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CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13.
Tien JC, Luo J, Chang Y, Zhang Y, Cheng Y, Wang X, Yang J, Mannan R, Mahapatra S, Shah P, Wang XM, Todd AJ, Eyunni S, Cheng C, Rebernick RJ, Xiao L, Bao Y, Neiswender J, Brough R, Pettitt SJ, Cao X, Miner SJ, Zhou L, Wu YM, Labanca E, Wang Y, Parolia A, Cieslik M, Robinson DR, Wang Z, Feng FY, Chou J, Lord CJ, Ding K, Chinnaiyan AM. Tien JC, et al. Among authors: zhou l. Cell Rep Med. 2024 Sep 26:101758. doi: 10.1016/j.xcrm.2024.101758. Online ahead of print. Cell Rep Med. 2024. PMID: 39368479
The role of JNK signaling pathway in organ fibrosis.
Yao Z, Lu Y, Wang P, Chen Z, Zhou L, Sang X, Yang Q, Wang K, Hao M, Cao G. Yao Z, et al. Among authors: zhou l. J Adv Res. 2024 Oct 2:S2090-1232(24)00431-4. doi: 10.1016/j.jare.2024.09.029. Online ahead of print. J Adv Res. 2024. PMID: 39366483 Free article. Review.
Global property rights and land use efficiency.
Ma J, Tian L, Zhang Y, Yang X, Li Y, Liu Z, Zhou L, Wang Z, Ouyang W. Ma J, et al. Among authors: zhou l. Nat Commun. 2024 Oct 2;15(1):8525. doi: 10.1038/s41467-024-52859-5. Nat Commun. 2024. PMID: 39358412 Free PMC article.
Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition.
Chang Y, Wang X, Yang J, Tien JC, Mannan R, Cruz G, Zhang Y, Vo JN, Magnuson B, Mahapatra S, Cho H, Dhanasekaran SM, Wang C, Wang Z, Zhou L, Zhou K, Zhou Y, Zhang P, Huang W, Xiao L, Liu WR, Hamadeh R, Su F, Wang R, Miner SJ, Cao X, Cheng Y, Mehra R, Ding K, Chinnaiyan AM. Chang Y, et al. Among authors: zhou y, zhou k, zhou l. Cell Rep Med. 2024 Sep 21:101752. doi: 10.1016/j.xcrm.2024.101752. Online ahead of print. Cell Rep Med. 2024. PMID: 39353441
Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury.
Zhou L, Pereiro MT, Li Y, Derigs M, Kuenne C, Hielscher T, Huang W, Kränzlin B, Tian G, Kobayashi K, Lu GN, Roedl K, Schmidt C, Günther S, Looso M, Huber J, Xu Y, Wiech T, Sperhake JP, Wichmann D, Gröne HJ, Worzfeld T. Zhou L, et al. Sci Transl Med. 2024 Oct 2;16(767):eadk5005. doi: 10.1126/scitranslmed.adk5005. Epub 2024 Oct 2. Sci Transl Med. 2024. PMID: 39356748
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