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ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies.
Raulin AC, Doss SV, Trottier ZA, Ikezu TC, Bu G, Liu CC. Raulin AC, et al. Mol Neurodegener. 2022 Nov 8;17(1):72. doi: 10.1186/s13024-022-00574-4. Mol Neurodegener. 2022. PMID: 36348357 Free PMC article. Review.
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its prevalence is rapidly increasing due to extended lifespans. Among the increasing number of genetic risk factors identified, the apolipoprotein E (APOE) gene remains …
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its prevalence is rapidly increasing due t …
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding beta-amyloidosis.
Kaji S, Berghoff SA, Spieth L, Schlaphoff L, Sasmita AO, Vitale S, Büschgens L, Kedia S, Zirngibl M, Nazarenko T, Damkou A, Hosang L, Depp C, Kamp F, Scholz P, Ewers D, Giera M, Ischebeck T, Wurst W, Wefers B, Schifferer M, Willem M, Nave KA, Haass C, Arzberger T, Jäkel S, Wirths O, Saher G, Simons M. Kaji S, et al. Immunity. 2024 Nov 12;57(11):2651-2668.e12. doi: 10.1016/j.immuni.2024.09.014. Epub 2024 Oct 16. Immunity. 2024. PMID: 39419029 Free article.
The seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer's disease (AD), but how this pathological cascade is initiated is not fully understood. Sporadic AD is linked genetically to apolipoprotein E (APOE) and o …
The seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer's disease (AD), but how this …
Apolipoprotein E in lipid metabolism and neurodegenerative disease.
Yang LG, March ZM, Stephenson RA, Narayan PS. Yang LG, et al. Trends Endocrinol Metab. 2023 Aug;34(8):430-445. doi: 10.1016/j.tem.2023.05.002. Epub 2023 Jun 24. Trends Endocrinol Metab. 2023. PMID: 37357100 Free PMC article. Review.
Dysregulation of lipid metabolism has emerged as a central component of many neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E (APOE), modulate risk and resilience in several neurodegenerative diseases including late …
Dysregulation of lipid metabolism has emerged as a central component of many neurodegenerative diseases. Variants of the lipid transp …
Risk factors for Alzheimer's disease.
A Armstrong R. A Armstrong R. Folia Neuropathol. 2019;57(2):87-105. doi: 10.5114/fn.2019.85929. Folia Neuropathol. 2019. PMID: 31556570 Free article. Review.
Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD) including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and associated co-morbidities such as vascular disease and infection. ...By …
Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD) including age, familial inherita …
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.
Long JM, Holtzman DM. Long JM, et al. Cell. 2019 Oct 3;179(2):312-339. doi: 10.1016/j.cell.2019.09.001. Epub 2019 Sep 26. Cell. 2019. PMID: 31564456 Free PMC article. Review.
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular beta-amyloid deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated tau as neurofibrillary tangles remains the primary n …
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular beta-amylo …
ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias.
Martens YA, Zhao N, Liu CC, Kanekiyo T, Yang AJ, Goate AM, Holtzman DM, Bu G. Martens YA, et al. Neuron. 2022 Apr 20;110(8):1304-1317. doi: 10.1016/j.neuron.2022.03.004. Epub 2022 Mar 16. Neuron. 2022. PMID: 35298921 Free PMC article. Review.
The epsilon4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy body dementia (LBD). ...Despite progress, it remains unclear how …
The epsilon4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for Alzheimer's dise …
Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis.
Chen Y, Strickland MR, Soranno A, Holtzman DM. Chen Y, et al. Neuron. 2021 Jan 20;109(2):205-221. doi: 10.1016/j.neuron.2020.10.008. Epub 2020 Nov 10. Neuron. 2021. PMID: 33176118 Free PMC article. Review.
Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer disease (AD). ...
Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in the central nervous …
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease.
Guo T, Zhang D, Zeng Y, Huang TY, Xu H, Zhao Y. Guo T, et al. Mol Neurodegener. 2020 Jul 16;15(1):40. doi: 10.1186/s13024-020-00391-7. Mol Neurodegener. 2020. PMID: 32677986 Free PMC article. Review.
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. ...We also discuss other critical factors that may affect AD pathogenesis, including genetics, aging, variables related to environment, lifestyle habits, an …
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. ...We also discu …
Multifaceted roles of APOE in Alzheimer disease.
Jackson RJ, Hyman BT, Serrano-Pozo A. Jackson RJ, et al. Nat Rev Neurol. 2024 Aug;20(8):457-474. doi: 10.1038/s41582-024-00988-2. Epub 2024 Jun 21. Nat Rev Neurol. 2024. PMID: 38906999 Review.
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age of onset and the lifetime risk of developing AD. ...
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest genetic modulator of sporadic Alz …
The cell biology of APOE in the brain.
Windham IA, Cohen S. Windham IA, et al. Trends Cell Biol. 2024 Apr;34(4):338-348. doi: 10.1016/j.tcb.2023.09.004. Epub 2023 Oct 5. Trends Cell Biol. 2024. PMID: 37805344 Free PMC article. Review.
Apolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular …
Apolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic …
2,301 results