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The following terms were not found in PubMed: RFXDC1, dJ955L16.1
Page 1
Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer.
Ekstrom TL, Rosok RM, Abdelrahman AM, Parassiadis C, Manjunath M, Dittrich MY, Wang X, Kutschat AP, Kanakan A, Rajput A, Schacherer N, Lukic T, Carlson DM, Thiel J, Kopp W, Stroebel P, Ellenrieder V, Gaedcke J, Dong M, Najafova Z, Truty MJ, Hessmann E, Johnsen SA. Ekstrom TL, et al. Gut. 2025 Jun 6;74(7):1112-1124. doi: 10.1136/gutjnl-2024-334374. Gut. 2025. PMID: 39884837
It has two major molecular subtypes: classical and basal, regulated by the master transcription factors (MTFs) GATA6 and deltaNp63, respectively. OBJECTIVE: This study sought to uncover the transcriptional regulatory mechanisms controlling PDAC subtype identity. ...Artific …
It has two major molecular subtypes: classical and basal, regulated by the master transcription factors (MTFs) GATA6 and deltaNp63, r …
An Inherited Allele Confers Prostate Cancer Progression and Drug Resistance via RFX6/HOXA10-Orchestrated TGFbeta Signaling.
Zhong M, Xu W, Tian P, Zhang Q, Wang Z, Liang L, Zhang Q, Yang Y, Lu Y, Wei GH. Zhong M, et al. Adv Sci (Weinh). 2024 Aug;11(32):e2401492. doi: 10.1002/advs.202401492. Epub 2024 Jun 26. Adv Sci (Weinh). 2024. PMID: 38932472 Free PMC article.
It is uncovered that rs339331 resides in a reprogrammed androgen receptor (AR) binding site in PCa tumors, with the T risk allele enhancing AR chromatin occupancy. RFX6, an AR-regulated gene linked to rs339331, exhibits synergistic prognostic value for PCa recurrenc …
It is uncovered that rs339331 resides in a reprogrammed androgen receptor (AR) binding site in PCa tumors, with the T risk allele enhancing …
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma.
Nassar AH, Abou Alaiwi S, Baca SC, Adib E, Corona RI, Seo JH, Fonseca MAS, Spisak S, El Zarif T, Tisza V, Braun DA, Du H, He M, Flaifel A, Alchoueiry M, Denize T, Matar SG, Acosta A, Shukla S, Hou Y, Steinharter J, Bouchard G, Berchuck JE, O'Connor E, Bell C, Nuzzo PV, Mary Lee GS, Signoretti S, Hirsch MS, Pomerantz M, Henske E, Gusev A, Lawrenson K, Choueiri TK, Kwiatkowski DJ, Freedman ML. Nassar AH, et al. Nat Commun. 2023 Jan 21;14(1):346. doi: 10.1038/s41467-023-35833-5. Nat Commun. 2023. PMID: 36681680 Free PMC article.
We integrate 153 individual data sets from 42 patients and nominate 50 histology-specific master transcription factors (MTF) to define RCC histologic subtypes, including EPAS1 and ETS-1 in ccRCC, HNF1B in pRCC, and FOXI1 in chRCC. We confirm histology-specific MTFs via imm …
We integrate 153 individual data sets from 42 patients and nominate 50 histology-specific master transcription factors (MTF) to define RCC h …
RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1.
Qiu Z, Wang C, Huang P, Yuan Y, Shi Y, Lin Z, Huang Z, Zuo D, Qiu J, He W, Shen J, Niu Y, Yuan Y, Li B. Qiu Z, et al. Clin Transl Med. 2023 Dec;13(12):e1511. doi: 10.1002/ctm2.1511. Clin Transl Med. 2023. PMID: 38093528 Free PMC article.
Chromatin immunoprecipitation, untargeted metabolome profiling and sequencing were performed to identify potential downstream genes and pathways regulated by RFX6. Metabolic assays were employed to investigate the effect of RFX6 on glycolysis in HCC cells. .. …
Chromatin immunoprecipitation, untargeted metabolome profiling and sequencing were performed to identify potential downstream genes a …
Intrinsic transcriptional heterogeneity in neuroblastoma guides mechanistic and therapeutic insights.
