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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 2
1980 1
1982 1
1984 1
1986 2
1987 3
1988 2
1989 5
1990 5
1991 3
1992 5
1993 6
1994 8
1995 7
1996 11
1997 9
1998 8
1999 23
2000 16
2001 13
2002 22
2003 19
2004 34
2005 27
2006 34
2007 40
2008 45
2009 37
2010 57
2011 54
2012 73
2013 81
2014 97
2015 131
2016 158
2017 189
2018 221
2019 201
2020 236
2021 285
2022 283
2023 272
2024 134

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2,532 results

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Page 1
Stepping forward in antibody-drug conjugate development.
Jin Y, Schladetsch MA, Huang X, Balunas MJ, Wiemer AJ. Jin Y, et al. Pharmacol Ther. 2022 Jan;229:107917. doi: 10.1016/j.pharmthera.2021.107917. Epub 2021 Jun 24. Pharmacol Ther. 2022. PMID: 34171334 Free PMC article. Review.
Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody, a linker and a small-molecule payload. ...The released toxic payloads can induce apoptosis through DNA damage or microtubule inhibition and can kill surrounding cancer cells through the …
Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody, a linker and a small-molecule payload. ...The …
Safety and Monitoring of Inflammatory Bowel Disease Advanced Therapies.
Bhat S, Click B, Regueiro M. Bhat S, et al. Inflamm Bowel Dis. 2024 May 2;30(5):829-843. doi: 10.1093/ibd/izad120. Inflamm Bowel Dis. 2024. PMID: 37450619 Review.
The recent approval of new medications with novel mechanisms of action and emergence of updated safety information for existing therapies has changed the treatment landscape of inflammatory bowel disease (IBD). ...In this updated review, we (1) examine the existing and upd …
The recent approval of new medications with novel mechanisms of action and emergence of updated safety information for existing thera …
Clinicians' Guide to Cannabidiol and Hemp Oils.
VanDolah HJ, Bauer BA, Mauck KF. VanDolah HJ, et al. Mayo Clin Proc. 2019 Sep;94(9):1840-1851. doi: 10.1016/j.mayocp.2019.01.003. Epub 2019 Aug 22. Mayo Clin Proc. 2019. PMID: 31447137 Free article. Review.
Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In June 2018, the first CBD-based drug, Epidiolex, was approved by the US Food and Drug Administration for treatment o …
Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In Jun …
Safety of folic acid.
Field MS, Stover PJ. Field MS, et al. Ann N Y Acad Sci. 2018 Feb;1414(1):59-71. doi: 10.1111/nyas.13499. Epub 2017 Nov 20. Ann N Y Acad Sci. 2018. PMID: 29155442 Free PMC article. Review.
Current folic acid fortification programs have been shown to support public health in populations, and the exposure levels are informed by and adherent to the precautionary principle. Additional research is needed to assess the health effects of folic acid supplement use w …
Current folic acid fortification programs have been shown to support public health in populations, and the exposure levels are informed
Overview of FDA Drug Approval and Labeling.
Clarridge KE, Chin SJ, Stone KD. Clarridge KE, et al. J Allergy Clin Immunol Pract. 2022 Dec;10(12):3051-3056. doi: 10.1016/j.jaip.2022.09.005. J Allergy Clin Immunol Pract. 2022. PMID: 36496207
The U.S. Food and Drug Administration (FDA) regulates a variety of products, including medical, food, and tobacco products. Prior to the creation of the FDA, there were few protections to the public around the contents and sale of food
The U.S. Food and Drug Administration (FDA) regulates a variety of products, including medical, food, and …
Drugs in Lactation.
Anderson PO. Anderson PO. Pharm Res. 2018 Feb 6;35(3):45. doi: 10.1007/s11095-017-2287-z. Pharm Res. 2018. PMID: 29411152 Review.
Measurement of drug concentrations in humans remains the gold standard, but computer modeling is promising. New FDA labeling requirements present an opportunity to apply modeling to preclinical drug development in place of conventional animal testing for d
Measurement of drug concentrations in humans remains the gold standard, but computer modeling is promising. New FDA labeling r …
Comparison of the EMA and FDA Guidelines on Ulcerative Colitis Drug Development.
Reinisch W, Gottlieb K, Colombel JF, Danese S, Panaccione R, Panes J, Peyrin-Biroulet L, Rubin D, Sands BE, Schreiber S, Vermeire S, Mulberg A, Sandborn B. Reinisch W, et al. Clin Gastroenterol Hepatol. 2019 Aug;17(9):1673-1679.e1. doi: 10.1016/j.cgh.2018.10.032. Epub 2018 Oct 26. Clin Gastroenterol Hepatol. 2019. PMID: 31352970 Review.
BACKGROUND & AIMS: In 2016, the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) released revised EMA and new FDA draft guidelines related to the development of drugs intended for the treatment of ulcerative coli …
BACKGROUND & AIMS: In 2016, the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA
Clinical Benefit and Regulatory Outcomes of Cancer Drugs Receiving Accelerated Approval.
Liu ITT, Kesselheim AS, Cliff ERS. Liu ITT, et al. JAMA. 2024 May 7;331(17):1471-1479. doi: 10.1001/jama.2024.2396. JAMA. 2024. PMID: 38583175
IMPORTANCE: The US Food and Drug Administration's (FDA) accelerated approval pathway allows approval of investigational drugs treating unmet medical needs based on changes to surrogate measures considered "reasonably likely" to predict clinical benefit …
IMPORTANCE: The US Food and Drug Administration's (FDA) accelerated approval pathway allows approval of investig …
Multimodal Analysis of FDA Drug Safety Communications: Lessons from Zolpidem.
Kesselheim AS, Sinha MS, Campbell EG, Schneeweiss S, Rausch P, Lappin BM, Zhou EH, Avorn J, Dal Pan GJ. Kesselheim AS, et al. Drug Saf. 2019 Nov;42(11):1287-1295. doi: 10.1007/s40264-019-00849-8. Drug Saf. 2019. PMID: 31302895
Because clinical trials conducted for US Food and Drug Administration (FDA) approval occur in carefully monitored settings and often have strict inclusion criteria for participation, new information about drug safety is commonly discovere …
Because clinical trials conducted for US Food and Drug Administration (FDA) approval occur in carefully monitore …
The Integrated Review: FDA Modernizes the Review of New Drug Marketing Applications.
Hearns-Stewart RM, Farley J, Lee KJ, Connelly S, Lowy N, Stein P, Bugin K. Hearns-Stewart RM, et al. Ther Innov Regul Sci. 2021 May;55(3):467-472. doi: 10.1007/s43441-020-00240-1. Epub 2020 Nov 24. Ther Innov Regul Sci. 2021. PMID: 33236259
New Drug Applications and Biologics Licensing Applications submitted to the US Food and Drug Administration (FDA) are reviewed by an interdisciplinary team of regulatory scientists that includes medical officers, clinical pharmacologists, toxico …
New Drug Applications and Biologics Licensing Applications submitted to the US Food and Drug Administration ( …
2,532 results