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Quoted phrase not found in phrase index: "(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one"
Page 1
1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure.
Yong C, Devine SM, Abel AC, Tomlins SD, Muthiah D, Gao X, Callaghan R, Steinmetz MO, Prota AE, Capuano B, Scammells PJ. Yong C, et al. ChemMedChem. 2021 Sep 16;16(18):2882-2894. doi: 10.1002/cmdc.202100363. Epub 2021 Jul 16. ChemMedChem. 2021. PMID: 34159741
Since the revelation of noscapine's weak anti-mitotic activity, extensive research has been conducted over the past two decades, with the goal of discovering noscapine derivatives with improved potency. To date, noscapine has been explored at the 1, 7, 6', an …
Since the revelation of noscapine's weak anti-mitotic activity, extensive research has been conducted over the past two decades, with …
Imidazo[2,1-b]thiazole-Coupled Natural Noscapine Derivatives as Anticancer Agents.
Nagireddy PKR, Kommalapati VK, Siva Krishna V, Sriram D, Tangutur AD, Kantevari S. Nagireddy PKR, et al. ACS Omega. 2019 Nov 5;4(21):19382-19398. doi: 10.1021/acsomega.9b02789. eCollection 2019 Nov 19. ACS Omega. 2019. PMID: 31763563 Free PMC article.
Noscapine, a phthalide isoquinoline alkaloid isolated from the opium poppy Papaver somniferum, is traditionally being used as an anticough drug. With a safe in vitro toxicological profile, noscapine and its analogues have been explored to show microtubule-regulating
Noscapine, a phthalide isoquinoline alkaloid isolated from the opium poppy Papaver somniferum, is traditionally being used as an anti
Noscapine: angioedema.
[No authors listed] [No authors listed] Prescrire Int. 2016 Mar;25(169):71. Prescrire Int. 2016. PMID: 27213192 No abstract available.
Antibacterial activity of noscapine analogs.
Ivanenkov YA, Yu Filyaeva K, Matniyazov RT, Baymiev AK, Baymiev AK, Vladimirova AA, Yamidanov RS, Mavzyutov AR, Zileeva ZR, Zainullina LF, Vakhitova JV, Marina VI, Terentiev VA, Osterman IA, Kartsev VG, Bezrukov DS, Dontsova OA. Ivanenkov YA, et al. Bioorg Med Chem Lett. 2021 Jul 1;43:128055. doi: 10.1016/j.bmcl.2021.128055. Epub 2021 Apr 21. Bioorg Med Chem Lett. 2021. PMID: 33892103
The antibacterial properties of close noscapine analogs have not been previously reported. We used our pDualrep2 double-reporter High Throughput Screening (HTS) platform to identify a series of noscapine derivatives with promising antibacterial activity. ...
The antibacterial properties of close noscapine analogs have not been previously reported. We used our pDualrep2 double-reporter High …
Noscapine comes of age.
Chen X, Dang TT, Facchini PJ. Chen X, et al. Phytochemistry. 2015 Mar;111:7-13. doi: 10.1016/j.phytochem.2014.09.008. Epub 2015 Jan 9. Phytochemistry. 2015. PMID: 25583437 Review.
Cultivated opium poppy plants remain the only commercial source of noscapine. Despite its isolation from opium more than two centuries ago, the almost complete biosynthesis of noscapine has only recently been established based on an impressive combination of molecul …
Cultivated opium poppy plants remain the only commercial source of noscapine. Despite its isolation from opium more than two centurie …
Development of 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents for the management of breast cancer.
Meher RK, Pragyandipta P, Reddy PK, Pedaparti R, Kantevari S, Naik PK. Meher RK, et al. J Biomol Struct Dyn. 2022;40(23):13136-13153. doi: 10.1080/07391102.2021.1982008. Epub 2021 Sep 29. J Biomol Struct Dyn. 2022. PMID: 34583618
We developed 1,3-diynyl derivatives of noscapine (an opium alkaloid) through in silico combinatorial approach and screened out a panel of promising derivatives that bind tubulin and display anticancer activity. The selected derivatives such as 9-4-(t)Bu-Ph-Diyne (20p), 9-3 …
We developed 1,3-diynyl derivatives of noscapine (an opium alkaloid) through in silico combinatorial approach and screened out a pane …
Elucidation of the Tubulin-targeted Mechanism of Action of 9-(3-pyridyl) Noscapine.
Pradhan S, Mahaddalkar T, Choudhary S, Manhcukonda N, Nagireddy PR, Kantevari S, Lopus M. Pradhan S, et al. Curr Top Med Chem. 2017;17(22):2569-2574. doi: 10.2174/1568026617666170104150304. Curr Top Med Chem. 2017. PMID: 28056737 Review.
We have recently reported the synthesis and antiproliferative potential of a series of biaryl type alpha-noscapine congeners. Among them, 9-(3-pyridyl) noscapine 3f (9-PyNos, henceforth), which was synthesized by adding pyridine unit to the tetrahydroisoquinoline pa …
We have recently reported the synthesis and antiproliferative potential of a series of biaryl type alpha-noscapine congeners. Among t …
Noscapine, an Emerging Medication for Different Diseases: A Mechanistic Review.
Rahmanian-Devin P, Baradaran Rahimi V, Jaafari MR, Golmohammadzadeh S, Sanei-Far Z, Askari VR. Rahmanian-Devin P, et al. Evid Based Complement Alternat Med. 2021 Nov 29;2021:8402517. doi: 10.1155/2021/8402517. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34880922 Free PMC article. Retracted. Review.
Furthermore, noscapine has indicated antiangiogenic and antimetastatic effects. ...In fact, this study aimed to elaborate on the possible mechanisms of noscapine against different disorders....
Furthermore, noscapine has indicated antiangiogenic and antimetastatic effects. ...In fact, this study aimed to elaborate on the poss …
Noscapine and Apoptosis in Breast and Other Cancers.
Calaf GM, Crispin LA, Quisbert-Valenzuela EO. Calaf GM, et al. Int J Mol Sci. 2024 Mar 21;25(6):3536. doi: 10.3390/ijms25063536. Int J Mol Sci. 2024. PMID: 38542508 Free PMC article. Review.
In Europe and the United States, it is the second leading cause of mortality, with an incidence rate of about 2.6 million cases per year. Noscapine, a well-known alkaloid used as a cough suppressant, demonstrated anti-tumor effects by triggering apoptosis in various cancer …
In Europe and the United States, it is the second leading cause of mortality, with an incidence rate of about 2.6 million cases per year. …
Biological and pharmacological activities of noscapine: Focusing on its receptors and mechanisms.
Nourbakhsh F, Askari VR. Nourbakhsh F, et al. Biofactors. 2021 Nov;47(6):975-991. doi: 10.1002/biof.1781. Epub 2021 Sep 17. Biofactors. 2021. PMID: 34534373 Review.
Noscapine has been mentioned as one of the effective drugs with potential therapeutic applications. ...Given the numerous results presented in this field and the role of different receptors in the therapeutic effects of noscapine, we aimed to review the properties,
Noscapine has been mentioned as one of the effective drugs with potential therapeutic applications. ...Given the numerous results pre
733 results