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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1977 1
1980 1
1981 1
1982 4
1983 2
1984 1
1985 1
1986 2
1987 1
1988 3
1989 1
1990 2
1991 3
1992 6
1993 11
1994 14
1995 9
1996 22
1997 15
1998 24
1999 13
2000 23
2001 18
2002 24
2003 39
2004 49
2005 38
2006 51
2007 75
2008 82
2009 125
2010 132
2011 165
2012 221
2013 240
2014 290
2015 336
2016 394
2017 489
2018 551
2019 632
2020 985
2021 1135
2022 1108
2023 1088
2024 1099
2025 1287
2026 579

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10,070 results

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Page 1
Doxil --the first FDA-approved nano-drug: lessons learned.
Barenholz Y. Barenholz Y. J Control Release. 2012 Jun 10;160(2):117-34. doi: 10.1016/j.jconrel.2012.03.020. Epub 2012 Mar 29. J Control Release. 2012. PMID: 22484195 Review.
Doxil , the first FDA-approved nano-drug (1995), is based on three unrelated principles: (i) prolonged drug circulation time and avoidance of the RES due to the use of PEGylated nano-liposomes; (ii) high and stable remote loading of doxorubicin driven by a transmemb …
Doxil , the first FDA-approved nano-drug (1995), is based on three unrelated principles: (i) prolonged drug circulation time a …
US-FDA Approved Drugs in 2020 and 2021: A Review.
Passi I, Salwan S, Kumar B. Passi I, et al. Mini Rev Med Chem. 2023;23(12):1273-1297. doi: 10.2174/1389557523666221208104530. Mini Rev Med Chem. 2023. PMID: 36503454 Review.
INTRODUCTION: Throughout the years, the disruption caused by COVID-19 continues to pose an excess of challenges for the pharmaceutical industry. Throughout the entire year, questions were raised that does COVID-19 have a negative impact on new drug approvals. ...The availa …
INTRODUCTION: Throughout the years, the disruption caused by COVID-19 continues to pose an excess of challenges for the pharmaceutical …
FDA-Approved Fluorinated Heterocyclic Drugs from 2016 to 2022.
Rizzo C, Amata S, Pibiri I, Pace A, Buscemi S, Palumbo Piccionello A. Rizzo C, et al. Int J Mol Sci. 2023 Apr 23;24(9):7728. doi: 10.3390/ijms24097728. Int J Mol Sci. 2023. PMID: 37175436 Free PMC article. Review.
This is demonstrated by the increasing number of newly synthesized fluorinated heterocyclic compounds among the Food and Drug Administration FDA-approved drugs. In this review, the biological activity, as well as the synthetic aspects, of 33 recently FDA …
This is demonstrated by the increasing number of newly synthesized fluorinated heterocyclic compounds among the Food and Drug Administration …
Evaluating physiochemical properties of FDA-approved orally administered drugs.
Reese TC, Devineni A, Smith T, Lalami I, Ahn JM, Raj GV. Reese TC, et al. Expert Opin Drug Discov. 2024 Feb;19(2):225-238. doi: 10.1080/17460441.2023.2275617. Epub 2024 Feb 1. Expert Opin Drug Discov. 2024. PMID: 37921049 Review.
INTRODUCTION: Analyses of orally administered FDA-approved drugs from 1990 to 1993 enabled the identification of a set of physiochemical properties known as Lipinski's Rule of Five (Ro5). ...Since many bioactive compounds do not conform to the Ro5, we validat …
INTRODUCTION: Analyses of orally administered FDA-approved drugs from 1990 to 1993 enabled the identification of a set …
Highlights on U.S. FDA-approved halogen-containing drugs in 2024.
Ali S, Tian X, Meccia SA, Zhou J. Ali S, et al. Eur J Med Chem. 2025 Apr 5;287:117380. doi: 10.1016/j.ejmech.2025.117380. Epub 2025 Feb 9. Eur J Med Chem. 2025. PMID: 39947048 Free PMC article. Review.
This comprehensive review offers an update on the FDA-approved halogen-containing drugs in 2024. The agency approved a total of 50 drugs, including small molecules and macromolecules. ...In addition, the specific role of halogens in these drugs …
This comprehensive review offers an update on the FDA-approved halogen-containing drugs in 2024. The agency approved a …
FDA-Approved Small Molecule Compounds as Drugs for Solid Cancers from Early 2011 to the End of 2021.
Sochacka-Ćwikła A, Mączyński M, Regiec A. Sochacka-Ćwikła A, et al. Molecules. 2022 Mar 31;27(7):2259. doi: 10.3390/molecules27072259. Molecules. 2022. PMID: 35408658 Free PMC article. Review.
The main challenge currently in drug development for tumors raised from solid organs is to find more selective compounds, which exploit specific molecular targets. In this work, the small molecule drugs registered by the Food and Drug Administration (FDA) for solid cancers …
The main challenge currently in drug development for tumors raised from solid organs is to find more selective compounds, which exploit spec …
Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments.
Zobdeh F, Ben Kraiem A, Attwood MM, Chubarev VN, Tarasov VV, Schiöth HB, Mwinyi J. Zobdeh F, et al. Br J Pharmacol. 2021 Dec;178(23):4588-4607. doi: 10.1111/bph.15657. Epub 2021 Sep 26. Br J Pharmacol. 2021. PMID: 34379793 Free article. Review.
In this review, we analyse historical and current pharmaceutical development approaches in acute and chronic migraine based on a comprehensive and systematic analysis of Food and Drug Administration (FDA)-approved drugs and those under investigation. . …
In this review, we analyse historical and current pharmaceutical development approaches in acute and chronic migraine based on a comp …
Highlights on U.S. FDA-approved fluorinated drugs over the past five years (2018-2022).
Ali S, Zhou J. Ali S, et al. Eur J Med Chem. 2023 Aug 5;256:115476. doi: 10.1016/j.ejmech.2023.115476. Epub 2023 May 13. Eur J Med Chem. 2023. PMID: 37207534 Free PMC article. Review.
The objective of this review is to provide an update on the fluorine-containing drugs approved by U.S. Food and Drug Administration in the span of past five years (2018-2022). ...We anticipate that this review may inspire the drug discovery and medicinal chemistry communit …
The objective of this review is to provide an update on the fluorine-containing drugs approved by U.S. Food and Drug Administration i …
Synthesis and clinical application of new drugs approved by FDA in 2023.
Wang YT, Yang PC, Zhang YF, Sun JF. Wang YT, et al. Eur J Med Chem. 2024 Feb 5;265:116124. doi: 10.1016/j.ejmech.2024.116124. Epub 2024 Jan 3. Eur J Med Chem. 2024. PMID: 38183778 Review.
Food and Drug Administration (FDA) granted approval to a total of 55 new drugs, comprising 29 new chemical entities (NCEs) and 25 new biological entities (NBEs). ...The purpose of this review is to provide an overview of the clinical uses and production techniques of 29 ne …
Food and Drug Administration (FDA) granted approval to a total of 55 new drugs, comprising 29 new chemical entities (NCEs) and 25 new …
New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use.
Benedetto Tiz D, Bagnoli L, Rosati O, Marini F, Sancineto L, Santi C. Benedetto Tiz D, et al. Molecules. 2022 Mar 2;27(5):1643. doi: 10.3390/molecules27051643. Molecules. 2022. PMID: 35268744 Free PMC article. Review.
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in the year 2021) containing at least one halogen atom (covalently bound). ...This underlines the emergent role of halogens and, in particular, of fluorine and chlorine in the …
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in the year 2021) containing at lea …
10,070 results
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