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Page 1
Neuroprotective compounds isolated from Cynanchum paniculatum.
Weon JB, Kim CY, Yang HJ, Ma CJ. Weon JB, et al. Arch Pharm Res. 2012 Mar;35(4):617-21. doi: 10.1007/s12272-012-0404-4. Epub 2012 May 3. Arch Pharm Res. 2012. PMID: 22553053
Ten compounds were isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa (Asclepiadaceae) and identified as paeonol (1), 4-acetylphenol (2), 2,5-dihydroxy-4-methoxyacetophenone (3), 2,3-dihydroxy-4-methoxyacetophenone (4), acetoveratrone (5), 2,5-dimet …
Ten compounds were isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa (Asclepiadaceae) and identified as paeo …
Isolation and characterization of a novel Rhodococcus strain with switchable carbonyl reductase and para-acetylphenol hydroxylase activities.
Zhang R, Ren J, Wang Y, Wu Q, Wang M, Zhu D. Zhang R, et al. J Ind Microbiol Biotechnol. 2013 Jan;40(1):11-20. doi: 10.1007/s10295-012-1199-5. Epub 2012 Sep 27. J Ind Microbiol Biotechnol. 2013. PMID: 23014895
This study identified for the first time a Rhodococcus strain with para-acetylphenol hydroxylase activity, which also contains highly enantioselective carbonyl reductase activity with potential applications for the asymmetric reduction of these less-explored but important ketones …
This study identified for the first time a Rhodococcus strain with para-acetylphenol hydroxylase activity, which also contains highly enanti …
Studies on some iridium(III) complexes with Schiff bases derived from amino carboxylic acids.
Sharma VK, Pandey OP, Sengupta SK. Sharma VK, et al. J Inorg Biochem. 1988 Dec;34(4):253-63. doi: 10.1016/0162-0134(88)83003-4. J Inorg Biochem. 1988. PMID: 3267018
The reactions of iridium(III) chloride with different Schiff bases gave complexes of types [Ir(SB)3], [Ir(SB')Cl(H2O)2], [Ir(SB'')Cl2]n, [Ir(SB'' ')Cl(H2O)]n (SBH = Schiff bases derived from anthranilic acid and benzaldehyde, acetophenone, vanillin, cinnamaldehyde or m- …
The reactions of iridium(III) chloride with different Schiff bases gave complexes of types [Ir(SB)3], [Ir(SB')Cl(H2O)2], [Ir(SB'')Cl2]n, [Ir …
Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step.
Han K, Kim C, Park J, Kim MJ. Han K, et al. J Org Chem. 2010 May 7;75(9):3105-8. doi: 10.1021/jo9027374. J Org Chem. 2010. PMID: 20345141
Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yield....
Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yie …
Direct Asymmetric Reductive Amination for the Synthesis of (S)-Rivastigmine.
Gao G, Du S, Yang Y, Lei X, Huang H, Chang M. Gao G, et al. Molecules. 2018 Aug 31;23(9):2207. doi: 10.3390/molecules23092207. Molecules. 2018. PMID: 30200331 Free PMC article.
The route started with readily available and cheap m-hydroxyacetophenone, through esterification, asymmetric reductive amination, N-diphenylmethyl deprotection and reductive amination, to provide the final (S)-rivastigmine in 82% overall yield and 96% enantioselecti …
The route started with readily available and cheap m-hydroxyacetophenone, through esterification, asymmetric reductive aminati …
Cyclized geranyl stilbenes from the rhizomes of Helminthostachys zeylanica.
Chen CC, Huang YL, Yeh PY, Ou JC. Chen CC, et al. Planta Med. 2003 Oct;69(10):964-7. doi: 10.1055/s-2003-45112. Planta Med. 2003. PMID: 14648406
Three new cyclized geranyl stilbenes, ugonstilbene A ( 1), ugonstilbene B ( 2), and ugonstilbene C ( 3), and one known compound 3-hydroxyacetophenone, were isolated from the dried rhizomes of H. zeylanica. The structures of these three new compounds were elucidated …
Three new cyclized geranyl stilbenes, ugonstilbene A ( 1), ugonstilbene B ( 2), and ugonstilbene C ( 3), and one known compound 3- …
Unveiling the atlas of associations between 1,400 plasma metabolites and 24 tumors: Mendelian randomization analyses.
Zhang J, Hao Z, Chen Z, Su X, Xu W, Jiang X, Nian X. Zhang J, et al. Transl Cancer Res. 2024 Sep 30;13(9):4938-4956. doi: 10.21037/tcr-24-359. Epub 2024 Sep 9. Transl Cancer Res. 2024. PMID: 39430859 Free PMC article.
RESULTS: In a combined sample of 291,202 cancer cases and 4,712,208 controls, a total of 55 plasma metabolites were identified as causally associated with nine types of cancer as a result of our MR analysis [P<0.05, false discovery rate (FDR) <0.2], including methionine sul …
RESULTS: In a combined sample of 291,202 cancer cases and 4,712,208 controls, a total of 55 plasma metabolites were identified as causally a …
Synthesis of 4-acetylbenzoxazolin-2(3H)-one reported from zea mays.
Kluge M, Sicker D. Kluge M, et al. J Nat Prod. 1998 Jun 26;61(6):821-2. doi: 10.1021/np970525d. J Nat Prod. 1998. PMID: 9644075
A three-step alternative synthesis of 4-acetylbenzoxazolin-2(3H)-one (4) is reported. Starting from inexpensive 3-hydroxyacetophenone (1) 3-hydroxy-2-nitroacetophenone (2) is prepared by nitration followed by catalytic hydrogenation to yield 2-amino-3-hydr
A three-step alternative synthesis of 4-acetylbenzoxazolin-2(3H)-one (4) is reported. Starting from inexpensive 3-hydroxyacetophen
Pretreatment of 3-hydroxyacetophenone in pharmaceutical wastewater using combined salting-out crystallization+ Fenton system and subsequent impact analysis of effluent water.
Nong G, Huang W, Meng L, Gao Y, Tian C, Zhang X, Lu L. Nong G, et al. Environ Technol. 2024 Nov;45(25):5259-5275. doi: 10.1080/09593330.2023.2287025. Epub 2023 Dec 7. Environ Technol. 2024. PMID: 38009063
In this study, pharmaceutical wastewater consisting of 45 g/L sodium bisulfate, 9 g/L 3-hydroxyacetophenone (3-HAP), and 36.75 g/L sulfuric acids,which is a kind of typical pharmaceutical wastewater, was used for the pretreatment case study, and the process was scre …
In this study, pharmaceutical wastewater consisting of 45 g/L sodium bisulfate, 9 g/L 3-hydroxyacetophenone (3-HAP), and 36.75 …
21 results