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Filters applied: . Clear all The following term was not found in PubMed: HOX3I
Page 1
HOXC10 overexpression promotes cell proliferation and migration in gastric cancer.
Kim J, Bae DH, Kim JH, Song KS, Kim YS, Kim SY. Kim J, et al. Oncol Rep. 2019 Jul;42(1):202-212. doi: 10.3892/or.2019.7164. Epub 2019 May 17. Oncol Rep. 2019. PMID: 31115563 Free PMC article.
By RNA-sequencing of AGS cells with ectopic HOXC10 expression, it was revealed that many genes were upregulated by HOXC10 overexpression. Among them, CST1 was predicted to be a HOXC10 direct target gene via prediction of HOXC10 binding si …
By RNA-sequencing of AGS cells with ectopic HOXC10 expression, it was revealed that many genes were upregulated by HOXC10 …
The lncRNA HMS recruits RNA-binding protein HuR to stabilize the 3'-UTR of HOXC10 mRNA.
Priyanka P, Sharma M, Das S, Saxena S. Priyanka P, et al. J Biol Chem. 2021 Aug;297(2):100997. doi: 10.1016/j.jbc.2021.100997. Epub 2021 Jul 22. J Biol Chem. 2021. PMID: 34302808 Free PMC article.
In order to identify the binding targets of HMS, we screened for cis-genes and discovered that HOXC10, an oncogene, is downregulated in the absence of HMS. Depletion of HMS does not affect the HOXC10 promoter activity but inhibits the HOXC10 3'-UTR-lin …
In order to identify the binding targets of HMS, we screened for cis-genes and discovered that HOXC10, an oncogene, is downreg …
HOXC10 promotes proliferation and invasion and induces immunosuppressive gene expression in glioma.
Li S, Zhang W, Wu C, Gao H, Yu J, Wang X, Li B, Jun Z, Zhang W, Zhou P, Shi J, Wang L, Gao Y, Li S, Tao B. Li S, et al. FEBS J. 2018 Jun;285(12):2278-2291. doi: 10.1111/febs.14476. Epub 2018 May 25. FEBS J. 2018. PMID: 29676849 Free article.
In addition, HOXC10 knock-down suppressed the expression of genes that are involved in tumor immunosuppression, including those for transforming growth factor-beta 2, PD-L2, CCL2 and TDO2. A ChIP assay showed that HOXC10 directly bound to the PD-L2 and TDO2 p …
In addition, HOXC10 knock-down suppressed the expression of genes that are involved in tumor immunosuppression, including thos …
Interleukin 1β-mediated HOXC10 Overexpression Promotes Hepatocellular Carcinoma Metastasis by Upregulating PDPK1 and VASP.
Dang Y, Chen J, Feng W, Qiao C, Han W, Nie Y, Wu K, Fan D, Xia L. Dang Y, et al. Theranostics. 2020 Feb 19;10(8):3833-3848. doi: 10.7150/thno.41712. eCollection 2020. Theranostics. 2020. PMID: 32206125 Free PMC article.
Luciferase reporter and chromatin immunoprecipitation assays were used to measure the transcriptional regulation of target genes by HOXC10. The effect of HOXC10-mediated invasion and metastasis were analyzed by Transwell assays and by an orthotopic metastasis …
Luciferase reporter and chromatin immunoprecipitation assays were used to measure the transcriptional regulation of target genes by …
HOXC10 indicates poor survival outcome in gastric cancer and promotes G1/S cell cycle transition through transcriptional repression of p21.
Lin ZH, He JM, Lai SC, Ding N, Jiang Y, He XK, Liu XS, Huang ZH. Lin ZH, et al. Neoplasma. 2022 Dec;69(6):1303-1313. doi: 10.4149/neo_2022_220609N615. Epub 2022 Oct 20. Neoplasma. 2022. PMID: 36264773
We illustrated the upregulation of HOXC10 in GC tissues and high HOXC10 expression related to poor survival outcome. ...Overexpression of HOXC10 accelerated G1/S cell cycle transition, whereas knocking down HOXC10 induced cell cycle arrest at the G1 ph …
We illustrated the upregulation of HOXC10 in GC tissues and high HOXC10 expression related to poor survival outcome. ...Overex …
HOXC10 promotes cell migration, invasion, and tumor growth in gastric carcinoma cells through upregulating proinflammatory cytokines.
