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Page 1
1,10-Phenanthroline phosphorylates (activates) MAP kinase in Xenopus oocytes.
Watanabe K, Tokumoto T, Ishikawa K. Watanabe K, et al. Cell Signal. 2003 Dec;15(12):1139-47. doi: 10.1016/s0898-6568(03)00116-5. Cell Signal. 2003. PMID: 14575869
The membrane-permeable intracellular heavy metal chelator, 1,10-phenanthroline, which prevents progesterone-induced germinal vesicle breakdown (GVBD), would be expected to regulate phosphorylation (activation) of the MAP kinase (MAPK) cascade in Xenopus oocytes. Here, our …
The membrane-permeable intracellular heavy metal chelator, 1,10-phenanthroline, which prevents progesterone-induced germinal vesicle …
The effects of 1,10-phenanthroline on the binding of activated rat hepatic glucocorticoid-receptor complexes to deoxyribonucleic acid-cellulose.
Schmidt TJ, Sekula BC, Litwack G. Schmidt TJ, et al. Endocrinology. 1981 Sep;109(3):803-12. doi: 10.1210/endo-109-3-803. Endocrinology. 1981. PMID: 7262022
Ferroin (1,10-phenanthroline-ferrous sulfate complex) and 1,7-phenanthroline (nonchelating isomer) also fail to inhibit DNA-cellulose binding. ...
Ferroin (1,10-phenanthroline-ferrous sulfate complex) and 1,7-phenanthroline (nonchelating isomer) also fail to inhibit …
Metal and pH dependence of heptapeptide catalysis by human matrilysin.
Cha J, Pedersen MV, Auld DS. Cha J, et al. Biochemistry. 1996 Dec 10;35(49):15831-8. doi: 10.1021/bi962085f. Biochemistry. 1996. PMID: 8961947
It hydrolyzes the fluorescent substrate Dns-PLALWAR at the Ala-Leu bond with a kcat of 3.1 s-1 and K(m) of 1.8 x 10(-5) M at pH 7.5, 37 degrees C, values closely similar to those for the matrilysin produced by activation of the Chinese hamster ovary and E. coli-expressed p …
It hydrolyzes the fluorescent substrate Dns-PLALWAR at the Ala-Leu bond with a kcat of 3.1 s-1 and K(m) of 1.8 x 10(-5) M at pH 7.5, 37 degr …
1,10-Phenanthroline increases nuclear accumulation of insulin in response to inhibiting insulin degradation but has a biphasic effect on insulin's ability to increase mRNA levels.
Harada S, Smith RM, Jarett L. Harada S, et al. DNA Cell Biol. 1994 May;13(5):487-93. doi: 10.1089/dna.1994.13.487. DNA Cell Biol. 1994. PMID: 8024692
The present study characterized the effects of 1,10-phenanthroline and its nonchelating isomer, 1,7-phenanthroline, on insulin degradation, nuclear accumulation, and stimulation of immediate-early gene expression. 1,10- but not 1,7-phenanthro
The present study characterized the effects of 1,10-phenanthroline and its nonchelating isomer, 1,7-phenanthroline, on …
Identification of the thyrotropin-releasing-hormone-degrading ectoenzyme as a metallopeptidase.
Czekay G, Bauer K. Czekay G, et al. Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):921-6. doi: 10.1042/bj2900921. Biochem J. 1993. PMID: 8096131 Free PMC article.
A time-dependent inhibition of the thyrotropin-releasing-hormone (TRH)-degrading ectoenzyme (EC 3.4.19.-) from rat brain by the metal-complexing agents imidazole, NaCN, EDTA and 1,10-phenanthroline could be demonstrated. In contrast, the inhibition by the non-chelating ana …
A time-dependent inhibition of the thyrotropin-releasing-hormone (TRH)-degrading ectoenzyme (EC 3.4.19.-) from rat brain by the metal …
The binding activity of estrogen receptor to DNA and heat shock protein (Mr 90,000) is dependent on receptor-bound metal.
