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The probabilistic model of Alzheimer disease: the amyloid hypothesis revised.
Frisoni GB, Altomare D, Thal DR, Ribaldi F, van der Kant R, Ossenkoppele R, Blennow K, Cummings J, van Duijn C, Nilsson PM, Dietrich PY, Scheltens P, Dubois B. Frisoni GB, et al. Nat Rev Neurosci. 2022 Jan;23(1):53-66. doi: 10.1038/s41583-021-00533-w. Epub 2021 Nov 23. Nat Rev Neurosci. 2022. PMID: 34815562 Free PMC article. Review.
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid hypothesis, in which a deterministic chain of events leads from amyloid deposition and then tau deposition to neurodegeneration and progressive cognitive impairment. ...Here we propo …
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid hypothesis, in which a deterministic chain of …
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease.
Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C. Bateman RJ, et al. Alzheimers Res Ther. 2011 Jan 6;3(1):1. doi: 10.1186/alzrt59. Alzheimers Res Ther. 2011. PMID: 21211070 Free PMC article.
Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. ...Clinical trials in autosomal-dominant Alzheimer's disease may …
Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of …
Disclosure of Genetic Risk Factors for Alzheimer's Disease to Cognitively Healthy Individuals-From Current Practice towards a Personalised Medicine Scenario.
Galluzzi S, Pievani M, Zanetti O, Benussi L, The Italian-DIAfN Working Group, Frisoni GB, Di Maria E. Galluzzi S, et al. Biomedicines. 2022 Dec 8;10(12):3177. doi: 10.3390/biomedicines10123177. Biomedicines. 2022. PMID: 36551936 Free PMC article. Review.
Alzheimer's disease (AD) is a genetically complex disorder. In addition to the relatively small number of pathogenic variants causing autosomal dominant AD, many others have been associated with the much more common sporadic form. ...Current gui …
Alzheimer's disease (AD) is a genetically complex disorder. In addition to the relatively small number of pathogenic va …
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease.
Weggen S, Beher D. Weggen S, et al. Alzheimers Res Ther. 2012 Mar 30;4(2):9. doi: 10.1186/alzrt107. Alzheimers Res Ther. 2012. PMID: 22494386 Free PMC article.
Mutations in both the amyloid precursor protein (APP) and the presenilin (PSEN) genes cause familial Alzheimer's disease (FAD) with autosomal dominant inheritance and early onset of disease. The clinical course and neuropathology of FAD a …
Mutations in both the amyloid precursor protein (APP) and the presenilin (PSEN) genes cause familial Alzheimer's disease …
Subcortical ischemic vascular dementia.
Chui HC. Chui HC. Neurol Clin. 2007 Aug;25(3):717-40, vi. doi: 10.1016/j.ncl.2007.04.003. Neurol Clin. 2007. PMID: 17659187 Free PMC article. Review.
Subcortical ischemic vascular dementia (SIVD) has been proposed as a subtype of vascular cognitive impairment. MRI often discloses "silent" hyperintensities in 20% to 40% of community-dwelling elderly. Efforts to relate MRI-measured lacunes and white matter changes to cogn …
Subcortical ischemic vascular dementia (SIVD) has been proposed as a subtype of vascular cognitive impairment. MRI often discloses "s …
How Do Modifiable Risk Factors Affect Alzheimer's Disease Pathology or Mitigate Its Effect on Clinical Symptom Expression?
Ourry V, Binette AP, St-Onge F, Strikwerda-Brown C, Chagnot A, Poirier J, Breitner J, Arenaza-Urquijo EM, Rabin JS, Buckley R, Gonneaud J, Marchant NL, Villeneuve S. Ourry V, et al. Biol Psychiatry. 2024 Jun 1;95(11):1006-1019. doi: 10.1016/j.biopsych.2023.09.003. Epub 2023 Sep 7. Biol Psychiatry. 2024. PMID: 37689129 Review.
Epidemiological studies show that modifiable risk factors account for approximately 40% of the population variability in risk of developing dementia, including sporadic Alzheimer's disease (AD). Recent findings suggest that these factors may also modify di …
Epidemiological studies show that modifiable risk factors account for approximately 40% of the population variability in risk of developing …
Dementia, Preclinical Studies in Neurodegeneration and its Potential for Translational Medicine in South America.
Cardona-Gómez GP, Lopera F. Cardona-Gómez GP, et al. Front Aging Neurosci. 2016 Dec 20;8:304. doi: 10.3389/fnagi.2016.00304. eCollection 2016. Front Aging Neurosci. 2016. PMID: 28066230 Free PMC article. Review.
In addition, to sporadic dementia type like Alzheimer, and vascular dementia (VaD) progression after Cerebrovascular disease is also found. These incidences are increased in Colombia by specific populations affected with pure Neurodegenerative and VaDs like Autosomi …
In addition, to sporadic dementia type like Alzheimer, and vascular dementia (VaD) progression after Cerebrovascular disease i …