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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 409
1829 568
1830 510
1831 579
1832 284
1833 221
1834 209
1835 222
1836 220
1837 281
1838 265
1839 289
1840 395
1841 829
1842 971
1843 813
1844 609
1845 681
1846 746
1847 774
1848 799
1849 744
1850 756
1851 773
1852 765
1853 901
1854 827
1855 1090
1856 1283
1857 1275
1858 1339
1859 1319
1860 1212
1861 945
1862 904
1863 824
1864 937
1865 937
1866 1238
1867 1434
1868 1510
1869 1533
1870 1475
1871 1855
1872 1920
1873 1982
1874 2122
1875 2094
1876 1892
1877 1966
1878 2201
1879 2140
1880 2407
1881 2578
1882 2103
1883 2569
1884 2600
1885 2819
1886 2952
1887 3413
1888 3356
1889 3750
1890 3609
1891 3221
1892 3715
1893 3961
1894 3429
1895 3684
1896 3858
1897 4124
1898 4078
1899 3566
1900 3396
1901 3500
1902 3538
1903 3532
1904 3727
1905 3741
1906 3618
1907 4105
1908 4304
1909 4527
1910 4637
1911 4857
1912 4781
1913 5070
1914 5075
1915 4557
1916 4367
1917 4122
1918 4093
1919 4440
1920 5037
1921 4703
1922 4193
1923 4519
1924 4945
1925 5058
1926 5397
1927 5945
1928 5537
1929 5798
1930 5694
1931 5572
1932 5629
1933 5695
1934 5577
1935 5736
1936 5448
1937 5378
1938 5829
1939 5616
1940 5024
1941 4865
1942 4800
1943 4543
1944 4764
1945 20489
1946 53908
1947 65016
1948 70700
1949 62795
1950 85769
1951 103729
1952 108065
1953 108904
1954 105914
1955 108544
1956 107007
1957 111522
1958 109458
1959 109962
1960 112139
1961 120104
1962 125636
1963 141521
1964 162087
1965 176646
1966 179742
1967 191521
1968 207852
1969 215034
1970 218965
1971 222921
1972 227508
1973 230625
1974 234521
1975 248214
1976 250708
1977 250850
1978 259382
1979 266800
1980 268281
1981 272563
1982 284077
1983 295781
1984 303802
1985 319987
1986 332511
1987 348605
1988 364945
1989 378934
1990 384209
1991 382194
1992 383917
1993 391907
1994 403331
1995 412758
1996 423146
1997 420961
1998 438861
1999 456410
2000 493356
2001 505967
2002 524115
2003 551887
2004 594803
2005 653940
2006 699392
2007 737085
2008 784398
2009 823082
2010 885452
2011 959668
2012 1025347
2013 1077207
2014 1129450
2015 1169861
2016 1200091
2017 1219652
2018 1262602
2019 1318620
2020 1499301
2021 1633078
2022 1611416
2023 145720
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Search Results

33,103,866 results
Results by year
Filters applied: . Clear all Quoted phrases not found in phrase index: "1 Phenylcyclohexanecarboxylic Acid 2 Morpholinoethyl Ester", "2 [4 Methoxy 3 (2 Phenylethoxy)phenyl] N", "Methyl 2 [1 Adamantyl(methyl)amino] Methyl 1 Phenylcyclopropanecarboxylate", "Priority Journal"
Page 1
Neuroprotective effect of CPCGI on Alzheimer's disease and its mechanism.
Wang X, Zhao J. Wang X, et al. Mol Med Rep. 2020 Jan;21(1):115-122. doi: 10.3892/mmr.2019.10835. Epub 2019 Nov 20. Mol Med Rep. 2020. PMID: 31939621 Free PMC article.
Cell viability and apoptosis were detected using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay and flow cytometry analysis respectively. ...It was found that CPCGI enhanced cell viability and reduce …
Cell viability and apoptosis were detected using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 …
Beta-amyloid monomers are neuroprotective.
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A. Giuffrida ML, et al. J Neurosci. 2009 Aug 26;29(34):10582-7. doi: 10.1523/JNEUROSCI.1736-09.2009. J Neurosci. 2009. PMID: 19710311 Free PMC article.
The 42-aa-long beta-amyloid protein--Abeta(1-42)--is thought to play a central role in the pathogenesis of Alzheimer's disease (AD) (Walsh and Selkoe, 2007). ...The neuroprotective action of Abeta(1-42) monomers was mediated …
The 42-aa-long beta-amyloid protein--Abeta(1-42)--is thought to play a central role in the pathogenesis of Al …
Methyl 3,4-dihydroxybenzoate protects primary cortical neurons against Aβ₂₅₋₃₅-induced neurotoxicity through mitochondria pathway.
Zhou XW, Zhang Z, Su CF, Lv RH, Zhou X, Cai L, Wang CY, Yan L, Zhang W, Luo HM. Zhou XW, et al. J Neurosci Res. 2013 Sep;91(9):1215-25. doi: 10.1002/jnr.23235. Epub 2013 Jul 3. J Neurosci Res. 2013. PMID: 23861072
Amyloid-beta peptides (Abeta), which can aggregate into oligomers or fibrils in neurons, play a critical role in the pathogenesis of Alzheimer's disease (AD). Methyl 3,4-dihydroxybenzoate (MDHB), a phenolic acid compo …
Amyloid-beta peptides (Abeta), which can aggregate into oligomers or fibrils in neurons, play a critical role in the pa …
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity.
