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1998 3
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368 results

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Page 1
ImPyβImPyβImβ-C3-18F.
Zhang H. Zhang H. 2008 Nov 4 [updated 2008 Dec 1]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2008 Nov 4 [updated 2008 Dec 1]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641251 Free Books & Documents. Review.
Polyamides (PAM) constructed from N-methylpyrrole (Py), N-methylimidazole (Im), 3-chlorothiophene (Ct), and N-methylhydroxypyrrole (Hp) amino acids comprise a class of synthetic oligomeric ligands that bind to the minor groove of DNA (1, 2). ...
Polyamides (PAM) constructed from N-methylpyrrole (Py), N-methylimidazole (Im), 3-chlorothiophene (Ct), and N-methylhydroxypyr …
CtPyPyIm-(R)H2Nγ-PyImPyPy-C3-18F.
Zhang H. Zhang H. 2008 Nov 4 [updated 2008 Dec 1]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2008 Nov 4 [updated 2008 Dec 1]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641478 Free Books & Documents. Review.
Polyamides (PAM) constructed from N-methylpyrrole (Py), N-methylimidazole (Im), 3-chlorothiophene (Ct), and N-methylhydroxypyrrole (Hp) amino acids comprise a class of synthetic oligomeric ligands that bind to the minor groove of DNA (1, 2). ...
Polyamides (PAM) constructed from N-methylpyrrole (Py), N-methylimidazole (Im), 3-chlorothiophene (Ct), and N-methylhydroxypyr …
Biology of N-methylpyrrole-N-methylimidazole hairpin polyamide.
Murty MS, Sugiyama H. Murty MS, et al. Biol Pharm Bull. 2004 Apr;27(4):468-74. doi: 10.1248/bpb.27.468. Biol Pharm Bull. 2004. PMID: 15056849 Free article. Review.
When covalently linked, hairpin polyamides made up of N-methylpyrrole (Py) and N-methylimidazole (Im) can bind to DNA in a sequence-specific manner. ...
When covalently linked, hairpin polyamides made up of N-methylpyrrole (Py) and N-methylimidazole (Im) can bind to DNA in a seq …
11-Methyl-2,3-benzodipyrrin-1-one.
Bonnett R, Motevalli M, Swanson FJ, Vallés MA. Bonnett R, et al. Acta Crystallogr C. 2004 Dec;60(Pt 12):o890-2. doi: 10.1107/S0108270104026708. Epub 2004 Nov 23. Acta Crystallogr C. 2004. PMID: 15579975
The title compound {alternative names: 11-methyl-2,3-benzopyrromethenone and 3-[(1-methylpyrrol-2-yl)methylidene]-2,3-dihydro-1H-isoindol-1-one}, C(14)H(12)N(2)O, was prepared by the base-catalysed condensation of phthalimidine with 2-formyl-1-methylpyrrole; yellow …
The title compound {alternative names: 11-methyl-2,3-benzopyrromethenone and 3-[(1-methylpyrrol-2-yl)methylidene]-2,3-dihydro-1H-isoindol-1- …
Carbocyclic Analogues of Distamycin and Netropsin.
Arciszewska K, Pućkowska A, Wróbel A, Drozdowska D. Arciszewska K, et al. Mini Rev Med Chem. 2019;19(2):98-113. doi: 10.2174/1389557518666181009143203. Mini Rev Med Chem. 2019. PMID: 30626311 Review.
The discovery of the details of minor groove binding drugs, such as netropsin and distamycin A, oligoamides built of 4-amino-1-methylpyrrole-2-carboxylic acid residues, allowed to develop various DNA sequence-reading molecules, named lexitropsins, capable of interac …
The discovery of the details of minor groove binding drugs, such as netropsin and distamycin A, oligoamides built of 4-amino-1-met …
Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates.
Belitsky JM, Leslie SJ, Arora PS, Beerman TA, Dervan PB. Belitsky JM, et al. Bioorg Med Chem. 2002 Oct;10(10):3313-8. doi: 10.1016/s0968-0896(02)00204-3. Bioorg Med Chem. 2002. PMID: 12150878
The cellular uptake and localization properties of DNA binding N-methylpyrrole/N-methylimidazole polyamide-dye conjugates in a variety of living cells have been examined by confocal laser scanning microscopy. ...
The cellular uptake and localization properties of DNA binding N-methylpyrrole/N-methylimidazole polyamide-dye conjugat …
Assessing Carbazole Derivatives as Single-Electron Photoreductants.
Weinhold TD, Reece NA, Ribeiro K, Lopez Ocasio M, Watson N, Hanson K, Longstreet AR. Weinhold TD, et al. J Org Chem. 2022 Dec 16;87(24):16928-16936. doi: 10.1021/acs.joc.2c02312. Epub 2022 Dec 6. J Org Chem. 2022. PMID: 36472491
Herein, eight carbazole derivatives were synthesized, characterized, and assessed as single-electron photoreductants in the hydrodehalogenation of aryl halides and the arylation of N-methylpyrrole....
Herein, eight carbazole derivatives were synthesized, characterized, and assessed as single-electron photoreductants in the hydrodehalogenat …
Targeting the minor groove of DNA.
Wemmer DE, Dervan PB. Wemmer DE, et al. Curr Opin Struct Biol. 1997 Jun;7(3):355-61. doi: 10.1016/s0959-440x(97)80051-6. Curr Opin Struct Biol. 1997. PMID: 9204277 Review.
Pairing rules have been developed to control rationally the sequence specificity of minor groove binding polyamides containing N-methylimidazole and N-methylpyrrole amino acids. Using simple molecular shapes and a two-letter aromatic amino acid code, pyrrole-imidazo …
Pairing rules have been developed to control rationally the sequence specificity of minor groove binding polyamides containing N-methylimida …
The Road Not Taken with Pyrrole-Imidazole Polyamides: Off-Target Effects and Genomic Binding.
Lin J, Nagase H. Lin J, et al. Biomolecules. 2020 Apr 3;10(4):544. doi: 10.3390/biom10040544. Biomolecules. 2020. PMID: 32260120 Free PMC article. Review.
The high sequence specificity of minor groove-binding N-methylpyrrole-N-methylimidazole polyamides have made significant advances in cancer and disease biology, yet there have been few comprehensive reports on their off-target effects, most likely as a conseq …
The high sequence specificity of minor groove-binding N-methylpyrrole-N-methylimidazole polyamides have made significan …
368 results