Oxidative stress: from basic research to clinical application.
Am J Med. 1991.
PMID: 1928209
Review.
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Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances.
Signal Transduct Target Ther. 2025 Jun 11;10(1):190. doi: 10.1038/s41392-025-02253-4.
Signal Transduct Target Ther. 2025.
PMID: 40500258
Free PMC article.
Review.
Mitochondrial dysfunction induces an imbalance between oxidation and antioxidation, mitochondrial DNA (mtDNA) damage, mitochondrial dynamics dysregulation, and changes in mitophagy. It results in oxidative stress due to excessive reactive oxygen species (ROS) genera …
Mitochondrial dysfunction induces an imbalance between oxidation and antioxidation, mitochondrial DNA (mtDNA) damage, mitochondrial dynamics …
Heavy Metal Exposure and Cardiovascular Disease.
Circ Res. 2024 Apr 26;134(9):1160-1178. doi: 10.1161/CIRCRESAHA.123.323617. Epub 2024 Apr 25.
Circ Res. 2024.
PMID: 38662861
Free article.
Review.
Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of reactive oxygen species, which can then exacerbate reactive oxygen species generation and induce inflammation, resulting in endothelial dysfunction, lipid meta …
Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of reactive oxygen spe …
Oxidative stress: from basic research to clinical application.
Am J Med. 1991 Sep 30;91(3C):31S-38S. doi: 10.1016/0002-9343(91)90281-2.
Am J Med. 1991.
PMID: 1928209
Review.
The steady-state formation of pro-oxidants is balanced by a similar rate of their consumption by antioxidants that are enzymatic and/or nonenzymatic. "Oxidative stress" results from imbalance in this pro-oxidant-antioxidant equilibrium in favor of the pro-oxidants. …
The steady-state formation of pro-oxidants is balanced by a similar rate of their consumption by antioxidants that are enzymatic and/or none …
Role of acetylation in doxorubicin-induced cardiotoxicity.
Redox Biol. 2021 Oct;46:102089. doi: 10.1016/j.redox.2021.102089. Epub 2021 Jul 31.
Redox Biol. 2021.
PMID: 34364220
Free PMC article.
Review.
In this review, we summarize the pivotal functions of HDACs and HATs in DOX-induced oxidative stress, the underlying mechanisms, the contributions of noncoding RNAs (ncRNAs) and exercise-mediated deacetylases to cardiotoxicity. Furthermore, we describe research …
In this review, we summarize the pivotal functions of HDACs and HATs in DOX-induced oxidative stress, the underlying mechanism …
Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics.
Redox Biol. 2022 Jul;53:102352. doi: 10.1016/j.redox.2022.102352. Epub 2022 May 27.
Redox Biol. 2022.
PMID: 35649312
Free PMC article.
Review.
The noninvasive nature, favorable safety profile, and common clinical application of HBOT make it a competitive candidate for several new indications, one of them being aging and age-related diseases. In fact, despite the conventional wisdom that excessive oxygen ac …
The noninvasive nature, favorable safety profile, and common clinical application of HBOT make it a competitive candidate for …
A comprehensive review of finerenone-a third-generation non-steroidal mineralocorticoid receptor antagonist.
Front Cardiovasc Med. 2024 Sep 23;11:1476029. doi: 10.3389/fcvm.2024.1476029. eCollection 2024.
Front Cardiovasc Med. 2024.
PMID: 39376623
Free PMC article.
Review.
Specifically, animal and cell-based experiments have demonstrated that this compound exerts multiple effects including fibrosis inhibition, reduced pulmonary artery pressure, improved diabetic retinopathy, enhanced endothelial functions, metabolic optimization as well as reduced …
Specifically, animal and cell-based experiments have demonstrated that this compound exerts multiple effects including fibrosis inhibition, …
The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview.
Arch Toxicol. 2016 Aug;90(8):1817-40. doi: 10.1007/s00204-016-1744-5. Epub 2016 Jun 3.
Arch Toxicol. 2016.
PMID: 27259333
Review.
Thanks to a high protein and vitamin content, Spirulina is used as a nutraceutical food supplement, although its other potential health benefits have attracted much attention. Oxidative stress and dysfunctional immunity cause many diseases in humans, including ather …
Thanks to a high protein and vitamin content, Spirulina is used as a nutraceutical food supplement, although its other potential health bene …
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases.
Signal Transduct Target Ther. 2024 Mar 1;9(1):50. doi: 10.1038/s41392-024-01756-w.
Signal Transduct Target Ther. 2024.
PMID: 38424050
Free PMC article.
Review.
PGC-1s are essential coordinators of many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, and inflammation. Accumulating evidence has shown that PGC-1s are implicated in many diseases, such as cancers, c …
PGC-1s are essential coordinators of many vital cellular events, including mitochondrial functions, oxidative stress, endoplas …
Pharmacological Effects and Molecular Protective Mechanisms of Astragalus Polysaccharides on Nonalcoholic Fatty Liver Disease.
Front Pharmacol. 2022 Mar 3;13:854674. doi: 10.3389/fphar.2022.854674. eCollection 2022.
Front Pharmacol. 2022.
PMID: 35308224
Free PMC article.
Review.
Lipid metabolism, insulin resistance (IR), oxidative stress (OS), endoplasmic reticulum stress (ERS), inflammation, fibrosis, autophagy, and apoptosis are some of the pathogenic pathways involved. ...All of the information presented in this review suggests th …
Lipid metabolism, insulin resistance (IR), oxidative stress (OS), endoplasmic reticulum stress (ERS), inflammation, fib …
Turmeric-Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Healing.
Adv Sci (Weinh). 2024 May;11(18):e2307630. doi: 10.1002/advs.202307630. Epub 2024 Mar 5.
Adv Sci (Weinh). 2024.
PMID: 38441389
Free PMC article.
This study aims to validate the efficacy of turmeric-derived nanoparticles (TDNPs) loaded with natural bioactive compounds. TDNPs can alleviate oxidative stress, promote fibroblast proliferation and migration, and reprogram macrophage polarization. ...This study hig …
This study aims to validate the efficacy of turmeric-derived nanoparticles (TDNPs) loaded with natural bioactive compounds. TDNPs can allevi …
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