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Quoted phrases not found in phrase index: "(2E)-2-methyl-2-butenedioic acid", "(E)-2-methyl-2-butenedioic acid", "(E)-2-methylbut-2-enedioic acid"
Page 1
Mesaconic acid as a key metabolite with anti-inflammatory and anti-aging properties produced by Lactobacillus plantarum 124 from centenarian gut microbiota.
Wu L, He H, Liang T, Du G, Li L, Zhong H, Li Y, Zhang J, Chen N, Jiang T, Yang J, Wang J, Feng S, Lu S, Zhao H, Gu Q, Gao H, Li G, Xie W, Wu L, Wu Q, Xie X, He X. Wu L, et al. NPJ Biofilms Microbiomes. 2025 Aug 19;11(1):165. doi: 10.1038/s41522-025-00812-9. NPJ Biofilms Microbiomes. 2025. PMID: 40830109 Free PMC article.
Animal experiments further verified that mesaconic acid from LP124 regulates the gut microbiota, is anti-inflammatory, relieves oxidative stress, maintains the intestinal barrier, and is the best-known anti-aging molecule. LP124 derived from the gut microbiota of ce …
Animal experiments further verified that mesaconic acid from LP124 regulates the gut microbiota, is anti-inflammatory, relieve …
Itaconate Isomers in Bread.
Gruenwald M, Chen F, Bähre H, Pessler F. Gruenwald M, et al. Antioxidants (Basel). 2022 Jul 16;11(7):1382. doi: 10.3390/antiox11071382. Antioxidants (Basel). 2022. PMID: 35883873 Free PMC article.
Engineering of thioesterase YciA from Haemophilus influenzae for production of carboxylic acids.
Pöschel L, Guevara-Martínez M, Hörnström D, van Maris AJA, Buchhaupt M. Pöschel L, et al. Appl Microbiol Biotechnol. 2023 Oct;107(20):6219-6236. doi: 10.1007/s00253-023-12691-1. Epub 2023 Aug 12. Appl Microbiol Biotechnol. 2023. PMID: 37572123 Free PMC article.
Screening a small semi-rational mutant library directly in M. extorquens yielded the F35L variant which showed a drastic product level increase for mesaconic acid (6.4-fold) and 2-methylsuccinic acid (4.4-fold) compared to the unaltered YciA enzyme. ...YciAHI F35N a …
Screening a small semi-rational mutant library directly in M. extorquens yielded the F35L variant which showed a drastic product level incre …
Improvement of dicarboxylic acid production with Methylorubrum extorquens by reduction of product reuptake.
Pöschel L, Gehr E, Buchhaupt M. Pöschel L, et al. Appl Microbiol Biotechnol. 2022 Oct;106(19-20):6713-6731. doi: 10.1007/s00253-022-12161-0. Epub 2022 Sep 15. Appl Microbiol Biotechnol. 2022. PMID: 36104545 Free PMC article.
In the past, two dicarboxylic acid products, namely mesaconic acid and 2-methylsuccinic acid, were successfully produced with heterologous thioesterase YciA from Escherichia coli, but the yield was reduced by product reuptake. ...Uptake of 2-methylsuccinic acid was …
In the past, two dicarboxylic acid products, namely mesaconic acid and 2-methylsuccinic acid, were successfully produced with …
Urinary metabolites associated with the long-term risk for chronic kidney disease incidence and progression in hypertensive patients.
Wang Z, Fei M, Qi Y, Yang Z, Li J, Ding S, Zhao W, Zhang Y, Wang N, Zhou P, Deng X, Jia P, Xue J, Zheng L, Liu J. Wang Z, et al. Metabolomics. 2025 Sep 26;21(5):142. doi: 10.1007/s11306-025-02341-0. Metabolomics. 2025. PMID: 41003842
Four metabolites-L-theanine, cysteine-s-sulfate, mesaconic acid, and 2-aminoadipic acid-were inversely associated with CKD incidence and progression. ...CONCLUSION: L-theanine, cysteine-s-sulfate, mesaconic acid, and 2-aminoadipic acid show an inverse …
Four metabolites-L-theanine, cysteine-s-sulfate, mesaconic acid, and 2-aminoadipic acid-were inversely associated with CKD inc …
Fecal and Serum Metabolome in Crohn's Disease is Linked With Future Flare.
