Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 2
1989 3
1991 3
1992 2
1993 1
1994 1
1995 1
1996 1
1997 1
2000 1
2001 1
2004 3
2006 1
2008 1
2009 2
2011 1
2012 1
2014 1
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

25 results

Results by year

Filters applied: . Clear all
Page 1
Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies.
Harris M, Zacharewski T, Astroff B, Safe S. Harris M, et al. Mol Pharmacol. 1989 May;35(5):729-35. Mol Pharmacol. 1989. PMID: 2542761
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) binds with moderate affinity to the aryl hydrocarbon (Ah) receptor protein (4.9 x 10(-8) M) but is a weak Ah receptor agonist. ...
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) binds with moderate affinity to the aryl hydrocarbon (Ah) receptor p …
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor.
Zacharewski T, Harris M, Biegel L, Morrison V, Merchant M, Safe S. Zacharewski T, et al. Toxicol Appl Pharmacol. 1992 Apr;113(2):311-8. doi: 10.1016/0041-008x(92)90130-k. Toxicol Appl Pharmacol. 1992. PMID: 1313996
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) is a relatively nontoxic analog of 2,3,7,8-tetrachlorodibenzo-p-dioxin. ...
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) is a relatively nontoxic analog of 2,3,7,8-tetrachlorodibenzo-p-diox …
6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.
Astroff B, Zacharewski T, Safe S, Arlotto MP, Parkinson A, Thomas P, Levin W. Astroff B, et al. Mol Pharmacol. 1988 Feb;33(2):231-6. Mol Pharmacol. 1988. PMID: 2828916
The results of the present study indicate that 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) effectively competes with [3H]TCDD for binding to the Ah receptor in rat liver cytosol. ...
The results of the present study indicate that 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) effectively competes …
Comparative antiestrogenic activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 6-methyl-1,3,8-trichlorodibenzofuran in the female rat.
Astroff B, Safe S. Astroff B, et al. Toxicol Appl Pharmacol. 1988 Sep 30;95(3):435-43. doi: 10.1016/0041-008x(88)90361-4. Toxicol Appl Pharmacol. 1988. PMID: 2847362
In contrast, the corresponding ED50 values for induction by the nontoxic 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) were 524 and 578 mumol/kg for AHH and EROD, respectively, and TCDD was greater than 1.5 X 10(5) more potent than MCDF as an agonist for …
In contrast, the corresponding ED50 values for induction by the nontoxic 6-methyl-1,3,8-trichlorodibenzofuran (M …
The effect of 6-nitro-1,3,8-trichlorodibenzofuran as a partial estrogen in the female rat uterus.
Dickerson R, Howie L, Safe S. Dickerson R, et al. Toxicol Appl Pharmacol. 1992 Mar;113(1):55-63. doi: 10.1016/0041-008x(92)90008-g. Toxicol Appl Pharmacol. 1992. PMID: 1313194
Administration of 6-nitro-1,3,8-trichlorodibenzofuran (6-NCDF) caused a dose- and time-dependent increase in uterine wet weight and cytosolic and nuclear estrogen receptor (ER) and progesterone receptor (PR) levels in immature female Sprague-Dawley rat …
Administration of 6-nitro-1,3,8-trichlorodibenzofuran (6-NCDF) caused a dose- and time-dependent increase in ute …
Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7.
Fretland AJ, Safe S, Hankinson O. Fretland AJ, et al. Chem Biol Interact. 2004 Nov 20;150(2):161-70. doi: 10.1016/j.cbi.2004.09.007. Chem Biol Interact. 2004. PMID: 15535986
The present study attempts to further define the molecular mechanism of action of the putative SAhRMs, 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF), and diindolylmethane (DIM), focusing particularly on the former. ...
The present study attempts to further define the molecular mechanism of action of the putative SAhRMs, 6-alkyl-1,3,8- …
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice.
Bannister R, Biegel L, Davis D, Astroff B, Safe S. Bannister R, et al. Toxicology. 1989 Feb;54(2):139-50. doi: 10.1016/0300-483x(89)90040-1. Toxicology. 1989. PMID: 2922766
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and TCDD plus MCDF were administered to C57BL/6 mice and their effects on several aryl hydrocarbon (Ah) receptor-mediated responses including hepatic microsomal ary …
6-Methyl-1,3,8-trichlorodibenzofuran (MCDF), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and TCDD plus MCDF were …
The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice.
Fritz WA, Lin TM, Safe S, Moore RW, Peterson RE. Fritz WA, et al. Biochem Pharmacol. 2009 Apr 1;77(7):1151-60. doi: 10.1016/j.bcp.2008.12.015. Epub 2008 Dec 31. Biochem Pharmacol. 2009. PMID: 19166822 Free PMC article.
Because AhR signaling pathway inactivation increased susceptibility to prostate tumorigenesis, we tested the hypothesis that a selective AhR modulator (SAhRM), 6-methyl-1,3,8-trichlorodibenzofuran (6-MCDF), can protect against prostate tumorigenesis. T …
Because AhR signaling pathway inactivation increased susceptibility to prostate tumorigenesis, we tested the hypothesis that a selective AhR …
6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats.
Astroff B, Safe S. Astroff B, et al. Toxicology. 1991;69(2):187-97. doi: 10.1016/0300-483x(91)90230-x. Toxicology. 1991. PMID: 1949047
The comparative antiestrogenic effects of 6-methyl-1,3,8-trichlorodibenzofuran (MCDF), 6-t-butyl-1,3,8-trichlorodibenzofuran (triCDF) and 6-cyclohexyl-1,3,8-triCDF were determined in immature female Sprague-Dawley rats. ...
The comparative antiestrogenic effects of 6-methyl-1,3,8-trichlorodibenzofuran (MCDF), 6-t-butyl-1,3 …
Computational prediction and analysis of breast cancer targets for 6-methyl-1, 3, 8-trichlorodibenzofuran.
Chitrala KN, Yeguvapalli S. Chitrala KN, et al. PLoS One. 2014 Nov 3;9(11):e109185. doi: 10.1371/journal.pone.0109185. eCollection 2014. PLoS One. 2014. PMID: 25365309 Free PMC article.
Dioxins on the other hand are a wide range of chemical compounds known to cause the effects on human health. Among them, 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) is a relatively non toxic prototypical alkyl polychlorinated dibenzofuran known to act …
Dioxins on the other hand are a wide range of chemical compounds known to cause the effects on human health. Among them, 6-Methyl-1, …
25 results