Common polygenic variation enhances risk prediction for Alzheimer's disease.
Brain. 2015.
PMID: 26490334
Free PMC article.
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Common polygenic variation enhances risk prediction for Alzheimer's disease.
Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N; GERAD/PERADES; IGAP consortia; Morgan K, Passmore P, Holmes C, Powell J, Brayne C, Gill M, Mead S, Goate A, Cruchaga C, Lambert JC, van Duijn C, Maier W, Ramirez A, Holmans P, Jones L, Hardy J, Seshadri S, Schellenberg GD, Amouyel P, Williams J.
Escott-Price V, et al.
Brain. 2015 Dec;138(Pt 12):3673-84. doi: 10.1093/brain/awv268. Epub 2015 Oct 21.
Brain. 2015.
PMID: 26490334
Free PMC article.
The identification of subjects at high risk for Alzheimer's disease is important for prognosis and early intervention. We investigated the polygenic architecture of Alzheimer's disease and the accuracy of Alzheimer' …
The identification of subjects at high risk for Alzheimer's disease is important for prognosis and early interve …
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Machine Learning Models of Polygenic Risk for Enhanced Prediction of Alzheimer Disease Endophenotypes.
Gunter NB, Gebre RK, Graff-Radford J, Heckman MG, Jack CR Jr, Lowe VJ, Knopman DS, Petersen RC, Ross OA, Vemuri P, Ramanan VK; Alzheimer's Disease Neuroimaging Initiative.
Gunter NB, et al.
Neurol Genet. 2024 Jan 10;10(1):e200120. doi: 10.1212/NXG.0000000000200120. eCollection 2024 Feb.
Neurol Genet. 2024.
PMID: 38250184
Free PMC article.
BACKGROUND AND OBJECTIVES: Alzheimer disease (AD) has a polygenic architecture, for which genome-wide association studies (GWAS) have helped elucidate sequence variants (SVs) influencing susceptibility. ...METHODS: We analyzed combined data from the Mayo Clin …
BACKGROUND AND OBJECTIVES: Alzheimer disease (AD) has a polygenic architecture, for which genome-wide association studi …
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