Shendy NAM, Zimmerman MW, Abraham BJ, Durbin AD. Shendy NAM, et al. Cell Rep Med. 2022 May 17;3(5):100632. doi: 10.1016/j.xcrm.2022.100632. Cell Rep Med. 2022. PMID: 35584622 Free PMC article. Review.
Cell state is controlled by master transcription factors (mTFs) that determine the cellular gene expression program. Cancer cells acquire dysregulated gene expression programs by mutational and non-mutational processes. ...The cellular populations that compri …
Cell state is controlled by master transcription factors (mTFs) that determine the cellular gene expression program. Cancer ce …
Replication and fine mapping for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese population.
Long QZ, Du YF, Ding XY, Li X, Song WB, Yang Y, Zhang P, Zhou JP, Liu XG. Long QZ, et al. PLoS One. 2012;7(5):e37866. doi: 10.1371/journal.pone.0037866. Epub 2012 May 25. PLoS One. 2012. PMID: 22662242 Free PMC article.
RESULTS: We successfully replicated the association of rs13385191 (located in the C2orf43 gene, P = 8.60 10(-5)), rs12653946 (P = 1.33 10(-6)), rs1983891 (FOXP4, P = 6.22 10(-5)), and rs339331 (GPRC6A/RFX6, P = 1.42 10(-5)) with prostate cancer. ...CONCLUSIONS: Our …
RESULTS: We successfully replicated the association of rs13385191 (located in the C2orf43 gene, P = 8.60 10(-5)), rs12653946 (P = 1.3 …
Association of THADA, FOXP4, GPRC6A/RFX6 genes and 8q24 risk alleles with prostate cancer in Northern Chinese men.
Li XH, Xu Y, Yang K, Shi JJ, Zhang X, Yang F, Yuan H, Zhu X, Zhang YH, Wang JY, Yang Z. Li XH, et al. J BUON. 2015 Sep-Oct;20(5):1223-8. J BUON. 2015. PMID: 26537068 Free article.
CONCLUSION: Our results provide further support for association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with Pca in Asian populations. Further work is still required to determine the functional variations and finally clarify the underlying biological mechani …
CONCLUSION: Our results provide further support for association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with Pca in As …
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.
Huang Q, Whitington T, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J, Wei GH. Huang Q, et al. Nat Genet. 2014 Feb;46(2):126-35. doi: 10.1038/ng.2862. Epub 2014 Jan 5. Nat Genet. 2014. PMID: 24390282
The risk-associated T allele at rs339331 increases binding of HOXB13 to a transcriptional enhancer, conferring allele-specific upregulation of the rs339331-associated gene RFX6. Suppression of RFX6 diminishes prostate cancer cell proliferation, migration and …
The risk-associated T allele at rs339331 increases binding of HOXB13 to a transcriptional enhancer, conferring allele-specific upregulation …
Aggressive serous ovarian cancer subtype defined by high centrality lncRNA profiles and master transcription factors.
Jeong S, Jo YS, Park S, Lee H, Park EG, Jung SG, Lee J. Jeong S, et al. Sci Rep. 2025 Jul 1;15(1):20631. doi: 10.1038/s41598-025-06262-9. Sci Rep. 2025. PMID: 40594853 Free PMC article.
In addition, the crosstalk between master transcriptional factors (MTFs) and lncRNAs remains unclear. Therefore, we aimed to classify HGSC based on lncRNA expression and identify the integrated MTFs for highly correlated mRNAs and lncRNAs. ...In vitro analyses were …
In addition, the crosstalk between master transcriptional factors (MTFs) and lncRNAs remains unclear. Therefore, we aimed to classify …
Construction of miRNA-mRNA-TF Regulatory Network for Diagnosis of Gastric Cancer.
Fu Z, Xu Y, Chen Y, Lv H, Chen G, Chen Y. Fu Z, et al. Biomed Res Int. 2021 Nov 18;2021:9121478. doi: 10.1155/2021/9121478. eCollection 2021. Biomed Res Int. 2021. PMID: 34840985 Free PMC article.
Then, DAVID annotated the functions of DEGs to understand the functions played in biological processes. The prediction of potential target genes of miRNA and key TFs of mRNA was performed by mipathDB V2.0 and CHEA3, respectively, and the gene list comparison was per …
Then, DAVID annotated the functions of DEGs to understand the functions played in biological processes. The prediction of potential target …
25 results