Abstract
Nitric oxide is a highly versatile heterodiatomic molecule that effects a variety of actions in the vasculture. Originally identified as a principal determination of vascular tone, nitric oxide has since been recognized to exert anti thrombotic, antiproliferative, and anti-inflammatory effects in the vasculture. At higher concentrations and in the setting of other oxidants, nitric oxide can promote vascular pathology. In this review, we summarize the molecular mechanisms of nitric oxides actions in vascular biology and pathology.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antioxidants / pharmacology
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Apoptosis
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Cell Adhesion
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Cell Division
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Endothelium, Vascular / pathology
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Endothelium, Vascular / physiology*
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Glutathione
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Humans
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Leukocytes / cytology
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Models, Biological
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Myocytes, Smooth Muscle / cytology
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Nitric Oxide / metabolism*
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Nitric Oxide Synthase / metabolism
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Oxidants / pharmacology
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Platelet Aggregation
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Reactive Oxygen Species
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Superoxides / metabolism
Substances
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Antioxidants
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Oxidants
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Reactive Oxygen Species
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Superoxides
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Nitric Oxide
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Nitric Oxide Synthase
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Glutathione