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Quoted phrase not found in phrase index: "steoroids"
Page 1
Kinetics of in Vitro Guanine- N7-Alkylation in Calf Thymus DNA by (2 S,3 S)-1,2-Epoxybutane-3,4-diol 4-methanesulfonate and (2 S,3 S)-1,2:3,4-Diepoxybutane: Revision of the Mechanism of DNA Cross-Linking by the Prodrug Treosulfan.
Romański M, Pogorzelska A, Główka FK. Romański M, et al. Mol Pharm. 2019 Jun 3;16(6):2708-2718. doi: 10.1021/acs.molpharmaceut.9b00251. Epub 2019 May 3. Mol Pharm. 2019. PMID: 31013419
Prodrug treosulfan, originally registered for treatment of ovarian cancer, has gained a use in conditioning prior to hematopoietic stem cell transplantation. ...
Prodrug treosulfan, originally registered for treatment of ovarian cancer, has gained a use in conditioning prior to hematopoietic st …
NTP Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CAS No. 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
National Toxicology Program. National Toxicology Program. Natl Toxicol Program Tech Rep Ser. 1988 Mar;329:1-176. Natl Toxicol Program Tech Rep Ser. 1988. PMID: 12732907 Free article.
1,2-Epoxybutane was selected for study because it is a short-chain epoxide that had been shown to be mutagenic and because no carcinogenicity data were available. ...Both chromosomal aberrations andsister chromatid exchanges were induced in cultured Chinese h …
1,2-Epoxybutane was selected for study because it is a short-chain epoxide that had been shown to be mutagenic and beca …
The role of estrogen in circular RNA and metabonomics in a Neisseria gonorrhoeae infection model.
Cai G, Long J, Yang H, Xie J, Zou R, Zheng C, Chen X, Liu S, Chen R. Cai G, et al. Ann Transl Med. 2022 Sep;10(18):999. doi: 10.21037/atm-22-3127. Ann Transl Med. 2022. PMID: 36267770 Free PMC article.
BACKGROUND: Previous study shows that estrogen exerts both immunosuppressive and immunostimulative effects. METHODS: In this study, estrogen was added to a Neisseria gonorrhoeae infection model, and transcriptome sequencing and metabolomics studies were performed to …
BACKGROUND: Previous study shows that estrogen exerts both immunosuppressive and immunostimulative effects. METHODS: In this study, …
An update of the National Toxicology Program database on nasal carcinogens.
Haseman JK, Hailey JR. Haseman JK, et al. Mutat Res. 1997 Oct 31;380(1-2):3-11. doi: 10.1016/s0027-5107(97)00121-8. Mutat Res. 1997. PMID: 9385384
Nearly 500 long-term rodent carcinogenicity studies carried out by the National Cancer Institute and the National Toxicology Program were examined, and 12 chemicals were identified that produced nasal tumors: allyl glycidol ether, p-cresidine, 1,2-dibromo-3-chloropropane, …
Nearly 500 long-term rodent carcinogenicity studies carried out by the National Cancer Institute and the National Toxicology Program …
New Pyrrole Derivatives as Promising Biological Agents: Design, Synthesis, Characterization, In Silico, and Cytotoxicity Evaluation.
Ivan BC, Barbuceanu SF, Hotnog CM, Anghel AI, Ancuceanu RV, Mihaila MA, Brasoveanu LI, Shova S, Draghici C, Olaru OT, Nitulescu GM, Dinu M, Dumitrascu F. Ivan BC, et al. Int J Mol Sci. 2022 Aug 9;23(16):8854. doi: 10.3390/ijms23168854. Int J Mol Sci. 2022. PMID: 36012121 Free PMC article.
The new pyrroles were obtained by reaction of benzimidazolium bromide derivatives with asymmetrical acetylenes in 1,2-epoxybutane under reflux through the Huisgen [3 + 2] cycloaddition of several ylide intermediates to the corresponding dipolarophiles. ...The …
The new pyrroles were obtained by reaction of benzimidazolium bromide derivatives with asymmetrical acetylenes in 1,2-epoxy …
Carcinogenicity study of trichloroethylene, with and without epoxide stabilizers, in mice.
