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Page 1
Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity.
Liu C, Somasundaram A, Manne S, Gocher AM, Szymczak-Workman AL, Vignali KM, Scott EN, Normolle DP, John Wherry E, Lipson EJ, Ferris RL, Bruno TC, Workman CJ, Vignali DAA. Liu C, et al. Among authors: somasundaram a. Nat Immunol. 2020 Sep;21(9):1010-1021. doi: 10.1038/s41590-020-0733-2. Epub 2020 Jul 13. Nat Immunol. 2020. PMID: 32661362 Free PMC article.
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.
Andrews LP, Somasundaram A, Moskovitz JM, Szymczak-Workman AL, Liu C, Cillo AR, Lin H, Normolle DP, Moynihan KD, Taniuchi I, Irvine DJ, Kirkwood JM, Lipson EJ, Ferris RL, Bruno TC, Workman CJ, Vignali DAA. Andrews LP, et al. Among authors: somasundaram a. Sci Immunol. 2020 Jul 17;5(49):eabc2728. doi: 10.1126/sciimmunol.abc2728. Sci Immunol. 2020. PMID: 32680952 Free PMC article.
Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8+ T Cells.
Somasundaram A, Cillo AR, Lampenfeld C, Workman CJ, Kunning S, Oliveri L, Velez M, Joyce S, Calderon M, Dadey R, Rajasundaram D, Normolle DP, Watkins SC, Herman JG, Kirkwood JM, Lipson EJ, Ferris RL, Bruno TC, Vignali DAA. Somasundaram A, et al. Cancer Immunol Res. 2022 Jul 1;10(7):885-899. doi: 10.1158/2326-6066.CIR-20-0736. Cancer Immunol Res. 2022. PMID: 35587532 Free PMC article.
Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer.
Chuckran CA, Cillo AR, Moskovitz J, Overacre-Delgoffe A, Somasundaram AS, Shan F, Magnon GC, Kunning SR, Abecassis I, Zureikat AH, Luketich J, Pennathur A, Sembrat J, Rojas M, Merrick DT, Taylor SE, Orr B, Modugno F, Buckanovich R, Schoen RE, Kim S, Duvvuri U, Zeh H, Edwards R, Kirkwood JM, Coffman L, Ferris RL, Bruno TC, Vignali DAA. Chuckran CA, et al. Among authors: somasundaram as. Sci Transl Med. 2021 Dec 8;13(623):eabf8495. doi: 10.1126/scitranslmed.abf8495. Epub 2021 Dec 8. Sci Transl Med. 2021. PMID: 34878821 Free PMC article.
Therapeutic targeting of regulatory T cells in cancer.
Shan F, Somasundaram A, Bruno TC, Workman CJ, Vignali DAA. Shan F, et al. Among authors: somasundaram a. Trends Cancer. 2022 Nov;8(11):944-961. doi: 10.1016/j.trecan.2022.06.008. Epub 2022 Jul 16. Trends Cancer. 2022. PMID: 35853825 Free PMC article. Review.
COVID-19 versus Non-COVID-19 Acute Respiratory Distress Syndrome: Comparison of Demographics, Physiologic Parameters, Inflammatory Biomarkers, and Clinical Outcomes.
Bain W, Yang H, Shah FA, Suber T, Drohan C, Al-Yousif N, DeSensi RS, Bensen N, Schaefer C, Rosborough BR, Somasundaram A, Workman CJ, Lampenfeld C, Cillo AR, Cardello C, Shan F, Bruno TC, Vignali DAA, Ray P, Ray A, Zhang Y, Lee JS, Methé B, McVerry BJ, Morris A, Kitsios GD. Bain W, et al. Among authors: somasundaram a. Ann Am Thorac Soc. 2021 Jul;18(7):1202-1210. doi: 10.1513/AnnalsATS.202008-1026OC. Ann Am Thorac Soc. 2021. PMID: 33544045 Free PMC article.
People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden.
Cillo AR, Somasundaram A, Shan F, Cardello C, Workman CJ, Kitsios GD, Ruffin AT, Kunning S, Lampenfeld C, Onkar S, Grebinoski S, Deshmukh G, Methe B, Liu C, Nambulli S, Andrews LP, Duprex WP, Joglekar AV, Benos PV, Ray P, Ray A, McVerry BJ, Zhang Y, Lee JS, Das J, Singh H, Morris A, Bruno TC, Vignali DAA. Cillo AR, et al. Among authors: somasundaram a. Cell Rep Med. 2021 Dec 21;2(12):100476. doi: 10.1016/j.xcrm.2021.100476. Epub 2021 Dec 2. Cell Rep Med. 2021. PMID: 34873589 Free PMC article.
Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19.
Peddireddy SP, Rahman SA, Cillo AR, Vijay GM, Somasundaram A, Workman CJ, Bain W, McVerry BJ, Methe B, Lee JS, Ray P, Ray A, Bruno TC, Vignali DAA, Kitsios GD, Morris A, Singh H, Sarkar A, Das J. Peddireddy SP, et al. Among authors: somasundaram a. Cell Rep. 2022 Jun 28;39(13):111020. doi: 10.1016/j.celrep.2022.111020. Epub 2022 Jun 13. Cell Rep. 2022. PMID: 35738278 Free PMC article.
Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study.
Hensley MK, Bain WG, Jacobs J, Nambulli S, Parikh U, Cillo A, Staines B, Heaps A, Sobolewski MD, Rennick LJ, Macatangay BJC, Klamar-Blain C, Kitsios GD, Methé B, Somasundaram A, Bruno TC, Cardello C, Shan F, Workman C, Ray P, Ray A, Lee J, Sethi R, Schwarzmann WE, Ladinsky MS, Bjorkman PJ, Vignali DA, Duprex WP, Agha ME, Mellors JW, McCormick KD, Morris A, Haidar G. Hensley MK, et al. Among authors: somasundaram a. Clin Infect Dis. 2021 Aug 2;73(3):e815-e821. doi: 10.1093/cid/ciab072. Clin Infect Dis. 2021. PMID: 33507235 Free PMC article.
Bifurcated monocyte states are predictive of mortality in severe COVID-19.
Cillo AR, Somasundaram A, Shan F, Cardello C, Workman CJ, Kitsios GD, Ruffin A, Kunning S, Lampenfeld C, Onkar S, Grebinoski S, Deshmukh G, Methe B, Liu C, Nambulli S, Andrews L, Duprex WP, Joglekar AV, Benos PV, Ray P, Ray A, McVerry BJ, Zhang Y, Lee JS, Das J, Singh H, Morris A, Bruno TC, Vignali DAA. Cillo AR, et al. Among authors: somasundaram a. bioRxiv [Preprint]. 2021 Feb 10:2021.02.10.430499. doi: 10.1101/2021.02.10.430499. bioRxiv. 2021. PMID: 33594364 Free PMC article. Preprint.
115 results