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Quoted phrases not found in phrase index: "2,3-dimethoxystrychnidin-10-one", "l-brucine"
Page 1
Nux Vomica.
[No authors listed] [No authors listed] 2023 Mar 3. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2023 Mar 3. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 37011123 Free Books & Documents. Review.
Nux vomica is an extract of the seeds of the Strychos nux-vomica or strychnine tree used in traditional and homeopathic medicine with purported benefits for a wide range of conditions including heart disease and cancer. Nux vomica contains strychnine and brucine, two toxic …
Nux vomica is an extract of the seeds of the Strychos nux-vomica or strychnine tree used in traditional and homeopathic medicine with purpor …
Biosynthesis of strychnine.
Hong B, Grzech D, Caputi L, Sonawane P, López CER, Kamileen MO, Hernández Lozada NJ, Grabe V, O'Connor SE. Hong B, et al. Nature. 2022 Jul;607(7919):617-622. doi: 10.1038/s41586-022-04950-4. Epub 2022 Jul 6. Nature. 2022. PMID: 35794473 Free PMC article.
Here we report the biosynthetic pathway of strychnine, along with the related molecules brucine and diaboline. Moreover, we successfully recapitulate strychnine, brucine and diaboline biosynthesis in Nicotiana benthamiana from an upstream intermediate, thus demonstr …
Here we report the biosynthetic pathway of strychnine, along with the related molecules brucine and diaboline. Moreover, we successfu …
Enantiopure spiro[3.3]heptane-2,6-dicarboxylic acid.
Tang HZ, Miura H, Kawakami Y. Tang HZ, et al. Enantiomer. 2002 Jan-Feb;7(1):5-9. doi: 10.1080/10242430210705. Enantiomer. 2002. PMID: 12043946
Using chiral HPLC and 13C NMR analyses, the optical purity of (+)-spiro[3.3]heptane-2,6-dicarboxylic acid (1) obtained by the known diastereomer method with brucine was first clarified to be 90% e.e., which was conventionally considered to be 100% e.e. ...
Using chiral HPLC and 13C NMR analyses, the optical purity of (+)-spiro[3.3]heptane-2,6-dicarboxylic acid (1) obtained by the known diastere …
Pharmacological investigation of brucine anti-ulcer potential.
Noman M, Qazi NG, Rehman NU, Khan AU. Noman M, et al. Front Pharmacol. 2022 Aug 17;13:886433. doi: 10.3389/fphar.2022.886433. eCollection 2022. Front Pharmacol. 2022. PMID: 36059979 Free PMC article.
The current study has been conducted to evaluate the brucine anti-ulcer effect. Brucine has binding energy values ranging from -2.99 to -8.11 kcal/mol against chosen targets, according to in silico research. ...In the reverse transcription-polymerase chain reaction, …
The current study has been conducted to evaluate the brucine anti-ulcer effect. Brucine has binding energy values ranging from …
Pseudopolymorphism in brucine: brucine-water (1/2), the third crystal hydrate of brucine.
Smith G, Wermuth UD, White JM. Smith G, et al. Acta Crystallogr C. 2007 Aug;63(Pt 8):o489-92. doi: 10.1107/S0108270107032295. Epub 2007 Jul 26. Acta Crystallogr C. 2007. PMID: 17675704 Free article.
The structure of a third pseudopolymorphic hydrate of brucine, brucine-water (1/2) [systematic name: 2,3-dimethoxystrychnidin-10-one-water (1/2)], C(23)H(26)N(2)O(4).2H(2)O, has been determined at 130 K. ...The two brucine molecules are linked peripherally to …
The structure of a third pseudopolymorphic hydrate of brucine, brucine-water (1/2) [systematic name: 2,3-dimethoxystrychnidin- …
Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology.
Lu L, Huang R, Wu Y, Jin JM, Chen HZ, Zhang LJ, Luan X. Lu L, et al. Front Pharmacol. 2020 Apr 3;11:377. doi: 10.3389/fphar.2020.00377. eCollection 2020. Front Pharmacol. 2020. PMID: 32308621 Free PMC article. Review.
Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents of Nux-vomica. Modern pharmacology studies and clinical practice demonstrate that brucine possesses wide pharmacological activities, such as anti-tumor, anti-inflammatory, …
Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents of Nux-vomica. Modern pharmacology stud …
Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate.
Cosmetic Ingredient Review Expert Panel. Cosmetic Ingredient Review Expert Panel. Int J Toxicol. 2008;27 Suppl 1:1-43. doi: 10.1080/10915810802032388. Int J Toxicol. 2008. PMID: 18569160 Review.
In those animals that died, respiratory arrest was the cause. The acute i.p. LD(50) for 15 ml/kg of Brucine base was 62.0 mg/kg, with central nervous system depression prior to the onset of convulsions, just as with oral Brucine. ...The available data, however, were …
In those animals that died, respiratory arrest was the cause. The acute i.p. LD(50) for 15 ml/kg of Brucine base was 62.0 mg/kg, with …
Brucine and two solvates.
Białońska A, Ciunik Z. Białońska A, et al. Acta Crystallogr C. 2004 Dec;60(Pt 12):o853-5. doi: 10.1107/S0108270104024874. Epub 2004 Nov 11. Acta Crystallogr C. 2004. PMID: 15579964
The crystal structures of brucine (2,3-dimethoxystrychnidin-10-one), C(23)H(26)N(2)O(4), brucine acetone solvate, C(23)H(26)N(2)O(4).C(3)H(6)O, and brucine 2-propanol solvate dihydrate, C(23)H(26)N(2)O(4).C(3)H(7)O.2H(2)O, have been determined. Crystals of …
The crystal structures of brucine (2,3-dimethoxystrychnidin-10-one), C(23)H(26)N(2)O(4), brucine acetone solvate, C(23)H(26)N( …
Brucine-Induced Neurotoxicity by Targeting Caspase 3: Involvement of PPARgamma/NF-kappaB/Apoptosis Signaling Pathway.
Lei Y, Hou F, Wu X, Yi Y, Xu F, Gong Q, Gao J. Lei Y, et al. Neurotox Res. 2022 Dec;40(6):2117-2131. doi: 10.1007/s12640-022-00581-9. Epub 2022 Sep 24. Neurotox Res. 2022. PMID: 36151391
Furthermore, molecular docking analysis predicted that brucine directly bound to caspase 3. Intriguingly, a caspase 3 inhibitor (Z-DEVE-FMK) largely abolished the neurotoxicity of brucine. ...These findings will provide a novel strategy against brucine-induce …
Furthermore, molecular docking analysis predicted that brucine directly bound to caspase 3. Intriguingly, a caspase 3 inhibitor (Z-DE …
Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones.
Hartmann RW, Batzl C, Pongratz TM, Mannschreck A. Hartmann RW, et al. J Med Chem. 1992 Jun 12;35(12):2210-4. doi: 10.1021/jm00090a010. J Med Chem. 1992. PMID: 1613747
The enantiomers of 2 were separated either by using HPLC on optically active sorbent or by crystallization of the brucine salt of the phthalamic acid of 2. The absolute configuration of the (+)- and (-)-enantiomers of 2 were assigned as S and R, respectively, by comparing …
The enantiomers of 2 were separated either by using HPLC on optically active sorbent or by crystallization of the brucine salt of the …
490 results