Gene-environment interactions in asthma and other respiratory diseases.
Annu Rev Med. 2005.
PMID: 15660518
Review.
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Environmental exposures and mechanisms in allergy and asthma development.
J Clin Invest. 2019 Apr 1;129(4):1504-1515. doi: 10.1172/JCI124612. Epub 2019 Feb 11.
J Clin Invest. 2019.
PMID: 30741719
Free PMC article.
Review.
Environmental exposures interplay with human host factors to promote the development and progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a result of complex gene-environment interactions that shape the immune …
Environmental exposures interplay with human host factors to promote the development and progression of allergic diseases. The worldw …
Gene-environment interactions in asthma and other respiratory diseases.
Annu Rev Med. 2005;56:383-400. doi: 10.1146/annurev.med.56.062904.144908.
Annu Rev Med. 2005.
PMID: 15660518
Review.
We discuss experimental approaches and challenges that must be overcome to identify disease genes for asthma, COPD and chronic bronchitis, and occupational lung diseases. In particular, common polymorphisms in CD14, glutathione S-transferase, and tumor necrosis fact …
We discuss experimental approaches and challenges that must be overcome to identify disease genes for asthma, COPD and chronic bronch …
The nature and nurture of ADHD and its comorbidities: A narrative review on twin studies.
Neurosci Biobehav Rev. 2020 Feb;109:63-77. doi: 10.1016/j.neubiorev.2019.12.017. Epub 2019 Dec 12.
Neurosci Biobehav Rev. 2020.
PMID: 31838192
Review.
Notably, a genetic overlap has been found between asthma and ADHD, particularly with respect to hyperactivity/impulsivity dimensions. ADHD also appears to represent a risk factor for disordered eating, and, more specifically, for binge eating and bulimia nervosa. ...
Notably, a genetic overlap has been found between asthma and ADHD, particularly with respect to hyperactivity/impulsivity dimensions. …
Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.
Pediatr Allergy Immunol. 2022 May;33(5):e13780. doi: 10.1111/pai.13780.
Pediatr Allergy Immunol. 2022.
PMID: 35616899
Free PMC article.
Review.
Investigation of gene-environment interactions (GxE) may provide important insights into the gene regulatory framework in response to environmental factors of relevance for childhood asthma. Over the years, different methodological strategies ha …
Investigation of gene-environment interactions (GxE) may provide important insights into the gene regulatory fra …
Precision/Personalized Medicine in Allergic Diseases and Asthma.
Arch Immunol Ther Exp (Warsz). 2018 Dec;66(6):431-442. doi: 10.1007/s00005-018-0526-6. Epub 2018 Sep 24.
Arch Immunol Ther Exp (Warsz). 2018.
PMID: 30251122
Free article.
Review.
Like many other chronic diseases, every allergic patient has different characteristics based on clinical course, treatment responsiveness and disease outcomes, which are associated with the genetic and epigenetic control of molecular mechanisms and environment. ...I …
Like many other chronic diseases, every allergic patient has different characteristics based on clinical course, treatment responsive …
Differences in asthma genetics between Chinese and other populations.
J Allergy Clin Immunol. 2014 Jan;133(1):42-8. doi: 10.1016/j.jaci.2013.09.018. Epub 2013 Nov 1.
J Allergy Clin Immunol. 2014.
PMID: 24188974
Review.
Asthma is caused by complex gene-gene and gene-environment interactions. Most asthma genes are not replicable across populations, which is possibly because of differences in the epidemiology of these genes. ...In conclusion, differ …
Asthma is caused by complex gene-gene and gene-environment interactions. Most asthma genes …
Glutathione S-Transferase Gene Associations and Gene-Environment Interactions for Asthma.
Curr Allergy Asthma Rep. 2021 May 10;21(5):31. doi: 10.1007/s11882-021-01005-y.
Curr Allergy Asthma Rep. 2021.
PMID: 33970355
Review.
The GST-environment interaction may depend on exposure type, asthma phenotype or endotype, ethnics, and other complex gene-gene interaction. Future studies could be improved by defining precise asthma endotypes, involving multiple …
The GST-environment interaction may depend on exposure type, asthma phenotype or endotype, ethnics, and other complex …
Epigenetics and the Environment in Airway Disease: Asthma and Allergic Rhinitis.
Adv Exp Med Biol. 2020;1253:153-181. doi: 10.1007/978-981-15-3449-2_6.
Adv Exp Med Biol. 2020.
PMID: 32445095
Review.
Asthma and rhinitis are complex, heterogeneous diseases characterized by chronic inflammation of the upper and lower airways. ...In allergic airway and other complex diseases, it is thought that epigenetic modifications, including DNA methylation, histone mod …
Asthma and rhinitis are complex, heterogeneous diseases characterized by chronic inflammation of the upper and lower airways. …
Gene-environment interactions in the study of asthma in the postgenomewide association studies era.
Curr Opin Allergy Clin Immunol. 2015 Feb;15(1):70-8. doi: 10.1097/ACI.0000000000000131.
Curr Opin Allergy Clin Immunol. 2015.
PMID: 25479314
Free article.
Review.
Understanding the mechanisms through which genes and environment interact represents one of the major challenges for pulmonary researchers. This review provides an overview of the recently published literature on gene-environment (G E) interactions in …
Understanding the mechanisms through which genes and environment interact represents one of the major challenges for pulmonary resear …
Gene-air pollution interactions in asthma.
Proc Am Thorac Soc. 2007 Jul;4(3):217-20. doi: 10.1513/pats.200701-031AW.
Proc Am Thorac Soc. 2007.
PMID: 17607002
Free PMC article.
Review.
Thus, there are few examples from the literature of specific gene-environment interactions in relation to asthma. The clearest examples of genetic interactions for inhaled pollutants exist for endotoxin, environmental tobacco smoke, and ozone. E …
Thus, there are few examples from the literature of specific gene-environment interactions in relation to asthma …
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