3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists.
Nature. 1957.
PMID: 13483658
No abstract available.
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3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists.
Nature. 1957 Nov 30;180(4596):1200. doi: 10.1038/1801200a0.
Nature. 1957.
PMID: 13483658
No abstract available.
The pharmacological actions of 3,4-dihydroxyphenyl-alpha-methylalanine (alpha-methyldopa), an inhibitor of 5-hydroxytryptophan decarboxylase.
Br J Pharmacol Chemother. 1960 Jun;15(2):319-27. doi: 10.1111/j.1476-5381.1960.tb01251.x.
Br J Pharmacol Chemother. 1960.
PMID: 13832156
Free PMC article.
alpha-Methyldopa (3,4-dihydroxyphenyl-alpha-methylalanine) is an inhibitor of 5-hydroxytryptophan decarboxylase which is effective in vitro and in vivo. ...A comparison is drawn between the actions of alpha-methyldopa and reserpine. The present …
alpha-Methyldopa (3,4-dihydroxyphenyl-alpha-methylalanine) is an inhibitor of 5-hydroxytryptophan decarboxylase …
The validity of animal models of depression.
Psychopharmacology (Berl). 1984;83(1):1-16. doi: 10.1007/BF00427414.
Psychopharmacology (Berl). 1984.
PMID: 6429692
Review.
Of the 18 models, five could only be assessed for predictive validity, seven could be assessed for predictive and face validity, and six could potentially have predictive, face and construct validity. Some traditional models (reserpine reversal, amphetamine potentiation) a …
Of the 18 models, five could only be assessed for predictive validity, seven could be assessed for predictive and face validity, and six cou …
Behavioral and biochemical effects of the 5-HT1A receptor agonists flesinoxan and 8-OH-DPAT in the rat.
Eur J Pharmacol. 1991 Aug 6;200(2-3):259-66. doi: 10.1016/0014-2999(91)90580-j.
Eur J Pharmacol. 1991.
PMID: 1838333
Regulation of dopamine and serotonin synthesis by acute administration of cocaine.
Synapse. 1990;6(1):63-72. doi: 10.1002/syn.890060108.
Synapse. 1990.
PMID: 2119072
This possibility was tested by measuring the effect of cocaine on 3,4-dihydroxyphenylalanine accumulation (DA synthesis) and 5-hydroxytryptophan accumulation (5HT synthesis) in vivo and in vitro after inhibition of aromatic amino acid decarboxyl …
This possibility was tested by measuring the effect of cocaine on 3,4-dihydroxyphenylalanine accumulation (DA synthesis …
Sarizotan, a serotonin 5-HT1A receptor agonist and dopamine receptor ligand. 1. Neurochemical profile.
J Neural Transm (Vienna). 2004 Feb;111(2):113-26. doi: 10.1007/s00702-003-0094-7. Epub 2003 Dec 31.
J Neural Transm (Vienna). 2004.
PMID: 14767715
Sarizotan exhibited high affinities only to serotonin 5-HT1A receptors and dopamine DA D4>D3>D2 receptors with the profile of a 5-HT1A agonist and DA antagonist demonstrated by the inhibition of cAMP-stimulation and guinea pig ileum contraction, decreased accumulatio …
Sarizotan exhibited high affinities only to serotonin 5-HT1A receptors and dopamine DA D4>D3>D2 receptors with the profile of a 5-HT1A …
Adrenergic nonspecific potentiation of yohimbine toxicity in mice by antidepressants and related drugs and antiyohimbine action of antiadrenergic and serotonergic drugs.
Psychopharmacology (Berl). 1980;70(2):179-85. doi: 10.1007/BF00435311.
Psychopharmacology (Berl). 1980.
PMID: 6776578
The inhibitor of brain serotonin synthesis p-chlorophenylalanine and a depletor of serotonin and catecholamine synthesis reserpine, enhanced yohimbine toxicity whereas serotonin and its precursors tryptophan and 5-hydroxytryptophan prolonged survival time. .. …
The inhibitor of brain serotonin synthesis p-chlorophenylalanine and a depletor of serotonin and catecholamine synthesis reserpine, e …
Direct and decarboxylation-dependent effects of neurotransmitter precursors on firing of isolated monoaminergic neurons.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 Jun;195(6):515-27. doi: 10.1007/s00359-009-0428-5. Epub 2009 Mar 10.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009.
PMID: 19274466
To elucidate mechanisms that underlie the profound physiological effects of the monoamine precursors 5-hydroxy-L-tryptophan (5-HTP) and L-3,4-dihydroxyphenylalanine (L-DOPA), we examined their action on single monoaminergic neurons isolated from the ganglia o …
To elucidate mechanisms that underlie the profound physiological effects of the monoamine precursors 5-hydroxy-L-tryptophan (5-HTP) and L- …
Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities.
Psychopharmacology (Berl). 1976 May 5;47(1):33-41. doi: 10.1007/BF00428698.
Psychopharmacology (Berl). 1976.
PMID: 1085452
Two novel agents, tandamine (TA; a thiopyrano (3,4-b) indole) and pirandamine (PA; an indeno (2,1-c)pyran), and the tricyclic antidepressants desimipramine (DMI), imipramine (I) and amitriptyline (A) were compared in various in vivo pharmacological tests and for nor …
Two novel agents, tandamine (TA; a thiopyrano (3,4-b) indole) and pirandamine (PA; an indeno (2,1-c)pyran), and the tricyclic …
1-Pyridyl-3,4-dihydro-beta-carbolines: synthesis and central action.
Pol J Pharmacol Pharm. 1986 Sep-Dec;38(5-6):555-65.
Pol J Pharmacol Pharm. 1986.
PMID: 3494988
1-Pyridyl-3,4-dihydro-beta-carbolines (2a-2f) were synthesized by two methods. The central action of these compounds was investigated in mice and rats using behavioral tests. The most active 6-methoxy-1-(3-pyridyl)-3,4-dihydro-beta-carboline (2e) posse …
1-Pyridyl-3,4-dihydro-beta-carbolines (2a-2f) were synthesized by two methods. The central action of these compounds was inves …
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