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1953 1
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1965 2
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1967 10
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1969 7
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1973 16
1974 5
1975 8
1976 9
1977 11
1978 7
1979 8
1980 11
1981 7
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1989 29
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1996 153
1997 205
1998 297
1999 348
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2001 392
2002 476
2003 618
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2005 691
2006 841
2007 900
2008 1005
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2013 1460
2014 1610
2015 1684
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2018 1850
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34,983 results

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Page 1
Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains.
Zhu B, Park JM, Coffey SR, Russo A, Hsu IU, Wang J, Su C, Chang R, Lam TT, Gopal PP, Ginsberg SD, Zhao H, Hafler DA, Chandra SS, Zhang L. Zhu B, et al. Sci Transl Med. 2024 Oct 30;16(771):eabo1997. doi: 10.1126/scitranslmed.abo1997. Epub 2024 Oct 30. Sci Transl Med. 2024. PMID: 39475571 Free PMC article.
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, and recent evidence suggests that pathogenesis may be in part mediated by inflammatory processes, the molecular and cellular architectures of which are largely unknown. ...By comparing this single-c …
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, and recent evidence suggests that pathogenesis may be in p …
Large-scale proteomic analyses of incident Parkinson's disease reveal new pathophysiological insights and potential biomarkers.
Gan YH, Ma LZ, Zhang Y, You J, Guo Y, He Y, Wang LB, He XY, Li YZ, Dong Q, Feng JF, Cheng W, Yu JT. Gan YH, et al. Nat Aging. 2025 Apr;5(4):642-657. doi: 10.1038/s43587-025-00818-0. Epub 2025 Feb 20. Nat Aging. 2025. PMID: 39979637
The early pathophysiology of Parkinson's disease (PD) is poorly understood. We analyzed 2,920 Olink-measured plasma proteins in 51,804 UK Biobank participants, identifying 859 incident PD cases after 14.45 years. We found 38 PD-related proteins, with six of the top …
The early pathophysiology of Parkinson's disease (PD) is poorly understood. We analyzed 2,920 Olink-measured plasma proteins i …
Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms.
Wallen ZD, Demirkan A, Twa G, Cohen G, Dean MN, Standaert DG, Sampson TR, Payami H. Wallen ZD, et al. Nat Commun. 2022 Nov 15;13(1):6958. doi: 10.1038/s41467-022-34667-x. Nat Commun. 2022. PMID: 36376318 Free PMC article.
Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using uniform standardized methods from start to end. We enrolled 490 PD and 234 control …
Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role of gut microbiome, we conducted …
Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease.
Kamath T, Abdulraouf A, Burris SJ, Langlieb J, Gazestani V, Nadaf NM, Balderrama K, Vanderburg C, Macosko EZ. Kamath T, et al. Nat Neurosci. 2022 May;25(5):588-595. doi: 10.1038/s41593-022-01061-1. Epub 2022 May 5. Nat Neurosci. 2022. PMID: 35513515 Free PMC article.
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular features associated with DA neuron vulnerability have not yet been fully identified. ...
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a defining pathological hallmark of Parkinson's …
Neurobiology of depression in Parkinson's disease: Insights into epidemiology, molecular mechanisms and treatment strategies.
Ahmad MH, Rizvi MA, Ali M, Mondal AC. Ahmad MH, et al. Ageing Res Rev. 2023 Mar;85:101840. doi: 10.1016/j.arr.2022.101840. Epub 2023 Jan 2. Ageing Res Rev. 2023. PMID: 36603690 Review.
Parkinson's disease (PD) is characterized mainly by motor dysfunctions due to the progressive loss of dopaminergic neurons. ...
Parkinson's disease (PD) is characterized mainly by motor dysfunctions due to the progressive loss of dopaminergic neurons. .. …
Mapping the Diverse and Inclusive Future of Parkinson's Disease Genetics and Its Widespread Impact.
Elsayed I, Martinez-Carrasco A, Cornejo-Olivas M, Bandres-Ciga S. Elsayed I, et al. Genes (Basel). 2021 Oct 23;12(11):1681. doi: 10.3390/genes12111681. Genes (Basel). 2021. PMID: 34828286 Free PMC article. Review.
Over the last decades, genetics has been the engine that has pushed us along on our voyage to understand the etiology of Parkinson's disease (PD). ...As we move forward, shedding light on the genetic architecture contributing to PD in non-European popu …
Over the last decades, genetics has been the engine that has pushed us along on our voyage to understand the etiology of Parkinson …
Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease.
Rutledge J, Lehallier B, Zarifkar P, Losada PM, Shahid-Besanti M, Western D, Gorijala P, Ryman S, Yutsis M, Deutsch GK, Mormino E, Trelle A, Wagner AD, Kerchner GA, Tian L, Cruchaga C, Henderson VW, Montine TJ, Borghammer P, Wyss-Coray T, Poston KL. Rutledge J, et al. Acta Neuropathol. 2024 Mar 11;147(1):52. doi: 10.1007/s00401-024-02706-0. Acta Neuropathol. 2024. PMID: 38467937 Free PMC article.
Parkinson's disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response. ...Here, we performed a large-scale, mul …
Parkinson's disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early- …
Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation.
Wang L, Tian S, Ruan S, Wei J, Wei S, Chen W, Hu H, Qin W, Li Y, Yuan H, Mao J, Xu Y, Xie J. Wang L, et al. Free Radic Biol Med. 2024 Apr;216:60-77. doi: 10.1016/j.freeradbiomed.2024.02.023. Epub 2024 Mar 12. Free Radic Biol Med. 2024. PMID: 38479634
Parkinson's disease (PD) is a prevalent progressive and multifactorial neurodegenerative disorder. ...
Parkinson's disease (PD) is a prevalent progressive and multifactorial neurodegenerative disorder. ...
Identification and Experimental Validation of Parkinson's Disease with Major Depressive Disorder Common Genes.
Wang H, Dou S, Wang C, Gao W, Cheng B, Yan F. Wang H, et al. Mol Neurobiol. 2023 Oct;60(10):6092-6108. doi: 10.1007/s12035-023-03451-3. Epub 2023 Jul 7. Mol Neurobiol. 2023. PMID: 37418066
Parkinson's disease (PD) is the second most common neurodegenerative disease that affects about 10 million people worldwide. ...
Parkinson's disease (PD) is the second most common neurodegenerative disease that affects about 10 million people world …
Advances in the genetics of Parkinson's disease.
Rosner S, Giladi N, Orr-Urtreger A. Rosner S, et al. Acta Pharmacol Sin. 2008 Jan;29(1):21-34. doi: 10.1111/j.1745-7254.2008.00731.x. Acta Pharmacol Sin. 2008. PMID: 18158863 Review.
Parkinson's disease (PD) is a neurodegenerative disorder affecting a significant proportion of the ageing population. ...To date, PD pharmacotherapy is symptomatic only and does not slow disease progression. Understanding how genetic mutations cause fa …
Parkinson's disease (PD) is a neurodegenerative disorder affecting a significant proportion of the ageing population. ...To da …
34,983 results
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