Sabbah M, Redeuilh G, Secco C, Baulieu EE. Sabbah M, et al. J Biol Chem. 1987 Jun 25;262(18):8631-5. J Biol Chem. 1987. PMID: 3597390 Free article.
1,10-Phenanthroline inhibited the DNA-cellulose binding of the transformed calf uterus estrogen receptor (homodimer of 66-kDa molecules: 5 S estrogen receptor) in a temperature- and concentration-dependent manner. ...Only a slight inhibition was observed in t …
1,10-Phenanthroline inhibited the DNA-cellulose binding of the transformed calf uterus estrogen receptor (homodimer of 66-kDa …
The effects of PAHs and N-PAHs on retinoid signaling and Oct-4 expression in vitro.
Beníšek M, Kubincová P, Bláha L, Hilscherová K. Beníšek M, et al. Toxicol Lett. 2011 Feb 5;200(3):169-75. doi: 10.1016/j.toxlet.2010.11.011. Epub 2010 Nov 25. Toxicol Lett. 2011. PMID: 21111795
Two of the studied compounds, benz[a]anthracene and benz[c]acridine significantly up-regulated ATRA-mediated response in the co-exposure with a range of ATRA concentrations. Another structural N-PAH variant, 1,7-phenanthroline, downregulated ATRA-mediated res …
Two of the studied compounds, benz[a]anthracene and benz[c]acridine significantly up-regulated ATRA-mediated response in the co-exposure wit …
1,10-Phenanthroline inhibition of lymphoblast cell cycle.
Falchuk KH, Krishan A. Falchuk KH, et al. Cancer Res. 1977 Jul;37(7 Pt 1):2050-6. Cancer Res. 1977. PMID: 861934
Incubation of CCRF-CEM lymphoblasts with 1,7-phenanthroline, a nonchelating analog of OP, did not affect the cell cycle. The data indicate that OP reversibly blocks progression of cells from G1 to S and through S by chelation of metals involved in processes e …
Incubation of CCRF-CEM lymphoblasts with 1,7-phenanthroline, a nonchelating analog of OP, did not affect the cell cycle …
Involvement of a metalloprotease in spontaneous and phorbol ester-induced release of natural killer cell-associated Fc gamma RIII (CD16-II).
Harrison D, Phillips JH, Lanier LL. Harrison D, et al. J Immunol. 1991 Nov 15;147(10):3459-65. J Immunol. 1991. PMID: 1834741
In this study, we demonstrate that a metalloprotease is involved in the spontaneous and PMA-induced release of CD16-II from NK cells. 1,10-phenanthroline, an inhibitor of Zn(2+)-dependent metalloproteases, efficiently inhibits CD16-II release. 1,7-phenanthroline
In this study, we demonstrate that a metalloprotease is involved in the spontaneous and PMA-induced release of CD16-II from NK cells. 1,10-p …
Synthesis and in vitro antitumor activity of an isomer of the marine pyridoacridine alkaloid ascididemin and related compounds.
Delfourne E, Kiss R, Le Corre L, Merza J, Bastide J, Frydman A, Darro F. Delfourne E, et al. Bioorg Med Chem. 2003 Oct 1;11(20):4351-6. doi: 10.1016/s0968-0896(03)00483-8. Bioorg Med Chem. 2003. PMID: 13129571
The isomer (9H-quino[4,3,2-de][1,7]phenanthroline-9-one) (2) of the marine alkaloid ascididemin (9H-quino[4,3,2-de][1,10]phenanthroline-9-one) (1) has been synthesized in six steps from 1,4-dimethoxyacridine (10) with an overall yield of 12%. Different relate …
The isomer (9H-quino[4,3,2-de][1,7]phenanthroline-9-one) (2) of the marine alkaloid ascididemin (9H-quino[4,3,2-de][1,1 …
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