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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 2
1980 1
1982 1
1984 1
1986 2
1987 3
1988 2
1989 5
1990 5
1991 3
1992 5
1993 6
1994 8
1995 7
1996 11
1997 9
1998 8
1999 23
2000 16
2001 13
2002 22
2003 19
2004 34
2005 27
2006 34
2007 40
2008 45
2009 37
2010 57
2011 54
2012 73
2013 81
2014 97
2015 131
2016 158
2017 190
2018 221
2019 202
2020 238
2021 284
2022 284
2023 276
2024 301
2025 111

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2,782 results

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Page 1
Stepping forward in antibody-drug conjugate development.
Jin Y, Schladetsch MA, Huang X, Balunas MJ, Wiemer AJ. Jin Y, et al. Pharmacol Ther. 2022 Jan;229:107917. doi: 10.1016/j.pharmthera.2021.107917. Epub 2021 Jun 24. Pharmacol Ther. 2022. PMID: 34171334 Free PMC article. Review.
Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody, a linker and a small-molecule payload. ...The released toxic payloads can induce apoptosis through DNA damage or microtubule inhibition and can kill surrounding cancer cells through the …
Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody, a linker and a small-molecule payload. ...The …
Safety and Monitoring of Inflammatory Bowel Disease Advanced Therapies.
Bhat S, Click B, Regueiro M. Bhat S, et al. Inflamm Bowel Dis. 2024 May 2;30(5):829-843. doi: 10.1093/ibd/izad120. Inflamm Bowel Dis. 2024. PMID: 37450619 Review.
The recent approval of new medications with novel mechanisms of action and emergence of updated safety information for existing therapies has changed the treatment landscape of inflammatory bowel disease (IBD). ...In this updated review, we (1) examine the existing and upd …
The recent approval of new medications with novel mechanisms of action and emergence of updated safety information for existing thera …
Safety of folic acid.
Field MS, Stover PJ. Field MS, et al. Ann N Y Acad Sci. 2018 Feb;1414(1):59-71. doi: 10.1111/nyas.13499. Epub 2017 Nov 20. Ann N Y Acad Sci. 2018. PMID: 29155442 Free PMC article. Review.
Current folic acid fortification programs have been shown to support public health in populations, and the exposure levels are informed by and adherent to the precautionary principle. Additional research is needed to assess the health effects of folic acid supplement use w …
Current folic acid fortification programs have been shown to support public health in populations, and the exposure levels are informed …
The Origins of "Confidential Commercial Information" at the FDA.
Daval CJR, Kesselheim AS. Daval CJR, et al. JAMA. 2024 Aug 20;332(7):533-534. doi: 10.1001/jama.2024.9639. JAMA. 2024. PMID: 39037797
This Viewpoint reviews regulations regarding FDA's handing of confidential commercial information, explains how these regulations serve as a barrier to disclosure of information in the interest of public health, and suggests how information could be ca …
This Viewpoint reviews regulations regarding FDA's handing of confidential commercial information, explains how these regulati …
Clinical Benefit and Regulatory Outcomes of Cancer Drugs Receiving Accelerated Approval.
Liu ITT, Kesselheim AS, Cliff ERS. Liu ITT, et al. JAMA. 2024 May 7;331(17):1471-1479. doi: 10.1001/jama.2024.2396. JAMA. 2024. PMID: 38583175 Free PMC article.
IMPORTANCE: The US Food and Drug Administration's (FDA) accelerated approval pathway allows approval of investigational drugs treating unmet medical needs based on changes to surrogate measures considered "reasonably likely" to predict clinical benefit …
IMPORTANCE: The US Food and Drug Administration's (FDA) accelerated approval pathway allows approval of investig …
Clinicians' Guide to Cannabidiol and Hemp Oils.
VanDolah HJ, Bauer BA, Mauck KF. VanDolah HJ, et al. Mayo Clin Proc. 2019 Sep;94(9):1840-1851. doi: 10.1016/j.mayocp.2019.01.003. Epub 2019 Aug 22. Mayo Clin Proc. 2019. PMID: 31447137 Free article. Review.
Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In June 2018, the first CBD-based drug, Epidiolex, was approved by the US Food and Drug Administration for treatment o …
Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In Jun …
Overview of FDA Drug Approval and Labeling.
Clarridge KE, Chin SJ, Stone KD. Clarridge KE, et al. J Allergy Clin Immunol Pract. 2022 Dec;10(12):3051-3056. doi: 10.1016/j.jaip.2022.09.005. J Allergy Clin Immunol Pract. 2022. PMID: 36496207
The U.S. Food and Drug Administration (FDA) regulates a variety of products, including medical, food, and tobacco products. Prior to the creation of the FDA, there were few protections to the public around the contents and sale of food …
The U.S. Food and Drug Administration (FDA) regulates a variety of products, including medical, food, and …
Drugs in Lactation.
Anderson PO. Anderson PO. Pharm Res. 2018 Feb 6;35(3):45. doi: 10.1007/s11095-017-2287-z. Pharm Res. 2018. PMID: 29411152 Review.
One impediment to breastfeeding is the lack of information on the use of many drugs during lactation, especially newer ones. The principles of drug passage into breastmilk are well established, but have often not been optimally applied prospectively. ...New FDA …
One impediment to breastfeeding is the lack of information on the use of many drugs during lactation, especially newer ones. The prin …
Zuranolone: The First FDA-Approved Oral Treatment Option for Postpartum Depression.
Barnes KN, Vogl CM, Nelson LA. Barnes KN, et al. Ann Pharmacother. 2024 Jul;58(7):728-734. doi: 10.1177/10600280231204953. Epub 2023 Oct 24. Ann Pharmacother. 2024. PMID: 37876133 Review.
RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE IN COMPARISON TO EXISTING DRUGS: Zuranolone is only the second medication approved by the Food and Drug Administration (FDA) for PPD and offers an advantage over brexanolone in that it can administered or …
RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE IN COMPARISON TO EXISTING DRUGS: Zuranolone is only the second medication approved by the …
Comparison of the EMA and FDA Guidelines on Ulcerative Colitis Drug Development.
Reinisch W, Gottlieb K, Colombel JF, Danese S, Panaccione R, Panes J, Peyrin-Biroulet L, Rubin D, Sands BE, Schreiber S, Vermeire S, Mulberg A, Sandborn B. Reinisch W, et al. Clin Gastroenterol Hepatol. 2019 Aug;17(9):1673-1679.e1. doi: 10.1016/j.cgh.2018.10.032. Epub 2018 Oct 26. Clin Gastroenterol Hepatol. 2019. PMID: 31352970 Review.
BACKGROUND & AIMS: In 2016, the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) released revised EMA and new FDA draft guidelines related to the development of drugs intended for the treatment of ulcerative coli …
BACKGROUND & AIMS: In 2016, the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA …
2,782 results