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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 2
2003 6
2004 7
2005 10
2006 12
2007 13
2008 8
2009 15
2010 16
2011 17
2012 7
2013 7
2014 14
2015 9
2016 7
2017 3
2018 5
2019 6
2020 5
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160 results

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Filters applied: . Clear all The following terms were not found in PubMed: RNF116, RNF196
Page 1
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P. Qu Y, et al. Clin Chim Acta. 2013 Sep 23;424:53-65. doi: 10.1016/j.cca.2013.05.002. Epub 2013 May 10. Clin Chim Acta. 2013. PMID: 23669186 Free article. Review.
Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Recent advancements in the …
Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Di …
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer.
Toshimitsu K, Takano A, Fujii M, Togasaki K, Matano M, Takahashi S, Kanai T, Sato T. Toshimitsu K, et al. Nat Chem Biol. 2022 Jun;18(6):605-614. doi: 10.1038/s41589-022-00984-x. Epub 2022 Mar 10. Nat Chem Biol. 2022. PMID: 35273398
Drug screening identified bromodomain and extra-terminal (BET) bromodomain protein inhibitor as a cancer-selective growth suppressor that targets genes aberrantly activated in CRC. A multi-omics analysis identified an association between checkpoint with forkhead and ring f …
Drug screening identified bromodomain and extra-terminal (BET) bromodomain protein inhibitor as a cancer-selective growth suppressor that ta …
Identification of Subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data.
Jammula S, Katz-Summercorn AC, Li X, Linossi C, Smyth E, Killcoyne S, Biasci D, Subash VV, Abbas S, Blasko A, Devonshire G, Grantham A, Wronowski F, O'Donovan M, Grehan N, Eldridge MD, Tavaré S; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium; Fitzgerald RC. Jammula S, et al. Gastroenterology. 2020 May;158(6):1682-1697.e1. doi: 10.1053/j.gastro.2020.01.044. Epub 2020 Feb 4. Gastroenterology. 2020. PMID: 32032585 Free PMC article.
Subtype 1 was characterized by DNA hypermethylation with a high mutation burden and multiple mutations in genes in cell cycle and receptor tyrosine signaling pathways. Subtype 2 was characterized by a gene expression pattern associated with metabolic processes (ATP …
Subtype 1 was characterized by DNA hypermethylation with a high mutation burden and multiple mutations in genes in cell cycle and rec …
Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation.
Shao J, Shi T, Yu H, Ding Y, Li L, Wang X, Wang X. Shao J, et al. EMBO J. 2021 Oct 18;40(20):e107480. doi: 10.15252/embj.2020107480. Epub 2021 Jul 16. EMBO J. 2021. PMID: 34269483 Free PMC article.
Mechanistically, under conditions of adequate nutrition, GDH1 maintains RP gene expression in a manner dependent on its enzymatic activity. ...Reduced KDM activity in turn leads to increased histone H3 lysine 9 and 27 methylation, further suppressing RP gene express …
Mechanistically, under conditions of adequate nutrition, GDH1 maintains RP gene expression in a manner dependent on its enzymatic act …
CHFR promoter hypermethylation and reduced CHFR mRNA expression in ovarian cancer.
Gao Y, Lou G, Zhang GM, Sun XW, Ma YY, Yang YM, Liu G. Gao Y, et al. Int J Biol Markers. 2009 Apr-Jun;24(2):83-9. doi: 10.1177/172460080902400204. Int J Biol Markers. 2009. PMID: 19634111 Free article.
CONCLUSIONS: In contrast to previous reports, we found that alterations in CHFR mRNA and CHFR methylation can be frequently found in ovarian cancers. CHFR hypermethylation was strongly associated with the loss of CHFR mRNA expression. ...
CONCLUSIONS: In contrast to previous reports, we found that alterations in CHFR mRNA and CHFR methylation can be frequently fo …
Predictive value of CHFR and MLH1 methylation in human gastric cancer.
Li Y, Yang Y, Lu Y, Herman JG, Brock MV, Zhao P, Guo M. Li Y, et al. Gastric Cancer. 2015 Apr;18(2):280-7. doi: 10.1007/s10120-014-0370-2. Epub 2014 Apr 21. Gastric Cancer. 2015. PMID: 24748501 Free PMC article.
METHODS: The methylation status of five DNA damage repair genes (CHFR, FANCF, MGMT, MLH1, and RASSF1A) was detected by nested methylation-specific PCR in 102 paraffin-embedded gastric cancer samples. ...In docetaxel-treated gastric cancer patients, resistance to doc …
METHODS: The methylation status of five DNA damage repair genes (CHFR, FANCF, MGMT, MLH1, and RASSF1A) was detected by nested …
Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas.
Soutto M, Peng D, Razvi M, Ruemmele P, Hartmann A, Roessner A, Schneider-Stock R, El-Rifai W. Soutto M, et al. Cancer. 2010 Sep 1;116(17):4033-42. doi: 10.1002/cncr.25151. Cancer. 2010. PMID: 20564104 Free PMC article.
Immunohistochemical analysis of CHFR protein expression showed absence or weak immunostaining for CHFR in 75% of EACs (56 of 75) compared with normal tissue samples. ...Nine tumors that showed loss of CHFR mRNA expression, in absence of promoter DNA hypermeth …
Immunohistochemical analysis of CHFR protein expression showed absence or weak immunostaining for CHFR in 75% of EACs (56 of 7 …
CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer.
Koga T, Takeshita M, Yano T, Maehara Y, Sueishi K. Koga T, et al. Int J Cancer. 2011 Mar 1;128(5):1009-17. doi: 10.1002/ijc.25447. Int J Cancer. 2011. PMID: 20473935 Free article.
Aberrant promoter methylation of the checkpoint gene with forkhead-associated domain and ring finger (CHFR) gene is frequently detected in human cancer. ...CHFR hypermethylation and EGFR mutation were mutually exclusive (p = 0.004). ...
Aberrant promoter methylation of the checkpoint gene with forkhead-associated domain and ring finger (CHFR) gene is fre …
Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias.
Homma N, Tamura G, Honda T, Jin Z, Ohmura K, Kawata S, Motoyama T. Homma N, et al. Virchows Arch. 2005 Feb;446(2):120-6. doi: 10.1007/s00428-004-1146-6. Epub 2004 Dec 10. Virchows Arch. 2005. PMID: 15735977
Hypermethylation was less frequent in L-NIN than H-NIN (P<0.05) for Chfr and was also less frequent in L-NIN than the others (P<0.05) for hMLH1. ...Thus, some gastric tumors with the foveolar or ordinary phenotype may develop as a result of age-related methylation of …
Hypermethylation was less frequent in L-NIN than H-NIN (P<0.05) for Chfr and was also less frequent in L-NIN than the others (P&lt …
Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers.
Kang HC, Kim IJ, Park JH, Shin Y, Park HW, Ku JL, Yang HK, Lee KU, Choe KJ, Park JG. Kang HC, et al. Oncol Rep. 2004 Jul;12(1):129-33. Oncol Rep. 2004. PMID: 15201973
CHFR is a recently identified mitotic stress check-point gene. CHFR is ubiquitously expressed in normal human tissues, whereas loss of CHFR expression has been observed in human tumors. ...Combination treatment of 5-aza-dC with trichostatin A showed a …
CHFR is a recently identified mitotic stress check-point gene. CHFR is ubiquitously expressed in normal human tissues, …
160 results