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261 results

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Quoted phrases not found in phrase index: "1,3-dimethyl propanedioate", "dimethyl propanedioate", "propanedioic acid dimethyl ester"
Page 1
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, Tourlomousis P, Däbritz JHM, Gottlieb E, Latorre I, Corr SC, McManus G, Ryan D, Jacobs HT, Szibor M, Xavier RJ, Braun T, Frezza C, Murphy MP, O'Neill LA. Mills EL, et al. Cell. 2016 Oct 6;167(2):457-470.e13. doi: 10.1016/j.cell.2016.08.064. Epub 2016 Sep 22. Cell. 2016. PMID: 27667687 Free PMC article.
RNA sequencing reveals that this combination induces a pro-inflammatory gene expression profile, while an inhibitor of succinate oxidation, dimethyl malonate (DMM), promotes an anti-inflammatory outcome. Blocking ROS production with rotenone by uncoupling mitochondr …
RNA sequencing reveals that this combination induces a pro-inflammatory gene expression profile, while an inhibitor of succinate oxidation, …
Asymmetric Total Synthesis of (+)-Alstonlarsine A.
Yao JJ, Ding R, Chen X, Zhai H. Yao JJ, et al. J Am Chem Soc. 2022 Aug 10;144(31):14396-14402. doi: 10.1021/jacs.2c06518. Epub 2022 Jul 27. J Am Chem Soc. 2022. PMID: 35894835
The prominent features of the current synthesis include the following: (i) a Pd/self-adaptable ligand complex-catalyzed asymmetric allylic alkylation of 2-methyl-2-cyclopentenyl carbonate with 2-indolylsubstituted dimethyl malonate to establish the key stereocenter …
The prominent features of the current synthesis include the following: (i) a Pd/self-adaptable ligand complex-catalyzed asymmetric allylic a …
Monocyte bioenergetics: An immunometabolic perspective in metabolic dysfunction-associated steatohepatitis.
Sangineto M, Ciarnelli M, Colangelo T, Moola A, Bukke VN, Duda L, Villani R, Romano A, Giandomenico S, Kanwal H, Serviddio G. Sangineto M, et al. Cell Rep Med. 2024 May 21;5(5):101564. doi: 10.1016/j.xcrm.2024.101564. Epub 2024 May 10. Cell Rep Med. 2024. PMID: 38733988 Free PMC article.
The enhancement of mt respiratory chain activity, especially complex II (succinate dehydrogenase [SDH]), is unbalanced toward the production of reactive oxygen species (ROS) and is sustained at the transcriptional level with the involvement of the AMPK-mTOR-PGC-1alpha axis. The m …
The enhancement of mt respiratory chain activity, especially complex II (succinate dehydrogenase [SDH]), is unbalanced toward the production …
Dimethyl malonate preserves brain and neurobehavioral phenotype following neonatal hypoxia-ischemia by inhibiting FTH1-mediated ferritinophagy.
Jin Y, Wang X, Xu X, Zhou X, Wang Q, Zhang L, Li L, Jin M, Ni H. Jin Y, et al. Redox Biol. 2025 Oct;86:103792. doi: 10.1016/j.redox.2025.103792. Epub 2025 Jul 29. Redox Biol. 2025. PMID: 40749519 Free PMC article.
Emerging evidence reveals ferroptosis as a critical mechanism within HIBD pathophysiology, positioning it as a promising therapeutic target. Dimethyl malonate (DMM), a competitive inhibitor of succinate dehydrogenase, has demonstrated neuroprotective properties acro …
Emerging evidence reveals ferroptosis as a critical mechanism within HIBD pathophysiology, positioning it as a promising therapeutic target. …
Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease.
Sangineto M, Ciarnelli M, Cassano T, Radesco A, Moola A, Bukke VN, Romano A, Villani R, Kanwal H, Capitanio N, Duda L, Avolio C, Serviddio G. Sangineto M, et al. Redox Biol. 2023 Oct;66:102846. doi: 10.1016/j.redox.2023.102846. Epub 2023 Aug 9. Redox Biol. 2023. PMID: 37586250 Free PMC article.
We showed that by inhibiting succinate dehydrogenase (SDH) with dimethyl malonate (DMM), it is possible to modulate the LPS-induced metabolic rewiring, facilitating an anti-inflammatory phenotype. ...
We showed that by inhibiting succinate dehydrogenase (SDH) with dimethyl malonate (DMM), it is possible to modulate the LPS-in …
Bis(dimethyl-malonato-κO,O')bis-[4-(4-pyridylamino-κN)pyridinium]nickel(II) hexa-hydrate.
Farnum GA, Laduca RL. Farnum GA, et al. Acta Crystallogr Sect E Struct Rep Online. 2008 Nov 22;64(Pt 12):m1603. doi: 10.1107/S160053680803835X. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21581200 Free PMC article.
In the title compound, [Ni(C(5)H(6)O(4))(2)(C(10)H(10)N(3))(2)].6H(2)O, divalent nickel ions situated on the crystallographic twofold axis are octa-hedrally coordinated by four O atoms from two dimethyl-malonate ligands in a 1,3-chelating mode and two N atoms from t …
In the title compound, [Ni(C(5)H(6)O(4))(2)(C(10)H(10)N(3))(2)].6H(2)O, divalent nickel ions situated on the crystallographic twofold axis a …
Sequential Knoevenagel Condensation/Cyclization for the Synthesis of Indene and Benzofulvene Derivatives.
Yamazaki S, Katayama K, Wang Z, Mikata Y, Morimoto T, Ogawa A. Yamazaki S, et al. ACS Omega. 2021 Oct 18;6(42):28441-28454. doi: 10.1021/acsomega.1c05283. eCollection 2021 Oct 26. ACS Omega. 2021. PMID: 34723041 Free PMC article.
The reaction of variously substituted aryl derivatives with dimethyl malonate gave indene and benzofulvene derivatives. The reactions of 2-(1-phenylvinyl)benzaldehyde with Meldrum's acid or malononitrile also gave cyclized compounds in the suitable sequential or ste …
The reaction of variously substituted aryl derivatives with dimethyl malonate gave indene and benzofulvene derivatives. The re …
Biosynthesis of angelyl-CoA in Saccharomyces cerevisiae.
Callari R, Fischer D, Heider H, Weber N. Callari R, et al. Microb Cell Fact. 2018 May 12;17(1):72. doi: 10.1186/s12934-018-0925-8. Microb Cell Fact. 2018. PMID: 29753326 Free PMC article.
In vivo analysis allowed identification of important intermediates in the pathway, including methyl-malonyl-CoA and 3-hydroxyl-2-methyl-butyryl-CoA. Furthermore, methyl-malonate supplementation and expression of matB CoA ligase from S. coelicolor allowed for methyl- …
In vivo analysis allowed identification of important intermediates in the pathway, including methyl-malonyl-CoA and 3-hydroxyl-2-methyl-buty …
261 results