Li J, Tong G, Huang C, Luo Y, Wang S, Zhang Y, Cheng B, Zhang Z, Wu X, Liu Q, Li M, Li L, Ni B. Li J, et al. J Cell Physiol. 2020 Apr;235(4):3579-3591. doi: 10.1002/jcp.29246. Epub 2019 Sep 25. J Cell Physiol. 2020. PMID: 31552684
HOXC10 plays a critical role in many cellular processes, such as proliferation, migration, and invasion, but the function of HOXC10 in gastric carcinoma is not clear. ...Overexpression of HOXC10 showed the opposite effect on PD gastric cancer cells. In additi …
HOXC10 plays a critical role in many cellular processes, such as proliferation, migration, and invasion, but the function of HOXC1 …
[The effect of HOXC10 gene on biological behaviors of glioma cells and mechanism in tumor microenvironment].
Jiang WY, Lei QY, Liu SS, Yang L, Yang B, Zhang Y. Jiang WY, et al. Zhonghua Zhong Liu Za Zhi. 2022 Mar 23;44(3):228-237. doi: 10.3760/cma.j.cn112152-20200326-00266. Zhonghua Zhong Liu Za Zhi. 2022. PMID: 35316872 Chinese.
Objective: To study the effects of Homeobox C10 (HOXC10) on biological characteristics such as migration, invasion and proliferation of glioma cancer cells and to explore the role of HOXC10 gene in glioma microenvironment. ...The expressions level of M1-relat …
Objective: To study the effects of Homeobox C10 (HOXC10) on biological characteristics such as migration, invasion and proliferation …
Transcription factor HOXC10 activates the expression of MTFR2 to regulate the proliferation, invasion and migration of colorectal cancer cells.
Xie Y, Chen R, Yan L, Jia Z, Liang G, Wang Q. Xie Y, et al. Mol Med Rep. 2021 Nov;24(5):797. doi: 10.3892/mmr.2021.12437. Epub 2021 Sep 15. Mol Med Rep. 2021. PMID: 34523692 Free PMC article.
However, the effects of HOXC10 and MTFR2 on colorectal cancer (CRC) remain poorly understood. ...Reverse transcription-quantitative PCR and western blotting were used to detect the expression levels of MTFR2 and HOXC10 in tissues and cells. To investigate the associ …
However, the effects of HOXC10 and MTFR2 on colorectal cancer (CRC) remain poorly understood. ...Reverse transcription-quantitative P …
Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression.
Tan Z, Chen K, Wu W, Zhou Y, Zhu J, Wu G, Cao L, Zhang X, Guan H, Yang Y, Zhang W, Li J. Tan Z, et al. Theranostics. 2018 Oct 6;8(18):5143-5158. doi: 10.7150/thno.27310. eCollection 2018. Theranostics. 2018. PMID: 30429891 Free PMC article.
A chromatin immunoprecipitation assay was applied to investigate the mechanism in which HOXC10 regulated VEGFA expression. Results: Overexpressing HOXC10 enhanced the capacity of glioma cells to induce tube formation, migration and proliferation of HUVECs, and neova …
A chromatin immunoprecipitation assay was applied to investigate the mechanism in which HOXC10 regulated VEGFA expression. Results: O …
Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations.
Chen Z, Wu J, Liu B, Zhang G, Wang Z, Zhang L, Wang K, Fan Z, Zhu P. Chen Z, et al. Cell Rep. 2021 Jul 27;36(4):109431. doi: 10.1016/j.celrep.2021.109431. Cell Rep. 2021. PMID: 34320348 Free article.
Mechanistically, cis-HOX binds to HOXC10 mRNA to attenuate its decay through blocking the K-homology splicing regulatory protein (KSRP)-binding sequence of HOXC10 3' UTR. HOXC10 is highly expressed in colorectal tumors and TICs and triggers Wnt/beta-catenin a …
Mechanistically, cis-HOX binds to HOXC10 mRNA to attenuate its decay through blocking the K-homology splicing regulatory protein (KSR …
43 results