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The following terms were not found in PubMed: RNF116, RNF196
Page 1
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P. Qu Y, et al. Clin Chim Acta. 2013 Sep 23;424:53-65. doi: 10.1016/j.cca.2013.05.002. Epub 2013 May 10. Clin Chim Acta. 2013. PMID: 23669186 Free article. Review.
Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Recent advancements in the …
Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Di …
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer.
Toshimitsu K, Takano A, Fujii M, Togasaki K, Matano M, Takahashi S, Kanai T, Sato T. Toshimitsu K, et al. Nat Chem Biol. 2022 Jun;18(6):605-614. doi: 10.1038/s41589-022-00984-x. Epub 2022 Mar 10. Nat Chem Biol. 2022. PMID: 35273398
Drug screening identified bromodomain and extra-terminal (BET) bromodomain protein inhibitor as a cancer-selective growth suppressor that targets genes aberrantly activated in CRC. A multi-omics analysis identified an association between checkpoint with forkhead and ring f …
Drug screening identified bromodomain and extra-terminal (BET) bromodomain protein inhibitor as a cancer-selective growth suppressor that ta …
Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation.
Shao J, Shi T, Yu H, Ding Y, Li L, Wang X, Wang X. Shao J, et al. EMBO J. 2021 Oct 18;40(20):e107480. doi: 10.15252/embj.2020107480. Epub 2021 Jul 16. EMBO J. 2021. PMID: 34269483 Free PMC article.
Mechanistically, under conditions of adequate nutrition, GDH1 maintains RP gene expression in a manner dependent on its enzymatic activity. ...Reduced KDM activity in turn leads to increased histone H3 lysine 9 and 27 methylation, further suppressing RP gene express …
Mechanistically, under conditions of adequate nutrition, GDH1 maintains RP gene expression in a manner dependent on its enzymatic act …
CHFR promoter hypermethylation and reduced CHFR mRNA expression in ovarian cancer.
Gao Y, Lou G, Zhang GM, Sun XW, Ma YY, Yang YM, Liu G. Gao Y, et al. Int J Biol Markers. 2009 Apr-Jun;24(2):83-9. doi: 10.1177/172460080902400204. Int J Biol Markers. 2009. PMID: 19634111 Free article.
CONCLUSIONS: In contrast to previous reports, we found that alterations in CHFR mRNA and CHFR methylation can be frequently found in ovarian cancers. CHFR hypermethylation was strongly associated with the loss of CHFR mRNA expression. ...
CONCLUSIONS: In contrast to previous reports, we found that alterations in CHFR mRNA and CHFR methylation can be frequently fo …
Epigenetic drivers of genetic alterations.
Toyota M, Suzuki H. Toyota M, et al. Adv Genet. 2010;70:309-23. doi: 10.1016/B978-0-12-380866-0.60011-3. Adv Genet. 2010. PMID: 20920753 Review.
DNA methylation also affects the expression of genes involved in maintaining the integrity of the genome through DNA repair and detoxification of reactive oxygen species. ...Epigenetic alteration of the genes involved in the induction of senescence is often associat …
DNA methylation also affects the expression of genes involved in maintaining the integrity of the genome through DNA repair and detox …
Predictive value of CHFR and MLH1 methylation in human gastric cancer.
Li Y, Yang Y, Lu Y, Herman JG, Brock MV, Zhao P, Guo M. Li Y, et al. Gastric Cancer. 2015 Apr;18(2):280-7. doi: 10.1007/s10120-014-0370-2. Epub 2014 Apr 21. Gastric Cancer. 2015. PMID: 24748501 Free PMC article.
METHODS: The methylation status of five DNA damage repair genes (CHFR, FANCF, MGMT, MLH1, and RASSF1A) was detected by nested methylation-specific PCR in 102 paraffin-embedded gastric cancer samples. ...In docetaxel-treated gastric cancer patients, resistance to doc …
METHODS: The methylation status of five DNA damage repair genes (CHFR, FANCF, MGMT, MLH1, and RASSF1A) was detected by nested …
Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics.
Banno K, Yanokura M, Iida M, Masuda K, Aoki D. Banno K, et al. J Obstet Gynaecol Res. 2014 Aug;40(8):1957-67. doi: 10.1111/jog.12442. J Obstet Gynaecol Res. 2014. PMID: 25131761 Review.
Many endometrial cancers show estrogen-dependent proliferation, but the carcinogenic mechanisms are unknown or not completely explained beyond mutations of single oncogenes and tumor suppressor genes. Possible carcinogenic mechanisms include imbalance between endometrial p …
Many endometrial cancers show estrogen-dependent proliferation, but the carcinogenic mechanisms are unknown or not completely explained beyo …
CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer.
Pelosof L, Yerram SR, Ahuja N, Delmas A, Danilova L, Herman JG, Azad NS. Pelosof L, et al. Int J Cancer. 2014 Feb 1;134(3):596-605. doi: 10.1002/ijc.28390. Epub 2013 Aug 24. Int J Cancer. 2014. PMID: 23873170 Free PMC article.
Differential sensitivity to docetaxel and gemcitabine was compared to potential predictive biomarkers CHFR methylation and MSI status. Cell lines that were MSI-H/CHFR-methylated, MSS/CHFR-methylated and MSS/CHFR-unmethylated were assessed for in vivo s …
Differential sensitivity to docetaxel and gemcitabine was compared to potential predictive biomarkers CHFR methylation and MSI status …
CHFR promotes metastasis of human gastric carcinoma by activating AKT and ERK via NRF2- ROS axis.
He F, Ye B, Wu X, Pan J, Wang J, Wang X. He F, et al. BMC Gastroenterol. 2023 Apr 6;23(1):114. doi: 10.1186/s12876-023-02724-4. BMC Gastroenterol. 2023. PMID: 37024798 Free PMC article.
Tumor suppressor gene CHFR (The Checkpoint with Forkhead-associated and Ring finger domains) is a mitotic checkpoint and frequently hypermethylated in gastric cancer. ...In this study, we tried to further elucidate the role and mechanism for CHFR in gastric c …
Tumor suppressor gene CHFR (The Checkpoint with Forkhead-associated and Ring finger domains) is a mitotic checkpoint and frequ …
Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia.
Honda T, Tamura G, Waki T, Kawata S, Nishizuka S, Motoyama T. Honda T, et al. Br J Cancer. 2004 May 17;90(10):2013-6. doi: 10.1038/sj.bjc.6601849. Br J Cancer. 2004. PMID: 15138487 Free PMC article.
While chromosomal instability is a common feature of human solid tumours, no abnormalities in genes involved in the mitotic checkpoint have been identified. However, recently, Chfr (checkpoint with forkhead associated and ring finger), a mitotic stress checkpoint …
While chromosomal instability is a common feature of human solid tumours, no abnormalities in genes involved in the mitotic checkpoin …
161 results