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Page 1
The effect of 2-(4-methyl-1-piperazinylmethyl) acrylophenone dihydrochloride on the alkylation of tubulin.
Luduena RF, Roach MC, Trcka PP, Mallevais ML, MacRae T. Luduena RF, et al. Arch Biochem Biophys. 1987 Jun;255(2):453-9. doi: 10.1016/0003-9861(87)90414-0. Arch Biochem Biophys. 1987. PMID: 3592685
2-(4-Methyl-1-piperazinylmethyl) acrylophenone dihydrochloride (MPMAP) is a novel inhibitor of microtubule assembly in vitro and in vivo whose molecular mechanism of action has not been investigated (M. ...
2-(4-Methyl-1-piperazinylmethyl) acrylophenone dihydrochloride (MPMAP) is a novel inhibitor of microtubule assembly in vitro and in v …
Expanding the Scope of Alkynes in C-H Activation: Weak Chelation-Assisted Cobalt-Catalyzed Synthesis of Indole C(4)-Acrylophenone via C-O Bond Cleavage of Propargylic Ethers.
Mahulkar PS, Joshi S, Banjare SK, Najiar LO, Ravikumar PC. Mahulkar PS, et al. Org Lett. 2024 Mar 15;26(10):2091-2096. doi: 10.1021/acs.orglett.4c00389. Epub 2024 Mar 5. Org Lett. 2024. PMID: 38441887
Herein, we report the facile synthesis of indole C(4)-acrylophenone using a C-H bond activation strategy. For this conversion, an unsymmetrical alkyne (phenylethynyl ether) in the presence of cobalt(III)-catalyst works efficiently. ...In addition, the applicability of obta …
Herein, we report the facile synthesis of indole C(4)-acrylophenone using a C-H bond activation strategy. For this conversion, an uns …
Amide derivatives of 2,3-diarylacrylophenone as estrogen receptor binding ligands.
Gupta A, Raghunandan R, Kumar A, Maulik PR, Dwivedy A, Keshri G, Singh MM, Ray S. Gupta A, et al. Med Chem. 2007 May;3(3):241-53. doi: 10.2174/157340607780620716. Med Chem. 2007. PMID: 17504195
In order to throw light on their SAR, In silico docking of the acrylophenone derivatives in the ligand binding site of the ERalpha and their comparison with pure steroidal estrogen antagonist ICI-164,384 and the non-steroidal antiestrogen raloxifene, was carried out. ...
In order to throw light on their SAR, In silico docking of the acrylophenone derivatives in the ligand binding site of the ERalpha an …
Inhibition of epidermal growth factor-mediated ERK1/2 activation by in situ electroporation of nonpermeant [(alkylamino)methyl]acrylophenone derivatives.
Brownell HL, Lydon NB, Schaefer E, Roberts TM, Raptis L. Brownell HL, et al. DNA Cell Biol. 1998 Mar;17(3):265-74. doi: 10.1089/dna.1998.17.265. DNA Cell Biol. 1998. PMID: 9539106
Two nonpermeant [(alkylamino)methyl]acrylophenone derivatives, [(dimethylamino)methyl] acrylo-para-[(benzoylsulfonyl)-oxy]phenone and [(dimethylamino)-methyl]acrylo-para-[(hydroxy-benzoylsulfonyl++ +)-oxy]phenone, were introduced by in situ electroporation into mouse or ra …
Two nonpermeant [(alkylamino)methyl]acrylophenone derivatives, [(dimethylamino)methyl] acrylo-para-[(benzoylsulfonyl)-oxy]phenone and …
2-(4-methyl-1-piperazinylmethyl) acrylophenone dihydrochloride: a new antimicrotubular drug.
Mallevais ML, Delacourte A, Lesieur I, Lesieur D, Cazin M, Brunet C, Luyckx M. Mallevais ML, et al. Biochimie. 1984 Jun;66(6):477-82. doi: 10.1016/0300-9084(84)90083-x. Biochimie. 1984. PMID: 6498230
One of them, 2-(4-methyl-1-piperazinylmethyl) acrylophenone, MPMAP, possesses antimicrotubular activities. This product inhibits 50% of the microtubule polymerization at a 3.10(-5) M concentration. ...
One of them, 2-(4-methyl-1-piperazinylmethyl) acrylophenone, MPMAP, possesses antimicrotubular activities. This product inhibits 50% …
Low-density lipoprotein for delivery of an acrylophenone antineoplastic molecule into malignant cells.
Lestavel-Delattre S, Martin-Nizard F, Clavey V, Testard P, Favre G, Doualin G, Houssaini HS, Bard JM, Duriez P, Delbart C, et al. Lestavel-Delattre S, et al. Cancer Res. 1992 Jul 1;52(13):3629-35. Cancer Res. 1992. PMID: 1617635
In order to achieve a selective delivery of these drugs via the LDL pathway, we have incorporated an AMA drug, 2-morpholinomethyl-2',3',4'- trimethoxy acrylophenone hydrochloride (ILE) into LDL particles. ILE spontaneously associated with LDL to produce an LDL-ILE complex …
In order to achieve a selective delivery of these drugs via the LDL pathway, we have incorporated an AMA drug, 2-morpholinomethyl-2',3',4'- …
Chemical and pharmacological studies of 2-(amino-methyl)acrylophenones.
Lesieur I, Lesieur D, Lespagnol C, Cazin M, Brunet C, Luyckx M, Mallevais ML, Delacourte A, Dubreuil L, Devos J, et al. Lesieur I, et al. Arzneimittelforschung. 1986;36(1):20-4. Arzneimittelforschung. 1986. PMID: 3954819
The structure-activity relationships of nine products of the acrylophenone family have been studied. In a previous report 2-(4-methyl-1-piperazinylmethyl)acrylophenone was shown to be an antimicrotubular drug. ...
The structure-activity relationships of nine products of the acrylophenone family have been studied. In a previous report 2-(4-methyl …
AgBF4-impregnated poly(vinyl phenyl ketone): an ethylene sensing film.
Green O, Smith NA, Ellis AB, Burstyn JN. Green O, et al. J Am Chem Soc. 2004 May 19;126(19):5952-3. doi: 10.1021/ja039203o. J Am Chem Soc. 2004. PMID: 15137745
Incorporation of silver tetrafluoroborate (AgBF4) into poly(vinyl phenyl ketone) (PVPK) renders the photoluminescent polymer responsive to ethylene. ...
Incorporation of silver tetrafluoroborate (AgBF4) into poly(vinyl phenyl ketone) (PVPK) renders the photoluminescent po …
32 results