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22 results

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Page 1
Neuroprotective compounds isolated from Cynanchum paniculatum.
Weon JB, Kim CY, Yang HJ, Ma CJ. Weon JB, et al. Arch Pharm Res. 2012 Mar;35(4):617-21. doi: 10.1007/s12272-012-0404-4. Epub 2012 May 3. Arch Pharm Res. 2012. PMID: 22553053
Ten compounds were isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa (Asclepiadaceae) and identified as paeonol (1), 4-acetylphenol (2), 2,5-dihydroxy-4-methoxyacetophenone (3), 2,3-dihydroxy-4-methoxyacetophenone (4), acetoveratrone (5), 2,5-dimet …
Ten compounds were isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa (Asclepiadaceae) and identified as paeo …
Isolation and characterization of a novel Rhodococcus strain with switchable carbonyl reductase and para-acetylphenol hydroxylase activities.
Zhang R, Ren J, Wang Y, Wu Q, Wang M, Zhu D. Zhang R, et al. J Ind Microbiol Biotechnol. 2013 Jan;40(1):11-20. doi: 10.1007/s10295-012-1199-5. Epub 2012 Sep 27. J Ind Microbiol Biotechnol. 2013. PMID: 23014895
This study identified for the first time a Rhodococcus strain with para-acetylphenol hydroxylase activity, which also contains highly enantioselective carbonyl reductase activity with potential applications for the asymmetric reduction of these less-explored but important ketones …
This study identified for the first time a Rhodococcus strain with para-acetylphenol hydroxylase activity, which also contains highly enanti …
Unveiling the atlas of associations between 1,400 plasma metabolites and 24 tumors: Mendelian randomization analyses.
Zhang J, Hao Z, Chen Z, Su X, Xu W, Jiang X, Nian X. Zhang J, et al. Transl Cancer Res. 2024 Sep 30;13(9):4938-4956. doi: 10.21037/tcr-24-359. Epub 2024 Sep 9. Transl Cancer Res. 2024. PMID: 39430859 Free PMC article.
RESULTS: In a combined sample of 291,202 cancer cases and 4,712,208 controls, a total of 55 plasma metabolites were identified as causally associated with nine types of cancer as a result of our MR analysis [P<0.05, false discovery rate (FDR) <0.2], including methionine sul …
RESULTS: In a combined sample of 291,202 cancer cases and 4,712,208 controls, a total of 55 plasma metabolites were identified as causally a …
Direct Asymmetric Reductive Amination for the Synthesis of (S)-Rivastigmine.
Gao G, Du S, Yang Y, Lei X, Huang H, Chang M. Gao G, et al. Molecules. 2018 Aug 31;23(9):2207. doi: 10.3390/molecules23092207. Molecules. 2018. PMID: 30200331 Free PMC article.
The route started with readily available and cheap m-hydroxyacetophenone, through esterification, asymmetric reductive amination, N-diphenylmethyl deprotection and reductive amination, to provide the final (S)-rivastigmine in 82% overall yield and 96% enantioselecti …
The route started with readily available and cheap m-hydroxyacetophenone, through esterification, asymmetric reductive aminati …
Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step.
Han K, Kim C, Park J, Kim MJ. Han K, et al. J Org Chem. 2010 May 7;75(9):3105-8. doi: 10.1021/jo9027374. J Org Chem. 2010. PMID: 20345141
Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yield....
Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yie …
Cyclized geranyl stilbenes from the rhizomes of Helminthostachys zeylanica.
Chen CC, Huang YL, Yeh PY, Ou JC. Chen CC, et al. Planta Med. 2003 Oct;69(10):964-7. doi: 10.1055/s-2003-45112. Planta Med. 2003. PMID: 14648406
Three new cyclized geranyl stilbenes, ugonstilbene A ( 1), ugonstilbene B ( 2), and ugonstilbene C ( 3), and one known compound 3-hydroxyacetophenone, were isolated from the dried rhizomes of H. zeylanica. The structures of these three new compounds were elucidated …
Three new cyclized geranyl stilbenes, ugonstilbene A ( 1), ugonstilbene B ( 2), and ugonstilbene C ( 3), and one known compound 3- …
Pretreatment of 3-hydroxyacetophenone in pharmaceutical wastewater using combined salting-out crystallization+ Fenton system and subsequent impact analysis of effluent water.
Nong G, Huang W, Meng L, Gao Y, Tian C, Zhang X, Lu L. Nong G, et al. Environ Technol. 2024 Nov;45(25):5259-5275. doi: 10.1080/09593330.2023.2287025. Epub 2023 Dec 7. Environ Technol. 2024. PMID: 38009063
In this study, pharmaceutical wastewater consisting of 45 g/L sodium bisulfate, 9 g/L 3-hydroxyacetophenone (3-HAP), and 36.75 g/L sulfuric acids,which is a kind of typical pharmaceutical wastewater, was used for the pretreatment case study, and the process was scre …
In this study, pharmaceutical wastewater consisting of 45 g/L sodium bisulfate, 9 g/L 3-hydroxyacetophenone (3-HAP), and 36.75 …
A Suspect Screening Method for Characterizing Multiple Chemical Exposures among a Demographically Diverse Population of Pregnant Women in San Francisco.
Wang A, Gerona RR, Schwartz JM, Lin T, Sirota M, Morello-Frosch R, Woodruff TJ. Wang A, et al. Environ Health Perspect. 2018 Jul 24;126(7):077009. doi: 10.1289/EHP2920. eCollection 2018 Jul. Environ Health Perspect. 2018. PMID: 30044231 Free PMC article.
We found demographic differences in DF for 13 suspect EOAs and confirmed the presence of 6 priority novel chemicals: 2,4-Di-tert-butylphenol, Pyrocatechol, 2,4-Dinitrophenol, 3,5-Di-tert-butylsalicylic acid, 4-Hydroxycoumarin, and 2'-Hydroxyacetophenone (or 3'-Hydroxyac …
We found demographic differences in DF for 13 suspect EOAs and confirmed the presence of 6 priority novel chemicals: 2,4-Di-tert-butylphenol …
Identification of potential biomarkers and pathways involved in high-altitude pulmonary edema using GC-MS and LC-MS metabolomic methods.
Si Y, Huang H, Pan J, Luo X, Zhang J, Guo Y, Liu D. Si Y, et al. Sci Rep. 2024 Dec 28;14(1):30978. doi: 10.1038/s41598-024-82047-w. Sci Rep. 2024. PMID: 39730680 Free PMC article.
Finally, 7 biomarkers, specifically S-nitroso-N-acetylcysteine, aminocaproic acid, emodin, threo-hydroxyaspartic acid, 6-hydroxynicotinic acid, 3-acetylphenol sulfate and cis-aconitic acid, were screened out through ROC analysis, which displayed high diagnostic accu …
Finally, 7 biomarkers, specifically S-nitroso-N-acetylcysteine, aminocaproic acid, emodin, threo-hydroxyaspartic acid, 6-hydroxynicotinic ac …
22 results