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Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity.
Liu C, Somasundaram A, Manne S, Gocher AM, Szymczak-Workman AL, Vignali KM, Scott EN, Normolle DP, John Wherry E, Lipson EJ, Ferris RL, Bruno TC, Workman CJ, Vignali DAA. Liu C, et al. Among authors: lipson ej. Nat Immunol. 2020 Sep;21(9):1010-1021. doi: 10.1038/s41590-020-0733-2. Epub 2020 Jul 13. Nat Immunol. 2020. PMID: 32661362 Free PMC article.
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.
Andrews LP, Somasundaram A, Moskovitz JM, Szymczak-Workman AL, Liu C, Cillo AR, Lin H, Normolle DP, Moynihan KD, Taniuchi I, Irvine DJ, Kirkwood JM, Lipson EJ, Ferris RL, Bruno TC, Workman CJ, Vignali DAA. Andrews LP, et al. Among authors: lipson ej. Sci Immunol. 2020 Jul 17;5(49):eabc2728. doi: 10.1126/sciimmunol.abc2728. Sci Immunol. 2020. PMID: 32680952 Free PMC article.
Tumor MHC Class I Expression Associates with Intralesional IL2 Response in Melanoma.
Pourmaleki M, Jones CJ, Ariyan CE, Zeng Z, Pirun M, Navarrete DA, Li Y, Zhang M, Nandakumar S, Campos C, Nadeem S, Klimstra DS, Temple-Oberle CF, Brenn T, Lipson EJ, Schenk KM, Stein JE, Taube JM, White MG, Traweek R, Wargo JA, Kirkwood JM, Gasmi B, Goff SL, Corwin AD, McDonough E, Ginty F, Callahan MK, Schietinger A, Socci ND, Mellinghoff IK, Hollmann TJ. Pourmaleki M, et al. Among authors: lipson ej. Cancer Immunol Res. 2022 Mar 1;10(3):303-313. doi: 10.1158/2326-6066.CIR-21-1083. Cancer Immunol Res. 2022. PMID: 35013003 Free PMC article.
Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells.
Somasundaram A, Cillo AR, Lampenfeld C, Workman CJ, Kunning S, Oliveri L, Velez M, Joyce S, Calderon M, Dadey R, Rajasundaram D, Normolle DP, Watkins SC, Herman JG, Kirkwood JM, Lipson EJ, Ferris RL, Bruno TC, Vignali DAA. Somasundaram A, et al. Among authors: lipson ej. Cancer Immunol Res. 2022 Jul 1;10(7):885-899. doi: 10.1158/2326-6066.CIR-20-0736. Cancer Immunol Res. 2022. PMID: 35587532 Free PMC article.
Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade.
Chen S, McMiller TL, Soni A, Succaria F, Sidhom JW, Cappelli LC, Casciola-Rosen LA, Morales IR, Sankaran P, Berger AE, Deutsch JS, Zhu QC, Anders RA, Hooper JE, Pardoll DM, Lipson EJ, Taube JM, Topalian SL. Chen S, et al. Among authors: lipson ej. J Transl Med. 2024 Mar 5;22(1):241. doi: 10.1186/s12967-024-04973-7. J Transl Med. 2024. PMID: 38443917 Free PMC article.
Beyond Checkpoint Inhibition: Keeping Therapeutic Options Open.
Joshi UM, Hundal J, Mata JR, Schollenberger MD, Warrier G, Luke JJ, Lipson EJ, Funchain P. Joshi UM, et al. Among authors: lipson ej. Am Soc Clin Oncol Educ Book. 2025 Jun;45(3):e473856. doi: 10.1200/EDBK-25-473856. Epub 2025 Apr 15. Am Soc Clin Oncol Educ Book. 2025. PMID: 40233298 Free article. Review.
Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors.
Kao C, Charmsaz S, Tsai HL, Aziz K, Shu DH, Munjal K, Griffin E, Leatherman JM, Lipson EJ, Ged Y, Hoffman-Censits J, Li HL, Hallab E, Brancati M, Nakazawa M, Alden S, Thoburn C, Gross NE, Hernandez AG, Coyne EM, Kartalia E, Baretti M, Jaffee EM, Bansal S, Tang L, Chandler GS, Mohindra R, Ho WJ, Yarchoan M, Zabransky DJ. Kao C, et al. Among authors: lipson ej. Nat Commun. 2025 Apr 21;16(1):3531. doi: 10.1038/s41467-025-58512-z. Nat Commun. 2025. PMID: 40258833 Free PMC article.
SITC vision: Opportunities for deeper understanding of mechanisms of anti-tumor activity, toxicity, and resistance to optimize cancer immunotherapy.
Sullivan RJ, Cillo AR, Ferris RL, Jenkins RW, Kluger HM, Kok M, Lipson EJ, Paruzzo L, Redmond WL, Ruella M, Schalper KA, Thommen DS, Tolley K, Yarchoan M, Garnett-Benson C. Sullivan RJ, et al. Among authors: lipson ej. J Immunother Cancer. 2025 Jun 25;13(6):e011929. doi: 10.1136/jitc-2025-011929. J Immunother Cancer. 2025. PMID: 40562704 Free PMC article.
123 results