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1992 1
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2011 2
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2014 4
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2019 3
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Page 1
mRNAsi Index: Machine Learning in Mining Lung Adenocarcinoma Stem Cell Biomarkers.
Zhang Y, Tseng JT, Lien IC, Li F, Wu W, Li H. Zhang Y, et al. Genes (Basel). 2020 Feb 27;11(3):257. doi: 10.3390/genes11030257. Genes (Basel). 2020. PMID: 32121037 Free PMC article.
The expression levels of key genes were validated in a pan-cancer scale. The pathological stage associated gene expression level and survival probability were also validated. ...Thirteen key genes (CCNB1, BUB1, BUB1B, CDC20, PLK1, TTK, CDC45, ESPL1, CC …
The expression levels of key genes were validated in a pan-cancer scale. The pathological stage associated gene expression lev …
Identification of aberrantly methylated differentially expressed genes and associated pathways in endometrial cancer using integrated bioinformatic analysis.
Liu J, Wan Y, Li S, Qiu H, Jiang Y, Ma X, Zhou S, Cheng W. Liu J, et al. Cancer Med. 2020 May;9(10):3522-3536. doi: 10.1002/cam4.2956. Epub 2020 Mar 14. Cancer Med. 2020. PMID: 32170852 Free PMC article.
Bioinformatic tools are increasingly developed to screen out molecular targets related to EC. In this study, GSE17025 and GSE40032 were obtained from Gene Expression Omnibus (GEO). "limma" package and Venn diagram tool were used to identify hub genes. ...This resear …
Bioinformatic tools are increasingly developed to screen out molecular targets related to EC. In this study, GSE17025 and GSE40032 were obta …
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation.
Guo G, Sun X, Chen C, Wu S, Huang P, Li Z, Dean M, Huang Y, Jia W, Zhou Q, Tang A, Yang Z, Li X, Song P, Zhao X, Ye R, Zhang S, Lin Z, Qi M, Wan S, Xie L, Fan F, Nickerson ML, Zou X, Hu X, Xing L, Lv Z, Mei H, Gao S, Liang C, Gao Z, Lu J, Yu Y, Liu C, Li L, Fang X, Jiang Z, Yang J, Li C, Zhao X, Chen J, Zhang F, Lai Y, Lin Z, Zhou F, Chen H, Chan HC, Tsang S, Theodorescu D, Li Y, Zhang X, Wang J, Yang H, Gui Y, Wang J, Cai Z. Guo G, et al. Nat Genet. 2013 Dec;45(12):1459-63. doi: 10.1038/ng.2798. Epub 2013 Oct 13. Nat Genet. 2013. PMID: 24121792 Free PMC article.
Here we report a genomic analysis of TCC by both whole-genome and whole-exome sequencing of 99 individuals with TCC. Beyond confirming recurrent mutations in genes previously identified as being mutated in TCC, we identified additional altered genes and pathways tha …
Here we report a genomic analysis of TCC by both whole-genome and whole-exome sequencing of 99 individuals with TCC. Beyond confirming recur …
Let-7c-5p Restrains Cell Growth and Induces Apoptosis of Lung Adenocarcinoma Cells via Targeting ESPL1.
Liu X, Zeng W, Zheng D, Tang M, Zhou W. Liu X, et al. Mol Biotechnol. 2022 Dec;64(12):1367-1375. doi: 10.1007/s12033-022-00511-2. Epub 2022 May 31. Mol Biotechnol. 2022. PMID: 35639278
Dual-luciferase reporter gene method verified the interaction between ESPL1 and let-7c-5p. ...Overexpressed ESPL1 promoted LUAD cells to invade, proliferate, and migrate. Furthermore, ESPL1 was a target gene of let-7c-5p. ...
Dual-luciferase reporter gene method verified the interaction between ESPL1 and let-7c-5p. ...Overexpressed ESPL1 promo …
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
Yang Q, Yu B, Sun J. Yang Q, et al. Biomed Res Int. 2020 Nov 17;2020:4625123. doi: 10.1155/2020/4625123. eCollection 2020. Biomed Res Int. 2020. PMID: 33282948 Free PMC article.
Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using the Database for Annotation, Visualization and Integrated Discovery (DAVID). ...Furthermore, Kaplan-Meier survival analysis was performed by UALCAN to v …
Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using the Database …
Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study.
Wang R, Zang W, Hu B, Deng D, Ling X, Zhou H, Su M, Jiang J. Wang R, et al. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820980785. doi: 10.1177/1533033820980785. Technol Cancer Res Treat. 2020. PMID: 33308056 Free PMC article.
Serum ESPL1 were detected and compared. RESULTS: ESPL1 level of integration group was significantly higher than that of non-integration group (346.7 vs 199.6 ng/ml, P = 0.000) and healthy control group (346.7 vs 41.3 ng/ml, P = 0.000). ...CONCLUSIONS: Chronic HBV-in …
Serum ESPL1 were detected and compared. RESULTS: ESPL1 level of integration group was significantly higher than that of non-in …
ESPL1 is a candidate oncogene of luminal B breast cancers.
Finetti P, Guille A, Adelaide J, Birnbaum D, Chaffanet M, Bertucci F. Finetti P, et al. Breast Cancer Res Treat. 2014 Aug;147(1):51-9. doi: 10.1007/s10549-014-3070-z. Epub 2014 Aug 3. Breast Cancer Res Treat. 2014. PMID: 25086634
ESPL1/separase is a putative oncogene of luminal B breast cancers. ...We also confirmed the observations made with experimental mouse models: ESPL1-overexpressing luminal tumors showed complex genomic profiles and molecular features of chromosomal instability and lo …
ESPL1/separase is a putative oncogene of luminal B breast cancers. ...We also confirmed the observations made with experimental mouse …
PER2 integrates circadian disruption and pituitary tumorigenesis.
Guo L, Cen H, Weng J, He Y, Guo X, He D, Liu K, Duan S, Yang J, Zhang X, Qin Z, Wan Y, Chen Z, Wu B. Guo L, et al. Theranostics. 2023 Apr 29;13(8):2657-2672. doi: 10.7150/thno.82995. eCollection 2023. Theranostics. 2023. PMID: 37215573 Free PMC article.
Subsequent in vivo and cell-based experiments validate that PER2 induces pituitary expression of Ccnb2, Cdc20 and Espl1 (three cell cycle genes) to facilitate cell cycle progression and inhibit apoptosis, thereby promoting pituitary tumorigenesis. ...HIF-1alpha tran …
Subsequent in vivo and cell-based experiments validate that PER2 induces pituitary expression of Ccnb2, Cdc20 and Espl1 (three cell c …
Pan-Cancer analysis and experimental validation identify the oncogenic nature of ESPL1: Potential therapeutic target in colorectal cancer.
Zhong Y, Zheng C, Zhang W, Wu H, Wang M, Zhang Q, Feng H, Wang G. Zhong Y, et al. Front Immunol. 2023 Mar 16;14:1138077. doi: 10.3389/fimmu.2023.1138077. eCollection 2023. Front Immunol. 2023. PMID: 37006282 Free PMC article.
Combining multi-omics data with bioinformatics, we have thoroughly described the function of ESPL1 in cancer. In addition, we examined the impact of ESPL1 on the proliferation of numerous cancer cell lines. ...To validate the oncogene nature of ESPL1, we have …
Combining multi-omics data with bioinformatics, we have thoroughly described the function of ESPL1 in cancer. In addition, we examine …
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas.
Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D. Mukherjee M, et al. Oncogene. 2014 Nov 27;33(48):5511-5522. doi: 10.1038/onc.2013.493. Epub 2013 Nov 25. Oncogene. 2014. PMID: 24276237 Free PMC article.
Separase, a protease encoded by the ESPL1 gene, cleaves the chromosomal cohesin during mitosis. Separase protein and transcripts are overexpressed in a wide range of human cancers. ...MMTV-Espl1 mice in a C57BL/6 genetic background develop aggressive, highly …
Separase, a protease encoded by the ESPL1 gene, cleaves the chromosomal cohesin during mitosis. Separase protein and transcrip …
50 results