis AM; RVTN-Sentinel Study Group. Chan LYH, et al. Epidemics. 2025 Mar;50:100815. doi: 10.1016/j.epidem.2025.100815. Epub 2025 Jan 18. Epidemics. 2025. PMID: 39864299 Free PMC article.
Insights from the largest diverse ancestry sex-specific disease map for genetically predicted height.
Papadopoulou A, Litkowski EM, Graff M, Wang Z, Smit RAJ, Chittoor G, Dinsmore I, Josyula NS, Lin M, Shortt J, Zhu W, Vedantam SL, Yengo L, Wood AR, Berndt SI, Holm IA, Mentch FD, Hakonarson H, Kiryluk K, Weng C, Jarvik GP, Crosslin D, Carrell D, Kullo IJ, Dikilitas O, Hayes MG, Wei W-, Edwards DRV, Assimes TL, Hirschhorn JN, Below JE, Gignoux CR, Justice AE, Loos RJF, Sun YV, Raghavan S, Deloukas P, North KE, Marouli E. Papadopoulou A, et al. NPJ Genom Med. 2025 Feb 27;10(1):14. doi: 10.1038/s41525-025-00464-w. NPJ Genom Med. 2025. PMID: 40016231 Free PMC article.
Head Motion in Diffusion Magnetic Resonance Imaging: Quantification, Mitigation, and Structural Associations in Large, Cross-Sectional Datasets Across the Lifespan.
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GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia.
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The Medical Segmentation Decathlon without a Doctorate.
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A technical assessment of latent diffusion for Alzheimer's Disease progression.
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The feasibility of sharing digital audio-recordings of clinic visits online with older adults in primary care settings: A multisite trial.
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A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome.
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