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237 results

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Page 1
6-(2-Hydroxybenzoyl)-5-(pyrrol-2-yl)-3H-pyrrolizine.
Dey SP, Dey DK, Mallik AK, Dahlenburg L. Dey SP, et al. Acta Crystallogr C. 2003 Jun;59(Pt 6):o321-2. doi: 10.1107/s0108270103008394. Epub 2003 May 20. Acta Crystallogr C. 2003. PMID: 12794351
The title compound, 2-hydroxyphenyl 5-(pyrrol-2-yl)-3H-pyrrolizin-6-yl ketone, C(18)H(14)N(2)O(2), was isolated from the base-catalyzed 1:2 condensation of 2-hydroxyacetophenone with pyrrole-2-carbaldehyde. The pyrrole N-H and hydroxybenzoyl O-H groups are hydrogen …
The title compound, 2-hydroxyphenyl 5-(pyrrol-2-yl)-3H-pyrrolizin-6-yl ketone, C(18)H(14)N(2)O(2), was isolated from the base-catalyzed 1:2 …
Multifunctional asymmetric catalysis.
Shibasaki M, Kanai M. Shibasaki M, et al. Chem Pharm Bull (Tokyo). 2001 May;49(5):511-24. doi: 10.1248/cpb.49.511. Chem Pharm Bull (Tokyo). 2001. PMID: 11383599 Free article. Review.
In the first part of this review, the first example of a catalytic enatioselective nitro-Mannich reaction as well as a direct catalytic enantioselective aldol reaction of 2-hydroxyacetophenone using bimetallic complexes is discussed. The new complex, composed of ytt …
In the first part of this review, the first example of a catalytic enatioselective nitro-Mannich reaction as well as a direct catalytic enan …
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Zhu G, Wang K, Shi J, Zhang P, Yang D, Fan X, Zhang Z, Liu W, Sang Z. Zhu G, et al. Bioorg Med Chem Lett. 2019 Oct 1;29(19):126625. doi: 10.1016/j.bmcl.2019.126625. Epub 2019 Aug 19. Bioorg Med Chem Lett. 2019. PMID: 31444085
A series of 2-acetylphenol-donepezil hybrids was designed and synthesized based on multi-target-directed ligands strategy. ...Therefore, the structure-active-relationship of 2-acetylphenol-donepezil hybrids could encourage the development of multifunct …
A series of 2-acetylphenol-donepezil hybrids was designed and synthesized based on multi-target-directed ligands strategy. ... …
2-Hydroxyacetophenone 4-phenylthiosemicarbazone.
Seena EB, Manoj E, Kurup MR. Seena EB, et al. Acta Crystallogr C. 2006 Aug;62(Pt 8):o486-8. doi: 10.1107/S0108270106014776. Epub 2006 Jul 22. Acta Crystallogr C. 2006. PMID: 16891727 No abstract available.
2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors.
Legoabe LJ, Petzer A, Petzer JP. Legoabe LJ, et al. Drug Des Devel Ther. 2015 Jul 15;9:3635-44. doi: 10.2147/DDDT.S86225. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 26203229 Free PMC article.
Analyses of the structure-activity relationships for MAO inhibition show that substitution on the C5 position of the 2-acetylphenol moiety is a requirement for MAO-B inhibition, and the benzyloxy substituent is particularly favorable in this regard. This study concl …
Analyses of the structure-activity relationships for MAO inhibition show that substitution on the C5 position of the 2-acetylpheno …
Direct O2 mediated oxidation of a Ni(II)N3O structural model complex for the active site of nickel acireductone dioxygenase (Ni-ARD): characterization, biomimetic reactivity, and enzymatic implications.
Kirsch KE, Little ME, Cundari TR, El-Shaer E, Barone G, Lynch VM, Toledo SA. Kirsch KE, et al. Dalton Trans. 2024 Nov 12;53(44):17852-17863. doi: 10.1039/d4dt02538e. Dalton Trans. 2024. PMID: 39421893
A new biomimetic model complex of the active site of acireductone dioxygenase (ARD) was synthesized and crystallographically characterized ([Ni(ii)(N-(ethyl-N'Me(2))(Py)(2-t-ButPhOH))(OTf)]-1). 1 displays carbon-carbon oxidative cleavage activity in the presence of O(2) towards t …
A new biomimetic model complex of the active site of acireductone dioxygenase (ARD) was synthesized and crystallographically characterized ( …
Efficient production of (S)-1-phenyl-1,2-ethanediol using xylan as co-substrate by a coupled multi-enzyme Escherichia coli system.
Rao J, Zhang R, Xu G, Li L, Xu Y. Rao J, et al. Microb Cell Fact. 2020 Apr 7;19(1):87. doi: 10.1186/s12934-020-01344-x. Microb Cell Fact. 2020. PMID: 32264866 Free PMC article.
(S)-carbonyl reductase II from Candida parapsilosis catalyzes the conversion of 2-hydroxyacetophenone to (S)-1-phenyl-1,2-ethanediol with NADPH as a cofactor. Glucose dehydrogenase with a Ala258Phe mutation is able to catalyze the oxidation of xylose with concomitan …
(S)-carbonyl reductase II from Candida parapsilosis catalyzes the conversion of 2-hydroxyacetophenone to (S)-1-phenyl-1,2-etha …
[Characterization of the affinity-tags-regulated (S)-carbonyl reductase 2 towards 2-hydroxyacetophenone reduction].
Li Y, Zhang R, Xu Y. Li Y, et al. Sheng Wu Gong Cheng Xue Bao. 2021 Dec 25;37(12):4277-4292. doi: 10.13345/j.cjb.210088. Sheng Wu Gong Cheng Xue Bao. 2021. PMID: 34984874 Free article. Chinese.
The (S)-carbonyl reductase 2 (SCR2) from Candida parapsilosis can reduce 2-hydroxyacetophenone, which is a valuable prochiral ketones. Different affinity tags, i.e. his-tag, strep-tag and MBP-tag, were attached to the N terminus of SCR2. These tagged SCR2 enzymes, i …
The (S)-carbonyl reductase 2 (SCR2) from Candida parapsilosis can reduce 2-hydroxyacetophenone, which is a valuable prochiral …
One-Pot Synthesis of Chromone-2-carboxylate Scaffold: An Important Pharmacophore with Diverse Biological Properties.
Tummanapalli S, Punna SK, Gulipalli KC, Endoori S, Bodige S, Pommidi AK, Medaboina S, Choppadandi S, Boya R, Ganapathi VK, Mamindla DY, Konakalla R, Bodala GK, Bakangari MR, Kottam SD, Jarikote D, Potewar T, Valluri M. Tummanapalli S, et al. J Org Chem. 2023 Jul 7;88(13):8387-8399. doi: 10.1021/acs.joc.3c00407. Epub 2023 Jun 26. J Org Chem. 2023. PMID: 37358465
The majority of the previously reported medicinal chemistry synthetic protocols primarily used only one procedure which follows a two-step strategy that needs to start with "2-hydroxyacetophenone". Our methodology not only serves as an alternative one-pot methodolog …
The majority of the previously reported medicinal chemistry synthetic protocols primarily used only one procedure which follows a two-step s …
237 results