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Page 1
Disposition of 1,2,3,7,8-pentachlorodibenzofuran in the rat.
Brewster DW, Birnbaum LS. Brewster DW, et al. Toxicol Appl Pharmacol. 1988 Sep 30;95(3):490-8. doi: 10.1016/0041-008x(88)90367-5. Toxicol Appl Pharmacol. 1988. PMID: 3188012
1,2,3,7,8-Pentachlorodibenzofuran (1PeCDF) is one of several toxic polychlorinated dibenzofurans (PCDFs) which are ubiquitous environmental contaminants. ...
1,2,3,7,8-Pentachlorodibenzofuran (1PeCDF) is one of several toxic polychlorinated dibenzofurans ( …
Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans.
Brewster DW, Banks YB, Clark AM, Birnbaum LS. Brewster DW, et al. Toxicol Appl Pharmacol. 1989 Jan;97(1):156-66. doi: 10.1016/0041-008x(89)90064-1. Toxicol Appl Pharmacol. 1989. PMID: 2916232
In order to examine the potential for systemic exposure following dermal exposure, the absorption, distribution, and elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2,3,7,8-pentachlorodiben …
In order to examine the potential for systemic exposure following dermal exposure, the absorption, distribution, and elimination of 2,3,7,8- …
Genetically mediated induction of aryl hydrocarbon hydroxylase activity in mice by polychlorinated dibenzofuran isomers and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Nagayama J, Kuroki H, Masuda Y, Handa S, Kuratsune M. Nagayama J, et al. Arch Toxicol. 1985 Feb;56(4):226-9. doi: 10.1007/BF00295158. Arch Toxicol. 1985. PMID: 3922333
In AHH-nonresponsive strains of mice, only TCDD significantly induced hepatic AHH activity, while in AHH-responsive strains, 2,3,7,8-tetrachlorodibenzofuran(2,3,7,8-TCDF), 1,2,3,7,8-pentachlorodibenzofuran(1,2,3,7,8-PCDF), 2,3,4,7,8-penta …
In AHH-nonresponsive strains of mice, only TCDD significantly induced hepatic AHH activity, while in AHH-responsive strains, 2,3,7,8-tetrach …
Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related congeners: mechanistic studies.
Harris M, Zacharewski T, Piskorska-Pliszczynska J, Rosengren R, Safe S. Harris M, et al. Toxicol Appl Pharmacol. 1990 Sep 1;105(2):243-53. doi: 10.1016/0041-008x(90)90186-x. Toxicol Appl Pharmacol. 1990. PMID: 2219118
The time- and dose-dependent induction of murine hepatic microsomal aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin O-deethylase (EROD) activities by five polychlorinated dibenzo-p-dioxin and dibenzofuran congeners showed that the order of induction potency was 2,3,7,8-tet …
The time- and dose-dependent induction of murine hepatic microsomal aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin O-deethylase (ERO …
The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.
Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N, Peterson RE. Van den Berg M, et al. Toxicol Sci. 2006 Oct;93(2):223-41. doi: 10.1093/toxsci/kfl055. Epub 2006 Jul 7. Toxicol Sci. 2006. PMID: 16829543 Free PMC article. Review.
Changes were decided by the expert panel for 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (TEF = 0.3), 1,2,3,7,8-pentachlorodibenzofuran (PeCDF) (TEF = 0.03), octachlorodibenzo-p-dioxin and octachlorodibenzofuran (TEFs = 0.0003), 3,4,4',5-te …
Changes were decided by the expert panel for 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (TEF = 0.3), 1,2,3,7,8 …
Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners.
Zacharewski T, Harris M, Safe S. Zacharewski T, et al. Arch Biochem Biophys. 1989 Aug 1;272(2):344-55. doi: 10.1016/0003-9861(89)90228-2. Arch Biochem Biophys. 1989. PMID: 2546497
Treatment of rat hepatoma H-4-IIE cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 1,2,3,7,8-pentachlorodibenzofuran (PeCDF), 1,2,7,8- …
Treatment of rat hepatoma H-4-IIE cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), …
In vitro and in silico derived relative effect potencies of ah-receptor-mediated effects by PCDD/Fs and PCBs in rat, mouse, and guinea pig CALUX cell lines.
Ghorbanzadeh M, van Ede KI, Larsson M, van Duursen MB, Poellinger L, Lücke-Johansson S, Machala M, Pěnčíková K, Vondráček J, van den Berg M, Denison MS, Ringsted T, Andersson PL. Ghorbanzadeh M, et al. Chem Res Toxicol. 2014 Jul 21;27(7):1120-32. doi: 10.1021/tx5001255. Epub 2014 Jun 18. Chem Res Toxicol. 2014. PMID: 24901989
In silico derived REP20TCDD values were generally consistent with the WHO-TEFs with a few exceptions. The QSAR models indicated that, e.g., 1,2,3,7,8-pentachlorodibenzofuran and 1,2,3,7,8,9-hexachlorodibenzofuran were more potent than giv …
In silico derived REP20TCDD values were generally consistent with the WHO-TEFs with a few exceptions. The QSAR models indicated that, e.g., …
Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells.
Larsson M, van den Berg M, Brenerová P, van Duursen MB, van Ede KI, Lohr C, Luecke-Johansson S, Machala M, Neser S, Pěnčíková K, Poellinger L, Schrenk D, Strapáčová S, Vondráček J, Andersson PL. Larsson M, et al. Chem Res Toxicol. 2015 Apr 20;28(4):641-50. doi: 10.1021/tx500434j. Epub 2015 Feb 13. Chem Res Toxicol. 2015. PMID: 25654323
Quantitative structure-activity relationship models were used to predict CTFs for untested WHO-TEF compounds, suggesting that the WHO-TEF value for 1,2,3,7,8-pentachlorodibenzofuran could be underestimated by an order of magnitude for bot …
Quantitative structure-activity relationship models were used to predict CTFs for untested WHO-TEF compounds, suggesting that the WHO-TEF va …
Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice.
Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D. Frawley R, et al. Toxicol Sci. 2014 Jun;139(2):488-500. doi: 10.1093/toxsci/kfu041. Epub 2014 Apr 8. Toxicol Sci. 2014. PMID: 24713691 Free PMC article.
To assess the humoral immunity relative potencies of PBDD/Fs and compare them to their chlorinated analogs, female B6C3F1/N mice received a single oral exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrabromodibenzofuran (TBDF), 2,3,7,8-tetrachlorodibenzofuran ( …
To assess the humoral immunity relative potencies of PBDD/Fs and compare them to their chlorinated analogs, female B6C3F1/N mice received a …
Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS.
Smialowicz RJ, DeVito MJ, Williams WC, Birnbaum LS. Smialowicz RJ, et al. Toxicol Appl Pharmacol. 2008 Mar 15;227(3):477-84. doi: 10.1016/j.taap.2007.11.018. Epub 2007 Dec 3. Toxicol Appl Pharmacol. 2008. PMID: 18190939
Mixture-1 (MIX-1) contained TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2,3,7,8-pentachlorodibenzofuran (1-PeCDF), 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF), and 1,2,3,4,6,7,8,9-octachl …
Mixture-1 (MIX-1) contained TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2, …
27 results