Levhar N, Hadar R, Braun T, Naamneh R, Efroni G, Agranovich B, Abramovich I, Asher AT, Picard O, Lahat A, Yablecovitch D, Kopylov U, Eliakim R, Ben-Horin S, Amir A, Haberman Y; Israeli IBD Research Nucleus (IIRN). Levhar N, et al. United European Gastroenterol J. 2025 Sep;13(7):1278-1288. doi: 10.1002/ueg2.70073. Epub 2025 Jul 12. United European Gastroenterol J. 2025. PMID: 40650893 Free PMC article.
New metabolites in isovaleric acidemia.
Truscott RJ, Malegan D, McCairns E, Burke D, Hick L, Sims P, Halpern B, Tanaka K, Sweetman L, Nyhan WL, Hammond J, Bumack C, Haan EA, Danks DM. Truscott RJ, et al. Clin Chim Acta. 1981 Mar 5;110(2-3):187-203. doi: 10.1016/0009-8981(81)90348-x. Clin Chim Acta. 1981. PMID: 6452974
Two metabolites, 4-hydroxyisovaleric acid and mesaconic acid, have been identified and quantified in the urine of a patient with isovaleric acidemia. ...The demonstration of 4-hydroxyisovaleric acid supports the contention that urinary methylsuccinic acid seen in pa …
Two metabolites, 4-hydroxyisovaleric acid and mesaconic acid, have been identified and quantified in the urine of a patient wi …
Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives.
Abidin MZ, Saravanan T, Zhang J, Tepper PG, Strauss E, Poelarends GJ. Abidin MZ, et al. Chemistry. 2018 Nov 27;24(66):17434-17438. doi: 10.1002/chem.201804151. Epub 2018 Oct 30. Chemistry. 2018. PMID: 30192043 Free PMC article.
Starting from simple non-chiral dicarboxylic acids (either fumaric acid or mesaconic acid), vitamin B(5) and both diastereoisomers of alpha-methyl-substituted vitamin B(5) , which are valuable precursors for promising antimicrobials against Plasmodium falciparum and …
Starting from simple non-chiral dicarboxylic acids (either fumaric acid or mesaconic acid), vitamin B(5) and both diastereoiso …
Integration of Metabolomics, Lipidomics, and Machine Learning for Developing a Biomarker Panel to Distinguish the Severity of Metabolic-Associated Fatty Liver Disease.
Hui Y, Qu J, Yang J, Zhang H, Liang C, Miao N, Zhang Q, Xu H, Li Y, Li Q. Hui Y, et al. Biomed Chromatogr. 2025 Jul;39(7):e70142. doi: 10.1002/bmc.70142. Biomed Chromatogr. 2025. PMID: 40522140
Ultimately, a biomarker panel comprising 5-aminolevulinic acid, mesaconic acid, shikimic acid, PC O-35:3, and PI 36:2 exhibited outstanding diagnostic performance in detecting the prevalence and severity of MAFLD, achieving an accuracy of 88.3% in the trainin …
Ultimately, a biomarker panel comprising 5-aminolevulinic acid, mesaconic acid, shikimic acid, PC O-35:3, and PI 36:2 e …
Biocompatible metal-organic frameworks for the storage and therapeutic delivery of hydrogen sulfide.
Chen FE, Mandel RM, Woods JJ, Lee JH, Kim J, Hsu JH, Fuentes-Rivera JJ, Wilson JJ, Milner PJ. Chen FE, et al. Chem Sci. 2021 Apr 30;12(22):7848-7857. doi: 10.1039/d1sc00691f. Chem Sci. 2021. PMID: 34168838 Free PMC article.
In particular, through gas adsorption measurements and density functional theory calculations we establish that H(2)S binds strongly and reversibly within the tetrahedral pockets of the fumaric acid-derived framework MOF-801 and the mesaconic acid-derived framework …
In particular, through gas adsorption measurements and density functional theory calculations we establish that H(2)S binds strongly and rev …
52 results