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1992 1
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53 results

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Page 1
PER2 integrates circadian disruption and pituitary tumorigenesis.
Guo L, Cen H, Weng J, He Y, Guo X, He D, Liu K, Duan S, Yang J, Zhang X, Qin Z, Wan Y, Chen Z, Wu B. Guo L, et al. Theranostics. 2023 Apr 29;13(8):2657-2672. doi: 10.7150/thno.82995. eCollection 2023. Theranostics. 2023. PMID: 37215573 Free PMC article.
Subsequent in vivo and cell-based experiments validate that PER2 induces pituitary expression of Ccnb2, Cdc20 and Espl1 (three cell cycle genes) to facilitate cell cycle progression and inhibit apoptosis, thereby promoting pituitary tumorigenesis. Mechanistically, P …
Subsequent in vivo and cell-based experiments validate that PER2 induces pituitary expression of Ccnb2, Cdc20 and Espl1 (three cell c …
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
Yang Q, Yu B, Sun J. Yang Q, et al. Biomed Res Int. 2020 Nov 17;2020:4625123. doi: 10.1155/2020/4625123. eCollection 2020. Biomed Res Int. 2020. PMID: 33282948 Free PMC article.
This study was aimed at identifying EC prognostic genes and investigating the molecular mechanisms of these genes in EC. METHODS: Two mRNA datasets of EC were downloaded from the Gene Expression Omnibus (GEO). ...Next, Gene Expression Profiling Interac …
This study was aimed at identifying EC prognostic genes and investigating the molecular mechanisms of these genes in EC. METHO …
ESPL1 is a candidate oncogene of luminal B breast cancers.
Finetti P, Guille A, Adelaide J, Birnbaum D, Chaffanet M, Bertucci F. Finetti P, et al. Breast Cancer Res Treat. 2014 Aug;147(1):51-9. doi: 10.1007/s10549-014-3070-z. Epub 2014 Aug 3. Breast Cancer Res Treat. 2014. PMID: 25086634
We also confirmed the observations made with experimental mouse models: ESPL1-overexpressing luminal tumors showed complex genomic profiles and molecular features of chromosomal instability and loss of tumor suppressor genes (P53 and Rb). ...Inhibiting ESPL1 …
We also confirmed the observations made with experimental mouse models: ESPL1-overexpressing luminal tumors showed complex genomic pr …
Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer.
Yang Y, Sheng Y, Zheng J, Ma A, Chen S, Lin J, Yang X, Liang Y, Zhang Y, Zheng X. Yang Y, et al. Biomarkers. 2024 Jun;29(4):185-193. doi: 10.1080/1354750X.2024.2339288. Epub 2024 Apr 11. Biomarkers. 2024. PMID: 38568742
Kaplan-Meier survival analysis and Cox regression analysis were performed to evaluate the diagnostic and prognostic significance of ESPL1 in EC. Gene Set Enrichment Analysis (GSEA) was employed to explore the potential signaling pathway of ESPL1 in EC. ...The …
Kaplan-Meier survival analysis and Cox regression analysis were performed to evaluate the diagnostic and prognostic significance of ESPL1 …
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERalpha)-positive mammary adenocarcinomas.
Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D. Mukherjee M, et al. Oncogene. 2014 Nov 27;33(48):5511-5522. doi: 10.1038/onc.2013.493. Epub 2013 Nov 25. Oncogene. 2014. PMID: 24276237 Free PMC article.
Separase, a protease encoded by the ESPL1 gene, cleaves the chromosomal cohesin during mitosis. Separase protein and transcripts are overexpressed in a wide range of human cancers. To investigate the physiological consequence of Separase overexpression in animals, w …
Separase, a protease encoded by the ESPL1 gene, cleaves the chromosomal cohesin during mitosis. Separase protein and transcrip …
Pan-Cancer analysis and experimental validation identify the oncogenic nature of ESPL1: Potential therapeutic target in colorectal cancer.
Zhong Y, Zheng C, Zhang W, Wu H, Wang M, Zhang Q, Feng H, Wang G. Zhong Y, et al. Front Immunol. 2023 Mar 16;14:1138077. doi: 10.3389/fimmu.2023.1138077. eCollection 2023. Front Immunol. 2023. PMID: 37006282 Free PMC article.
Combining multi-omics data with bioinformatics, we have thoroughly described the function of ESPL1 in cancer. In addition, we examined the impact of ESPL1 on the proliferation of numerous cancer cell lines. ...To validate the oncogene nature of ESPL1, we have …
Combining multi-omics data with bioinformatics, we have thoroughly described the function of ESPL1 in cancer. In addition, we examine …
Genetically engineered ERα-positive breast cancer mouse models.
Dabydeen SA, Furth PA. Dabydeen SA, et al. Endocr Relat Cancer. 2014 May 6;21(3):R195-208. doi: 10.1530/ERC-13-0512. Print 2014 Jun. Endocr Relat Cancer. 2014. PMID: 24481326 Free PMC article. Review.
Where available, information on cancer pathology and gene expression profiles is referenced to assist in understanding which histological subtype of ER+ human cancer each model might represent. ESR1, CCDN1, prolactin, TGFalpha, AIB1, ESPL1, and WNT1 overexpression, …
Where available, information on cancer pathology and gene expression profiles is referenced to assist in understanding which histolog …
Antagonistic functional duality of cancer genes.
Stepanenko AA, Vassetzky YS, Kavsan VM. Stepanenko AA, et al. Gene. 2013 Oct 25;529(2):199-207. doi: 10.1016/j.gene.2013.07.047. Epub 2013 Aug 9. Gene. 2013. PMID: 23933273 Review.
Similar behavior was evidenced for dozens of cancer genes. Gene function is dependent on genetic network, which is defined by the genome context. The overall changes in karyotype can result in alterations of the role and function of the same genes and pathway …
Similar behavior was evidenced for dozens of cancer genes. Gene function is dependent on genetic network, which is defined by …
Let-7c-5p Restrains Cell Growth and Induces Apoptosis of Lung Adenocarcinoma Cells via Targeting ESPL1.
Liu X, Zeng W, Zheng D, Tang M, Zhou W. Liu X, et al. Mol Biotechnol. 2022 Dec;64(12):1367-1375. doi: 10.1007/s12033-022-00511-2. Epub 2022 May 31. Mol Biotechnol. 2022. PMID: 35639278
This work intended to study the molecular mechanism of ESPL1 in LUAD. Bioinformatics analysis was performed for pan-cancer and prognosis analysis as well as target gene prediction. ...Furthermore, ESPL1 was a target gene of let-7c-5p. Let-7c-5p was dow …
This work intended to study the molecular mechanism of ESPL1 in LUAD. Bioinformatics analysis was performed for pan-cancer and progno …
Identification and analysis of genes associated with epithelial ovarian cancer by integrated bioinformatics methods.
Gui T, Yao C, Jia B, Shen K. Gui T, et al. PLoS One. 2021 Jun 18;16(6):e0253136. doi: 10.1371/journal.pone.0253136. eCollection 2021. PLoS One. 2021. PMID: 34143800 Free PMC article.
METHODS: Overlapping DEGs were screened out from three independent gene expression omnibus (GEO) datasets and were subjected to Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses. ...Through PPI network analysis, …
METHODS: Overlapping DEGs were screened out from three independent gene expression omnibus (GEO) datasets and were subjected to Ge …
53 results