Abstract
Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of neuraminidase in the subunit vaccine gives increased protection. This article describes current knowledge on the structure, enzyme activity, and antigenic significance of neuraminidase.
© 2011 Blackwell Publishing Ltd.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Antiviral Agents / pharmacology
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Enzyme Inhibitors / pharmacology
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Influenza Vaccines / immunology
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Models, Molecular
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Neuraminidase / antagonists & inhibitors
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Neuraminidase / chemistry*
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Neuraminidase / immunology
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Neuraminidase / metabolism*
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Orthomyxoviridae / drug effects
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Orthomyxoviridae / enzymology*
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Protein Conformation
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Viral Proteins / antagonists & inhibitors
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Viral Proteins / chemistry*
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Viral Proteins / immunology
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Viral Proteins / metabolism*
Substances
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Antiviral Agents
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Enzyme Inhibitors
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Influenza Vaccines
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Viral Proteins
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Neuraminidase