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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 409
1829 568
1830 510
1831 579
1832 284
1833 221
1834 209
1835 222
1836 220
1837 281
1838 265
1839 289
1840 395
1841 829
1842 971
1843 813
1844 609
1845 681
1846 746
1847 774
1848 799
1849 744
1850 756
1851 773
1852 765
1853 901
1854 827
1855 1090
1856 1283
1857 1275
1858 1339
1859 1319
1860 1210
1861 945
1862 904
1863 823
1864 937
1865 936
1866 1238
1867 1433
1868 1510
1869 1533
1870 1475
1871 1855
1872 1920
1873 1982
1874 2117
1875 2094
1876 1892
1877 1966
1878 2201
1879 2137
1880 2407
1881 2578
1882 2103
1883 2568
1884 2599
1885 2819
1886 2951
1887 3413
1888 3356
1889 3749
1890 3609
1891 3220
1892 3715
1893 3961
1894 3429
1895 3684
1896 3858
1897 4123
1898 4078
1899 3566
1900 3396
1901 3500
1902 3538
1903 3532
1904 3727
1905 3741
1906 3618
1907 4105
1908 4303
1909 4527
1910 4637
1911 4857
1912 4781
1913 5070
1914 5075
1915 4557
1916 4367
1917 4122
1918 4093
1919 4440
1920 5037
1921 4703
1922 4192
1923 4519
1924 4945
1925 5058
1926 5397
1927 5945
1928 5537
1929 5798
1930 5694
1931 5572
1932 5629
1933 5695
1934 5577
1935 5736
1936 5448
1937 5378
1938 5829
1939 5615
1940 5024
1941 4865
1942 4800
1943 4543
1944 4764
1945 20489
1946 53908
1947 65016
1948 70700
1949 62795
1950 85769
1951 103729
1952 108065
1953 108904
1954 105914
1955 108544
1956 107007
1957 111522
1958 109458
1959 109962
1960 112139
1961 120103
1962 125636
1963 141521
1964 162087
1965 176643
1966 179739
1967 191499
1968 207846
1969 215029
1970 218962
1971 222868
1972 227468
1973 230604
1974 234498
1975 248184
1976 250205
1977 249496
1978 257849
1979 265101
1980 266764
1981 271188
1982 282724
1983 294357
1984 302275
1985 318438
1986 330888
1987 346792
1988 363067
1989 376981
1990 381807
1991 379219
1992 380688
1993 388447
1994 399929
1995 409185
1996 419305
1997 416943
1998 434544
1999 451663
2000 487968
2001 500396
2002 518292
2003 545852
2004 588504
2005 646910
2006 691753
2007 729282
2008 775988
2009 814464
2010 876538
2011 950807
2012 1016792
2013 1067412
2014 1119248
2015 1159035
2016 1190733
2017 1210931
2018 1253322
2019 1308389
2020 1487182
2021 1620988
2022 1601168
2023 151720
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Search Results

32,870,740 results
Results by year
Filters applied: . Clear all Quoted phrases not found in phrase index: "1 (5 Bromopyrimidin 2 Yl) N (2", "4 Dichlorobenzyl)pyrrolidin 3 Amine Methanesulfonate Hydrate", "2 Amino 2 (2 Carboxycyclopropyl) 3 (xanthen 9 Yl)propionic Acid", "4 Amino 2 Oxabicyclo[3 1 0]hexane 4", "Ly 2389575", "Ly 566332", "Priority Journal", "Alzheimer Disease Complications Drug Therapy Metabolism", "Amyloid Beta Peptides Drug Effects Metabolism", "Astrocytes Drug Effects Metabolism", "Neurons Drug Effects Metabolism", "Psychotic Disorders Drug Therapy Etiology Metabolism", "Metabotropic Glutamate Drug Effects Metabolism Physiology", "4 Dichlorobenzyl) Pyrrolidin 3 Amine Methanesulfonate Hydrate", "2 Amino 2 (2 Carboxycyclopropyl) 3 (xanthen 9 Yl) Propionic Acid", "4 Amino 2 Oxabicyclo [3 1 0] Hexane 4"
Page 1
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol.
Wang H, Kulas JA, Wang C, Holtzman DM, Ferris HA, Hansen SB. Wang H, et al. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2102191118. doi: 10.1073/pnas.2102191118. Proc Natl Acad Sci U S A. 2021. PMID: 34385305 Free PMC article.
Alzheimer's disease (AD) is characterized by the presence of amyloid beta (Abeta) plaques, tau tangles, inflammation, and loss of cognitive function. ...We find that the targeted deletion of astrocyte cholesterol synthesis robustly reduce
Alzheimer's disease (AD) is characterized by the presence of amyloid beta (Abeta) plaques, tau tangles, i
Association between chronic stress and Alzheimer's disease: Therapeutic effects of Saffron.
Saeedi M, Rashidy-Pour A. Saeedi M, et al. Biomed Pharmacother. 2021 Jan;133:110995. doi: 10.1016/j.biopha.2020.110995. Epub 2020 Nov 21. Biomed Pharmacother. 2021. PMID: 33232931 Free article. Review.
Chronic stress and high levels of glucocorticoids produce functional and structural changes in brain and especially in the hippocampus, an important limbic system structure that plays a key role in cognitive functions including learning and memory. Alzheimer's di
Chronic stress and high levels of glucocorticoids produce functional and structural changes in brain and especially in the hippocampus, an i …
MFG-E8 reverses microglial-induced neurotoxic astrocyte (A1) via NF-κB and PI3K-Akt pathways.
