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Quoted phrases not found in phrase index: "1,2-benzoisoxazole", "1-oxa-2-aza-1H-indene", "1-oxa-2-azaindene"
Page 1
Zonisamide.
Kadian R, Patel P, Kumar A. Kadian R, et al. 2025 Feb 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2025 Feb 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 29939680 Free Books & Documents.
Zonisamide is a sulfonamide antiepileptic drug that is chemically distinct from other antiepileptic medications. As a 1,2-benzisoxazole derivative, it may be indicated for both epileptic and non-epileptic conditions. ...
Zonisamide is a sulfonamide antiepileptic drug that is chemically distinct from other antiepileptic medications. As a 1,2-b …
1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology.
Uto Y. Uto Y. Curr Pharm Des. 2016;22(21):3201-11. doi: 10.2174/1381612822666160224142648. Curr Pharm Des. 2016. PMID: 26907942 Review.
Furthermore, an updated and detailed account of the pharmacological properties of 1,2-benzisoxazole derivatives as therapeutics for CNS disorders is described. And finally, outlooks on current issues and future directions in this field are also provided. RESU …
Furthermore, an updated and detailed account of the pharmacological properties of 1,2-benzisoxazole derivatives as ther …
Monoamine oxidase inhibition properties of 2,1-benzisoxazole derivatives.
Shetnev A, Kotov A, Kunichkina A, Proskurina I, Baykov S, Korsakov M, Petzer A, Petzer JP. Shetnev A, et al. Mol Divers. 2024 Jun;28(3):1009-1021. doi: 10.1007/s11030-023-10628-4. Epub 2023 Mar 19. Mol Divers. 2024. PMID: 36934384 Free PMC article.
It is interesting to note that 3-(2-aminoethoxy)-1,2-benzisoxazole derivatives, the 1,2-benzisoxazole, zonisamide, as well as the isoxazole compound, leflunomide, have been described as MAO inhibitors. This is however the first report of …
It is interesting to note that 3-(2-aminoethoxy)-1,2-benzisoxazole derivatives, the 1,2-benzisoxazole …
Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF)-1alpha Inhibitors.
Xue Z, Li H, Xie W, Xu Y, Zhou L, Qu ZB. Xue Z, et al. ACS Med Chem Lett. 2022 Sep 13;13(12):1864-1869. doi: 10.1021/acsmedchemlett.2c00308. eCollection 2022 Dec 8. ACS Med Chem Lett. 2022. PMID: 36518694 Free PMC article.
It is found to play significant roles in pathologic conditions such as tumor development and metastasis. Here, we first report benzo[d]isoxazole analogues as HIF-1alpha transcription inhibitors. Thereby, we designed and synthesized 26 benzo[d] …
It is found to play significant roles in pathologic conditions such as tumor development and metastasis. Here, we first report benzo[ …
Structure Revision of Anti-Inflammatory Indole Alkaloids with a 1,2-Benzisoxazole Ring.
Lee JR, Park KJ, Ham SL, Kim J, Kim CS. Lee JR, et al. ACS Omega. 2023 Apr 6;8(15):13967-13970. doi: 10.1021/acsomega.3c00408. eCollection 2023 Apr 18. ACS Omega. 2023. PMID: 37091423 Free PMC article.
(R)- and (S)-2-(benzo[d]isoxazol-3-yl)-2-ethylindolin-3-one [( )-1] were previously isolated from NIRAM, a natural blue dye from Polygonum tinctorium, and their structures were initially proposed to possess a 1,2-benzisoxazole ring. In this study, the structu …
(R)- and (S)-2-(benzo[d]isoxazol-3-yl)-2-ethylindolin-3-one [( )-1] were previously isolated from NIRAM, a natural blue dye from Polygonum t …
Zonisamide: in Parkinson's disease.
Yang LP, Perry CM. Yang LP, et al. CNS Drugs. 2009 Aug;23(8):703-11. doi: 10.2165/00023210-200923080-00007. CNS Drugs. 2009. PMID: 19594199
Zonisamide, a widely available antiepileptic drug, has been approved in Japan as adjunctive therapy with levodopa for the treatment of previously treated patients with Parkinson's disease. It is an oral 1,2-benzisoxazole-3-methanesulfonamide and is associated …
Zonisamide, a widely available antiepileptic drug, has been approved in Japan as adjunctive therapy with levodopa for the treatment of previ …
Studies on 3-substituted 1,2-benzisoxazole derivatives. 6. Syntheses of 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives and their anticonvulsant activities.
Uno H, Kurokawa M, Masuda Y, Nishimura H. Uno H, et al. J Med Chem. 1979 Feb;22(2):180-3. doi: 10.1021/jm00188a011. J Med Chem. 1979. PMID: 423197
Several 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives were synthesized from 3-(bromomethyl)-1,2-benzisoxazole by the reaction with sodium bisulfite followed by chlorination and amination. ...Among these compounds, 3-(sulfamoylmethyl)- …
Several 3-(sulfamoylmethyl)-1,2-benzisoxazole derivatives were synthesized from 3-(bromomethyl)-1,2-be …
Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles.
Strupczewski JT, Allen RC, Gardner BA, Schmid BL, Stache U, Glamkowski EJ, Jones MC, Ellis DB, Huger FP, Dunn RW. Strupczewski JT, et al. J Med Chem. 1985 Jun;28(6):761-9. doi: 10.1021/jm00383a012. J Med Chem. 1985. PMID: 2861286
The most potent compound in both assays was 6-fluoro-3-[1-[3-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl) propyl]-4-piperidinyl]-1,2-benzisoxazole (11b)....
The most potent compound in both assays was 6-fluoro-3-[1-[3-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl) propyl]-4-piperidinyl]-1,2 …
139 results