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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1977 1
1980 1
1981 1
1982 4
1983 2
1984 1
1985 1
1986 2
1987 1
1988 3
1989 1
1990 2
1991 3
1992 6
1993 10
1994 14
1995 9
1996 22
1997 15
1998 24
1999 13
2000 22
2001 18
2002 24
2003 39
2004 49
2005 38
2006 51
2007 75
2008 82
2009 125
2010 132
2011 165
2012 221
2013 240
2014 290
2015 336
2016 394
2017 490
2018 551
2019 632
2020 985
2021 1135
2022 1106
2023 1082
2024 1098
2025 440

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8,804 results

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Page 1
Doxil--the first FDA-approved nano-drug: lessons learned.
Barenholz Y. Barenholz Y. J Control Release. 2012 Jun 10;160(2):117-34. doi: 10.1016/j.jconrel.2012.03.020. Epub 2012 Mar 29. J Control Release. 2012. PMID: 22484195 Review.
Doxil, the first FDA-approved nano-drug (1995), is based on three unrelated principles: (i) prolonged drug circulation time and avoidance of the RES due to the use of PEGylated nano-liposomes; (ii) high and stable remote loading of doxorubicin driven by a transmembr …
Doxil, the first FDA-approved nano-drug (1995), is based on three unrelated principles: (i) prolonged drug circulation time an …
US-FDA Approved Drugs in 2020 and 2021: A Review.
Passi I, Salwan S, Kumar B. Passi I, et al. Mini Rev Med Chem. 2023;23(12):1273-1297. doi: 10.2174/1389557523666221208104530. Mini Rev Med Chem. 2023. PMID: 36503454 Review.
INTRODUCTION: Throughout the years, the disruption caused by COVID-19 continues to pose an excess of challenges for the pharmaceutical industry. Throughout the entire year, questions were raised that does COVID-19 have a negative impact on new drug approvals. ...The availa …
INTRODUCTION: Throughout the years, the disruption caused by COVID-19 continues to pose an excess of challenges for the pharmaceutical …
FDA-Approved Fluorinated Heterocyclic Drugs from 2016 to 2022.
Rizzo C, Amata S, Pibiri I, Pace A, Buscemi S, Palumbo Piccionello A. Rizzo C, et al. Int J Mol Sci. 2023 Apr 23;24(9):7728. doi: 10.3390/ijms24097728. Int J Mol Sci. 2023. PMID: 37175436 Free PMC article. Review.
This is demonstrated by the increasing number of newly synthesized fluorinated heterocyclic compounds among the Food and Drug Administration FDA-approved drugs. In this review, the biological activity, as well as the synthetic aspects, of 33 recently FDA …
This is demonstrated by the increasing number of newly synthesized fluorinated heterocyclic compounds among the Food and Drug Administration …
Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021.
Wu Q, Qian W, Sun X, Jiang S. Wu Q, et al. J Hematol Oncol. 2022 Oct 8;15(1):143. doi: 10.1186/s13045-022-01362-9. J Hematol Oncol. 2022. PMID: 36209184 Free PMC article. Review.
A total of 228 of these 1050 drugs were identified as cancer therapeutics or cancer-related drugs, and 120 of them were classified as therapeutic drugs for solid tumors according to their initial indications. ...However, the available targets are still mainly …
A total of 228 of these 1050 drugs were identified as cancer therapeutics or cancer-related drugs, and 120 of them were classi …
FDA-Approved Drugs to Treat Schizophrenia.
[No authors listed] [No authors listed] J Psychosoc Nurs Ment Health Serv. 2021 Dec;59(12):5-6. doi: 10.3928/02793695-20211026-79. Epub 2021 Dec 1. J Psychosoc Nurs Ment Health Serv. 2021. PMID: 34846247 No abstract available.
FDA-Approved Small Molecule Compounds as Drugs for Solid Cancers from Early 2011 to the End of 2021.
Sochacka-Ćwikła A, Mączyński M, Regiec A. Sochacka-Ćwikła A, et al. Molecules. 2022 Mar 31;27(7):2259. doi: 10.3390/molecules27072259. Molecules. 2022. PMID: 35408658 Free PMC article. Review.
The main challenge currently in drug development for tumors raised from solid organs is to find more selective compounds, which exploit specific molecular targets. In this work, the small molecule drugs registered by the Food and Drug Administration (FDA) for solid cancers …
The main challenge currently in drug development for tumors raised from solid organs is to find more selective compounds, which exploit spec …
Highlights on U.S. FDA-approved fluorinated drugs over the past five years (2018-2022).
Ali S, Zhou J. Ali S, et al. Eur J Med Chem. 2023 Aug 5;256:115476. doi: 10.1016/j.ejmech.2023.115476. Epub 2023 May 13. Eur J Med Chem. 2023. PMID: 37207534 Free PMC article. Review.
The objective of this review is to provide an update on the fluorine-containing drugs approved by U.S. Food and Drug Administration in the span of past five years (2018-2022). ...We anticipate that this review may inspire the drug discovery and medicinal chemistry communit …
The objective of this review is to provide an update on the fluorine-containing drugs approved by U.S. Food and Drug Administration i …
A Survey of the Structures of US FDA Approved Combination Drugs.
Das P, Delost MD, Qureshi MH, Smith DT, Njardarson JT. Das P, et al. J Med Chem. 2019 May 9;62(9):4265-4311. doi: 10.1021/acs.jmedchem.8b01610. Epub 2018 Nov 30. J Med Chem. 2019. PMID: 30444362 Review.
Combination drugs are an important class of US FDA approved pharmaceuticals. These drugs have been on a continuous growth trajectory since the first combination drugs were approved in the 1940s. In this Perspective, we report the first comprehen …
Combination drugs are an important class of US FDA approved pharmaceuticals. These drugs have been on a continuo …
Highlights on U.S. FDA-approved halogen-containing drugs in 2024.
Ali S, Tian X, Meccia SA, Zhou J. Ali S, et al. Eur J Med Chem. 2025 Apr 5;287:117380. doi: 10.1016/j.ejmech.2025.117380. Epub 2025 Feb 9. Eur J Med Chem. 2025. PMID: 39947048 Review.
This comprehensive review offers an update on the FDA-approved halogen-containing drugs in 2024. The agency approved a total of 50 drugs, including small molecules and macromolecules. ...In addition, the specific role of halogens in these drugs …
This comprehensive review offers an update on the FDA-approved halogen-containing drugs in 2024. The agency approved a …
Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments.
Zobdeh F, Ben Kraiem A, Attwood MM, Chubarev VN, Tarasov VV, Schiöth HB, Mwinyi J. Zobdeh F, et al. Br J Pharmacol. 2021 Dec;178(23):4588-4607. doi: 10.1111/bph.15657. Epub 2021 Sep 26. Br J Pharmacol. 2021. PMID: 34379793 Free article. Review.
In this review, we analyse historical and current pharmaceutical development approaches in acute and chronic migraine based on a comprehensive and systematic analysis of Food and Drug Administration (FDA)-approved drugs and those under investigation. . …
In this review, we analyse historical and current pharmaceutical development approaches in acute and chronic migraine based on a comp …
8,804 results