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Page 1
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.
Marogianni C, Sokratous M, Dardiotis E, Hadjigeorgiou GM, Bogdanos D, Xiromerisiou G. Marogianni C, et al. Int J Mol Sci. 2020 Nov 10;21(22):8421. doi: 10.3390/ijms21228421. Int J Mol Sci. 2020. PMID: 33182554 Free PMC article. Review.
In this review, we highlight the binary role of microglia activation in the pathophysiology of the disorder, both neuroprotective and neuromodulatory. ...The gut-brain axis and the possible contribution of the peripheral bowel inflammation to neuronal death, mainly dopamin …
In this review, we highlight the binary role of microglia activation in the pathophysiology of the disorder, both neuroprotective and …
Neurons and Glia Interplay in α-Synucleinopathies.
Mavroeidi P, Xilouri M. Mavroeidi P, et al. Int J Mol Sci. 2021 May 8;22(9):4994. doi: 10.3390/ijms22094994. Int J Mol Sci. 2021. PMID: 34066733 Free PMC article. Review.
Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous inclusions represents the key histophathological hallmark of a spectrum of neurodegenerative disorders, referred to by the umbrella term a-synucleinopathies. Even though alpha-synuclein i …
Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous inclusions represents the key histophathological hallm …
The effect of truncation on prion-like properties of α-synuclein.
Terada M, Suzuki G, Nonaka T, Kametani F, Tamaoka A, Hasegawa M. Terada M, et al. J Biol Chem. 2018 Sep 7;293(36):13910-13920. doi: 10.1074/jbc.RA118.001862. Epub 2018 Jul 20. J Biol Chem. 2018. PMID: 30030380 Free PMC article.
Previous studies have shown that alphaS truncation might have an important role in alphaS aggregation. However, little is known about how this truncation influences alphaS's propagation properties. ...
Previous studies have shown that alphaS truncation might have an important role in alphaS aggregation. However, little is known about …
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.
Badanjak K, Fixemer S, Smajić S, Skupin A, Grünewald A. Badanjak K, et al. Int J Mol Sci. 2021 Apr 28;22(9):4676. doi: 10.3390/ijms22094676. Int J Mol Sci. 2021. PMID: 33925154 Free PMC article. Review.
In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that microglia have a significant neuroprotective role, and that impaired and over activated microglial phenotypes are present in brains of …
In recent years, inflammatory processes have emerged as prominent contributors to the pathology of PD. There is great evidence that m …
[Aggregation and spread of synuclein in Parkinson's disease].
Bezard E, Dehay B. Bezard E, et al. Med Sci (Paris). 2022 Jan;38(1):45-51. doi: 10.1051/medsci/2021241. Epub 2022 Jan 21. Med Sci (Paris). 2022. PMID: 35060886 Free article. Review. French.
The vast majority of neurodegenerative diseases are associated with an accumulation of undegraded and aggregated proteins. Hence the word proteinopathies is now used to refer to these neurodegenerative diseases. ...Experimental evidence suggests that under pathol …
The vast majority of neurodegenerative diseases are associated with an accumulation of undegraded and aggregated proteins. Hence the …
Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.
Takeda A, Mallory M, Sundsmo M, Honer W, Hansen L, Masliah E. Takeda A, et al. Am J Pathol. 1998 Feb;152(2):367-72. Am J Pathol. 1998. PMID: 9466562 Free PMC article.
To clarify the patterns of accumulation and differences in abnormal compartmentalization, we studied NACP immunoreactivity using double immunolabeling and laser scanning confocal microscopy in the cortex of patients with various neurodegenerative disorders. In Lewy body va …
To clarify the patterns of accumulation and differences in abnormal compartmentalization, we studied NACP immunoreactivity using double immu …
Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a-synuclein in mouse brain.
Samantha Sykioti V, Karampetsou M, Chalatsa I, Polissidis A, Michael IP, Pagaki-Skaliora M, Nagy A, Emmanouilidou E, Sotiropoulou G, Vekrelli S K. Samantha Sykioti V, et al. J Neurochem. 2021 Jun;157(6):2024-2038. doi: 10.1111/jnc.15199. Epub 2020 Oct 19. J Neurochem. 2021. PMID: 32974895
Upon in vivo administration of alpha-syn pre-formed fibrils (PFF), alpha-syn pathologic accumulations were evident both in the brains of Klk6(-/-) mice and wt mice without significant differences. ...These findings suggest that in the in vivo setting of PFF pathology …
Upon in vivo administration of alpha-syn pre-formed fibrils (PFF), alpha-syn pathologic accumulations were evident both in the brains …
Drug repurposing of dimethyl fumarate in Parkinson's disease: a promising disease-modifying strategy.
Salvadè M, Gardoni F. Salvadè M, et al. Eur Rev Med Pharmacol Sci. 2025 Sep;29(9):443-451. doi: 10.26355/eurrev_202509_37406. Eur Rev Med Pharmacol Sci. 2025. PMID: 41059754 Free article. Review.
Through this mechanism, DMF counters oxidative stress, reduces neuroinflammation, promotes mitochondrial quality control, and impedes pathological protein aggregation. These biological effects translate into the preservation of dopaminergic neurons and improvements in moto …
Through this mechanism, DMF counters oxidative stress, reduces neuroinflammation, promotes mitochondrial quality control, and impedes pat …
Targeted protein degradation for the treatment of Parkinson's disease: Advances and future perspective.
Amirian R, Badrbani MA, Derakhshankhah H, Izadi Z, Shahbazi MA. Amirian R, et al. Biomed Pharmacother. 2023 Oct;166:115408. doi: 10.1016/j.biopha.2023.115408. Epub 2023 Aug 29. Biomed Pharmacother. 2023. PMID: 37651798 Free article. Review.
Parkinson's disease (PD) is a progressive disorder that belongs to a class of neurodegenerative disorders (NDs) called Synucleinopathies. It has characterized by the misfolding and aggregation of a-synuclein. Our understanding of PD continues to evolve, and so does our app …
Parkinson's disease (PD) is a progressive disorder that belongs to a class of neurodegenerative disorders (NDs) called Synucleinopath …
Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.
Kumaran R, Cookson MR. Kumaran R, et al. Hum Mol Genet. 2015 Oct 15;24(R1):R32-44. doi: 10.1093/hmg/ddv236. Epub 2015 Jun 22. Hum Mol Genet. 2015. PMID: 26101198 Free PMC article. Review.
We will particularly discuss evidence for a role of PD proteins in microglial activation and regulation of the autophagy-lysosome system that is dependent on microtubule transport in neurons. ...
We will particularly discuss evidence for a role of PD proteins in microglial activation and regulation of the autophagy-lysosome …
27 results