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G. Marrazzo A, et al. Neuroreport. 2005 Aug 1;16(11):1223-6. doi: 10.1097/00001756-200508010-00018. Neuroreport. 2005. PMID: 16012353
Beta-amyloid protein(25-35)-induced neuronal death was substantially attenuated by the sigma1 receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate. The neuroprotect …
Beta-amyloid protein(25-35)-induced neuronal death was substantially attenuated by the sigm …
TL-2 attenuates β-amyloid induced neuronal apoptosis through the AKT/GSK-3β/β-catenin pathway.
Zhu X, Wang S, Yu L, Yang H, Tan R, Yin K, Jin J, Zhao H, Guan D, Xu Y. Zhu X, et al. Int J Neuropsychopharmacol. 2014 Sep;17(9):1511-9. doi: 10.1017/S1461145714000315. Epub 2014 Mar 19. Int J Neuropsychopharmacol. 2014. PMID: 24641999 Free article.
beta-amyloid (Abeta)-mediated neuronal apoptosis contributes to the progression of Alzheimer's disease (AD), although the exact mechanism remains unclear. ...TL-2 also inhibited Abeta(1-42)-induced neuronal apoptos …
beta-amyloid (Abeta)-mediated neuronal apoptosis contributes to the progression of Alzheimer's disease …
Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.
do Carmo Carreiras M, Ismaili L, Marco-Contelles J. do Carmo Carreiras M, et al. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126880. doi: 10.1016/j.bmcl.2019.126880. Epub 2019 Dec 9. Bioorg Med Chem Lett. 2020. PMID: 31864798 Review.
Current options for the treatment of Alzheimers disease have been restricted to prescription of acetylcholinesterase inhibitors or N-methyl-d-aspartate receptor antagonist, memantine. Propargylamine-derived multi-target directed ligands, …
Current options for the treatment of Alzheimers disease have been restricted to prescription of acetylcholinesterase inhibitors …
C-terminal peptide of γ-enolase impairs amyloid-β-induced apoptosis through p75(NTR) signaling.
Pišlar AH, Kos J. Pišlar AH, et al. Neuromolecular Med. 2013 Sep;15(3):623-35. doi: 10.1007/s12017-013-8247-9. Epub 2013 Jul 11. Neuromolecular Med. 2013. PMID: 23842744
gamma-Enolase acts as a neurotrophic-like factor promoting growth, differentiation, survival and regeneration of neurons. It is shown in this study to exert a protective effect against amyloid-beta-peptide (Abeta)-induced neurotoxicity in rat ph …
gamma-Enolase acts as a neurotrophic-like factor promoting growth, differentiation, survival and regeneration of neurons. It is shown …
Phosphatidylcholine protects neurons from toxic effects of amyloid β-protein in culture.
Ko M, Hattori T, Abdullah M, Gong JS, Yamane T, Michikawa M. Ko M, et al. Brain Res. 2016 Jul 1;1642:376-383. doi: 10.1016/j.brainres.2016.04.035. Epub 2016 Apr 14. Brain Res. 2016. PMID: 27086970
Amyloid beta-protein (Abeta) is the major component of extracellular plaques in the brains of patients with Alzheimer's disease. ...PC containing unsaturated long-chain acyl groups, 1,2-dioleoyl-PC (DOPC), also prevented neurona …
Amyloid beta-protein (Abeta) is the major component of extracellular plaques in the brains of patients with Alzheime …
Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β.
Yin Y, Cha C, Wu F, Li J, Li S, Zhu X, Zhang J, Guo G. Yin Y, et al. Mol Med Rep. 2019 Jun;19(6):4897-4905. doi: 10.3892/mmr.2019.10158. Epub 2019 Apr 12. Mol Med Rep. 2019. PMID: 31059028 Free PMC article.
Amyloid beta (Abeta) has been reported to have an important role in the cognitive deficits of Alzheimer's disease (AD), as oligomeric Abeta promotes synaptic dysfunction and triggers neuronal death. ...In the present study, whole- …
Amyloid beta (Abeta) has been reported to have an important role in the cognitive deficits of Alzheimer's disease …
Epigallocatechin Gallate Reduces Amyloid β-Induced Neurotoxicity via Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis.
Du K, Liu M, Zhong X, Yao W, Xiao Q, Wen Q, Yang B, Wei M. Du K, et al. Mol Nutr Food Res. 2018 Apr;62(8):e1700890. doi: 10.1002/mnfr.201700890. Epub 2018 Mar 23. Mol Nutr Food Res. 2018. PMID: 29446867
SCOPE: We investigated the role of endoplasmic reticulum (ER) stress in the protective effects of EGCG against the neuronal apoptosis in Abeta(1-42) -induced SH-SY5Y cells and APP/PS1 transgenic mice. ...Consistent with the in vitro study, EGCG …
SCOPE: We investigated the role of endoplasmic reticulum (ER) stress in the protective effects of EGCG against the neuronal …
33,103,866 results
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