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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 1
1997 52
1998 101
1999 92
2000 110
2001 96
2002 77
2003 87
2004 92
2005 77
2006 83
2007 63
2008 63
2009 63
2010 63
2011 61
2012 50
2013 49
2014 37
2015 27
2016 23
2017 24
2018 27
2019 6
2020 0
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Page 1
Contributions of nitric oxide and prostanoids and their signaling pathways to the renal medullary vasodilator effect of U46619 (9-11-dideoxy-11 alpha,9a-epoxymethano-prostaglandin F(2a)) in the rat.
Oyekan AO. J Pharmacol Exp Ther 2003. PMID 12538801
We recently demonstrated that U46619 (9-11-dideoxy-11 alpha,9a-epoxymethano-prostaglandin F(2a)) evoked a medullary vasodilation and a reduction in blood pressure despite a potent cortical vasoconstriction in the anesthetized rat. ...N(omega)-L-Nitro-arginine methyl ester (5 mg/kg), the inhibitor of NO production, attenuated the increase in MBF (75 +/- 8%, p < 0.05) as did indomethacin (10 mg/kg), the inhibitor of cyclooxygenase (38 +/- 5%, p < 0.05), suggesting the involvement of NO and dilator prostanoids. ...
We recently demonstrated that U46619 (9-11-dideoxy-11 alpha,9a-epoxymethano-prostaglandin F(2a)) evoked a …
Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.
Giménez-Bastida JA, et al. FASEB J 2019. PMID 30096040 Free PMC article.
Acetylation of Ser530 inhibits catalysis by preventing access of arachidonic acid substrate in the COX-1 isoenzyme. Acetylated COX-2, in contrast, gains a new catalytic activity and forms 15 R hydroxy-eicosatetraenoic acid (15 R-HETE) as alternate product. ...We conclude that acetylation of Ser530 in COX-2 not only triggers formation of 15 R-HETE but also allows oxygenation and cyclization of arachidonic acid to a 15 R-PG endoperoxide. 15 R-PGs are novel products of aspirin therapy via acetylation of COX-2 and may contribute to its antiplatelet and other pharmacologic effects....
Acetylation of Ser530 inhibits catalysis by preventing access of arachidonic acid substrate in the COX-1 isoenzyme. Acetylated COX-2, …
Two novel, putative mechanisms of action for citalopram-induced platelet inhibition
Roweth HG, et al. Sci Rep 2018. PMID 30420683 Free PMC article.
We have previously shown that this action is independent of citalopram's ability to block serotonin uptake by the serotonin transporter and must therefore be mediated via distinct pharmacological mechanisms. ...
We have previously shown that this action is independent of citalopram's ability to block serotonin uptake by the serotonin transporter and …
Resolvin E1, resolvin D1 and resolvin D2 inhibit constriction of rat thoracic aorta and human pulmonary artery induced by the thromboxane mimetic U46619
Jannaway M, et al. Br J Pharmacol 2018. PMID 29352769 Free PMC article.
BACKGROUND AND PURPOSE: The ω-6 fatty acid-derived lipid mediators such as prostanoids, thromboxane and leukotrienes have well-established roles in regulating both inflammation and smooth muscle contractility. ...
BACKGROUND AND PURPOSE: The ω-6 fatty acid-derived lipid mediators such as prostanoids, thromboxane and leukotrienes have well-establ …
Adaptation to acute pulmonary hypertension in pigs
Mechelinck M, et al. Physiol Rep 2018. PMID 29512293 Free PMC article.
., 56:449-58) 10 animals showed stable arterial blood pressures, whereas 12 pigs exhibited a significant drop of 16.4 ± 9.9 mmHg. ...
., 56:449-58) 10 animals showed stable arterial blood pressures, whereas 12 pigs exhibited a significant drop of 16.4 ± 9.9 mm …
Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity
Cao J, et al. Eur J Pharmacol 2004. PMID 14757156
For this purpose, the effects of TP receptor agonists and antagonists were investigated by a contraction study and by a binding study. 9,11-Dideoxy-9 alpha, 11 alpha-methanoepoxy-prosta-5Z,13E-dien-1-oic acid (U46619, 1 nM-10 microM), a stable thromboxane A(2) mimetic, caused tetrodotoxin-resistant contraction in both longitudinal and circular muscles of the uterine cornu. ...The ranking order of competition by TP receptor agonists and antagonists (with pK(i) values in parentheses) was [1S-[1,2(Z),3(1E,3S*),4]]-7-[3-[3-Hydroxy-4-(4-iodophenoxy)-1-butenyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid (I-BOP, 7.70)>SQ29548 (7.39)>7-[3-(3-Hydroxy-1-octenyl)bicycle[3.1.1]hept-2-yl]-,[2S-[2 alpha(Z),3 beta(1E,3R*)]]-5-heptenoic acid (CTA(2), 6.55)>7-[3-(3-hydroxy-1-octenyl)-6,6-dimethylbicyclo[3.1.1]hept-2-yl-,[1S-[1 alpha,2 beta(Z),3 alpha(1E,3R*),5 alpha]]-5-heptenoic acid (PTA(2), 6.50)>U46619 (6.41)>7-[5-(3-hydroxy-1-octenyl)-2-oxabicyclo[2.2.1] hept-6yl]-,[1S-[1 alpha,4 alpha,5 alpha(1E,3R*),6 beta(Z)]]-5-heptenoic acid (U44069, 6.34), and this order is consistent with current TP receptors. ...
For this purpose, the effects of TP receptor agonists and antagonists were investigated by a contraction study and by a binding study. 9
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