Henschler D, Elsässer H, Romen W, Eder E. Henschler D, et al. J Cancer Res Clin Oncol. 1984;107(3):149-56. doi: 10.1007/BF01032599. J Cancer Res Clin Oncol. 1984. PMID: 6736101 Free PMC article.
To test this hypothesis, Swiss mice (ICR/HA) of both sexes, bred and kept in SPF conditions, were dosed daily with TRI in corn oil by gavage (males: 2.4 g/kg, females: 1.8 g/kg) with or without the addition of epichlorohydrin (EPC, 0.8%, w/w), 1,2-epoxybutane …
To test this hypothesis, Swiss mice (ICR/HA) of both sexes, bred and kept in SPF conditions, were dosed daily with TRI in corn oil by gavage …
Cob(I)alamin for trapping butadiene epoxides in metabolism with rat S9 and for determining associated kinetic parameters.
Motwani HV, Fred C, Haglund J, Golding BT, Törnqvist M. Motwani HV, et al. Chem Res Toxicol. 2009 Sep;22(9):1509-16. doi: 10.1021/tx900088w. Chem Res Toxicol. 2009. PMID: 19764821
Methods have been developed for trapping electrophilically reactive compounds by exploiting this property of cob(I)alamin. 1,3-Butadiene (BD) has recently been classified as a group 1 human carcinogen by the International Agency for Research on Cancer (IARC). The carcinoge …
Methods have been developed for trapping electrophilically reactive compounds by exploiting this property of cob(I)alamin. 1,3-Butadiene (BD …
Conjugation of carcinogens by theta class glutathione s-transferases: mechanisms and relevance to variations in human risk.
Guengerich FP, Thier R, Persmark M, Taylor JB, Pemble SE, Ketterer B. Guengerich FP, et al. Pharmacogenetics. 1995;5 Spec No:S103-7. doi: 10.1097/00008571-199512001-00010. Pharmacogenetics. 1995. PMID: 7581478
A genetic deficiency in the GSH S-transferase mu class gene M1 has been hypothesized to lead to greater risk of lung cancer in smokers. Recently a gene deletion polymorphism involving the human theta enzyme T1 has been described: the enzyme is present in erythrocytes and c …
A genetic deficiency in the GSH S-transferase mu class gene M1 has been hypothesized to lead to greater risk of lung cancer in smoker …
Activation of Prodrug Treosulfan at pH 7.4 and 37°C Accompanied by Hydrolysis of Its Active Epoxides: Kinetic Studies with Clinical Relevance.
Romański M, Urbaniak B, Kokot Z, Główka FK. Romański M, et al. J Pharm Sci. 2015 Dec;104(12):4433-4442. doi: 10.1002/jps.24662. Epub 2015 Sep 30. J Pharm Sci. 2015. PMID: 26422826
Treosulfan (TREO), originally registered for treatment of ovarian cancer, is currently being investigated for conditioning prior to hematopoietic stem cell transplantation. TREO is a prodrug, which undergoes a pH- and temperature-dependent two-step conversion to active mon …
Treosulfan (TREO), originally registered for treatment of ovarian cancer, is currently being investigated for conditioning prior to h …
Development of a simple and efficient solution-phase parallel synthesis of flexible non-steroidal estradiol mimics.
Djigoué GB, Maltais R, Poirier D. Djigoué GB, et al. Comb Chem High Throughput Screen. 2014;17(9):734-44. doi: 10.2174/1386207317666140915125620. Comb Chem High Throughput Screen. 2014. PMID: 25230027
An efficient parallel synthesis was designed to provide libraries of estradiol mimics that can potentially interact with different biological targets associated with estradiol-related diseases. ...The resulting secondary amines next reacted with 4-bromo-1, …
An efficient parallel synthesis was designed to provide libraries of estradiol mimics that can potentially interact with different bi …
11 results