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Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses.
Dugourd A, Kuppe C, Sciacovelli M, Gjerga E, Gabor A, Emdal KB, Vieira V, Bekker-Jensen DB, Kranz J, Bindels EMJ, Costa ASH, Sousa A, Beltrao P, Rocha M, Olsen JV, Frezza C, Kramann R, Saez-Rodriguez J. Dugourd A, et al. Among authors: sciacovelli m. Mol Syst Biol. 2021 Jan;17(1):e9730. doi: 10.15252/msb.20209730. Mol Syst Biol. 2021. PMID: 33502086 Free PMC article.
The metabolic alterations of cancer cells.
Sciacovelli M, Gaude E, Hilvo M, Frezza C. Sciacovelli M, et al. Methods Enzymol. 2014;542:1-23. doi: 10.1016/B978-0-12-416618-9.00001-7. Methods Enzymol. 2014. PMID: 24862258 Review.
Fumarate induces redox-dependent senescence by modifying glutathione metabolism.
Zheng L, Cardaci S, Jerby L, MacKenzie ED, Sciacovelli M, Johnson TI, Gaude E, King A, Leach JD, Edrada-Ebel R, Hedley A, Morrice NA, Kalna G, Blyth K, Ruppin E, Frezza C, Gottlieb E. Zheng L, et al. Among authors: sciacovelli m. Nat Commun. 2015 Jan 23;6:6001. doi: 10.1038/ncomms7001. Nat Commun. 2015. PMID: 25613188 Free PMC article.
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.
Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa AS, Gaude E, Drubbel AV, Theobald SJ, Abbo SR, Tran MG, Rajeeve V, Cardaci S, Foster S, Yun H, Cutillas P, Warren A, Gnanapragasam V, Gottlieb E, Franze K, Huntly B, Maher ER, Maxwell PH, Saez-Rodriguez J, Frezza C. Sciacovelli M, et al. Nature. 2016 Aug 31;537(7621):544-547. doi: 10.1038/nature19353. Nature. 2016. PMID: 27580029 Free PMC article.
Fumarate drives EMT in renal cancer.
Sciacovelli M, Frezza C. Sciacovelli M, et al. Cell Death Differ. 2017 Jan;24(1):1-2. doi: 10.1038/cdd.2016.137. Epub 2016 Nov 25. Cell Death Differ. 2017. PMID: 27886164 Free PMC article. No abstract available.
Fumarate hydratase in cancer: A multifaceted tumour suppressor.
Schmidt C, Sciacovelli M, Frezza C. Schmidt C, et al. Among authors: sciacovelli m. Semin Cell Dev Biol. 2020 Feb;98:15-25. doi: 10.1016/j.semcdb.2019.05.002. Epub 2019 May 22. Semin Cell Dev Biol. 2020. PMID: 31085323 Free PMC article. Review.
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
Bodineau C, Tomé M, Courtois S, Costa ASH, Sciacovelli M, Rousseau B, Richard E, Vacher P, Parejo-Pérez C, Bessede E, Varon C, Soubeyran P, Frezza C, Murdoch PDS, Villar VH, Durán RV. Bodineau C, et al. Among authors: sciacovelli m. Nat Commun. 2021 Aug 10;12(1):4814. doi: 10.1038/s41467-021-25079-4. Nat Commun. 2021. PMID: 34376668 Free PMC article.
27 results