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Botulinum toxin: chemistry, pharmacology, toxicity, and immunology.
Brin MF. Brin MF. Muscle Nerve Suppl. 1997;6:S146-68. Muscle Nerve Suppl. 1997. PMID: 9826987 Review.
The seven serotypes of botulinum toxin (BTX) produced by Clostridium botulinum exert their paralytic effect by inhibiting acetylcholine release at the neuromuscular junction. ...Development of resistance to BTX-A therapy, characterized by absence of any benef …
The seven serotypes of botulinum toxin (BTX) produced by Clostridium botulinum exert their paralytic effect by inhibiti …
[Botulinum neurotoxin].
Poulain B. Poulain B. Rev Neurol (Paris). 2010 Jan;166(1):7-20. doi: 10.1016/j.neurol.2009.09.004. Epub 2009 Oct 28. Rev Neurol (Paris). 2010. PMID: 19846187 French.
Botulinum toxin is a multi-molecular complex comprised of a neuro-active moiety (i.e. botulinum neurotoxin) and several associated non-toxic proteins. The toxin dissociates rapidly at plasmatic pH, thereby releasing neurotoxin. Nerve term …
Botulinum toxin is a multi-molecular complex comprised of a neuro-active moiety (i.e. botulinum neurotoxin) and several …
Scorpion toxins for the reversal of BoNT-induced paralysis.
Lowery CA, Adler M, Borrell A, Janda KD. Lowery CA, et al. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6743-6. doi: 10.1016/j.bmcl.2013.10.029. Epub 2013 Oct 25. Bioorg Med Chem Lett. 2013. PMID: 24252544 Free PMC article.
The botulinum neurotoxins, characterized by their neuromuscular paralytic effects, are the most toxic proteins known to man. ...Herein, we report the synthesis of charybdotoxin, a 37 amino acid peptide, and detail its activity, along with iberiotoxin and margatoxin, …
The botulinum neurotoxins, characterized by their neuromuscular paralytic effects, are the most toxic proteins known to man. . …