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414 results

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Quoted phrase not found in phrase index: "hexane-1,6-diol"
Page 1
Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization.
Liu X, Jiang S, Ma L, Qu J, Zhao L, Zhu X, Ding J. Liu X, et al. Genome Biol. 2021 Aug 17;22(1):230. doi: 10.1186/s13059-021-02455-3. Genome Biol. 2021. PMID: 34404453 Free PMC article.
However, the global role played by condensates in 3D chromatin organization remains unclear. At present, 1,6-hexanediol (1,6-HD) is the only available tool to globally disrupt condensates, yet the conditions of 1,6-HD vary considerably between studies and may …
However, the global role played by condensates in 3D chromatin organization remains unclear. At present, 1,6-hexanediol …
Coactivator condensation at super-enhancers links phase separation and gene control.
Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, Malik S, Hnisz D, Lee TI, Cisse II, Roeder RG, Sharp PA, Chakraborty AK, Young RA. Sabari BR, et al. Science. 2018 Jul 27;361(6400):eaar3958. doi: 10.1126/science.aar3958. Epub 2018 Jun 21. Science. 2018. PMID: 29930091 Free PMC article.
Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation.
Yamazaki T, Souquere S, Chujo T, Kobelke S, Chong YS, Fox AH, Bond CS, Nakagawa S, Pierron G, Hirose T. Yamazaki T, et al. Mol Cell. 2018 Jun 21;70(6):1038-1053.e7. doi: 10.1016/j.molcel.2018.05.019. Mol Cell. 2018. PMID: 29932899 Free article.
Paraspeckles exhibit phase-separated properties including susceptibility to 1,6-hexanediol treatment. RNA fragments of the NEAT1_2 subdomains preferentially bound NONO/SFPQ, leading to phase-separated aggregates in vitro. ...
Paraspeckles exhibit phase-separated properties including susceptibility to 1,6-hexanediol treatment. RNA fragments of …
1,6-Hexanediol regulates angiogenesis via suppression of cyclin A1-mediated endothelial function.
Jiang Y, Lei G, Lin T, Zhou N, Wu J, Wang Z, Fan Y, Sheng H, Mao R. Jiang Y, et al. BMC Biol. 2023 Apr 7;21(1):75. doi: 10.1186/s12915-023-01580-8. BMC Biol. 2023. PMID: 37024934 Free PMC article.
Here, we investigated the potential role of LLPS in angiogenesis and endothelial function. RESULTS: We found 1,6-hexanediol (1,6-HD), an inhibitor of LLPS, but not 2,5-hexanediol (2,5-HD) dramatically decreases neovascularization of Matrigel plug and angiogen …
Here, we investigated the potential role of LLPS in angiogenesis and endothelial function. RESULTS: We found 1,6-hexanediol …
Phase separation of Hippo signalling complexes.
Bonello TT, Cai D, Fletcher GC, Wiengartner K, Pengilly V, Lange KS, Liu Z, Lippincott-Schwartz J, Kavran JM, Thompson BJ. Bonello TT, et al. EMBO J. 2023 Mar 15;42(6):e112863. doi: 10.15252/embj.2022112863. Epub 2023 Feb 20. EMBO J. 2023. PMID: 36807601 Free PMC article.
Here we show that activation of Hpo also involves the formation of supramolecular complexes with properties of a biomolecular condensate, including concentration dependence and sensitivity to starvation, macromolecular crowding, or 1,6-hexanediol treatment. O …
Here we show that activation of Hpo also involves the formation of supramolecular complexes with properties of a biomolecular condensate, in …
1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells.
Itoh Y, Iida S, Tamura S, Nagashima R, Shiraki K, Goto T, Hibino K, Ide S, Maeshima K. Itoh Y, et al. Life Sci Alliance. 2021 Feb 3;4(4):e202001005. doi: 10.26508/lsa.202001005. Print 2021 Apr. Life Sci Alliance. 2021. PMID: 33536240 Free PMC article.
These droplets are important for concentrating certain molecules and facilitating spatiotemporal regulation of cellular functions. 1,6-hexanediol (1,6-HD), an aliphatic alcohol, inhibits weak hydrophobic protein-protein/protein-RNA interactions required for t …
These droplets are important for concentrating certain molecules and facilitating spatiotemporal regulation of cellular functions. 1, …
Impact of 1,6-hexanediol on Schizosaccharomyces pombe genome stability.
Jones CE, Forsburg SL. Jones CE, et al. G3 (Bethesda). 2023 Aug 9;13(8):jkad123. doi: 10.1093/g3journal/jkad123. G3 (Bethesda). 2023. PMID: 37284815 Free PMC article.
A frequently chosen tool for global disruption of phase separation via weak hydrophobic interactions is treatment with 1,6-hexanediol. This study evaluates the cytotoxic and genotoxic effects of treating live fission yeast with 1,6-hexanediol …
A frequently chosen tool for global disruption of phase separation via weak hydrophobic interactions is treatment with 1,6- …
1,6-Hexanediol, commonly used to dissolve liquid-liquid phase separated condensates, directly impairs kinase and phosphatase activities.
Düster R, Kaltheuner IH, Schmitz M, Geyer M. Düster R, et al. J Biol Chem. 2021 Jan-Jun;296:100260. doi: 10.1016/j.jbc.2021.100260. Epub 2021 Jan 8. J Biol Chem. 2021. PMID: 33814344 Free PMC article.
However, little is known about potential side effects of 1,6-hexanediol, which could compromise data interpretation and mislead the scientific debate. To examine this issue, we analyzed the effect of 1,6-hexanediol on the activities of va …
However, little is known about potential side effects of 1,6-hexanediol, which could compromise data interpretation and …
Stereocontrolled Total Synthesis of Nonenolide.
Sudina PR, Motati DR, Seema A. Sudina PR, et al. J Nat Prod. 2018 Jun 22;81(6):1399-1404. doi: 10.1021/acs.jnatprod.8b00001. Epub 2018 Jun 11. J Nat Prod. 2018. PMID: 29889525
Herein, we report the successful synthesis of 1 by employing a MacMillan alpha-hydroxylation to generate three chiral centers in both the key fragments, starting from 1,6-hexanediol and 1,4-butanediol, followed by Steglich esterification of compounds 2 and 3. …
Herein, we report the successful synthesis of 1 by employing a MacMillan alpha-hydroxylation to generate three chiral centers in both the ke …
414 results