Xu X, Zhang A, Zhu Y, He W, Di W, Fang Y, Shi X. Xu X, et al. J Cell Physiol. 2018 Jan;234(1):904-914. doi: 10.1002/jcp.26918. Epub 2018 Aug 4. J Cell Physiol. 2018. PMID: 30076715
Recent evidence have suggested that neuroinflammation and ischemia induce the activation of two different types of reactive astrocytes, termed A1 and A2. Additionally, A1 astrocytes contribute to the death of neurons and oligodendrocytes in neurodegenerative disease …
Recent evidence have suggested that neuroinflammation and ischemia induce the activation of two different types of reactive astrocytes
APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation.
Lee SI, Jeong W, Lim H, Cho S, Lee H, Jang Y, Cho J, Bae S, Lin YT, Tsai LH, Moon DW, Seo J. Lee SI, et al. Stem Cell Reports. 2021 Sep 14;16(9):2128-2137. doi: 10.1016/j.stemcr.2021.07.017. Epub 2021 Aug 26. Stem Cell Reports. 2021. PMID: 34450034 Free PMC article.
The epsilon4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk factors for Alzheimer's disease (AD). One of the overarching questions is whether and how this astrocyte-enriched risk factor initiates AD-associated …
The epsilon4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk factors for Alzheimer's dis
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ. Jo S, et al. Nat Med. 2014 Aug;20(8):886-96. doi: 10.1038/nm.3639. Epub 2014 Jun 29. Nat Med. 2014. PMID: 24973918 Free PMC article.
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts patients and their families. Although reactive astrocytes have been observed around amyloid plaques since the disease was first described, their ro …
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts patients and their families. …
Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer's Disease.
Ali T, Kim T, Rehman SU, Khan MS, Amin FU, Khan M, Ikram M, Kim MO. Ali T, et al. Mol Neurobiol. 2018 Jul;55(7):6076-6093. doi: 10.1007/s12035-017-0798-6. Epub 2017 Nov 23. Mol Neurobiol. 2018. PMID: 29170981
Well-established studies have shown an elevated level of reactive oxygen species (ROS) that induces oxidative stress in the Alzheimer's disease (AD) patient's brain and an animal model of AD. Herein, we investigated the underlying anti-ox …
Well-established studies have shown an elevated level of reactive oxygen species (ROS) that induces oxidative stress in the Alzheimer
Angelica polysaccharide ameliorates memory impairment in Alzheimer's disease rat through activating BDNF/TrkB/CREB pathway.
Du Q, Zhu X, Si J. Du Q, et al. Exp Biol Med (Maywood). 2020 Jan;245(1):1-10. doi: 10.1177/1535370219894558. Epub 2019 Dec 17. Exp Biol Med (Maywood). 2020. PMID: 31847588 Free PMC article.
This study aimed to investigate the effect of Angelica sinensis polysaccharides (ASP) on Alzheimer's disease (AD) and its underlying mechanisms. In our study, we build the AD model by injecting Abeta(25-35). ...The neuronal apoptosis was detected by TU …
This study aimed to investigate the effect of Angelica sinensis polysaccharides (ASP) on Alzheimer's disease (AD) and i …
Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions.
Ikram M, Jo MH, Choe K, Khan A, Ahmad S, Saeed K, Kim MW, Kim MO. Ikram M, et al. Cells. 2021 Oct 11;10(10):2719. doi: 10.3390/cells10102719. Cells. 2021. PMID: 34685699 Free PMC article.
Here, we have unveiled the effects of cycloastragenol against Abeta (Amyloid-beta)-induced oxidative stress, neurogenic dysfunction, activated mitogen-activated protein (MAP) kinases, and mitochondrial apoptosis in an Abeta-induced mouse mode
Here, we have unveiled the effects of cycloastragenol against Abeta (Amyloid-beta)-induced oxidative stress, neurogenic …
Potential of astrocytes in targeting therapy for Alzheimer's disease.
Bi W, Lei T, Cai S, Zhang X, Yang Y, Xiao Z, Wang L, Du H. Bi W, et al. Int Immunopharmacol. 2022 Dec;113(Pt A):109368. doi: 10.1016/j.intimp.2022.109368. Epub 2022 Oct 29. Int Immunopharmacol. 2022. PMID: 36330912 Review.
When the glutamate produced by the neurons is not cleared by astrocytes, neurons undergo apoptosis due to blocked cell metabolism. Therapies for astrocytes are highly efficient, and these include stem cell therapy, gene edit …
When the glutamate produced by the neurons is not cleared by astrocytes, neurons undergo apoptosis due to blocked cell
PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer's Disease.
Papotti B, Adorni MP, Marchi C, Zimetti F, Ronda N, Panighel G, Lupo MG, Vilella A, Giuliani D, Ferri N, Bernini F. Papotti B, et al. Int J Mol Sci. 2022 Oct 13;23(20):12192. doi: 10.3390/ijms232012192. Int J Mol Sci. 2022. PMID: 36293049 Free PMC article.
The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) involvement in Alzheimer's disease (AD) is poorly investigated. ...PCSK9 increased cholesterol synthesis and reduced the uptake of apoE-HDL-derived cholesterol (-36%; p < 0.0001), as well …
The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) involvement in Alzheimer's disease (AD) is poorly inve …
32,870,740 results
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