Novel alpha6 preferring GABA-A receptor ligands based on loreclezole.
Simeone X, Ernst M, Seidel T, Heider J, Enz D, Monticelli S, Vogel FD, Koniuszewski F, Langer T, Scholze P, Pace V, Miele M.
Simeone X, et al.
Eur J Med Chem. 2022 Dec 15;244:114780. doi: 10.1016/j.ejmech.2022.114780. Epub 2022 Sep 17.
Eur J Med Chem. 2022.
PMID: 36279694
This new loreclezole derivative, [3-(2-chloro-4-methylphenyl)-3-methylbutanenitrile (40)], was shown to display stronger modulatory action in concatenated alpha6beta3gamma2 receptors compared to their alpha1beta3gamma2 counterpart. ...
This new loreclezole derivative, [3-(2-chloro-4-methylphenyl)-3-methylbutanenitrile (40)], was shown to display stronger modul …